Just found your lecture. My son had extra material on the distal arm of his 11th chromosome. They called it 11q+ syndrome, for lack of a better term. In the 23 years that he lived I was never given any explanation about what that meant or any positive prognosis on how he would develop. Tho I and my husband were not exposed to radiation in our environment, we were both exposed to high lead levels, and he in his work place, to trichlorethylene and other industrial solvents, which he brought home on his clothes. Your lecture has done more to explain the several possibly actions of chromosome's than all the doctors I had my son to in the 23 years of his life. I thank you, even tho he is now deceased, for clarifying in my mind his chromosomal anomaly and the mechanics of how he received it.
Hi Lesa, So sorry for your loss. I have a 5 year old son with a Micro-Duplication on his 5p13 and 8q11 chromosomes, and he presents with mild Autistic-like symptoms and Apraxia - he can’t talk yet, just babbles. Although, he seems happy and is affectionate. It’s so sad, and we don’t have any about his Prognosis because all the Doctors and Geneticists we’ve seen are near-useless! Every answer to any of our questions is: “Oh well, Yes & No”; or “Possibly”; or “We don’t really know...who can say?” I’m was concerned hearing about your Son who tragically passed at 23... my Wife & I have never been told of any shorter Life Expectancy for our Son...? He’s is perfect health. Do you mind if I ask you if his passing was attributed in any way to his Micro-Duplication? Thank You so much for your help 🙏
@@markyaus2011 Only in the sense that it left him very vulnerable to colds, flu's, and pneumonia. He died of H1N1-A in 2009. His heart and lungs simply could not handle the severe form of this flu.
I cannot really express how thankful I am for this lecture of yours. I have a report regarding this tomorrow and I was really on the edge of breaking down when I saw this video of yours. Thank you very much.
You have helped me through undergrad, studying for the MCAT, and now medical school. Your videos and explanations are amazing. I just want to say thank you!
@@ph1lodox361 yeah we obviously learn this before med school but we forget it. This a review in med school. Just like the kreb cycle, some things you learn it 50x in school and still have to relearn it.
fantastic content, and 100% applicable to the chapter I'm studying on "Large-scale chromosome changes." I give you credit for being a much more focused person than I am.
Thanks for the video! I'm curious if there's a particular phase in the cell cycle where translation can occur or can it be during any phase of the cell cycle?
Thank you! You made it fun to follow along 🤓 So with a translocation, will the segment that breaks off attach at the corresponding sequence of the new chromosome?
I'm in awe 😳😳. Don't mean to bash my lecturer....but he confused me and did not explain this topic well... when I heard your explanation I was so grateful for the clear and concise explanation!!!! Thank you❤❤
Shannon Mace Sorry about the volume Shannon, I did not realize the mic volume was not calibrated at the time of recording! Luckily I realized pretty quickly (only after several lectures) :)
Man! You are an amazing teacher! I have a question: does the duplication occur just in this way? Is it possible that a gene duplicates bc of an error of the DNApol? I mean, is it possibile that 2 homologous both have the gene and in one there is also an extra copy that doesnt derive from the homologous but from an error in duplication?
How does the detached DNA sequence insert itself into another chromosome, whether or no homologous? Do the DNA strands of the DNA disjoin to let the detached sequence in?
quick question, the chromosome breakage that is being caused by radiation, are the factors such as radiation or viral infection called clastogens? I read about this in my book, but I gotta make sure :)
My partner has pericentric inversion of chromosome 9, p11q13. What does that mean for having children in future? Are we at a higher risks for having children with health problems?!
Regarding duplication, you stated that it was a GENE that would break off and reattach to the other chromosome. In the other 3 structural pathways then, are those segments of DNA genes too or can they be any random bits?
