Pharmacokinetics and Pharmacodynamics 

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Hi, I finished my step 1 on July 30 and got 238. I am so happy. Thanks to you atleast i got 10 or more than 10 questions correct only because of dirty medicine videos. Thank you so much 🙏🏻🙏🏻

I hated this subject so much while in school. The way you’re breaking this dry material down is amazingly good Thank you!

Mnemonic for drugs that follow 0 order kinetics: Zero WATT Power. Zero: 0 order kinetics W: warfarin A: alcohol T: Tolbutamide T: Theophylline Power: Phenytoin

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One unstated fact that needs to be made clear: Reaching "steady state" requires *repeated* constant doses of the drug being taken, not a mere single dose followed by a number of half-lives. Taking a drug once will result in elimination until it's all gone from the body, never reaching "steady state". Another subtopic worthy of attention is the affect of an initial *"loading dose"* (typically a double dose) on kinetics and attainment of steady state at a serum level that is still determined based on the subsequent regular dose -- *not* based on the loading dose. Naproxen is a familiar nonprescription drug that has label directions that allow for an initial *double* (loading) dose followed by the normal dose at regular intervals of 12 hours.

So Clearly explained. Keep up the good work. Thank you

This was the most instructive insightful easily understandable video on Pharmacokinetics I have ever encountered on video and in Pharmacy school!!!!

What a Wonderful summery. Thanx big, bless u

Ive seen a question solely testing on this same principle that the first part of the elimination graph for 1st order kinetics Is not the elimination but the redistribution itself! Amazing work as usual Dirty !!

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Awesome presentation. Thank u

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Great video. Thank you very much

wonderful stuff keep going, I now know everything about steady state and pharmacokinetics

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Thank you! Can you please make a video on diuretics?

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Please please dirty make one video on renal pharmacology. I wasn't listening to u before. But i just started with one and it went on. Now i really really feel something missing when doing renal pharmacology. Please make one!

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Tysm!

Good lecture overall. Though probably not pertinent to USMLE questions, I would point out though that 1/2 life is NOT the time for which 1/2 the amount of drug is eliminated from the body, but the time needed to cut the the plasma concentration of a drug in half (and those measurements are not the same nor the same amount of time required necessarily ).... A clinically relevant clarification, though, again, maybe not important for USMLE purposes. I am a physician/pharmacist.

Amazing lecture!

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11:03... thank you kind sir

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Are those equations about Loading Dose and Maintenance Dose High-Yield for the Step 1 or not that much?

Powerful

Does this apply to vaccines?

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HI this is very useful and informative video ,but what about pharmacodynamics ,do we need to subscribe first to get the rest of the video?

Where can i find a video of Henderson-Hasselbalch equation?

Hey dirty please make video on pprf lesion

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commenting down here for the algorithm

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Aspirin phenytoin and …? Zero order ! Answer

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1 day too late

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