As always, Joe Beechem gets right to the point. What matters is 1. how many genes you can detect and 2. how many total transcripts you can discriminate per cell. The end. That outcome is ultimately limited by the detection chemistry. Fundamentally, CosMx chemistry is the smallest and the most scalable. Moreover, it only relies on two basic physical processes; hybridization and photocleavage. No complicated enzymology and bulky synthesis states. Whatever shortcomings there are now will resolve as CosMx technology continues to mature. Spatial Multiomics will advance according to the tool set available, so choose your tools rationally and objectively. As always, as a scientist.
