www.ibiology.o... Examples of chromosomal alterations found in tumor cells, including translocation in the Philadelphia chromosome, and loss of heterozygosity in retinoblastoma.
Didn't really understand how LOH (loss of heterozygosity) worked until Professor Haber's explanation and this video right here. I like how he breaks it down to 2 cases with mitotic crossing over leading to recessive allele x 2 or just lost of a dominant allele (either case I guess could be pathogenic). The explanations I had read of LOH weren't as helpful as this video - keep it up iBiology and Professor Haber!!
+Stone Blizzard You can see the whole video here www.ibiology.org/ibioseminars/genetics-gene-regulation/jim-haber-part-1.html or search for it on RU-vid (there are two long parts, this is just a short clip!)
