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Isotype switching | class switching recombination | Antibody class switching | antibody diversity 

Animated biology With arpan
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Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG.

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2 авг 2020

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Комментарии : 168   
@tomasmalinauskas2892
@tomasmalinauskas2892 3 года назад
Amazing man, that´s a perfect review of a theme that takes a long time to understand!
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please check out my entire immunology playlist and share my channel link with your friends
@briarjames4038
@briarjames4038 3 года назад
A tip : watch movies at flixzone. I've been using it for watching a lot of movies these days.
@enriqueharper6270
@enriqueharper6270 3 года назад
@Briar James Yup, have been watching on flixzone} for since december myself :D
@josiahkairo5916
@josiahkairo5916 3 года назад
@Briar James Yup, been watching on Flixzone} for since december myself =)
@CancerEnthusiast
@CancerEnthusiast 3 года назад
final in 10 days! best believe I am binging ur videos!
@swetathakur7227
@swetathakur7227 3 года назад
This is the best explanation I could ever found .. thank you
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@almasfathima5511
@almasfathima5511 11 месяцев назад
Thank you very much. Now the concept is more clear
@animatedbiologywitharpan
@animatedbiologywitharpan 11 месяцев назад
Please share my channel link with your friends and help me to reach big audiance
@dstan16224
@dstan16224 3 года назад
Truly an incredible explanation Arpan! I was finding it so difficult until I saw your video.. Thank you very much and take care!
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience.
@rudrakshisharma3128
@rudrakshisharma3128 3 года назад
I have immunology exam tomorrow. This is so helpful and lucid to understand. Thank you 😊
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Share my immunology playlist with your friends and help me to reach big audience.
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Glad to know that my connect is useful
@manalidhotre268
@manalidhotre268 3 года назад
Amazingly explained in detail 🙂 very easy language gud teaching helps me to better undertood I really liked this video plz keep doing👍
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@manalidhotre268
@manalidhotre268 3 года назад
@@animatedbiologywitharpan sure definitely 👍
@juliettese5630
@juliettese5630 2 года назад
Amazing ! Thanks to you i've understand in time for my exam this notion ! It is very well explained thank you !
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@mahela1993
@mahela1993 4 месяца назад
This was perfectly clear! Thank you very much. :D
@animatedbiologywitharpan
@animatedbiologywitharpan 4 месяца назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@barathrajkumar1999
@barathrajkumar1999 3 года назад
Great video!!
@menasalman8534
@menasalman8534 2 года назад
This video is amazing. Thank you so much!!
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience . Don't forget to check out all my playlists. Wide collection of immunology videos are there.
@nitibhatwal715
@nitibhatwal715 2 месяца назад
THANK YOU FOR THIS AMAZING VIDEO
@animatedbiologywitharpan
@animatedbiologywitharpan 2 месяца назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@latifaalnaemi412
@latifaalnaemi412 3 года назад
Amazing !!!!!!
@yousradjoudi4500
@yousradjoudi4500 2 года назад
thank you so much, I'm a french med student, it was a very difficult topic to me but you explained it in an easy way. :)
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your medschool friends . If you want any topic on which you want an explanation please put it in comments
@yoaimou9798
@yoaimou9798 Год назад
Cool work man , clear and clean keep up
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
@marywainaina1352
@marywainaina1352 Месяц назад
Thank you for the great explanation 😢
@animatedbiologywitharpan
@animatedbiologywitharpan Месяц назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@avinashselva9636
@avinashselva9636 3 года назад
This is soooooooo good.
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@prashantpathak6589
@prashantpathak6589 Год назад
Tomorrow in my immunology exam... The videos of ARPAN DADA... are so easy and lucid to understand that it boosts my confidence level.. 😅 Thank you DADA for ur lovely animated video's.
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
All the best for your exam
@kevinbenjaminbassler9530
@kevinbenjaminbassler9530 11 месяцев назад
3 more days for me. I also enjoy the content alot! Greetings from germany
@animatedbiologywitharpan
@animatedbiologywitharpan 11 месяцев назад
Please share my channel link with your friends and help me to reach big audiance. I have an entire immunology playlist
@kevinbenjaminbassler9530
@kevinbenjaminbassler9530 11 месяцев назад
I Tutor organic chem. For next Semester Preperation i will mention you 🙏
@animatedbiologywitharpan
@animatedbiologywitharpan 11 месяцев назад
@@kevinbenjaminbassler9530 that would be very kind of you. Thanks in advance
@jenniferellsworth1226
@jenniferellsworth1226 2 года назад
Thank you. I was searching our University library, and nothing was so concise as this.
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Even after working really hard I can't reach s lot of viewers
@jenniferellsworth1226
@jenniferellsworth1226 2 года назад
@@animatedbiologywitharpan certainly 👌
@f-man3274
@f-man3274 2 года назад
Thank you, sir Arpan. I am a medical student who tries to understand immunogenetics and your channel is the best thing I could hope for
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your medschool friends and help me to reach big audiance.
@pranav6143
@pranav6143 2 года назад
@@animatedbiologywitharpan if the subset of t helpers(viz th1,th2,th17 etc )decides the Ig to be released, by the thier specific cytokines released to the B cell(antigen presenting),then how could we say, In primary infection,Ig M will be more and in 2ndry infection IgG will be more in serum? ie,if Th1 is the helper subset formed,would it only cause for IgG producing effector B cell synthesis,so from the first occurance of that infection,IgG may be the main Ig in serum.Is this possible sir?
@vanditasrivastava17
@vanditasrivastava17 2 года назад
Your videos are just amazing🙌😀 Difficult topics explained in such an easy way. Sometimes it becomes difficult to visualise all the text we have read in books but ur videos made it easy for me Thank you❤️ Great job, keep up the good work👍
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and juniors.
@irshadahmad642
@irshadahmad642 2 года назад
Salute to your art sir.... Your are great and intellegent teacher... I always search for your videos if I need any topic
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
glad to hear from you....thanks a lot for the complement
@Muslema4
@Muslema4 3 года назад
Amazing! I shared the link with my friends in the faculty although we speak Arabic but the explanation deserves
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Glad to hear that it was helpful for you....comments like yours motivated me to do more
@dimeili3887
@dimeili3887 Год назад
Thank you!
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
@mohamadkanjo5965
@mohamadkanjo5965 4 месяца назад
Incredible!
@animatedbiologywitharpan
@animatedbiologywitharpan 4 месяца назад
please share my chanel link. Here is the link for the entire immunonology playlist: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-MQzE_WcXkGI.html
@sama_albairmani
@sama_albairmani 3 года назад
Thank you so much, very informative
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends
@talayashabbir8735
@talayashabbir8735 3 года назад
Excellent i just understand each and every detail clearlt
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
ru-vid.com/show-UC4IpyopsGWSjaPACNTZLuqg please subscribe to my second channel as well
@suhailsmirat7633
@suhailsmirat7633 2 года назад
koszonom szépen from Hungary
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@b2bunny
@b2bunny 2 года назад
you're amazing! ty!
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Thanks Julia for your comment. Please share my channel link with your friends and help me to reach big audience. Also check out my entire immunology playlist.
@taousdaisy9173
@taousdaisy9173 3 года назад
THANK YOU SOME MUCHE YOU HAVE AMAZING EXPLAINE
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@siddharthkumar1529
@siddharthkumar1529 3 года назад
Excellent !
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
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@vishaka1315
@vishaka1315 2 года назад
Amazing man!!!
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@stephendaniels4818
@stephendaniels4818 Год назад
Amazing explanation!!
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.
@ali-ej8km
@ali-ej8km 3 года назад
explained in details !!
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@Drstar-rg9wp
@Drstar-rg9wp 2 года назад
Much appreciated ❤️❤️❤️
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@anushabhat4135
@anushabhat4135 3 года назад
Awesome explanation
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends
@jaiparkash498
@jaiparkash498 Месяц назад
Thank you sir ❤
@animatedbiologywitharpan
@animatedbiologywitharpan Месяц назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@salomezhozhadze9071
@salomezhozhadze9071 7 месяцев назад
thank you
@animatedbiologywitharpan
@animatedbiologywitharpan 7 месяцев назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
@barathrajkumar1999
@barathrajkumar1999 3 года назад
Very well explained !!❤️
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@barathrajkumar1999
@barathrajkumar1999 3 года назад
@@animatedbiologywitharpan Sure❤️
@Pulaobiryani95
@Pulaobiryani95 3 года назад
Amazing video👍🏻
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me reach out to big audience
@Pulaobiryani95
@Pulaobiryani95 3 года назад
@@animatedbiologywitharpan of course! Keep up the great work👍🏻
@mofe620
@mofe620 Год назад
Thanks a lot.
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
Please share my channel link with your friends and help me to reach big audiance
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
@abrahem9282
@abrahem9282 2 года назад
damit man, you content is lit👊👍
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
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@abrahem9282
@abrahem9282 2 года назад
@@animatedbiologywitharpan sure man👍.
@swethagajula9154
@swethagajula9154 3 года назад
Thank u so much
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share among friends and help me to reach big audience
@josa5463
@josa5463 3 года назад
Woooooooow nice explanation
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@mustafaustun6961
@mustafaustun6961 3 года назад
Very nice and basic explanation
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
My channel has very low visibility currently, please share my channel link with your friends and help me to reach big audience
@user-ut3lb4fn1r
@user-ut3lb4fn1r 2 года назад
you are amazing
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
@shubhamkrrai1142
@shubhamkrrai1142 4 года назад
Nice explanation..👍
@animatedbiologywitharpan
@animatedbiologywitharpan 4 года назад
shubham kr rai please share my channel link with your friends and colleagues
@dewanchettri2580
@dewanchettri2580 2 года назад
Wonderfully explained sir 🙏🙏🙏🙏🙏
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@dewanchettri2580
@dewanchettri2580 2 года назад
@@animatedbiologywitharpan sure sir 🙏🙏.
@drpranabmd725
@drpranabmd725 3 года назад
Well done bro.
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please subscribe to my other channel ru-vid.com/show-UC4IpyopsGWSjaPACNTZLuqg
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share among friends and help me to reach big audience
@layeredmusic13
@layeredmusic13 2 года назад
hi, class switching can also occur before germinal center formation
@unadavidovic4909
@unadavidovic4909 2 года назад
Thank you so much! Btw which program did you use to film your display?
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Obs studio
@quickbiology5159
@quickbiology5159 2 года назад
Wow amazing you explain in detail,what do you prefer to prepare for content
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Kuby immunology
@xenzif4764
@xenzif4764 7 месяцев назад
As far as I know both no affinity and high affinity get destroyed by negetive selection and only T cell with low affinity survives through positive selection
@niraxlevi9930
@niraxlevi9930 Месяц назад
Thank you sir for the video❤i have a question please: so if i understood, isotype switching happens to the Ab produced not the BCR and one B cell either makes igM or IgD or IgE or IgA or IgG right ?
@animatedbiologywitharpan
@animatedbiologywitharpan Месяц назад
ya soluble anyibodies are generated and constant regions are changed
@ajaxschmidt2238
@ajaxschmidt2238 2 года назад
Hello is interferon y secretion is required for all the antibody isotypes or is it only for igg
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
IFN-gamma inhibits the secretion of IgG3, IgG2b, IgG1, and IgE, and enhances the secretion of IgG2a.
@selindinckal4313
@selindinckal4313 Год назад
thank you for amazing explanation. you mentioned B cell isotype switching is antigen dependent and requires mhc 2 cd40 co stimulation so can we say its also t cell dependent ? is this the case where polysaccharide and conjugated vaccines differ ? polysaccahride vaccines activate b cells indepent from t cells so no somatic hypermutation and generation of high affinity antibodies and ig G thats what i understand
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
T cell stimulates strong b cell activation which is a prerequisite for isotype switching. Moreover, T cells provide essential cytokine signals, such as IL-4 and IL-21, which direct B cells to undergo isotype switching, resulting in the production of antibodies with different effector functions. This T cell-dependent process enhances the adaptability and effectiveness of the immune response.
@debosmitaghosh2383
@debosmitaghosh2383 3 года назад
So there is a question. After the AID enzyme comes into action, what really recruits the repair enzyme? And why not any other repair enzyme with high fidelity?
@bhuvi4890
@bhuvi4890 2 года назад
If you will go in more and more detailing you will get a pH, ions presence, and many many other factors 😑
@stephendaniels4818
@stephendaniels4818 Год назад
When the naive B cell encounters a pathogen, is this with the help of the dendritic cell traveling to the lymphoid with parts of the pathogen covering it? Or does the pathogen make its way to the lymph, and the B cell directly recognizes it and takes a piece from it?
@animatedbiologywitharpan
@animatedbiologywitharpan Год назад
Dendritic cells take the antigen and move towards the lymph node
@czechmeoutbabe1997
@czechmeoutbabe1997 3 года назад
Arpan the GOAT
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
I don't understand any context of your comment.
@czechmeoutbabe1997
@czechmeoutbabe1997 3 года назад
@@animatedbiologywitharpan don't worry, it means you're the Greatest Of All Time 🐐 for making Immunology make sense 😎
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Ok now I understand.... Quite funny...please share my channel link with your friends
@Drstar-rg9wp
@Drstar-rg9wp 2 года назад
🙏❤️❤️❤️❤️
@srijandey87
@srijandey87 3 года назад
Can you make a video on carrier options after msc from any life science stream in future?
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
ru-vid.com/show-UC4IpyopsGWSjaPACNTZLuqg my second channel would deal with all of these topics
@srijandey87
@srijandey87 3 года назад
@@animatedbiologywitharpan OK but please make a video on those 3 phases of Tifr interview.BTW video was very helpful for my upcoming gat b exam and all thank you.
@latifaalnaemi412
@latifaalnaemi412 3 года назад
I have a question regarding the naive B cell . So it can produce IgM and IgD without encountering a pathogen ? But why does they use IgM and IgD levels to see if the patient has immunity to a specific disease?
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Very good question....let me tell you that with all infection it's not true that there would be class switching as a result only IgM could be produced.Now b cell has IgM by default but its membrane bound ,after infection secreted IgM is synthesized which is specific to the antigen coming from a bacteria let's say.
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@dreameducation586
@dreameducation586 3 года назад
Sir,May you please tell me if pathfinder is sufficient for csir NET JRF LIFESCIENCE Immunology portion along with some RU-vid vedios.
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
When CSIR NET is concerned I would suggest Kuby immunology
@bhagyashreebehera7106
@bhagyashreebehera7106 2 года назад
❤️
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big audience
@DieBlaueKiwi
@DieBlaueKiwi 3 года назад
Do different cytokines all lead to STAT activation?
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Yes they do
@xiwu8458
@xiwu8458 2 года назад
Thank you for your video! Can hyper IgM syndrome generate IgD?
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Nope its not possible in my opinion
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Please share my channel link with your friends and help me to reach big aidiance
@xiwu8458
@xiwu8458 2 года назад
@@animatedbiologywitharpan Sure! Thank you for your efforts!
@giakolou2876
@giakolou2876 2 года назад
Why is isotope switching occur ? It only changes the conserved heavy chains which don’t bind to pathogens only to the own B cells, so why do we need different types of conserved regions if they don’t select for pathogens ?
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules. Example : IgM interacts with complement better than others...IgG is better in terms of crossing placenta etc.
@raresciencesimple5626
@raresciencesimple5626 2 года назад
Good lecture but B cells mature in bone marrow only and not in lymph node, I believe
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
No, maturation doesn't take place in bone marrow, it's always in the lymph node
@zizoilham
@zizoilham Месяц назад
So class switching is simply T dependent activation ?
@animatedbiologywitharpan
@animatedbiologywitharpan Месяц назад
Class switching happens in B cells but not in T cells. if there is no strong T cell dependent B cell activation then class switching would not happen
@zizoilham
@zizoilham Месяц назад
@@animatedbiologywitharpan wow that was a quick response ,thank you so much for clarifying it
@JillAndJuji4Life
@JillAndJuji4Life 3 года назад
Can you please provide a reference for this video?
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Kuby immunology 7th edition
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Please share my channel link with your friends and help me to reach big audience
@TilleTheo
@TilleTheo 2 года назад
Great video but the sound was not too good.
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Thanks for your comment. Please share my channel link with your friends and help me to reach big audience. I will improve the sound quality next time
@livefulangels5329
@livefulangels5329 2 года назад
Allah yihmeek.
@animatedbiologywitharpan
@animatedbiologywitharpan 2 года назад
Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
@bluejay8836
@bluejay8836 3 года назад
Can you please improve the audio quality? Its horrible
@animatedbiologywitharpan
@animatedbiologywitharpan 3 года назад
Thanks for this suggestion....I will try to improve the quality in subsequent videos.
@Manoj-MRM
@Manoj-MRM 7 месяцев назад
Thank you sir ❤
@animatedbiologywitharpan
@animatedbiologywitharpan 7 месяцев назад
Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.
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