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Dr.B discusses how Tecfidera works in MS on periscope

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Dr.B reviews how Tecfidera (dimethyl fumerate) works to treat multiple sclerosis. This is an oral pill taken twice daily for relapsing forms of multiple sclerosis. (Recorded LIVE via PERISCOPE)
Tecfidera plays a trick on the cells. By stimulating the NEF2 pathway, it tricks cells into thinking they are under oxidative stress. As a result the tricked cells respond with an anti-oxidant cascade that ultimately slows down MS disease activity! Fascinating and novel mechanism of action.
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These videos do not provide medical advice and are for informational/educational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos.

Опубликовано:

9 окт 2016

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Комментарии : 57

@Squeaky_Bean 3 года назад

Oh wow that's fascinating! Thank you! I've been on Tecfidera twice a day for 4 years. I wish I had a neuro that would take the time to explain things to me better. Think I need a new neuro...

@Itsme1. 2 года назад

I’m 22 and just got diagnosed with MS 2 months ago , I started with Tecfidera and hope it works well with me

@luvdaband6018 2 года назад

I just started taking it also.. I hope it does well for me also

@Shark999i Год назад

How are you now on tec??

@Itsme1. Год назад

@@Shark999i really good it’s been 9 months

@Shark999i Год назад

@@Itsme1. when its start working for you and feel better?

@Shark999i Год назад

@@Itsme1. i am glad to hear that ❤

@Petra44YT 3 года назад

Oh, thanks for explaining! ... I've been taking Tecfidera for about ten years now, and finally, someone told me how it actually works. :-)

@suebarnes2793 4 года назад

Love tecfidera been on it for several years Its amazing.

@lorraineallbutt4504 3 года назад

Good to hear 🌈stay well 👍

@y.ldealisticky7353 Месяц назад

I am on T240mg for 8 months now. My MRI shows no new lesions and those who where there, are no active. So 🎉 thank you Tecfidera ❤

@courtneycarone 2 года назад

im on tecfidera. i love it.

@jorgem2331 5 лет назад

Hoping to get started on Tecfidera. Diagnosed ten months ago and as of now not on any medication. Thank you for your time.

@AaronBosterMD 5 лет назад

Right on Jorge! #WeHaveMS

@waynesalvador9925 2 года назад

Been on it for a month. And it works👍👍👍👍

@LITTLEMUSTANGFILLY 5 лет назад

I'm on 120mg once a day right now. I was barfing constantly when we went to the higher dose. So we're just taking things way slower.

@athenasheffield2836 6 лет назад

Thank you for explaining how Tecfidera works (as wellas other drugs in different videos). I've been on Tecfidera for 4 or so years, and though it was rough in the beginning, and it is working amazingly for me. My black holes are virtually nonexistent (that one stumped me and my neuro couldn't believe it so she pulled up an old MRI and compared them side by side). I'm no longer bothered by the flushing other than once in a while. While I'm singing Tecfidera's praises, I must admit to one MAJOR delinquency; the instructions on the insert specifically state not to open the capsule, but unfortunately I'm too inquisitive and opened one and was tickled to find little bitty Barbie marshmallows inside. Can you please tell me how often I should be having labs done? What about the JCV test? I'm JCV+ and haven't been retested since diagnosed, but I sometimes wonder if the levels can fluxuate. I'm so glad I found your RU-vid page and thanks again!

@AaronBosterMD 6 лет назад

Athena, Here's a video I did on this topic recently: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-T3ENqDN0Q6g.html Generally speaking most recommend labs (complete blood counts and liver function tests) every 3-6 months. The JCV antibody test isn't "indicated" for use with interpreting PML risk with Tecfidera. That said, many of us check it, but that's very provider/center specific. I think it's awesome that you opened a capsule and found little bitty Barbie marshmallows!

@LITTLEMUSTANGFILLY 5 лет назад

I opened one too lol. Curiosity got the better of me. 😂

@Siouxsiebecksable 5 лет назад

Hi everyone, I am on day 3. The first 2 days were great some itching but that was it. Now today I am feeling like I have been hit by a truck. Feels like a bad flu without the head cold or sore throat. Has anyone else experienced this?

@sstojsin 5 лет назад

The main question about Tecfidera is, why is it so expensive(?)... When you consider, dimethyl fumarate it self is very cheap. 500 or so US dolars per kg i believe? With 1kg, you can make almost lifetime of supply of pills with it. So far, i've managed to find out it's all about acid resistant capsules, since once dimethyl enters human body, it does some funky stuff to it. Heck, it even makes skin reacts to it. But, once it enters small intestines it's not that volatile, or is it delayed release of it, or both combined? But it is good pathway, better to digest pills then to pin yourself almost every day untill the rest of your life. I hate niddles, not very fond of them.

@AaronBosterMD 5 лет назад

Pills are certainly easier to take than needles Sasa!

@rosered3919 Год назад

@@difranophile I want to talk with people like yourself on MS topic. Would appreciate any leads or links. Thankyou

@dennyweinberg1923 5 лет назад

Hello, thanks for the video. Would it be possible to give your opinion about Tecfidera vs. Ocrevus regarding side effects, PML risk, long term support...? I have RRMS and take Tecfidera for around 2 years, but I have stomach issues (and fatigue). Thanks

@AaronBosterMD 5 лет назад

My opinion is that Ocrevus is a highly effective DMT and Tecfidera is a moderately effective DMT. I have videos that review side effects and safety on both drugs (look under the "How do MS Drugs Work" playlist!)

@buffalobob870 5 лет назад

Thanks for you comments on Tecfidera as I'm currently on this...love your videos and plug your name to anyone interested in another point of view! As I'm contemplating switching therapies, is there a resource or even you own practice of "washout" periods for various medications...as I understand it, Tecfidera does not stay in your system very long, so I'd think a long "washout" period could invite the return of disease activity...Your insights or resources would be appreciated

@AaronBosterMD 5 лет назад

This would make a good video topic I think!

@buffalobob870 5 лет назад

yes it would...I've been scouring the internet for information and seems to be a judgement call based on a number of factors depending on what is be switched to and from and the relative health of the immune system. To me, it is a very important choice as I've had most of my disease activity 3-4 months following starting a DMT and most have just the voice ( a very important one) from their neurologist

@moonlookingforthesun1866 3 года назад

I'm on half dose. One pill a day, have you ever heard about it?

@juanquirarte3091 4 года назад

how's Tecfidera in 2020? I know this is an old video, I'm in Tecfidera for 6 months now, and my Neurologist, toll me my last MRI is worst than the one before;

@SaucyNetworkEntertainment 3 года назад

the medicine takes about 6 months to fully become active. so the first MRI after 6 months is your baseline.

@shalinidhir5335 4 года назад

Please make a video on aubagio...teriflunomide Is it better than tacfidera??? Waiting for ur reply.

@AaronBosterMD 4 года назад

1. studio.ru-vid.comWi7Ta8z9uEk/edit?Fmy_videos 2. studio.ru-vid.comDvUnjCwS_fI/edit?Fmy_videos 3. studio.ru-vid.comeFVkRIMuhDM/edit?Fmy_videos

@junior10199 4 года назад

Why is there not more polypharmacy in ms? Glatiramir acetate is relatively innocuous, right? Why not take it with another disease modifying med?

@samahelleacy4132 5 лет назад

Hi DR How long I can take TYSABRI( JC virus negative)? Thank you

@Katie-vy5rd 2 года назад

I am a nurse and have a pt that I give meds to, Tecfidera, and have tried to help him understand his need diagnosis and the pharmacodynamics and kinetics of this med as he has is discouraged by the side effects currently 2 weeks in on his taper up dose. He doesn't have unlimited resources as this is in a prison setting. I've been trying to gather helpful info but the only thing I've found is that it helps to take with food and the active metabolite's half life is about an hour this past part not so helpful. And an aside is that dimethyl fumarate is available, in which setting i don't know, for about $50 per metric ton! ... is it very helpful to separate the doses ? Eg. 120 BID vs 240 QD as far as side effects go? Thanks so much in advance!! And can he expect side effects to abate after a few more days? Weeks? Months?

@doctorken2k 6 лет назад

Would you go with Copaxone or Tecfidera.

@AaronBosterMD 6 лет назад

I have a video on my opinions of Copaxone in 2018: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Sd69KmEpsWM.html

@mrsminnamorato 5 лет назад

There’s mannitol, a gluten/wheat derivative in Copaxone. With me being highly gluten/wheat/celiac sensitive, I had horrible experiences while on it and thus quit while firing my neurologist because how do you advise and encourage a patient to take something before due diligence and knowledge of my sensitivity? We trust physicians for this, but so thankful I did my own as my RRMS was progressively worsening. So, in my personal experience, if you have any type of reaction to wheat/manna, or a derivative of manna such as mannitol, stay away from Copaxone. I’m currently on Tecfidera and I feel much better. Good luck and blessings to you with your decision as well as your future health!

@momtazjee 5 лет назад

Hi Dr.Boster would tecfidera help in lowering my edss my latest is 4.5 which is alarming right now.

@AaronBosterMD 5 лет назад

Howdy Vick! Tecidera and all the other DMTs are primarily intended to decrease or prevent FUTURE MS damage, but not really to give back damage that has already occurred. There are some small percentages of PwMS in clinical trials that experienced confirmed disability improvement. CDI is not a "strong suit" with tecidera but that doesn't mean it's not possible. I would just not personally choose this specific medication for that specific reason. Here's a video on CDI: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-TYvdnulc1Sk.html

@momtazjee 6 лет назад

coming off betaseron and looking to see if I get the go ahead to start BG12, what is the lymphocytes levels to watch out for ? they can’t be below a certain level?

@AaronBosterMD 6 лет назад

I would talk to your MS provider about this one. We often are concerned when absolute lymphocyte counts go below 0.8, but everyone is different. Worth discussing at your next visit with your MS provider for sure!

@momtazjee 6 лет назад

That’s good to know Aaron, I will certainly ask about next follow up.

@AaronBosterMD 6 лет назад

#WeHaveMS