DOCTOR reacts to CELLS AT WORK! // Episode 8 // "Blood Circulation" 

Thank you for your patience everyone; I promised this video last week but only just got around to completing the edit... I was pleasantly surprised how Cells at Work handled general physiology rather than immunology, so looking forward to seeing what happens next! Hope everyone is having a super week! X

_Anime characters being anime characters_ Dr Hope: This is exactly what happens in our body Heard here first folks anime is real

The gargoyle-like statues are likely a reference to Kaminarimon Gate in Asakusa, which leads to Sensoji temple. The gate is flanked by statues of the thunder and wind gods. It fits with the temple like depiction of the heart. Though I suppose the thunder god could reference the electrical impulses of the heart, and the wind god could reference the breath oxygenating the blood.

Wait, did red blood cell _finally_ , legit, for once, navigate her way though the blood circulation system without losing her way? *Coagulations* !

*I legit turned pale when I heard "Krebs' Cycle"* The damn thing was the bane of all people studying for the metabolism exam, and I swear I had nightmares after that. Luckily, we all remembered that in the end of the day, *mitochondria is the powerhouse of the cell.*

I thought it was funny for some reason that you memorized those virus depictions and are able to distinguish them now. "Hi I'm Dr Hope and I specialize in anime viruses taxonomy"

"... a process called the Krebs cycle ..." **shivers down my spine from the PTSD**

Oh my God Ed, when you said "you must say, it's the powerhouse of the cell", I lost it. I'm a biology teacher, and I feel like that's our motto

I've watched this anime twice and I never even noticed the jacket color detail! What a nice touch!!

*He got anime and medication on his side!* Edit: My highest liked comment ever. Thanks.

I was talking about you with my friends and I was talking so fast I accidentally merged 'anime' with 'medication' and ended up saying: 'animedication' and we all laughed about it

8:48 “This is exactly what you’d see!” Tiny bells and festival stands?

"Still doesn't stop them claiming my videos though :)" You've made my day, Ed😄

The man, The Myth THE DOCTOR is back at with the cells at work review!

“The only artery that carries deoxygenated blood” Haha. Boy are med students happy every single time that questions pops up in the exams 😂

The statues look like Raijin and Fuujin, gods of Lightning and Wind. Lightining = electrical impulses, wind = gas transfer.

Love this series! As a med student myself, there was one aspect in this episode that I was surprised that you did not comment on - namely, local differences in blood pressure! Like how the red blood cell is wandering aimlessly in the vena cava, but is getting a huge speed boost once inside the aorta.

This and the MCU medical analysis series are really enjoyable!

Dr Hope is the Powerhouse of the Sick Notes!

Your commentary is uncontestably wholly transformative; don't let the copy claims get you down!

i wish they animate cells at work BLACK so you can review it... its same but in a perspective of a person that does not take care of his/her body...

by the time he finishes this season, the next season will be already out

6:17 It's so wholesome how he's bobbing his head to the music. 😭

"Cool... so the Red Blood Cell is... lost again." I'm laughing so hard.

They break down the red blood cell *white blood cell incoming* BUT NOT TODAY This whole episode was so wholesome. Red blood cell was out here doin her best and wbc was keeping an eye on her from afar was the cutest thing I’ve ever watched

Welcome back! Yeah I agree that by congestion I think they mean heavy traffic. Not much to add on the circulation episode, it's all quite chill, which is probably needed after the last one. The first pathogen you show, I suspect to be Shigella for a few reasons: 1) Rod-shaped and spiky, though that can also describe any of the Bacilli. 2) Pink face, suggesting gram negative. This rules out the Bacilli. 3) Haemolytic action as first attack. This narrows it down to species which are notably haemolytic, so we run the gram neg rod list: 3.1) Salmonella ferments for energy and mostly takes free nutrients, so no. 3.2) Vibrio (cholera) isn't noted for it, and we've already seen it in show. 3.3) Pseudomonas is haemolytic, but has already been seen in-show as the one-eyed bogie, so no. 3.4) Serratia tends more towards tissue destruction. Still on the table as it's an opportunist and our patient is a week post-cancer, but no. Most common in HIV patients, and our T cells and macrophages seem in full vigour! 3.5) Escherichia depends on strain and is a good candidate, but seems the kind of bug that they'd save for an episode. Maybe a special like the common cold. Escherichia is my second choice for this. 3.6) Klebsiella does look like this, with that thick white sugar capsule, but it's another fermenter which munches on the free glucose. I don't remember (though it's been a long time, I may be wrong) that KP has any notable haemolytic attacks, so no. 4) Having said all that, we seem to be going for a very Japanese flavour with this episode. The temple, the statues, et al. Shigella ticks all the boxes, is strongly haemolytic, and was discovered over a century ago in Japan by a famous Japanese doctor, Kiyoshi Shiga. I submit to you that the spiky bacterium is *Shigella sonnei* in particular. Thankfully Neutrophil got in there quick before the patient started peeing blood.

I'm sorry if this has already been pointed out somewhere. It is said in the video that the mitral valve was not described in the video, but I think the two gargoyles pointed out in the video are the description of the mitral valve. By the way, those gargoyles are properly called Niou statues. They are there to protect the temple from the bad guys. The mitral valve is known as the "僧帽弁" in Japan. The Chinese character for "僧" in 僧帽弁 to a monk in a temple. I think that scene probably depicts the mitral valve in the form of a Niou statue, hooked to the kanji that refers to monks in temples. ... It might be hard to convey this feeling unless you're Japanese or have lived in Japan before. Being Japanese, I didn't understand English, so I relied on translation sites for everything. I'm sorry if there are any oddities. I apologize for the long text.

Oh my goodness! I've been Hopeful that you'd continue. Thank you so much, Doc Hope

There's a manga called Cells at work Black It's in another body and shows smoking, drinking, etc. I remember it showing the macrophage in the liver degrading a eutrocyte

Broke- Doctor reacts to Cells at Work Woke- Cells at Work: Extended Doctor's Edition

Not even one minute in, and Dr. Hope already blew my mind. When I watched the episode back when it released I didn’t even notice they switched the Jacket’s color depending on it’s oxygenation!

I am a freshman student nurse and I couldn't be more proud that I understand all of this. Thank you so much for explaining some key points in the anime that I've failed to recognize. It really helped me especially during my term exams.

After watching these videos it's really cool to see how much the writers of this anime did their research even with the smallest and unnoticeable details like 1:08 and you manage to notice them and explain everything in a clear manner, i like the kind of reaction channels where i can leave with a medical degree pretty much.

My life is a mess but feeling smart from learning new terms makes me happy, thanks for letting us watch that show for free.

There's a part where she and her other blood cells are walking through the inferior vena cava and above them is a large dark blue pipe. Very clever seeing as how veins are blue on the outside of the body, they made the pipes above the veins blue. It just goes to show you how much thought and detail they put into this anime.

i presonally loved the detail of using a temple bell for the heartbeat itself, rather than reverberating the whole room

yaaaayy the moment weve all been waiting for! :D

Finally! 😂 Who else has been waiting for this? 😂

Doc Hope never fail as a hope, we have been granted a new episode of cells at work reactions/breakdowns. Grab your notes everyone!

Yaaaaay! A new one! It’s been a long time. ❤️

My dad is a consultant at a training hospital in my city and also the dean of our university medical school. I showed him some clips of this anime because I really love it and he found it cute. He also seems to approve some of the medical info they share. So if it's good enough for him, it's good enough for me to continue watching.

Somebody already mentioned this, you should review John wicks injuries. Love your Cells at Work series btw.

I really miss the series. Thank you for continuing them! Much love

One thing I loved about this episode is how Red Blood Cell was so determined to circulate by herself, and how White Blood Cell helped her and defended her when Killer T was putting down her efforts. Neutrophil spoke very kindly about how she may have this weakness of getting lost, but she is an extremely hard worker and determined to do it right; and besides, doesn’t everyone have areas of weakness? And then, even though he already knew about RBC’s entire journey, he sat down and listened to _her_ tell it with a pleasant smile on his face. I know it’s not related to medicine specifically, but I just love that. As someone with ADHD, it can be tough when, like our favorite RBC, you struggle to complete tasks that everyone else just does effortlessly. The world needs more people like Neutrophil U-1146, who listen patiently and appreciate the efforts of everyone, and RBC AE-3803, who give it their all despite the challenges they face.

Learning about circulation makes my head spin but explained this way makes it easier to understand. Thanks for the video Dr. Hope!

Wait that collar switch on her jacket thats such a cool attention to detail im amazed you noticed that!

I'm in EMT school and my class had a brief glimpse at the circulatory system. Watching this episode after that lesson was like a complete nerd-out moment for me! I was able to point out the major parts of the heart and trace out the path of the oxygen-depleted blood, oxygen-rich blood, and so on!

ive watched the anime and also read the manga and thought that those 2 statues were actually the bicuspid valves ahaha

YAAAAAAAASSSSS!!! WEEB DOCTOR IS BACK!!!!

Cells at work, my favorite series!

When I get sick I rewatch Cells at Work to remind myself how hard my cells are working to keep me alive. This anime has inspired me to take better care of myself 💝💝

I can tell that you genuinely enjoy Cells at Work, and that makes me happy when I'm watching.

I've been hoping that you would review this light-hearted but very educational episode which has helped many pass their tests on circulation. And as always great review, love the way you describe what is happening and the various details. Regarding the two statues, if memory serves me correct these are two of gods found in the taoist pantheon relating to the beginning and the end. Quite fitting given the role of the heart.

FIRST! This episode is one of my favorites! What I loved about this episode was how much White Blood Cell cared for Red. I was half expecting you to talk about some memories of doing rounds all on your own. The next episode will be interesting, giving insight on why Killer T cell needs to watch his salt intake.

After watching these videos from episode 1 to now it absolutely blows my mind how our bodies are designed for so many different jobs, its incredible.

It's both an education and a story as in this episode Red puts the effort to get her job done all on her own so you can't help but cheer her on

I actually am a heart parent who had a heart murmur which turned out to be my mitral valve never closing properly, never knew the actual word for the specific condition though!

Even though I know absolutely nothing about Cells at work I always enjoy your explanations of these medical terms it just brings a smile to my face every time I see a notification of yours. I learned something new in 1 minute in about the inferior and superior vein thing and that Deoxygenated. Im just so glad I found your channel I mean this just helps me out so much I can't thank you enough for all these videos. So once again Thank you Dr Hope.

11:31 they are the guardian deities found infront of shrines in japan and one reprisents intake and the other reprisents release or outtake

I must say, watching this again is making me feel really conscious of how I overwork my heart and cute little blood cells. Having a doctor explain the human body using an anime of the subject is a dream come true.

It's been a long time coming! Btw, a second season had been announced for this series! Thank you so much for all your detailed explanations! It's still a long way, but there was like an extra episode (Episode 13, essentially) after Episode 12, talking about colds and I was very confused by that episode so looking forward to hearing your explanations on the upcoming episodes!! Thank you so much!

Ohfuck, finally another Cells At Work episode, lol

Oh my god I didn't realise that you'd resumed this series!!!!! What an absolutely lovely surprise, thank you doctor!

HE'SSSSS BACCCKKKK And those statues out the lung is just some reference to certain temples that are guarded by different deities/kami (like a wind god or something) at certain gates

OMG! I clicked as soon as I saw it. I've been wondering if you would continue to do these. I am so happy.

I always love watching these. Pros: a anime worth checking out and also hearing someone passionately geek out on something they love. Cons: none at all

If I had to take a quiz after watching an episode of Cells at Work, I'd ace it. What an incredibly genius way to teach! And I learn even more from Dr. Hope. 🙏🏻💕

It keeps amazing me how mechanical bodies are, with the pumps, valves, electrical signals, etc., yet so intricate we're nowhere near fully replicating it.

I love your reactions, and i like learning all these things, especially from you doc, its a win win, continue to make great videos ❤!

It's been so long!!! I was missing your excellent reviews on this show. Thanks for getting back to it ^^

It was really cool to see you explain all the process showed in this episode. This definitely worth the wait.

I love how your videos are always well explained. It shows that you're not reacting at it just for views (because of its popularity), but rather because you find it good and want to share interesting points with us (that only you could explain so well!!)👍 You've got a new subscriber~

Thank you, Dr. Hope :D I reaaaaally have been waiting for this video - not only because I'm learning to understand English watching your content but also it brightens my day hearing your calming voice and looking at this funny entertainment. Keep up the good work but take your time. It's a lot of work producing these clips. I'm looking forward for your next video, greetings from Germany/Bavaria/UpperPalatinate

You are very helpful, I had a "systems of the body" pop quiz and I remembered this. Thank you😇

The heart is depected as a Shinto-Buddhist temple, and the statues are common guardian statues at temples in Japan. They're there to decorate the gateway back into the heart and denote the "temple" as a holy place.

About the heart and the statues, the heart itself is based on japanese shrines and temples (in Japan the two are slightly different, one word means budist and the other Shinto, a traditional japanese religion, but dont remember wich one). Japaneses are not really religious, but they have a strong tradition of going to a shrine / temple in January 1st and it always got HUGE amounts of people (imagine an entire city going to the same church at the same time, its crazy). That "somewhere where everyone goes in regular basis" and the drums / bells (representing heartbeats) makes that symbology really good, but hard to understand to non-japanese people. The two statues (and the big bell, and the Toriis in the scene where they're waiting in line) are traditional symbology of a shinto shrine/temple. That's not a medicine thing (except the bell and the drums, they are both religious symbolism and heartbeats).

Been awhile, Doc! These videos really help to understand the show more while waiting for the second season.

It is always good to see you again no matter how long the wait. Awesome video as always.

Dr. Hope... what are you doing? Why are you doing this to me? WHY ARE YOU MAKING ME LEARN SO MUCH?! And you know the worst -best- part? I LOVE IT!!!

1:07 I never noticed the color change before! Good catch doc!

*Dr. Hope! Love this! You are such a phenomenal doc and creator! Just wanted to share that my Cells At Work review is up! Thanks for all of your help with it

I love how you're so hyped when the anime makes clever analogies

Upon watching the episode, I just loved how the heart was this crowded temple, as in many festivities, the temples do get incredibly crowded (and the overview shots just help us realize their berets are shaped like blood cells xD) and I actualy measured the sound of the drums to my own heartbeat, and in some scenes, the drum actualy matched my rate (which was at normal speed, I can assure you).

I'm japanese. The Gargoyle is 「阿吽像（AUN-zou）」. This mean is 「阿（A）＝born」「吽（UN）＝death」、set mean is 「the Life」. Because, in Heart scene is very near likeness,「浅草（Asakusa）」at「New Year's Eve pilgrimage（大晦日oomisoka）」. Bell, gate（鳥居tri-）, and congestion,very near！

Man, whenever I see a heart diagram I always confused if the right side is my right or my left since it's mirrored

This and a English Dub announced this has been a great week for cells at work content for me

I'm a Cardiovascular ultrasound tech and this episode brought me back to my anatomy and physiology course. Loved it!

Yaaaay another one!!! These videos bring me such joy, especially since I've recently developed an issue in my body due to poor blood circulation so it was pretty cool to learn some additional information from you. Can't wait for the next one!

"the truth is the mitochondria is not the only way we produce energy" those 51 dislikes are all the mitochondria that got WiFi connection

You being a doctor, you probably film these vids on your free time. Its understandable when you don't get them out right away BTW another great vid 👍

I just realised that in all of these Cells at work episodes Dr Hope keeps a very consistent wardrobe!!

On the veins appearing blue through the skin factoid - not sure how true it is, but I've heard that this is the origin of the term 'blue blood' to refer to royalty/nobility; basically the peasants spent most of their time working outdoors so would develop tans and thus it'd be harder to see the veins while the nobs could afford to spend time out of the sun/be covered up, so tended to have paler skin, and thus it was easier to see the veins and because as you noted they look blue through the thinner layers of skin/tissue, people mistook that for them having blue blood.

I've been waiting for this 😄✨

I was really sad when you couldn’t post episode 7

I love the way you explain things. I can actually understand stuff! This episode was especially interesting to me because I've had two valve replacements, an aneurysm and an aortic dissection. I read all the documents from my doctors and a bunch of stuff online and I didn't understand half of it. It's a bit frustrating when you don't know what went down in your own body and how exactly it's affecting your present and future. If you ever want to and have the time, it would be so cool if you did a miniseries or something about every system in the human body and how they work.

Not sure if anyone's mentioned that the heart is depicted as a Buddhist temple, with a Japanese style walkway where festivals are held (and yes, they can get rather crowded); so the two statues are Nio, which kind of accentuate the aesthetic. They are kind of wrathful guardian guards and manifestations of the Bodhisattva Vajrapāṇi. They are also an interesting case of Greco-Buddhist influence on East Asian Buddhist art. In Alexandria Eschate, an ancient Greek city in modern day Tajikistan, there's an old carving of Vajrapāṇi appearing as Heracles, defending the Buddha. As the art moved east along the silk road, it ultimately became that

I see a hope cells at work reaction,I get to the video as quickly as possible!

Hey doc!! I saw the notification and just... stopped everything I was doing. Really enjoy this series!! I was starting to miss it.

I love Cells at Work, and I love how educational your videos are! Glad to see this series back

I have been waiting for this reaction for a long time