DHEA, Testosterone, HRT & More 

I plan to stay natural like Mike O' Hearn.

I’ve been taking 10 mg and now 20 mg for last 7 months. Losing fat around the belly, sleeping great.

Thanks Mike! I am 40, and began taking 35mg DHEA at bedtime about 2 weeks ago. Since then I have noticed a slight improvement in sense of well-being but I'm already a pretty happy guy. But even better, my libido, playful aggression and bedroom performance have seen a very pleasant increase. My wife and I are thoroughly enjoying the benefits.

The reason I started taking DHEA was for aches and pains, especially in the morning but no one ever talks about this sense taking them I don’t wake up with sore muscles I’m 62 and feel great been taking DHEA for at least 20 years now

The body's natural rhythm is to release DHEA primarily in the morning. Thus most expert literature suggests mimicking this natural rhythm, by taking DHEA only in the morning. Further, some more in-depth medical literature suggests that taking DHEA at night could upset the circadian rhythm and negatively impact sleep. Can you please elaborate further on why you'd suggest taking this as night?

My DHEA / Cortisol were really high (33,M). My functional doctor told me the remedy was high dose melatonin and now I understand why. I was having high anxiety and hair loss, with the latter not being something that ran in my family.

My wife and I are in our 50s. We've been taking DHEA for a couple of years. It makes a big difference. We will start taking it in the night rather than morning now.

I was told to take it in the morning because that's when your body releases it. I have never taken a test. I was in a wheelchair. I started taking gnc testosterone blind vitamins. Then I started supplementing twenty five milligrams dhea. I'm out of the wheelchair and on to the dean's list.

My experience with DHEA is that it's best taken in small doses in small bursts (2-3 days and then off for weeks). I'm talking about breaking open a 25mg capsule and putting about 2-5mg of the powder into water and drinking it. Pull back if you feel any sensitivity on the nipples. The DHEA metabolites like 3a-diol are potent neurosteroids but they'll also cause acne and increased hair loss, so be careful with this one. Benefits include acute increases in strength, fullness in the muscle, better skin, neuronal drive, and improvement in CNS function - even at these small doses.

Love it Mike. My perspective is DHEA is great. It CAN raise T in men. But shouldn’t be the main reason you take it. It’s just one of the side benefits

I did some before and after blood work with 50 mg a day. It actually lowered my testosterone and it did so by raising my e2. Pre-dhea my e2 was 32. On the next blood panel it was all the way up at 54. Lh was lower and this is likely why the testosterone was as well. Now just doing low dose trt but I did experiment with this first. Did not have good long-term results even though I felt better the first couple weeks I took it

Excellent discussion, Mike; as a clinician, I feel that the shifts in DHEA are one of the first changes that occur in perimenopause; I definitely like to track DHEA levels in serum and the DUTCH; I do find that certain products, like 7-Keto DHEA by DFH are less likely to aromatize to estrogen in my female patients. This can be an easy "gateway" to other strategies in middle age and beyond

It has been over 3 months now since I stopped taking DHEA and started having sleeping issues. Resuming supplementation tonight. STET:) And yes, I just placed a new order from your myoxcience store. Thanks for all you do!!!

Hey Mike. Great video and great responses and engagement as well. In my clinical experience I’ve never seen DHEA supplements, increase testosterone in men, but certainly can do so in. women. There’s a lot of hype regarding the benefits of DHEA potentially in men in particular. There have been a few meta-analysis. Looking into this. In general, there seems to be get support for cardiovascular benefit. In older men, there seems to be support for the idea that DHEA can help with bone density. And then we have some interesting studies like the study out of UCLA and the journals cell that combined DHEA with human growth hormone a met Forman, which seems to have improved immunosenescence and reversed epigenetic aging markers.

Thank you for this informational video. I tested my DHEA-S in saliva test, later also blood test. My level was only 1/4 to 1/5 of normal, maybe that is why I felt so tired most days. I tried doses and it made me very amped up and anxious. I could never take it at night, it can cause insomnia even when taken in morning. What I cautiously did was take 2.5 to 5 mg every other day. Besides making hormones, DHEA also has neuro stimulating effects on the brain. I am over 40 and can’t take that 40 mg suggested dose. I’d recommend for men to go low and slow, try only 5 mg, perhaps daily or every other day, see how you feel and sleep. It can make your skin oily also. Also be sure to monitor DHEA-S levels periodically. And some sort of cycle with off times. More energy and vitality is good, but anxiety and insomnia is not. Low & slow.

i am 68 yrs old. i take 50 mg's about every 3 days. i have no idea if it helps me in any way. i am not married, don't chase skirts anymore, so can't comment on libido. no hair loss so far. and i also take L-Arganine, L Glutimine, and a daily vitamin for over 60 males. my blood test's at the VA are always near perfect tolerances, BP is perfect, i take no prescribed meds. I just thought i would add my 2 cents. i used to work out at home, but (still do on occasion)i am getting lazy. i watch video's like this just to stay up to date.

I'm conflicted on dhea.i hear alot of people say good things about it and then others say it's a waste of money.ive taken it myself and noticed good things like more libido for maybe like a week and then nothing.i was taking it basically just to try to boost test but it can also be converted to estrogen so it's kind of a gamble when you take it from what I understand. Instead I'm now taking enclomiphene bcuz I know exactly what it does and it does exactly what I want.blocks estrogen and boosts natural test.alot of trt clinics are now prescribing it as a matter of fact

I have hypothyroidism, low T, and low dhea level, started replacement therapy on all 3 for 2 months and feel so much better.

I'm 28 and I feel like a superhero in the gym with DHEA

I was hoping you would get to this outside of your courses because your research analysis helps me a lot quicker than all of the rating I would have to do on my own

The most substantial benefit from this product for myself at 45 years old is the massive impact on improvement of my mood and being able to deal with people less reactionary and more positive overall 💫🏆 if you’re over 40, 100 mg of DHEA every day is a winner 🥇

I like aroung 10-25mg DHEA ,with Chrysin for aromatase inhibition. Also liking Pregnenolone which is a precursor to all of the hormones and good for memory.

I think the main problem is the fact that everyone consumes caffeine which literally prevents your DHEA from working as the caffeine is stressing out your adrenal glands when the DHEA is trying to repair your cells.

Taking dhea I've noticed slight body composition change and more muscular physique. Nothing massive but it worked a tad. It also helps with mood and in the bedroom.

Good to see you post this. I take it at 47yrs old alongside Pregnenolone. Interesting to hear many call both the mother of all hormones. I would consider pregnenolone the owner of that title but both are important for sure. I was taking it early but maybe will try the evening to see the sleep effect.

I take 25mg dhea a day at my doctors advice. Luckily that was the right amount and my blood tests come back on the high end of normal now.

46y/o Male My DHEA was like 3'-5's , I tried TRT Gel from my doc but he didn't tell me it would BRICK Dhea levels to 1 within 13 days. Taking as little 10mg every other day works for me, but 20mg of DHEA every other day put my levels at 16.8ng within 15hrs of taking it. Mixed feelings of how I feel on it, sex is more a little bloat, big increase in nitric oxide. I don't know how people can tolerate higher doses, I get a spike in Aggression going to 30mg. Thank you for your Video!

Don't randomly mess with your hormones. Get a panel and see where you it stand and how you are feeling. Discuss with a Dr and come up with a solution.

Cannot get dhea over the counter in Canada, and doctors wont prescribe it.

Keep your body/mind strong & healthy with good nutritional habits & consistent workouts, you don't need any other bs after 40.

Great video - I think you mis-spoke in the end though: "If you're a woman, just take 50mg times 2.5". Think you meant 2.5 mg times 5 (per each decade).

Thanks again for the info. I've been checking my DHEA levels for a while. And was off and on with DHEA supps. My test in May of this year showed a 76 level. I started taking 25 mg a day. My functional doctor wanted me to take 50mg a day but I said I would do 25 first. Im a male 59 yrs old. I checked my DHEA again In October and my level was 146. I increased my dosage to 50mg for a month then back to 25mg this month. Can't really say with certainty that I feel any different. I started taking it because I was feeling real sluggish at that time. I wanted to see if this would help. I still believe in this hormone so not giving up. Recently I happened to check my old labs that were taken September 2021. My pregnenolone level was 67 out of a range of 25/260. Now my thinking is trying to raise this too because its considered the "mother" of hormones and makes DHEA too. I just ordered more DHEA 25mg micronized that dissolve under the tongue. I plan on taking 10mg of pregnenolone and 25mg of DHEA. ill re test in 30 days.

Anecdotally, at mid 30s I once out of the blue took I think it was a 25mg dhea, didn't notice much that evening but the next day I woke up and felt incredible the entire day. I felt like I thought I should feel, calm, confident, strong, at ease with anything, anxiety was just gone(very rare for me). But never got the same result again, even with the same bottle. Years later I tried again but started with 10mg per day, to ease into it so I could notice which dose size was best. Did it for a week or so and noticed slightly enhanced energy, but one day I suddenly crashed energy wise. I was brutally lethargic which was extremely odd, and since there wasn't any other change in my routine I confidently attributed it to the dhea and haven't tried again. It's tricky because that one day when it worked was amazing, so much that a decade later I haven't forgotten, but haven't been able to recreate it and that lethargy was brutal. I wonder what that was about? Estrogen crash or something? No bloods to confirm but I highly suspect I'm reasonably low T due to reckless use of aas in mid 20s.

I’m a 50 year old male and have been taking DHEA periodically since I was probably in my late 30’s. I tend to take a low 10 mg tablet twice a week which I’m sure is super low for some people. But I also didn’t want to have any side effects to have it cause other issues. In high amounts it can also cause insomnia so I tend to take it upon waking which is what’s suggested anyway. Definitely noticeable improvement in mood, energy, libido and muscle tone when I take it. I also workout regularly and have been since I was a teenager.

Amazing content Sir. Would there be any possible reason/benefits to cycling DHEA? Thanks!

Mike, appreciate the video, wanted to know if you or anyone else here has thoughts on pregnalone vs dhea? I was thinking that they are both precursors to testosterone but dhea comes from pregnalone. What is a reason why one would not use pregnalone instead of dhea? I realize this may be a more nuanced and in depth answer than just a couple of lines.

I started taking 50g about a year ago. Last time I found it, it only came in 100g per pill so I take maybe 4 times per week. No problems.

Im post menopause and started progesterone cream with Dhea 10 mg a day and has made such a difference in my pain and energy this I discover on my own after researching and youtubers like you 🤗🤗 My question to you is should i alternate taking 10 mg one day and 20 mg the next for ex. to help me a bit more im 53 and struggling with insomnia joint pain and low libido amongst a list of other symptons im dealing with menopause and fibromyalgia.

20+ years ago, when I used to lift seriously, I used to take DHEA. I had it dosed in a liquid transport and would apply it to my inner thigh. The transport was nothing more than a clear, watery lotion with DMSO. It would allow the DHEA to penetrate the inside of the thigh and go straight to the bloodstream. This way, the bioavailability was through the roof compared to taking it orally and having your stomach acids and liver destroying most of it. At that time, I was at the greatest peak of my physical abilities in my life and got the most insane gains I have ever had. According to my wife, it had two major problems. 1) The sex-drive was ridiculously high and it would never let up. NEVER. 2) She didn't like kissing me when I was taking DHEA because she said it made my breath smell like rotten vegetables.

Your videos are always very educative, thank you and I appreciate you.

dhea is a precursor to androstenedione which is a precursor to testosterone. i tried androstenedione decades ago back in my bodybuilding days and found it indeed did work, but as most scientists tell you: it increased testosterone for a few weeks, which then leveled off because of the body's reaction in reducing its natural testosterone in response. thus the requirement for cycling, just to keep a somewhat consistent level. the added testosterone, on top of making me edgy like way too much coffee, yielded hair loss from the testosterone breakdown to DHT. between the body's own reduction reaction, the unnatural feel of the added testosterone, and the hair loss, i decided to stop taking it and stay natural. i was in my 30s at the time, and even over 50 today, i will not go that route.

I am a 58 postmenopausal woman. I have been taking 10 mg each day and it caused my face to break out. My doctor told me to cut back to cut back to 5 for a time and slowly increase it.

Thanks for the info! What are your thoughts on 7-keto DHEA?

I tried to dial in my DHEA even though I was in the normal range. Doctor said higher would be optimal. I'm certainly open to such an easy and cheap way to get my testosterone higher but even at 5mg my levels went up enough to get acne. My body likes to aromatize testosterone into estrogen at a high rate. I tell anyone wanting a testosterone boost to try some DHEA first before getting into injections. Cheap, tiny pill, and usually no side effects.

Hi Mike. I’ve been taking DHEA and last week was diagnosed with breast cancer. The cancer is hormone positive. I’m 58 and muscular and to not want to lose my hormones for several reasons but- cancer. Love any info-

not in Canada it isnt

Hey Mike, this stuff made me feel really good, must have really needed it I want to experiment with higher doses, any suggestions on things to watch for?

Please don't let PP bully you into discontinuing DHEA, myoxcience is the only brand I have found that doesn't cause breakouts and other unwanted side effects.

Can you please do a video on Oral DHEA vs Topical DHEA Cream? Also, can you address why oral DHEA causes increases in C-Reactive Protein inflammatory markers?

CIstanche, maybe pregnenolone. Oysters and sardines for breakfast.

I heard take it when you get up in the morning when your testosterone is high.

Thanks Mike. I was unaware of this. Thanks for shedding light on this topic.

DHEA is a concern with prostate growth in some studies as well..

Are there natural ways (diet,exercise, etc.) that will boost DHEA levels, without resorting to taking DHEA itself as a supplement?

Yes it does help sleep when taking in the evening, also helps ed ,at least for me. I'm at 400mg and test at 600 ,but I'm doing TRT and Dhea effects free testosterone levels,at least in lab results but not in how I feel

Was drinking 60-100 oz. of high wack coffee a day... weened myself off over the holiday weekend. Wow, feeling weird in a good way. Hoping my adrenals right themselves.

great video and supplements you offer. I have been taking myoscience for years and love the quality

I’ve actually heard that taking DHEA before bed can interrupt sleep

Hey Mike! Quick question, im reviewing your various vids on DHEA as I begin taking it myself. In this and another vid you recommend taking it at night. But in the info vid with your product on Myoxcience you suggest taking it in the morning. If you have a chance to make a follow up video or short clarifying when to take it (or why one might take it AM vs PM), I'd be so grateful! there is so much fear-mongering esp for women looking for info on how to take it, I'd love to get this advice from you as someone I trust! I always appreciate your content. Thank you.

People get confused with DIM too

I AM 77 FIT 5 10 150 LBS MY HIGH SCHOOL WEIGHT, WALK 2-3 MILES DAILY, WORK OUT PUSH UPS LUNGES. STARTED ON STIX AND TWO WEEKS NOW ON DHEA COMBO BY LIFE EXTENSION. AMAZING MENTAL CLARITY, STRENGTH , VITALITY. WHAT DO YOU SUGGEST FOR FLEXIBILITY??

I took it for years and had no effect. My Dr just asked me to start taking it again. Fingers crossed.

So this will cause hairloss in men?

Thanks for the great info, Mike!

Wow....I needed this video.

Thank you for your education, Mike. I am 62 years old. 25 mg of DHEA seems to be sufficient for me. I can see changes in my body/muscles after being on it. The DHEA at night helped with my libido, but interfered with my sleep, so I take it in the morning. I also have BPH and unfortunately, DHEA also raises estrogen, which may make my BPH worse. Any suggestion on estrogen blockers? I'm taking a Broccoli extract powder and spirulina hoping it will help block.

Thank You, Mike. Much Appreciated !

Definitely be careful with the stuff. Only was on it for a week, then got some bloodwork done. AST and ASL levels increased by 50%, and my CK Creatine Kinase went from 400 to 1000. Start with a lower dose, get your bloodwork done and go from there.

DHEA supplementation is a MASSIVE game changer.

Even if you are low t and take DHEA, it’s not going to make your body produce more testosterone, the small amount that dhea converts to is way less than actual testosterone production from the testes

In the studies that were done, men were given 100 mg a day I think 40 mg is way too low

By supplementing dhea will my body stop producing dhea naturally???

Some suggest that taking dhea in the morning is the best because thats when our body testosterone is the highest hence the dhea helps boost it, is it accurate? Appreciate your view Mike

Is it only for men over 40?

Another great and informative video. Is there any information re benefit to taking in conjunction with Tongat Ali

The few articles I read said DHEA converted more to estr in men and testosterone in women.

Thank you.

About to start a daily oral hrt: DHEA test pregnenolone 30/100/5 compounded.

I thought that pregnenolone was the mother hormone and that your body uses it to make DHEA. Either way I take pregnenolone and DHEA twice a day

How to know or estimate the ratio of andogenicity versus estrogenicity of supplemental DHEA in adult men?

You have to take dhea with DIM or I3C to prevent aromatase?

Thank you so much for your videos

Thanks for another great video Mike. Would you say DHEA can still be beneficial if already on TRT?

I have sky high DHEA but low testosterone, why and do I need TRT in this situation?

Thank you!!

Will finasteride take care of the dht increase from taking DHEA?

On taking before bed for sleep, what about shift workers? It’s hard to interpret a lot of of this information in regard to sleep because we’re on opposite schedules. All the while, many of the most important jobs in the world involve shift work and schedules that fight against the circadian rhythm… namely medical professionals, but maybe even more important from a day to day perspective, and almost never mentioned among these, truck drivers. We make the world go round. Help us out with some nuanced interpretation of the data if you can. We need it bad.

Get tested before dosing!

Here's the issue with supplementing DHEA that my hormonal groups have found, it's a lost cause if cortisol levels are also off... and if DHEA is off, you can have a darn near sure bet your cortisol levels are also off. And the common ways doctors test adrenals are not adequate for detecting anything beyond Cushings and Addison levels and being in range is also not the same as optimal cortisol levels. ._. And I'd say based on the things I saw as a former health group admin, that there is a growing problem with adrenal issues in people... just crazy common. Which is very bad, because it's not just adrenals, that effects sex hormones and thyroid too, they're all very interconnected.

I know you mentioned sulfate at the end of speaking about the DHEA test and I was wondering if you can get a lot of that from eggs? I eat a lot of eggs for the protein and the cholesterol, I actually boiled 10 eggs this morning for breakfast to go with my asparagus but the more you talk about this the more I want to look into it

Some doctors say u should take pregnenolone if u are on DHEA? What do u think doctor?

Dhea supps should be avoided by younger guys and anyone who has good T levels in many sporting events it is classed as a banned substance. I went from 334 to 960 in around 3 months all natural no TRT. This book should be essential reading for all men. Written by a 50s guy with natural T levels of a 20s guy Complete guide to testosterone by james Francis

Does DHEA suppress natural production of natural dhea or other hormones? I need to know this before starting, I don't like to be dependent on anything.

I was wondering why you did not mention that oral intake is Not recommend as 80 % is metabolzed..DHEA should always be used as creme

Where does this 10mg per decade of life recommendation come from? The human body only makes so much DHEA per day. The question is what a peak adult (in the prime of their life) would make per day of DHEA, find out what that level is, and then supplement to up to that level. So you're saying that a person of 70 would supplement 70mg? Does a human even make that much DHEA each day? That is a huge dose.

Buddy, I like your videos by the way, how much DHEA is converted into Testosterone per average male? Hope you get this, thanks!💯👍🔥

Unfortunately I can't get it shipped to Australia

Major Risk for Women: DHEA and testosterone ride around on albumin molecules. Years of testosterone production tends to also occupy DHEA sites on albumin when DHEA is in short supply. Then, when you supplement with DHEA, once the DHEA sites on the albumin have been occupied, it starts kicking off the misplaced testosterone - which briefly makes a testosterone peak - but it also produces a brief testosterone overdoes that long-term down-regulates the sensitivity of the testosterone receptors. The net effect is that ladies' libido is DESTROYED for a decade or so - which is a real life-wrecker. DHEA supplementing is usually a really BAD idea for women, but for those who want to risk it, they MUST understand this risk, so they can immediately stop supplementing at the first signs of their libido running out of control. Again, this can be a real life-wrecker.

Can you take one pill every other day / every 3 days? I am 45, female, my DHEA is ~ 50 ug/dl (ref range 26-460) and my free T is clinically low (0.1 ng/dl). I bought 25 mg dose and don't want to waste it. I have been dragging my butt around in the last year, normally I am highly energized.

For those of us with big bellies who have issues with aromatase/estradiol, how does DHEA fit into that picture? Does it increase all hormones equally? Obviously, I want more testosterone, but not if I get more estrogen at the same time.