I'd forgotten that you were into rock climbing - nice. I bouldered a bit when I was a kid, thinking of Huxley's "Island" probably... Two people whose work I appreciate....cheers! PS: your silver triflate experience reminds me of a paper that did me like that - it was a procedure that converted bromoaryls to iodoaryls (was of interest in the production of 4-trufluoro analogs of 2-CB and DOB....as I remember it involved a silver reagent as well!)
I've been looking forward to this for a while, super interesting chat! Re: selenium chemistry, I did a reaction with elemental selenium during my PhD and it was by far the most disgusting smell I've experienced in the lab. I had to leave the lab quickly to avoid puking. I did this reaction on the weekend for a reason. Not me, but a chemist in an old lab I was in worked on making a heteroaryl SF5 compound. The paper we adapted from set up everything in the glovebox and I think that is pretty key, especially storing KF in the glovebox because we could not get it to work without one, even with rigorously dried KF and a very experienced synthetic chemist. If anyone can scale that chemistry up without a glovebox I'll be super impressed. I think adapting that chem to making a phenethylamine would be super challenging, better to start with the 1-SF5-4-nitrobenzene and build up from there because it's reasonably cheaply available.
A little disappointed in the way you guys downplayed glyphosate at around the one hour mark….. I live in New Brunswick, they do aerial application for forestry and everyone been complaining and petitioning for years trying to get them to stop. It used to be DDT. NB has the highest incidence of non hoskins lymphoma and there’s a neurological syndrome they’re covering up, they’re blaming blue green algae but I think it’s the compounding effect of pesticides / herbicides.
Two RU-vid legends in one place? I’ve been a huge fan of you since I was like 14, Hamilton’s Pharmacopeia was single-handedly keeping Vice relevant. It’s awesome to see an unedited version of you here on this channel, thank you for giving us such awesome content for free. I’m not even in the chemistry field, but I’ve learned enough from you to understand it!
Ahh thank you!!! Been watching that chemist for a while and I can't tell you how grateful I am for you making these available for us broke non patreon users. I still listen to the Dr. Nichols episode at least once a month 💜 the work you're doing documenting all of these chemist stories is a very important addition to the historical record.
I love chemistry channels. I saw his channel and some new smaller channels popping off lately. I've always wanted to make my own videos doing similar things, but until that day these wonderful channels keep me very entertained!
Hamilton, thanks for providing That Chemist with a different perspective. So many people don't consider the folks on the other end are still people. That empathy is so important to understand and connect with people. I hope your words connect with more people and inspire more people to consider this approach.
Hello Hamilton, i would like to pay my respects. Thanks for your researchs, productions, talks, shows ETC. You truely changed and educated my viewpoint about drugs chemistry, their pharmacology and relation to biology. I'm totally in love with your personality, the way you love to make informations accessible to everybody for free. Thanks for everything, i was able to educate myself with insane book and references, and thanks to tihkal pihkal i got to experiment over the course of 8 years so many life changing compounds
I really love that Hamilton is able to negotiate the social situations required to get information on all the topics he chooses, and that he genuinely has a humble attitude and is able to understand the people he interviews perspective and to distill the best from that. Thanks for doing what you do, Big Ham. (i apologize if you dont like that nickname, felt right at the time).
You guys should really do a series literally teaching chem theory like a prof. Almost like organic chemistry tutor but with your ad lib and your advice on how to understand mechanisms and such
I’m in my second semester of organic chemistry (love it so much) and I applied to transfer as a biochemistry major… reallllly reallly thinking about changing my major to medicinal chemistry now (I contemplate this every time I watch/listen to Hamilton).
When Josiah Wedgewood was testing new glazes and other chemicals for the production of high-end, mass produced pottery, he wrote down every single test result in longhand, in a great big ledger. These books still exist and contain every single misstep and explosion, as well as the successes. I think a channel doing these type of tests and listing the results would be shockingly popular. People really do care about process and the real life trials that real things must pass through.
I'm so excited that you two collaborated. The both of you picking each other's Brains 🧠 is a recipe for wonderfully creative ideas 💡 that definitely will come from this.
Hamilton, I've stumbled onto your content recently and have been enjoying a few of your podcasts while on the road I'm learning that I've got an aptitude for chemistry and while I've no formal training, I got a lot out of your chat together with ThatChemist (also a fan!) In a way that can only be described as tacit learning. It's contributions like this that take the (sometimes) seemingly unreachable experience you both have had, sharing it in a way that many can learn from. Thanks very much from Canada
Thank you for the effort. Its a huge problem in academia, and I hope one of the decent journals will find a way to test the experimental part before the publication getting finally approved.
HM- you should talk with Dan Kaszeta- author of 'Toxic: A History of Nerve Agents, from Nazi Germany to Putin's Russia.' Very good info on the history of nerve agents and the efficacy of chemical weapons in war in general. There's a whole chapter on Aum Shinrikyo and their manufacturing of Sarin (and LSD and other psychs).
If it were not illicit MDMA synthesis would be an awesome 4th year lab practical final exam. It literally uses everything you will learn in basic O Chem. 🤪
I can feel that pain of trying to recreate synthesis from papers! Throughout the cubane journey I’ve found out the hard way that papers will leave out some pretty important details. Getting closer each day but it’s been quite the challenge.
good podcast, always great content hamilton keep it up. If i had money i'd pay for your patreon, but i always upvote and watch as much as i can! Keep it up
I stand behind That Chemist on his toughts about collaboration and I confirm Hamilton's video with E&F was a total and very pleasant surprise. It was very unexpected for me, given the very different angles on chemistry both have. I even rewatch this video 2 more times on random coffee afternoons just becouse I like to see people talk with passion about their work. Very similar vibes from this video too. So thank you. And the colab-lab just sound cool , and the argument about setups for youtube videos (either a garage or a personal lab) is very strong - there must be some middle ground where someone can film and present their work safely, without having to buy $100,000 worth of lab equipment before their first ever video.
my current idea beyond the chemistry influencer lab, is more like a chemistry studio lab, where people could come and film stuff and the studio would help make things happen (it will be a long time before I can finance that, though).
@@That_Chemist It sounds good. Maybe you can consider opening the idea a bit more to the public and design a program for non-youtube makers - like the open space lab Hamilton mentions, where people from the public can make use of the lab (well obv. for people with chem background, not every rando), but with the added clause you have some rights on filming. Maybe define 2 separate major services the lab provides - for collab with youtube creators and for the public. I can imagine it will require some good protocols for review on legal and safety standpoint (or is it possible to use a blanket waiver, that whatever happens is the responsibility of the guest user). But you mentioned something i hadn't even consider - youtube lawyers, in any case there must be a solid protocol to judge if the content can be monetized to help with the expenses, but that sounds a lot less like chemistry and a lot more like paperwork, so I understand any hesitation on that. In the end expanding on an idea is not that hard, it's way harder to take only the viable bits and focus your available time and energy where it wont be wasted on overhead legal work. I wish you success in any case. That's some good stuff.
whoever edted this video my heart goes out to them. you did a great job cutting down this video for time. like frfr no sarcasm. i imagine it was like a 4 hr vid to begin with.
Hamilton I'd love to hear more about your chemistry journey and schooling and how you arrived in the chemistry field today. Super inspiring, would love to follow in your footsteps of academia
RE: Nerve agents, the Aum Shinriyko cult "onboarded" chemists who had access to government documents on synthesis of various nerve agents, so even if they'd have banned the knowledge to the public, the cult would have still been able to produce it due to their size and reach in society. They had numerous front businesses in the umbrella, so they were able to order the reagents and equipment without arousing suspicion.They were pretty much untouchable until they actually started doing the attacks because of the size and power of the org.
The thing about glyphosate is its effect on bacteria, not its direct effect on human physiology. It was originally patented as an antibiotic against digestive bacteria in the soil. Its action as an herbicide is dependent on this as it eliminates the bacteria plants require to digest food, essentially starving it to death. Since the development of varieties of wheat and other crops which are able to withstand glyphosate, the standing crop can be sprayed with it, permitting widespread consumption of it on a worldwide scale. Humans also require digestive bacteria in order to obtain nutrition from food. This is why so many of us now need probiotic bacterial cocktails periodically in order to regulate our guts. It's not a big reach to the idea that this is likely to be affecting many other species as well.
But then also, I think he's slowly sliding into professional life. Totally fine and understandable, but I'm afraid, Tom's not gonna be around much longer
Such a good chemistry between you two! Or should I say 'My Chemical Bromance' Jokes aside, it is very interesting and nice to watch and thank you both for your work!
cannaclear dudes are pretty cool i remember when they founded the subreddit guilded chat and were really into the whole thing themselves, they're out there.
As to Linus Pauling, overdosing vitamin C is actually sometimes recommended by urologists to acidify urine that is too basic, to prevent UTI. You shouldn't do more than say 3g/day because around 10g there is the risk that in the body ascorbate is degraded to substantial amounts of oxalate, leading to kidney stones.
Are you going to do a Hamilton's Pharmacopeia episode on Catha edulis? There's a huge lack of content about Khat, it's a real shame since there's so much propaganda stigmatizing it when it's a relatively safe substance with a rich history. Thanks, I love everything you do 🙏
the story of you thinking you had selenosis reminds me of that thing you wrote about gaboxadol, and a test accidentally showing it as ibotenic acid, which you then freaked yourself out about lesions is this something that just happens when you work with chemicals, as you said jason wallach sometimes has odd behaviors like not eating any food that touched plastic and so on?
Would love to see an interview with Chemdelic. A small chemistry youtuber, clearly focused on mostly psychoactive molecule synthesis and extraction. But an interesting character, and quite funny as well. He did a short series trying to extract pure salvinorin-A from Salvia divinorum. Took a few tries and some insight from commenters like myself, but he did it. He has some other good content too. Just posted a video where he made drug testing reagents. Interesting to watch his evolution as a chemistry student. He's got some real potential in my opinion. More so than Nile red, and the guy is working out of his kitchen with minimal equipment.
Hey I love these guys! It's like the whole McDonald's Chemists get to gether. Grimis and the Cheese Burglar talk about organic chem. This is a fever dream I had months ago and if I had told anyone they'd of 5150'd my ass to haloparadise
@@mj.l yeah that chemists alter ego is grimis. And hammy looks like the hamburglar lol. Can you tell I used to do a lot of organ chems? I mean , I still do but I used to, too
1:02:41 "I think that all information should be available and we should just try to cultivate a society that's mature enough to exist in harmony with dangerous information" I think that it's a happy accident that it's difficult to make nuclear or chemical weapons and relatively easy to spot when someone is doing so, but it may be that the physics of our universe contains within it the possibility for even more destructive technologies that could be produced by a single bad or careless actor. If one person in any corner of the world could end civilization if given the right information, simply hoping we can produce a society entirely free of the kinds of people who might do so seems hopelessly naïve.
Love you hamilton. I was in contact with soren during your show and one of my great regrets in life is not taking the chance to come show yall something. Be safe out there!
Interview Darron Price! Recently released with a tracker while being charged with the death of his wife who was killed when his PCP lab blew up in San Francisco.
Have you just mentioned NileRed? :D that canadian chemist youtuber? Wow, world's small. we share a common pool of interests. Community is a great thing!
24:15,….A pocket reference guide to emergency incidents for solo clandestine synthesis, does such a document exist? Or a safe practices-strategies & tactic’s protocol for emergency incidents specific to Solo Clandestine Synthesis?
Just my 2 cents. Using microwave energy can make stuff react in unusual ways, especially making stuff that would take an eternity to react do so in minutes, also will make stuff that would be destroyed at higher temperatures react at much lower temperature. One thing it is particularly good for isomerization without causing polymerization. ❤
Kind of glad to hear that your conversion of ketamine to its thioketone analog failed. In general thioketones are avoided in med chem because of they are generally toxic as well as reactive. That chemist is a fun youtube channel. As a practicing organic chemist I enjoy his tier lists and best organic papers that he produces. I have been on safety teams in several companies and have seen the two extremes of safety from negligence to over cautious. While I always sought to work safely for my own and labmates safety, after a while it is easy to become a bit cavalier. I can say I have rarely read chemical data safety sheets on chemicals that I bought but that is because they were usually less informative but just a legal requirement for the seller and shipper. Many of the clandestine labs may have those who are just to stoned to take safety seriously as you pointed out. I am always worried about these labs and those who operate them since I am used to working in the opposite spectrum of quality equipment and environmental conditions.
Have you’ve heard about the “newer” drug called Tucibi or tuci/pink cocaine? It’s becoming popular around where I’m from and I can’t find much info about it or what it contains would love a break down on it
is he talking about the episode with the younger looking guy with bleached blond hair who was making meth or E at home where they showed it happening ? i cant find info online with imagines for this episode. i was one on vice like 6 years ago where he showed a home lab beginning to end and watched them use the product.
Wanted to try Delta 8 since it was so cheap but it's cheaper because it's half the potency of Delta 9 and HHO is a different kind of feeling altogether. THC-P is stronger but it's also 3x the price.
