This video would answer several questions such as What is Chédiak-Higashi syndrome? How does Chediak Higashi syndrome occur? What are the symptoms of Chediak Higashi Syndrome? How does Chediak Higashi syndrome affect phagocytosis?
Thank you for such an informative video ,but i want to know what is the relationship between platelet dysfunction and LYST gene mutation and why the cytokines cant release its perforins and granzymes?
It seems that this (LYST protein) does NOT only regulate the phagosomes' fusion to lysosomes in case of phagocytosis ; but also regulates the exocytosis of different intracellular secretory vesicles & granules as in Tc cells & platelets , respectively . Remember the term " trafficking regulator " implies a bi-directional process : ENDOCYTOTIC as well as EXOCYTOTIC .