Pathophys: tumors → secrete serotonin/histamine/kallikrein → broken down / excreted as 5-hydroxyindoleacetic acid (5-HIAA) in the urine
Usual location is gut: vasoactive substances usually metab in liver
Only get symptoms if liver mets, cirrhosis, or tumor outside gut
Signs / symptoms:
Flushing; Diarrhea
Wheezing / bronchospasm
Right-sided cardiac abnormalities (fibrous deposits on valves or myocardium)
Lung metabolism of serotonin prevents left-sided involvement
Wide swings in blood pressure
Cardiac arrhythmias
Diagnosis: urine 5-HIAA
Treatment: surgical resection and/or octreotide
29 дек 2023
