Calcineurin Inhibitors (Tacrolimus and Cyclosporine) IL2 - Mechanism of action, adverse effects 

Highly appreciate those like you who do not subject people to a 20 second intro for a serious study topic

Filling some of the gap of sketchy pharm. Nice!

I have watched your videos for the past 10 years. I just realised that I have not clicked the subscribe button 😅😅😅 sorry, the progress is amazing. It almost feels like seeing someone grow.

Mechanism of action of calcineurin inhibitors is suppressing synthesis of pro-inflammatory cytokines. In the cytoplasm of the target cells, pimecrolimus and tacrolimus bind to the intracellular protein macrophilin-12, also called FKBP (FK506-binding protein). Similarly, cyclosporine A binds to cyclophilin.👍

Bro you can see the matrix...this channel is insanely great....

We should also know the mnemonic: Hot T Bone stEAk Hot (fever) = IL-1 T cell simulator = IL-2 Bone marrow stimulator (sim to GM-CSF) = IL-3 IgE = IL-4 and IgA = IL-5 Thanks for the short and very informative video. I have just subscribed. Btw, please share with me what apps or softwares that you use to draw, to make your videos? Thanks!

Hello Armando, I came here because I wanted to comment in a recent video, so it’s more probable, that you will read it. I needed to understand how do interact Calcium levels, vitamin D and PTH, so I went to your video, which explains it. I have multiple sclerosis and I’m following a therapy called Coimbra Protocol, which is based in a few pillars: - Ultra high Dosis of vitamin D3 (50.000 units in my case to set my immune system back to “default”) - Very low calcium diet (to avoid to much calcium to filter) - More than 2,5 L of liquids per day (to avoid high concentration in Urine) - Regular sport (to build bone tissue up) - Avoid stress and unhealthy food My question is, *why, when a low level of Calcium in blood stimulates the production, did my PTH level increased from 21 pg/ml to 31?* The second time I checked this value, it only increased from 19,5 to 21 in the same time frame. I ate a bit more calcium-rich food in this time, so my body should have absorbed way more calcium. I just don’t get it A video about the coimbra protocol, how it works and what are its dangers, would be really nice. I can provide you with sources of information, if you want ;) I also would share it, with MS-Groups of Facebook, because it would be reeeeeally interesting to see how it works internally.

thank you for your very simple explaination

Awesome! Very clear and easy explanation.

Very informative😊

Thank you so much for the video,Found very useful for my Pharmacy study..

thank u for this video

Thanks , you're awesome♥️

Wow ,! Its fun way to learn . Thank you sir

thank you

Well explained

0:10 upto 1:44

Thanks you so much

Amazing. Do you have a video on mycophenolate, azathioprine, and other immunosuppressants?

Wowwwwwwwie😍. Thankyou sir!

Amazing video, Thank you

Wow , amazing

life-saving video

Amazing 👏🏻

Super!!!

Plz upload physics and chemistry lecture

sir please make the full digation video

Keep it up ❤❤❤

Thank you for accepting the request on posting a videos on immunosuppressants, even if you haven't read my previous comment..still thanks😇❤

Best

What's your effect or tools to make this video plz 😍😍😍

Genial

Millions subs ..still less likes

🌹🌹

👏👏

Can you also make a video about Tuberculosis please? The pathophysiology is very complex and difficult to understand by reading alone

Sir , I am teaching in Jr. College so need to take online classes coz of this pandemic. Can you plz tell me what have you used here to get such screen.? Is it a App? Of Device ? My issue is we don't get clearly when i stand in front of board and teach. So this way of yours is best . Can you guide plz

I looked up this video just to find out how to pronounce tacrolimus