Epigenetic Age Test #6: My Youngest Data For Horvath, DunedinPACE 

4:36 lycopene (tomatoes) protects against iron induced stress, and parsley is an iron chelator

I would champion you and Bryan Johnson in that Rejuvenation Olympics any day. Both awesome individuals.

Congrats on the prospective rejuvenation Olympics leaderboard ranking. Also, you're the first RU-vidr I've heard say Dunedin correctly. But maybe that's from listening to presentations by the scientists involved. ; - )

Congrats! Been following your progress for awhile. Thanks for all that you do

Oh my, the long-awaited Horvath data! You also gave the correlations. That's terrific, so thanks a lot, Michael! And what a VERY strong correlation between body weight and Hovath! 6% body fat is very, very low, but that makes me even more curious how you will feel when you reached that and even more if it turns out that the Horvath clock age further falls! I know you mentioned somewhere, but I cannot rember, so can you share what your height is? Also, fantastic to see the strong correlation between parsley, tomatoes and the Horvath clock. I banned the cinnamon because of the fact of more biomarkers going in the wrong direction, but your data makes me want to introduce it again. Do you use Ceylon or Cassia? Again, thanks for sharing your information Michael and keep up the good work. 🙏

Wow, that is great news! To get more parsley I have been juicing fresh bunches in my Breville juicer. I read a paper that said 70% of the flavonoids are in the juice and 30% remain in the pulp. I suppose one could add the pulp to stews or something.

It will be very interesting to see the effect of increasing salt while decreasing coconut butter on your HDL level. Since we saw in earlier videos that higher coconut butter and salt intakes may raise your HDL level.

ohno thanks for this. today i had 6 pieces of dates and seeing this made me realise that eating fewer dates may actually be better

I see salt has a positive correlation again. I wonder about taking 67% potassium chloride salt rather than 100% sodium chloride ?

Congrats on the 0.76!! The correlations withDunedinPace will take you to the next level, I'm sure.

Great video and congrats on the improvements. However the wrong statistical tests were used. At 12:18 when you ask the question "Which variables are significantly correlated with DunedinPace?", the correct statistical test would be a two-tailed hypothesis test. The statistical test shown in the results was for the Pearson correlation coefficient. With this test, you are not just testing for whether a correlation exists, but for the significance of the magnitude of that correlation (i.e. the r-value). However the questions you are asking do not regard the magnitude of the correlation, just whether the correlation is nonzero, in which case the two-tailed hypothesis test is appropriate. If you reevaluated your results with the two tailed hypothesis test, I think you may very well find that body weight and perhaps also calorie intake are in fact correlated with the DunedinPace measurements, given the magnitude of the r-values combined with the relatively low p-values under the Pearson test.

I find your information and analysis to be insightful and I am thankful for all the work you do. I have always wondered how much one can "effort" reducing the impact of aging. For all of the effort that you put into your personal health regimen, there does not seem to be much return on investment (if any) based on Horvarth and having a resulting intrinsic age that is mostly the same as chronological age. I suppose that there could be a much greater delta between intrinsic and chronological age (in the wrong direction) if you put in less or no effort. If in an ideal hypothetical world we had comparison data with a lazy identical twin, that might tend to show greater ROI and something closer to actual ROI. I have seen octogenarians outperform most everyone in certain physical fitness feats. They surely have some better markers of aging through effort and genetics. I think effort can certainly help with lifespan and healthspan to a degree. The question I ponder is how much can "effort" help and whether there is point of diminishing returns with increased effort. The low hanging fruit appears to be resistance and cardio exercise, unprocessed diet, good sleep, good relationships. I wonder how much "extra"," if any, one gets by going above and beyond the aforementioned basics in the previous sentence.

The parsley is probably Apigenin. I would just use liposomal Apigenin from Codeage or RenueByScience if you dont want to increase dietary intake.

Would be curious to see how your fitness metrics compare to the DunedinPACE? For example, what is your VO2max, how much time do you spent at 85%+ HR per week, how much time do you spend right below the lactate threshold for aerobic training per week, and any strength benchmarks you have. Thanks!

Excellent! Could it be a very good idea to interview Eliana Gomez or Gabriela wang, or even both? in order to know their habits that allow them to have such a low rate of aging

would be interesting to see how centerians score on a horvath map... it measures actual DNA methylation which is believed (!) to decrease metabolic flexibility. But it is not a constant. Would it then feasible to expect a strong relation to SAM and homocysteine and NAD? If you try to correlate the scored sum of the foods that act on NAD\CD38\methylation ?

Michael, do you speculate as I do that since parsley is a top source of apigenin which has been shown to lower CD38 thereby helping NAD levels, that is helping to slow your aging?

Hi Dr! if you don't mind, can you share which deodorant you use?

Good luck with the aging olympics FYI would you suggest Liposomal Apigenin for those who cant STAND parsley ? LOL

I wish I could understand how limiting sulfur containing amino acids (meth, cyst) extends lifespan, and increasing GlyNAC also extends lifespan. How is this possible?

Do you think epigenetic reprogramming will come fast enough for us? problem seems to be these jumping genes & then things like somatic mosaicism. i'm sure there are way more problems too, most obviously not being able to reset epigenetic resetting without resetting cell identity. ugh..

So what does this 50.78 mean compared to previous tests which show your age to be younger? Does this go hand in hand with the rate of aging where say you can claim to be as healthy as someone in their early 30's so you are looking at something like living 30% longer than you would have barring any further rejuvenation science to come?

It appears that epigenetics is an or the indicator of biological age. But is it the or one of the causes or drivers of biological age or just an indicator of biological age?

Which company do you use for testing IEAA and DunedinPACE? Is it just the 'TruAge PACE' test?

Is there a way to measure "stress" versus "distress" and correlate those with aging?

Cinnamon might be lowering your blood glucose slighly, which could be one of the indicators.

Have you considered that the epigenetic clocks may be more responsive than some of the other biomarkers? Maybe you could reanalyse using different time lengths before the test. Hopefully the results would be similar, but if not.... at a minimum you might be able to identify which are robust and which are not.... . [This is a common error in this type of study -- mismatched time scales].

So assuming that my DunedinPAC value is 0.8, in 10 years would I have aged 8 years? Which means that I age 20% slower than the normal population?

Thx Prof. LUSTGARTEN for this another great and helpful presentation. Intresting to see that dates have been shown in one of your previous videos ( ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-gWeht1QdpLc.html) to be associated with a shortening of telomeres. And in the present video, we again see that dates have a negative impact on your biological age. Therefore are you going to stop consuming dates even if it happens that they are actually healthy for you as far as the "big picture" is concerned ? Are you consuming dried prunes, dried grapes or dried figs and may I ask you if these dried fruits have a negative or neutral impact on your biological age ?

I noticed in the list of people most are female. Since women live longer maybe it's normal. Is there 2 DunedinPace calcularions, one for man one for women, or only one for both?

are you still taking 1000mg NMN? don't you think the positive effect just started taking place?

Mike, We have talked about this before. I am not clear how you can ignore methylation defects or methylation donors/ consumers when nterpreting dunedin. For example, if one has a genetic methylation defect like A1298 or the other synp, isnt it lofical that methylation on cpg would be affected? How about dietary methyl donors or consummers ( like high dose niacin)?? Clearly these should affect dunedin or horvath. Not taking this into consideration is lkke not consideting refined sugar intake when interpreting a1c. This area needs more study.

Michael, do you know what the other folks high on the leaderboard are doing? Are some just genetically gifted or are all LE hacking?

Since there is two types of cinnamon, one that is supposed to be slightly toxic, which one are you using? Are you able to reach out to Eliana Perez to find out what she is doing or if she is just younger?

Yikes; how does one have enough time to do this. Impressive.