Diagnosing Celiac Disease - Current Standards and Debate 

Glad it was helpful!

Did you bother to go strict GF to see if your symptoms improved?

We agree, we will try and see if we can get him in board for some new things!

I have the same exact thing. Did you find out yours?

The majority of people w/ CD have specific alleles in the HLA-DQ1 and HLADQB1 genes (HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302). The presence of these HLA alleles implies an increased risk for celiac disease. These can be detected through a DNA test.

For someone to develop celiac disease they need to carry a single gene of DQ2 or DQ8 or a combination of these two overlapping genes. Which gene you carry may increase or decrease you overall risk for developing CD in your lifetime. If an individual does not carry these genes, they are highly unlikely to develop CD. DQ2.5 is a variant of the DQ2 molecule. For our community, the most important take home message is that in order to develop celiac disease you must carry the genes.

@@CCACeliac Then is HLA DQa1:05 an allele on the HLA DQ2 molecule why to doctors insist on a biopsy if all the symptoms are present?

CD occurs in 2-5% of people with selective IgA deficiency. All symptomatic IgA deficient patients should be referred for endoscopic small intestinal biopsies regardless of their serology results, as false negatives can occur. In asymptomatic individuals with IgA deficiency, the lab may be able to perform IgG-TTG or an IgG-deamidated gliadin peptide (IgG-DGP). Note - Negative HLA-DQ2 or DQ8 genetic tests are helpful to exclude the diagnosis of CD because over 99% of patients with CD are positive for HLA-DQ2 or DQ8. However, approximately 30% of the general population tests positive for one of these HLA types and most do not develop CD. www.celiac.ca/healthcare-professionals/management/

People make 5 types of antibodies (immunoglobulins): IgA, IgD, IgE, IgG and IgM. IgA is the major type of antibody made by the immune cells in the lining of the digestive tract. About 1 in 500 to 700 otherwise healthy people do not make IgA: this condition is known as IgA deficiency. Patients with IgA deficiency are at increased risk of infections to their respiratory and digestive tracts. For some reason, celiac patients are more likely to have an IgA deficiency. This is important because if you are IgA deficient, some of the key tests that doctors order to figure out if you have celiac disease may be normal, even if, in fact, you do have celiac disease.

@@CCACeliac Yes, I am aware. I know this, so why don't doctors understand it?

@@blondsinger38 For those who are symptomatic and have a negative TTG-IGA, it would be beneficial for them to ask their physician if they may be IGA deficient. As TTG-IGA is IGA dependent,, and with a deficiency the bloodwork may show a false negative.

Me ether, didn't show in anything but by Biopsy...

@@kstef8526 What about your Hla marker ? Positive for dq2 or dq8?

I had high EOS and have both genetic markers for celiac. Did you have any leg tingling, burning stomach issues, or sleep disturbances? Since stopping gluten, all symptoms have gone away except for the sleep issues.

​@philmcrackinnow The fact symptoms went away on diet confirmed gluten was the ptoblem.

Doesn't need to be banned just avoid it.

Glad it was helpful!