DOCTOR reacts to CELLS AT WORK! // Episode 9 // "Thymocytes"

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Complete with clickbait thumbnail! I breakdown scenes from Thymocytes (episode 9) of Cells at Work (Hataraku Saibou) from a real doctor's perspective. I'll be reacting to scenes and attempting to share a little bit more about the science behind the anime!
In this episode we cover the T cell development, the thymus, positive and negative selection, and even have time for a baby photo too.
This is a particularly heavy immunology episode, I've tried to simplify it as best I can, I'll include clarifications in the description here as they crop up... which they will because of the complexity of the subject!
This is part of a series reviewing Cells at Work, you can find the whole playlist here:
• Doctor reacts to Cells...
You can watch Cells at Work! here:
crunchyroll.com/cells-at-work/...
If you enjoyed this please check out my other reviews of Medical TV dramas; House MD, Scrubs, The Good Doctor, Grey’s Anatomy, The Resident and ER! And also I did a series on Marvel movies too, more on that soon.
Instagram: / drhopesicknotes
Twitter: / drhopesicknotes
FB: / drhopesicknotes
Clips used under fair use (education and review):
THANK YOU FOR NOT COPY STRIKING THIS VIDEO SO I CAN CONTINUE TO USE THESE GREAT SHOWS FOR EDUCATION AND REVIEW.
ALL Cells At Work! Clips owned by Kodansha / Kodansha USA and distributor Sony Music Entertainment (Japan) Inc.
Thank you to all the artists that make their music available for these videos:
Song 'Escapists' by The AutoDisko
Song 'First Day' by Huma-Huma
Song ‘Finding Me’ by Eveningland
#doctorreacts #doctorwatches #cellsatwork

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5 июн 2019

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Комментарии : 1,2 тыс.

@mirandabee2323 5 лет назад

Ah yes, the three types of T cells: jock, nerd, and boss lady.

@skybattler2624 5 лет назад

You'll see the boss lady having pity with Cancer Cell, triggering cancer part 2

@DonoZeek 5 лет назад

Not really, she's only defending him because she's in charge of defending body cells and since cancer cell is a cell. She's forced to defend him unless of course, he's not a cell.

@Tamaki742 4 года назад

@@DonoZeek SIKE, HE'S A CEL.

@CodexSan 4 года назад

What about the NK Cell?

@julianakarasawa315 4 года назад

🤣🤣🤣

@michaelramsey1299 5 лет назад

“Let’s get a bit nerdy here” we’re watch a doctor on you tube explaining an anime about how cells work...can we get nerdier?

@Fede_uyz 5 лет назад

Only if there are nerdy medical puns... Oh wait... there are. Nevermind

@joekenorer 5 лет назад

Unnerving epiphany.

@funfaxwithyaboi6483 5 лет назад

Michael Ramsey. Wait till I arrive at the scene.

@inggridprinsia6516 5 лет назад

I was thingking the same thing

@Alcadeias123 5 лет назад

I can only remember chemistry jokes but I know I wouldn't get a reaction.

@EarlyOwOwl 5 лет назад

Nobody: Dendritic Cell: Here's the story of this cell's entire life.

@ibudorongsapi6770 5 лет назад

You have a very cultured profile picture

@EarlyOwOwl 5 лет назад

@@ibudorongsapi6770 N E N E P A P A

@n-extrafries-surprise 5 лет назад

Mysterious Kitten M A R U K A I T E C H I K Y U U

@n-extrafries-surprise 5 лет назад

Mysterious Kitten seriously, because of Hetalia, I fall in love with Italy and their culture.

@Smeepsy 5 лет назад

@@EarlyOwOwl I came here to escape Hetalia for a while. Apparently it isn't that easy X9

@elysseussy 5 лет назад

i love that ed gets so into his immunology that he ends up spoiling the episode subject 5 minutes in by accident XD

@myanimeaddict 4 года назад

That's why I watch the episode before I watch the youtube video.

@fluffycat1293 4 года назад

myanimeaddict you probably meant ‘rogue’, not ‘rouge’ which means ‘red’.

@ghost-wl3pm 3 года назад

@Olivier Dubreuil-Gagnon i think that they meant rogue not rouge

@Thompson8200 5 лет назад

You may be a Junior Doctor in the UK but you're the Senior Doctor in my heart.

@artoriapendragonidilfitri7414 5 лет назад

Now that's just cute or in this case KAWAII.

@ayyylmao101 4 года назад

What a sentiment, lmao.

@julianakarasawa315 4 года назад

Are we calling him Hope-senpai now? 😅

@namelessaiz 4 года назад

@@julianakarasawa315 Hope-sensei

@UniversalDirp 3 года назад

Woah! Hes in your heart? What type of cell is he

@monjurakil2392 5 лет назад

Whenever someone says, " Let's get a little bit nerdy for a minute." you just know s**t's about to go down. Awesome episode.

@Durio_zibethinus 5 лет назад

*00:00 Sipping my luwak coffee gently at the beginning * 11:00 gulping my coffee, fixing my posture, and I know it's time for concentrate.

@LofiLoliCatGirl 4 года назад

999 likes on the brink of reaching the 1k mark

@immortalsun 2 года назад

You _are_ allowed to swear on the Internet.

@drmette 5 лет назад

"Can I have your autograft?" I'm just here for the awful dad jokes :-D

@chizomni 5 лет назад

I found that quite hilarious

@drmette 5 лет назад

@@chizomni It was!

@lightofjustice8459 4 года назад

Doctor jokes?

@Neis999 4 года назад

I kind of want to learn immunology and all other medical terms just to make jokes like these.

@Vekcrazah 4 года назад

chizomni that's the irony... terrible dad jokes are the hilarious ones, as dad jokes are always cringey

@dakotaferrero7454 5 лет назад

cells at work has been confirmed for a second season hope you do more reaction videos when it comes out.

@Genin99 5 лет назад

Since Dr Hope Loves Cells at Work and loves how it's a lesson gold mine and an Immunology refresher. The chance of him reacting to season 2 is high.

@CryingZombie666 5 лет назад

Yeah, seen that news. It's great.

@SiesVE 5 лет назад

They are also putting out a dubbed version that is coming out in August!

@tintillor 5 лет назад

I hope we get Cells at work black adapted in the future too.

@daa3930 5 лет назад

At this rate, he has to change the name of the channel to "Cells at work with Dr Hope"

@Bananaguy7 5 лет назад

9:40 “Let’s get a little nerdy for a minute...” Doc, we’re watching you react to an anime series about the inner workings of the human body, we really cannot possibly get any nerdier

@yourpalbryan1442 3 года назад

A comment above would beg to differ

@Immortal_Mentor 3 года назад

Fuckin lol bryan

@likemike3030 5 лет назад

Start writing some notes on grafts: Note 1: Nail an autograft joke Note 2: immediately regret said joke

@forcommentpurposes 5 лет назад

That was funny

@alkatron768 5 лет назад

you explain things in a way that even a stupid person like myself could understand, you're great

@SillyMakesVids 5 лет назад

If you understood it, are you really stupid?

@nyurai 5 лет назад

You're not a stupid if you attempted to understand something. One who never learns is an actual stupid.

@jonson856 5 лет назад

It's your! Not you're! Oh wait.... :P

@DarkHarlequin 5 лет назад

Here is the thing: we all apreciate some healthy self deprecation but mostly it's less about stupid or not stupid and more about explaining (really) complex issues broken down and then connected in a way that makes sense base on your existing knowledge & experiences. That's why doing this in the context of an anime helps and that's what Ed Hope does well. Use examples that we can understand (remember the 'bus' metaphore) and then recombine it in the context of the show.

@emilymorla1734 5 лет назад

Same

@angavel1221 5 лет назад

This is should be teacher's first choice to teach biology

@MegaHuntress 5 лет назад

Once Upon a Time... Life is also a pretty good condender if you ask me.

@Emisop 5 лет назад

Except school's won't allow it because there is blood/violence in the show.

@animesenpai1163 5 лет назад

Imagine watching anime in biology class lmao

@gladzmt6505 4 года назад

immunology and serology subject for medical technologist

@jameswashbuirn580 4 года назад

it is in China

@Chiasa7 5 лет назад

Sees notification. Grab popcorns and notes. Class is on lads, make sure you take your notes. Edit: Good, seems like most of you are taking notes, proud of you all

@enriquesol 5 лет назад

Of course

@nicnic4275 5 лет назад

always

@Lugia21 5 лет назад

I seriously wished shows like this were shown when I was in school, it would've made things far easier to understand and kept my motivation going.

@Creatorsan 5 лет назад

@@Lugia21 I would of loved science class instead of those boring vids.

@majourvelencianna5810 4 года назад

@@Lugia21 Agreed, petition to have anime as educational shows in school! 😂😂😂

@piros100 5 лет назад

friends invite me to hang out. me: "I can't I need to see a doctor" friend: "sorry to hear that, get well soon" me: * stays at home, binge watches Dr. Hope's Sick Notes * "technically I didn't lie"

@brycevo 5 лет назад

1:17 Thank you for the Dad Joke

@Kai-vo5zq 5 лет назад

I like how you have Master Chief as your profile pic and the time stamp the joke is on is at 1:17 lol

@brycevo 5 лет назад

@@Kai-vo5zq 😉

@Ithilion 5 лет назад

I almost had the impulse to click the dislike button after that joke 😂

@brycevo 5 лет назад

Thank you for the ❤️, Doctor Hope

@Colopty 5 лет назад

I demand more bad medical jokes.

@DrHopeSickNotes 5 лет назад

You are in the right place!

@usspaceforcethreatsandrese1915 3 года назад

@@DrHopeSickNotes I GET IT HAHA

@setsu-chon 5 месяцев назад

Take another one, then: Why is the killer T cells' work environment so toxic? Because they're cytoTOXIC

@elizabethlestrad5282 5 лет назад

Came for the click-bait thumbnail. Left with an education and no regrets.

@immortalsun 2 года назад

I like how Hope hearted this comment 😂

@imclearlybeast5044 5 лет назад

I’ll count this as my biology revision for tomorrow

@roynettle6864 5 лет назад

lol same here

@caitlynway5274 5 лет назад

GCSE exams?

@roynettle6864 5 лет назад

@@caitlynway5274 Yes i'm doing combined biology paper 2 tomorrow.

@caitlynway5274 5 лет назад

Fun... My sister is currently doing her GCSE's and in doing my A-Levels so there's a lot of stress in this household 😂😂

@jessicaahlgren1462 5 лет назад

Im ClearlyBeast GCSE squad call

@dokidokieienni1622 5 лет назад

2 Cells at Work Videos back-to-back within 2 weeks?! Doc, you spoil us~ Thanks for all your hard work!

@AlexSander-jr9et 5 лет назад

I don't get the spoiler...

@dokidokieienni1622 5 лет назад

@@AlexSander-jr9et There's no spoilers of the narrative type here.

@MALEMization 5 лет назад

@@AlexSander-jr9et Spoiling as in PAMPERING!

@gamelairtim 5 лет назад

Doctor Hope doesn't realize it but he is slowly creating the Cells At Work home tabletop game.

@VanRukh 5 лет назад

I am very pleased you still have that cell "family tree" and expanded it again 👍

@CryingZombie666 5 лет назад

One of the best parts of this series!

@MsKuroneko92 5 лет назад

He should frame it at the end of the season.. lol

@CryingZombie666 5 лет назад

@kuro neko Definitely!

@Nejove 5 лет назад

And to think he still hasn't added the basophils and mast cells from the allergy episode. That's a pretty big "family."

@CryingZombie666 5 лет назад

@Nejove Basophil is too mysterious to be added in the official family tree xD . As for mast cell, yeah...

@TriceeXO 5 лет назад

“Welcome to hell, you useless runts!” “Oh the flashback to medical school” “...i’m kidding” Hahahahaha. As a medical student, I feel you

@figgot1571 5 лет назад

I am learning so much from you, thank you. Now if only there was an anime about calculus...

@ThePigKnight 5 лет назад

1, 2, 3, 4 we are Integers at Work!

@CryingZombie666 5 лет назад

Hope Dr. Stone is adapted into an anime.

@magna8738 5 лет назад

@@CryingZombie666 it is going to be there is already a trailer out.

@CryingZombie666 5 лет назад

@Magna Nice.

@chexmex5845 5 лет назад

There's the Manga Guide to Calculus

@capobvious6999 5 лет назад

"You learn something every day!" is a beautiful line when you don`t know something. I`m gonna use it while passing my exams

@mindcaztackerman1160 5 лет назад

Your highschool Biology teacher explaining Ah , sh*t here we go again. Dr. Hope explaining. Oh , sh*t where's my notes....even though i already graduated.

@DarkHarlequin 5 лет назад

While it also shows what a difference a good teacher makes this is one of the anoyances of my life. I had such a large span of my life dedicated to learning and I resisted so much and now (that I have a full time job an 'adult timetable') and need to squeeze learning into my day I CRAVE new information and whenever I feel I didn't learn anything new in a day I feel really dissatified. Oh Brain and your ways of working xD

@DanielRenardAnimation 5 лет назад

I'm not big on "reaction" videos and it could write up a thorough treatise on why that is _(but I shan't),_ HOWEVER, I was pleased that I made an exception, for this particular video. It's like an extended education, on an already educational animated show, as well confirmation and explanations to what we're seeing; I quite like that! I know "react" is a popular term on RU-vid, but I feel "Confirm" or any other fitting synonym would be more fitting. I have not watched _'Cells at Work'_ myself, even though it looks pretty entertaining, on top of being informative, as is intended. I DID however watch _'Once Upon a Time... Life', (1987~88)_ which was MY generations _'Cells at Work',_ I suppose. Clumsier animation, but still left me with vital information about my body, that I remember to this day. I hope _'Cells at Work'_ will do the same, a whoppin' 30+ years later! *Quick edit:* I just went back to see the first episode of the series, and you DO mention _'Once Upon a Time... Life'._ SPLENDID! 😄

@Genin99 5 лет назад

I can't wait until Dr Hope gets to the Heat Stroke episode, because I'm sure he's going get a kick out of the ending.

@CryingZombie666 5 лет назад

No spoiler, please!

@JohnnyShagbot 5 лет назад

I can't wait until he gets to the finale

@Genin99 5 лет назад

@@CryingZombie666 I'm not going to spoil anything.

@CryingZombie666 5 лет назад

@Genin99 You did by revealing the episode's title.

@alliew31 5 лет назад

I hadn’t even realized that was next. I really liked that ending, but I feel like it kind of lessened the finale.

@flowerdolphin5648 5 лет назад

You explained how they become helper t cells & cytotoxic t cells. But how do they become Regulatory t cells? That's what I wonder.

@Vernoberno 5 лет назад

Flower Dolphin Treg are a subset of CD4 helper T Cells

@flowerdolphin5648 5 лет назад

@@Vernoberno ah, thank you

@Vernoberno 5 лет назад

Mr. Al Natural Killer Cells are somewhat separate, although they are also lymphocytes they are part of the innate immune system where the Helper T cells, Cytotoxic T cells and B cells are all part of the adaptive immune system. All come from the same progenitor but NK are sort of separate from the rest

@CodexSan 4 года назад

And NK Cells? 🤔 🤔

@ohlookmarki 5 лет назад

That autograft joke lol. Even before you finished telling the joke, your face looked so done 😂

@hikaru9624 5 лет назад

Nice to see that the cat approves of your artwork.

@CryingZombie666 5 лет назад

Cat:"6/10, not a CATastrophe"

@hikaru9624 5 лет назад

@@CryingZombie666 I could say something about that clawful cat pun but i play monster hunter where there is no shortage if cat puns!

@CryingZombie666 5 лет назад

@Hikaru WDM Meow God, such a purrfect display of cat pun, Nyaa!

@hikaru9624 5 лет назад

@@CryingZombie666 lmao why thank you! I've literally had years of practice with my cats in mh (seriously the puns are bad in mh).

@CryingZombie666 5 лет назад

@Hikaru WDM You have cats? Which breeds?

@zjzr08 5 лет назад

Additional notes: 1. We found out this episode that Helper T Cell was actually a pretty good combatant, kind of like a prodigy. Meanwhile, Killer T C was actually kind of a runt, working hard to just be competitive. The dynamic remind many of Naruto and Sasuke, with Regulatory T Cell I guess representing Sakura. 2. Helper T was actually not that nice towards Killer T, but they were forced to be in the same room. Because of that Helper T finally saw that Killer T is more than meets the eye, and that he is working hard to be the best T Cell. 3. It all showed up when Helper T saw Killer T secretly training that "technique", which because of that, Helper T helped Killer T overcome his fears by reminding him of that "technique" which helped him "graduate" (albeit accidentaly). 4. At the end the two had the animé cliché of punching each other, showing themselves as sort of best friends now, even though they still kinda hate each other's guts hehe.

@TGNXAR 5 лет назад

"Flashbacks to med school. Ha! I'm kidding." Your face says you're not.

@DecadentCupcake123 5 лет назад

Doc looks just as handsome in 360p as he does in 1080p.

@Asdayasman 5 лет назад

I would give the good Doctor a cuddle if he wanted it. :3 uwu

@ThePigKnight 5 лет назад

He teacc He reacc But most import He absolute snacc

@CryingZombie666 5 лет назад

I bet he still looks handsome even in NES sprites!

@ohlookmarki 5 лет назад

I diagnose all of you with extreme dehydration because y’all are T.H.I.R.S.T.Y. 😂

@lucidrii1490 4 года назад

6:29 "Welcome to Hell, you useless runts!" Dr. Hope : Ahh, the flashbacks...to medical (school)...... Me : Yes, that's me everyday.

@paigelego4027 5 лет назад

After 20 minutes now understand the T cell differentiations better than I did after 12 weeks of immunology ^^;

@glattmasmas1485 5 лет назад

i loved this episode ^^ , showing the photos of the in-anime cells on the drawings helped, i must say

@spambaconeggspamspam 5 лет назад

Your "Nerding out" session gets this Medical Biologist's seal of approval! Well done!

@razieldolomite698 4 года назад

I love it when you get into the grit of how the processes CAW tries to simplify work. I think the T-cell selection process you laid out was pretty easy to follow, and offered an insight that I frankly didn't get when I watched CAW the first time through. In the show it seemed a bit more 'random' which cells were gonna pass and fail.

@chapdattext3167 5 лет назад

Whenever you say "I'm kidding", I send my condolences 😅

@thesterndragoon9159 5 лет назад

The process of how Helper T and Killer T cells are made is one of if not the COOLEST thing I've ever learned.

@Giovanna-rv3gx 5 лет назад

"Let's get a little bit nerdy" as if this entire video isn't a nerd fest

@darthcalanil5333 5 лет назад

Ahhh, Major Histocompatibility Complex 1 and 2.... this brings back so many good memories from my immunology courses :D

@wambam3 2 года назад

i'm a vet nurse who regularly needs to know and understand veterinary medicine, but especially ongoing patient care and management. And holy shit, THANK YOU. I have learnt so much from you and your educational break down of complex systems esp throughout this series. I have pretty dibilitating ADHD and struggle with learning ANYTHING even if its life or death - but you, sir, are incredible. You are indeed filling the shoes of those who taught and inspired you and i hope to do the same. Thank you so much for these video's and your patience in teaching us all things about our own bodies (and those of our pet's too)

@thifa5041 5 лет назад

Me 3 Minutes Ago: *Watching another video* "After this video I'm going to sleep" *Video finishes* *Sees notifications* "Never mind, gonna watch this one first."

@dennisnedry8126 5 лет назад

new sick note CAW reaction video: exists sleep: am i a joke to you?

@Pnutbjtime 5 лет назад

TIL Dr. Hope isn't actually a doctor. His print of "MHC" was far too legible to be written by an actual doctor.

@roxrequiem2935 5 лет назад

Lol my mom is a Doctor I can relate to this. It took me 14 years to eventually read the shopping list she makes.

@kathyhalton8352 5 лет назад

🎵🎵 autograft repair, autograft replace 🎵🎵

@MischievousBastard 5 лет назад

I'm enjoying how much you can see their adult personalities in them. Helper T is always trying to get the most out of Killer T, and during the final exam he provokes an appropriate immune response from Killer T. Meanwhile Regulatory T is forever telling Killer T and Helper T to calm it down and focus on the job. Their professional qualities are their innate qualities which the thymocyte has simply nurtured.

@ranran_giran 5 лет назад

These videos are really good! I'm not a med student but the detailed explanations you provide are really interesting to watch.

@fizzledimglow3523 5 лет назад

I sat through an entire wix ad, enjoy your revenue, you champion.

@alliew31 5 лет назад

That baby picture was so adorable! Also, will definitely be coming back to this video when I have to memorize immune cell development.

@darthcalanil5333 5 лет назад

I always get baffled by how much care and details they manage to get into this series even down to representing the proteins and receptors. Truly marvilous^^

@dralarco 5 лет назад

Thanks for sticking with Cells at work! You gave a great explanation of stuff most would have missed.

@mindral1289 5 лет назад

That Autograf joke calls for a continuation. Dr. Hope reacting to medical dad jokes?! Great video as always!!

@Congele_ 5 лет назад

That would be an awesome video!

@kaisap112 5 лет назад

Have you had a look at HBO's Chernobyl yet? It's a very accurate portrayal of radiation-related illnesses on top of the amazing history and other details. I'm very curious about a medical professional's thoughts on the infamous nuclear disaster and its aftermath.

@bellota182 5 лет назад

+1 to this!

@AnakinandPadme1231 5 лет назад

Ikr same

@-Meric- 5 лет назад

It's not really accurate for the medical part. It's dramatized and made more extreme.

@melvinshine9841 5 лет назад

I loved Cells At Work already, but this series makes me appreciate the creativity and the science of the show even more.

@echo1878 5 лет назад

Oh my goooood, I love this anime so much. I love how you break it down while giving info in a way that’s easy for someone (with minimal medical knowledge) to follow. ♥️

@CryingZombie666 5 лет назад

It's like Dr. Hope is stomach acid that break down food so the body can absorb nutrients- "Warning, incoming KFC, please clear the road." Oh shit!

@echo1878 5 лет назад

StygianTraveler141 exactly 😂😂

@CryingZombie666 5 лет назад

@PrezSnow Glad you like my horrible joke. I usually make better ones than that but my health is not quite good today ( probably because my body is the equivalent of CAW Black, but not that extreme lol )

@echo1878 5 лет назад

StygianTraveler141 get better soon!! (And, hey, that was a pretty good joke for a sick person)

@CryingZombie666 5 лет назад

@PrezSnow Yeyyyyy- Wait. "Pretty good joke for a sick person"? But I didn't even use my dirty jokes! ( xD )

@andrewmirror4611 5 лет назад

A minute?! I came here to become nerdy for 18 minutes and 10 seconds, man!

@petreasupagain5036 5 лет назад

Emily: I want to draw something too! Ed: please don't

@justabrown-y 5 лет назад

Oh my goodness judging by that photo of "young you", you were always meant to be a doctor! 😁

@gedo1919 5 лет назад

I am taking AQA a Level Biology and I literally just had a question on CD4 helper T cells for my paper 1 today 😂

@msoberano98 5 лет назад

They should have a Special Edition set with you as commentary explaining the medical terms and situations. I would totally buy it.

@Durio_zibethinus 5 лет назад

3:35 I count that as an approval of your work. What a magnificent pawwriting 👏

@CryingZombie666 5 лет назад

That's the Pawsome Seal of Approval, sir. Meow!

@therealserenedestroyer7748 5 лет назад

Welp😁

@ovo-ovo 5 лет назад

Because of Dr. Hope the demo teaching I did went well. Lol. Because I picked the cells as the topic. I even used the visuals of cells at work. Ahaha

@ryma8983 5 лет назад

This is my favorite class

@CryingZombie666 5 лет назад

Nothing like homeschooling yourself with Dr. Hope.

@vitoriadias7990 5 лет назад

Me: There's no way Doctor Hope can get more adorable ! Doc: *shows a baby pic of his* Me: ....Oh. My. God.

@mirandabee2323 5 лет назад

That was my reaction too

@HoshiArt 5 лет назад

Never have I been so excited to see an educational video from a doctor come out

@thomaspernorio346 5 лет назад

i love how you still have that cell flow chart. It lasted WAY longer that i thought it would and it keeps growing! Even your cat likes it

@SamuriX2010 5 лет назад

Really hope Cells at Work: Black gets animated. I would love to see him react to the cells in an unhealthy body.

@CryingZombie666 5 лет назад

Me too. It'd be great!

@Whatareevenbirds 4 года назад

they just released the trailer!!

@fijit4 5 лет назад

You didn't cover how the regulatory T cells are picked. :(

@iammumei7034 4 года назад

When Dentritic Cell laugh I instantly knew that the voice actor was Nobuhiko Okamoto

@rurii8682 5 лет назад

Immunology makes so much more sense now. Haha. Love the simple explanation about cell differentiation. Also, I laughed really hard on the autograft joke! Amazing video as always!

@drmisbad 5 лет назад

I subscribed because I love your coverage of cells at work and I was so happy to see the notification that you've got another episode of it up. Great job on the video and can't wait to see the rest of the series covered.

@heatherhutton1117 5 лет назад

Learning more than I ever did in school. Thank you. You teach in a very refreshing way ❤❤😊😊

@thegkoshow7885 5 лет назад

Man I just found your reactions to Cells at Work yesterday and binged them all! Thank you for making me enjoy a show that I loved even more than I already did! The depth that you go in to detail breaking things down has made this such an enjoyable experience!

@grrman 5 лет назад

Honestly, I really enjoy the extra explanations for the various cells and their functions. You are doing an excellent job!

@isgota 5 лет назад

Fantastic reaction and explanation!! I knew a bit about the selection of T-cells in the thymus, but your explanation expanded my knowledge, thank you! This is the best show about immunology ever made. For physiology, I think Once upon a time... Life is ahead, any plans of reacting to it in the future? I think you'll enjoy expanding on it as much as you do on Cells at Work. Best!

@Kotorfreak 5 лет назад

Love these videos. Educational with a fun spin! :D I'm also a fan of Cells at Work and anime in general so that's a plus too :)

@pokemastericon 5 лет назад

I can't wait to see you get to the last few episodes. Now those will be a lot of fun for both you and us. Keep up the good work!

@Haplo-san 2 года назад

I like how you go deep on explanation the production and selection mechanics. Thank you.

@alex53748 5 лет назад

I hope we get a little bit more information about how Regulatory T Cells are formed, as the episode mainly focused on the Killer and Helper T Cells.

@gtf234 5 лет назад

It's mostly the same process, different proteins tested but the concept is the same. Tregs are selected in the negative selection; in the long and short is Tregs are what become of t-cells that don't respond strong enough to trigger the death signal but too strong to become mature naive Effector T's. It's called a Goldilocks process, not too strong, not too weak but just right. That being said, Regulatory T was present in the same bootcamp as Helper T and the Killer T captain- she's with them in most of the training scenes and that's kind of all there is to it, there's not much materially different to show regarding how she differentiated. They all started as the same progenitor cell and specified during this period in the Thymus.

@kellycamara2652 4 года назад

7:23 “separate the useful from the useless” ...in the English Dubbed version they use “separate the T-Cells from the Wannabe cells” 🤣

@araragi5322 5 лет назад

I only started watching when you made the first episode reaction to Cells at Work and I've watched every video, not just cells at work since. You are doing a great thing teaching people in bite-sized and easily consumable ways. I find myself learning, actually learning new things whilst enjoying doing so.

@stephaniest.5336 5 лет назад

Great epusode to watch and learn from. And as always great way of explaining all the fine details and what is going on in the episode in a way that's just as fun as the episode itself. Also like the little detail you added at the end when you asked the rhetoric question.

@kikimoreland5491 5 лет назад

i learned a lot omg!! thank you for the insight into positive and negative selection~~

@CryingZombie666 5 лет назад

*16 minutes later, still at 360p* Oi, youtube, process faster. I want my CAW dose fresh and juicy.

@anneenguyen4791 3 года назад

Been studying immunology for my new job and this has been so helpful -- thank you for helping me catch up!

@nitorishogiplayer3465 5 лет назад

Didn't think the macrophages they showed also played a part. That is indeed nice detail on their part and there was a lot of explanation in this video in particular. The parts about positive and negative selection was very clear.

@gtf234 5 лет назад

The thymic macrophages are the antigen presenters actually producing the class 1 and 2 MHC used to put the developing T's through the selection processes, plus you know, eating all the ones that die from failing either test.

@xx_1dreamstanlegend_xx422 5 лет назад

This man is becoming a weeb by the second with all this anime he's watching. That's a compliment and I _Hope_ he doesn't stop.

@SonGoku-777 5 лет назад

Don't worry.... I'll pack your stuff

@SatishYadav-fo8yt 5 лет назад

Don't stop making *Cells at Work* reaction videos! Waiting for the next one

@Koibito247 5 лет назад

I always drop what I’m doing when I see you release one of these. Love this! Thank you & looking forward to more!

@PawDK88 5 лет назад

i love when you do these Dr. Hope, please do them more often

@mandeep3.14 5 лет назад

Each of these videos make me appreciate the anime more ^^ 👍🏼

@SomeUnsoberIdiot 5 лет назад

Show is called "Cells at Work", and is a sort of entutainment show about.. cells. "I didn't think we'd cover quite so many cells."

@rgm96x49 5 лет назад

Thank you once again! This is personally one of my favorite episodes partly because Regulator T has a fair amount of lines here. Gotta love Hayamin's voice.

@zazoo5557 5 лет назад

Your videos are so comprehensive! Love them!

@delphoxoa9677 5 лет назад

So Dr. Hope, based on these first 9 episodes, would you say the creators of this show have definitely done their research? Is this show accurate while showing their information in creative ways?

@annyborg9158 5 лет назад

The show is based on a comic/manga though, and the author has done a lot of research and has medical advise as well to keep it as true as possible while still keeping it entertaining. I really recommend the original work (which is available in English) too! It's great!

@CryingZombie666 5 лет назад

Also, read CAW Black for your own... entertainment ;)

@delphoxoa9677 5 лет назад

@@annyborg9158 Oh my bad, I'm in the bad habit of always assuming the show is the original. Sorry!

@stilmaho 5 лет назад

@@delphoxoa9677 Keep in mind that anime are often adaptations of manga or light novel (and sometimes games). Not that remembering this will change a lot in your life though :)

@gtf234 5 лет назад

It's very on the nose in a lot of places, not just in how they mechanically work but how they are visually designed (ex. Eosinophil and Basophil's pink and blue uniforms match their Gram stain colors); not quite right or oversimplified in others. Most of the inaccuracies are mainly just conceits required for having persistent characters to follow or to make the information digestible and easier to understand. Examples: the average lifespan of a platelet is about a week, so we would not actually be seeing Leader and Backwards Cap-kun (yes that's his name) as often as we do; similarly, a Neutrophil's lifespan is measured in hours, so U-1146 is not surviving a week long battle against an influenza infection. Slightly more complex example, the Monocyte scenario (coming up in a later episode) is a little oversimplified and omits the connection to Dendritic Cells, but it gets the visual point across about differentiation. So all that being said, the main series author, Akane Shimizu, is very well researched for the series as well as the the now 5 spinoffs she's involved in.