Is it OK to prepare final dilution of standard using a dissolution media containing a higher percentage of surfactant compared to the dissolution media?? (Media has a 0.2% surfactant whereas final dilution with same pH media but a higher concentration of surfactant, how will this be justified?)
1st is it same for both assay and dissolution. 2nd how I would perform dissolution accuracy for different concentration of finished tablet. As we take one tablet for each disolution vessel. for validation purpose
Hi sir, thanks for the information. We getting 85% of the dissolution if we add enzyme for accelerated condition. But for long term no need of adding enzyme. Then what will be the final dissolution media.
how much active atleast should be present in tablet for dissolution test requirement? if tablet contain 5 or 25 mg active ingredient should we perform dissolution test on it or not require?