EARTH DEFENSE FORCE: WORLD BROTHERS 2 - Character Farm m51 Inferno (feat. Most Overpowered Weapon) 

A fully charged Champion Glove can do over 1.2 million damage if it fully hits every 4.5 seconds or so. This is stronger than the most powerful special moves since the Samurai and the Genocide gun both do a tiny bit over 1 million total base damage.