Detecting Alzheimer's 20 years before onset

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Biomarkers for Alzheimer's disease begin to change many years before symptoms present and a diagnosis is made.
Shuheng Wang and Bote Zhao worked on a long term study tracking these changes. The team took samples from participants' cerebrospinal fluid, imaged their brain and carried out cognitive assessments over a 20 year period. They found one biomarker (amyloid-beta 42) began to differ, compared to participants who didn't go on to develop the disease, 18 years prior to diagnosis and many others would deviate in the years preceding. It's hoped these findings will lead to early diagnosis and intervention for those with Alzheimer's disease.
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Опубликовано:

30 сен 2024

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Комментарии : 35

@ilyakolmanovsky 3 дня назад

Quite remarkable, thanks for sharing. It would be great if you could always provide a link to an actual study. I can't even figure out how recent that is

@michaeljmcguffin 3 дня назад

I think you can find it if you go to google scholar and search for this: Biomarker Changes during 20 Years Preceding Alzheimer’s Disease. I won't include a link because that could cause my comment to be auto blocked.

@ledjfou125 3 дня назад

Agreed !

@LeDechaine 3 дня назад

Agreed (Febuary 2024 according to google, by the way, just google their names).

@jasonarthur3640 20 часов назад

Sometimes the info that you really want is hidden in the video description, so always remember to click on it to see what’s written in there. ;-)

@ilyakolmanovsky 20 часов назад

@@jasonarthur3640 they just added this, which is great

@Notacladist 3 дня назад

Among patients with both biomarkers, what percentage DO NOT go on to develop Alzheimer's?

@matthewpobox День назад

Ill be impressed when their findings are reproduced by another group

@grougrouhh1727 3 дня назад

how is year before onset defined in the control group ?

@roidroid 3 дня назад

It's not easy to collect that fluid, a spinal tap is very uncomfortable to go through.

@grdfhrghrggrtwqqu 3 дня назад

Joy Milne's idea of smelling biomarkers from the spine was way more fascinating than this.

@livephysiology 3 дня назад

It's also a crucial discovery as some targets aim to slow the disease rather than prevent Alzheimer's disease entirely. Imagine slowing the disease starting 20 years before onset. How many more years would it be before the onset if the treatments to delay onset were started that much sooner?

@SK-lt1so 23 часа назад

Nothing new in treatments offered here- It's all the same advice your primary care doctor has been telling you for years- Get enough sleep, don't smoke/drink ETOH, watch your BP/weight, exercise, correct your hearing and vision. People just don't listen to their primary care MD, and watch these videos instead.

@felipeteran429 3 дня назад

Really good insight on Alzheimer's, it could help develop better habits for people to avoid it

@oreopoj 3 дня назад

But that assumes habits have anything to do with it. The causes of the changes could be purely genetic in nature with no epigenetic connection.

@平和-v1z 3 дня назад

This is fascinating, thanks a lot!

@katoy9976 3 дня назад

Avrupadan amerikaya kim giderse gitsin. Ama asyadan kimse gitmemeli.

@SK-lt1so 23 часа назад

Then what?

@kcChicken123 3 дня назад

Holy

@jonr6680 3 дня назад

An animation of a fictional graphic is a new low point in 'science' journalism. The lab coat wearing speakers of a script likewise seem ... odd. And actually this only confirms an assumption, doesn't take a step towards understanding WHY, or what to do for prevention. So, meh.

@SocialistSociopathPK442 3 дня назад

Balance U R Sodium and sugar then no problem and ⚖️ u r life style

@whitemale6227 3 дня назад

Why do they speak like robots?

@edmond4005 3 дня назад

I'd like to hear your Chinese.

@clarissa3850 3 дня назад

Not only is their first language a language with completely different phonetics, they’re using scientific jargon that can be difficult for even native English speakers. They probably also have a script since this is significant research they want to clearly present. Please be respectful and more understanding