Epigenetic Aging: How old is your DNA?

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Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging - a type of "clock" - based on the methylation pattern of an organism's genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence - a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon!
Get the show notes here:
www.foundmyfitness.com/episod...
Episode chapters:
00:00 - Biological vs chronological age
00:40 - Estimating biological age with epigenetics
01:17 - The Horvath clock
01:54 - The GrimAge clock
02:19 - Altering biological age
About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer, and nutrition.
It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com
This episode was fiscally sponsored through The Film Collaborative and a grant from a generous anonymous donor. www.thefilmcollaborative.org
#Epigenetics #Longevity #DNAMethylation

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4 авг 2024

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Комментарии : 319

@FoundMyFitness 3 года назад

Interview with Dr. Steve Horvath coming out next week. Let's get 2021 kicked off with a bang with a whole bunch of great new videos. Don't forget to *like and subscribe* and maybe even switch the bell notification to the on position. Show notes for this primer here → www.foundmyfitness.com/episodes/epigenetic-clock

@thepamo2812 3 года назад

Rhonda would you be happy to share your results of your test! It would be fascinating to see how your supplementation and lifestyle choices have played a role in this :) thanks for all you do! 👍 😀

@gururajbsavakar7154 3 года назад

Interesting, ANTI- AGING EPIGENETICS awaiting your interview with Dr Steve Horvath THANKS DR R. P.

@FoundMyFitness 3 года назад

@@thepamo2812 The test was a derivative of the actual chronological one (rather than the biological age grimage one), so it's not too surprising that it nailed my actual chronological age almost perfectly. Glad you asked!

@archiehickox6518 3 года назад

Fluoroquinolone Toxicity

@SamStormbornOrmandy 3 года назад

Are you kidding, I've been subscribed since the very first video I saw and I always watch until the end. 😃 Thank you and a very Merry Christmas to you Dr Rhonda 🎁🎄⭐

@TheSheekeyScienceShow 3 года назад

Epigenetics is the reason I decided to specialise in Biochemistry .

@MrRobertFarr 2 года назад

Hi there, I am interested in genetics. It's really difficult. Where, Scientific work is surely going to drastically age people. Even in finding out about D.N.A. it kind of wastes, so much time. It's very difficult, to communicate about these issues with the general public. I can see people learning about this type of information but by observing their actions. I am really not seeing them understanding this issue.

@thomasfresolone4441 3 года назад

Dr. Rohnda rocks!!!!

@robertkopp873 3 года назад

She does...

@mickz4601 3 года назад

Yes she does 🤙🏻

@joesmith-ju7hh 2 года назад

The perfect lady. All talent and looks with a traditional attitude.

@John-hj6ed 3 года назад

I taught courses in biological, marine and environmental sciences at the college level ... before I retired (20 years ago) I developed a course: The Biology of Obesity, Ageing and Disease and have followed the research in these areas ever since. In my estimation Drs. Rhonda Patrick and Valter Longo are absolute leaders in the field in presenting emerging scientific research in terms understandable by anyone.

@KenOtwell 3 года назад

I'm 64... the faster you get this info out, the better! lol.

@sleepsmartsmashstress740 3 года назад

Dear Ken over 96% human lifestyle decisions are based on emotions or what makes them feel good or avoid feeling lousy. Information is the LAST thing that impacts human lifestyle choice. So, presenting information to humans is largely wasted effort. Hounds of brilliant scholars like Dr. Patrick and Dr. James Hansen of NASA have gone hoarse trying to make public listen to science but all human chase after is short term dopamine highs not long-term outcomes. People refuse to tolerate the discomfort of a face mask while risking long term disability from COVID19. In short humans are scientifically stupid or decision ally dumb. Despite all the research and lecturing on longevity and turning back the clock the lifespan has shrunk in the US for the past 3 years in a row and that is about to speed up with COVID19. The best use humans would derive out of the research on epigenetics is to speed up the aging clock by drinking more etc. The sales of alcohol have gone up about 20% in the pandemic as there has been a drop in the physical activity by a similar volume. My anti-aging research work tells me that aging would remain incurable because humans are effectively a stupid species an stupidity is incurable. I have offered thousands to comply with my sleep and stress combatting strategies thus far zero takers. Humans dont really want to live longer unless they can get it in a pill like MNM.

@cameradudeNYC 3 года назад

@@sleepsmartsmashstress740 Very well put! Thankfully, stupidity is not evenly distributed, I am happy that things that I have learned have led to changes in diet, exercise, etc. Some of us will benefit greatly from this research!

@KenOtwell 3 года назад

@@sleepsmartsmashstress740 I'm not speaking for anyone but myself.

@micahwilson4244 3 года назад

@@sleepsmartsmashstress740 the more educated people are (with information), the more rational and reasonable they are. But I doubt you’ll take this to heart, it’s information, and you’re a stupid human.

@lpg12338 3 года назад

@@onlyhis5870 Well said. 👍

@aemind 3 года назад

I love these infographic style videos. They're so engaging.

@phoenixgazette5947 3 года назад

I think you mean simplistic.

@jonny1943 3 года назад

LOL

@inzo313 3 года назад

I can't wait to see the upcoming interview you mentioned.

@FoundMyFitness 3 года назад

That's great! Make sure to subscribe with bell notification! It's coming out next week.

@antoniomele436 3 года назад

Rhonda, this video is fantastic! You have made massive improvements since your original videos on magnesium and athletic performance. Congratulations! You are on your way to becoming one of the most influential science communicators of the 21st century.

@anisheshdas362 3 года назад

Thank You, Dr.Patrick. I recently stumbled across your channel and I have been on a spree since then. Thank you for putting such amazing content out here for free.

@daxd8358 3 года назад

Great , clear , at moving pace to absorb information, thank our Dr. Patrick. Layout of information w/ graphics to me with a form of dyslexia makes for attention getting Video . Please keep it coming and enjoy your interviews .

@kepdani 3 года назад

Can't wait to see the interview, I'm really excited to learn more about this topic

@mcgeebag1 3 года назад

Great content as usual and very nicely produced!

@alexnickolaev 3 года назад

Awesome visuals. And awesome news. Thanks for your work Rhonda!

@timmothyburke 3 года назад

I love your videos, your enthusiasm for helping people is so admirable.

@bloodsport326 3 года назад

Your the best Rhonda. You make it look easy, keeping it clear and easy to follow ❤

@TMPCarbs 3 года назад

Great video. Excellent lighting and composition. I like the background music.

@catalyticcentaur5835 3 года назад

Thanks, Dr. Patrick, for this/your presentation.

@diego_sarkaglobal1793 3 года назад

I'm excited to learn more! Dr. Rohnda, looking forward to the interview!

@tjames22123 3 года назад

Definitely changing it for the better, Dr Rhonda!! Basing that off your enthusiasm levels!

@vishnukrishnaprasad424 3 года назад

Love the short videos, please make more of these from the longer interviews with specific topics

@casey8974 3 года назад

Hello, on youtube search for “fmf clips”

@timothymiz9275 3 года назад

Dr. Rhonda is always on point! She breaks it done better than anyone on the subject of aging.

@Anthony1337 3 года назад

Outstanding video Dr. Rhonda Patrick! I’m sitting in the sauna right now! Great work, and thank you for Inspiring so many lives for the better.

@ComedyJesus 3 года назад

Another outstanding video, thanks DRP!

@stevesimmons6849 3 года назад

Wow ! Very much looking forward to that interview 🙂

@sleepsmartsmashstress740 3 года назад

How do you plan to benefit personally from that interview?

@antokindness 3 года назад

Fantastic, as usual of you!

@davidstrong7854 3 года назад

Can’t wait for the interview , thanks you ,,

@FoundMyFitness 3 года назад

Subscribe with bell or get on my newsletter to make sure you know when it comes out! :)

@sednolb 3 года назад

I am so into your work Dr. Rhonda Patrick!

@FoundMyFitness 3 года назад

Thank you!

@arnavdeshpande3764 2 года назад

Amazing. Short. Crisp. Loved it

@masa26762 3 года назад

Thanks! The video and the graphic really helped me understand this. It's hard to come by youtube video that's this complete.

@sxsxpl 3 года назад

Love those shorts, great animations as well.

@tyrone1son 3 года назад

Excellent video all the way around

@cherylnegus2441 3 года назад

Absolutely brilliant, thank you so much DrRhondaPatrick for sharing your genius with us.

@neobellator 3 года назад

😮 Really interesting! Great work with the infographic. Makes things easy to understand. 👍

@fabianwahle5119 3 года назад

Love the animation upgrade :-) (and the content as always)

@johntibaldi9496 3 года назад

I love this style of video!

@markrice3019 3 года назад

Excellent Review!!

@enriquecastellanos8214 3 года назад

I love you Dearest Dr. Rohnda, thank you so much for shared, thanks a lot!!

@TheJugga21 3 года назад

Wild!! Thanks again Dr. Patrick

@altargull 3 года назад

This is really good.

@AndreObradovicAus 3 года назад

love your work Rhonda I am proud to be a paid up member and love the T'shirts also, thank you I love my Sauna also

@steelrain52 3 года назад

new video! yay! keep'em coming!!

@FoundMyFitness 3 года назад

New interview next week! Make sure to subscribe with the bell notification so that you know when it hits.

@steelrain52 3 года назад

@@FoundMyFitness I will! thank you for your amazing videos!!

@Diamond4Jesus 3 года назад

You are the most phenomenal doctor I've ever met! And you are one beautiful angel 😘💗

@erkutgurun 7 месяцев назад

Subscribed dear Rhonda. Just started my Reversing-Aging journey. I have about 20 youtube videos of yours lined up next. :)

@RobertWadlow292 3 года назад

Thanks for all your work breaking down the science on topics for some of us lay people. I enjoyed watching your tryptophan metabolism and fish roe videos. I have now added that to my diet. Any new insights on the potential advantages of that over regular fish DHA? Also, could you do a video on the benefits or Red Light devices?

@susymay7831 3 года назад

Well done lead in to your personal introduction and content.

@anasputra2140 2 года назад

dr rondha never skipped her video as other ppl do.... just amazing...

@stevediben7900 3 года назад

Love the production quality of the video!

@philosophicalmonkachu7711 3 года назад

Nice information,video editing is quite a lot improved....makes it easier to understand.. Thank you for sharing ma'am

@FoundMyFitness 3 года назад

Thank you! This new video format is just the tip of the iceberg. We're gearing up for a lot of amazing new content. Join our member program to get extra science emails, a t-shirt, and other great stuff. FMF premium membership is the mechanism we're going to use to bring more *free* and *open* content to the public, all-the-while giving members a really great and cool members only extra content stream that wouldn't exist otherwise. Learn more at foundmyfitness.com/crowdsponsor

@kenycharles8600 3 года назад

Thank you.

@DoctorHemi 3 года назад

Very cool research! Thanks for the video.

@sleepsmartsmashstress740 3 года назад

Should we not call sauna research hot ?

@BottomG187 3 года назад

Great content!!

@namek3163 3 года назад

Great animations and edits!

@alexandrucolta6765 3 года назад

You are the best !

@sleepsmartsmashstress740 3 года назад

Are you sure or just a bit infatuated with her ?

@laurajackson6860 3 года назад

Thanks, Rhonda! Epigenetics - fascinating!

@sleepsmartsmashstress740 3 года назад

Did you know that Epigenetics is also largely pre-determined. Your epigenetic fate is decided by what your grandmother ate or did not do etc.? You are much better off working on the microbiome or microbogenome which does interplay with epigenome.

@alpha.0 3 года назад

Fabulous, looks amazing, where can we find this wondrous interview Rhonda?

@FoundMyFitness 3 года назад

It's coming next week! Make sure you're on my newsletter so that you get a notification. foundmyfitness.com/newsletter-2

@snorgonofborkkad 3 года назад

Wow, someone got a motion graphics animator to help them out. Very ambitious. Looking forward to all the new video styles you'll be experimenting with.

@FoundMyFitness 3 года назад

Expect more like this. Not only that, my members platform is getting better at the exact same time. Short, science-focused curated segments from interviews with helpful explainers are now coming out approximately weekly. www.foundmyfitness.com/aliquot (This paid content is a great value add mechanism FoundMyFitness has that helps us put out better and better *free content* on places like RU-vid).

@keepmoving1185 3 года назад

Well done!

@Beyond_Partisan 3 года назад

She is getting much better at relaying this information in layman's terms ❤ Can I ask my Family doctor to order me some of these tests? 😊😊

@sleepsmartsmashstress740 3 года назад

Even if the doctor does order them and you get the tests taken, the key is in the interpretation. An why not just assume that there is some minor flaw with the testing and that there is some aging and take preventive steps anyway e.g. assume that you are going to develop diabetes and modify your lifestyle to prevent that from hitting you. Good idea?

@sleepsmartsmashstress740 3 года назад

@@onlyhis5870 Satanism is STUPIDITY not Science Leave Dr. Patrick out of this insanity Post elsewhere Get lost !

@tryptaminenurse9851 3 года назад

Dr. Rhonda Patrick is 42 and looks like she’s 32. Thank you for all of this life saving information Dr. You are helping thousands around the world.

@marian.trandafir 3 года назад

NOW THIS IS TRULY EXCITING! Capital letters exciting level 😂😂

@miguelbertonatti 3 года назад

Wow. Amazing!

@Dmadiroe 3 года назад

Awesome video! The music is a bit too loud and distracting in my ooinion. Appreciating the production value tho! 😊 All the best. Dan

@xavierghazi4939 3 года назад

Exciting to say the least and looking forward to watching the interview. A note in passing though. I wish there was no background music added to this introduction video or any other similar videos. I struggled to listen to what you were saying with the interfering music on. I suffer from Misophonia (literally hatred of noise) and this condition is more common than many suspect and noise/sound make us immensely uncomfortable. Thank you either way.

@xavierghazi4939 3 года назад

What is Misophonia: www.webmd.com/mental-health/what-is-misophonia#1

@gracelebleu7216 3 года назад

Love the graphics/animations!

@sherievaughn6475 3 года назад

Looking forward to that interview to see if dr. Horvath talks about fasting and how it triggers change through epigenetics...

@jeffreyleung5603 3 года назад

I love Dr. Rhonda Patrict!

@moonoom764 3 года назад

Awesome video, Rhonda! Have you heard about Cipro toxicity? Do you know what to do about it?

@bapcorp8303 3 года назад

This research is Amazing, look forward to more. We are told that heat stress is extremely positive for the body.

@captainnemonic 3 года назад

That bit in the sauna at the end made me lol. Great stuff! I hope the sauna is working to positively change your epigenome.

@larrykraft2743 3 года назад

Loved the playful P.S. at the end of this video. Given that you, “turned up [your] heat shock proteins”, yes, I imagine you must have changed your epigenome. Thanks as always for your evenhanded explanation of the science that is being done in this area. Thanks also for the reminder that I intended to get a sauna after seeing the evidence you shared about that before!

@JakeRichardsong 3 года назад

Thanks.

@patricfarah2858 3 года назад

That's amazing.

@majluke 3 года назад

you are one hell of a lady, I enjoy watching your vivid and expressional videos

@ericschneider7294 3 года назад

Half of what you say I don't understand, but taking out the big words I get the just of it. That's what matters. Thank you for sharing your knowledge! : )

@sleepsmartsmashstress740 3 года назад

Would you mind sharing the summary of what you learnt. She does talk some foreign language I think

@MMcGui 3 года назад

Dear Dr Rhonda, It seems that you geared up the stuff; the content format! I am looking forward to see you enlightening us with your humanistic work with also other practices and molecules such as Honokiol, berberine, hydroxycitrate and so forth! Best,

@FoundMyFitness 3 года назад

We're going to do so many great videos in this upcoming year! Make sure that if you've subscribed on our channel, that you've clicked the bell on... because it's going to be nothing but great videos for the next year. You won't want to miss out!

@higherresolution4490 3 года назад

Excellent presentation. Much appreciated. Fascinating subject. Apart from methylation of histone proteins, 8 of which form the basis of chromosone packaging when the double helix of DNA wraps around themj, histone modification also takes place at different locations on different amino acids in the form of phosphorylation, acetylation, ubiquitylation and sumoylation. By no means is methylation the only game in town.

@bneymanov 3 года назад

Words cannot express how excited I am about this! I notice that this video doesn't mention NAD boosters, hope you cover this topic in the interview though!

@FoundMyFitness 3 года назад

We did do a really in-depth video on NAD+ a while back... www.foundmyfitness.com/episodes/nad-nr-nmn

@bneymanov 3 года назад

@@FoundMyFitness And that video without any exaggerations is to day my most favorite video on all of RU-vid. :) It's incredible content explained really well at perfect pace, so thank you for that! Why I hope that you touched this topic with Dr. Horvath, is trying to get a diverse set of opinions and to see how it contrasts with his own research. :)

@sleepsmartsmashstress740 3 года назад

NAD would be only remotedly linked to epigenome if at all so that would have been deemed outside the scope of the talk. One cannot be totaly inclusive. What role the NAD boosters play in the rate of aging ?

@ste-fi1qy 3 года назад

Sounds awesome

@t5o7m 3 года назад

Credit where credit is due ... here because of comments below a Dr Eric Berg video ... so, I SUBSCRIBED and rang the BELL "All" ... looking forward to learning more about you and from you :)

@qmm6054 3 года назад

Yes, I do think the sauna is changing your epigenome! Thanks for the awesome video. I look forward to the interview with Dr. Horvath!

@Pyriphlegeton 3 года назад

Goddamn, the quality of the graphics is fantastic!

@FoundMyFitness 3 года назад

Like, subscribe, and become a frickin' member for more like it! The FoundMyFitness premium membership comes with some really cool perks where we're shipping something cool every single week. Totally worth it and it helps us "next level" our content like this video did today! www.foundmyfitness.com/crowdsponsor

@didinx8417 3 года назад

The Horvath Clock....still sounds like an Umberto Eco novel.....😊

@kral3046 3 года назад

Rhonda, i don't if you upped your skin-care game or actually reduced your biological age but you look soo healthy and fresh in this video which makes me produce lots of serotonin alongside the trajectory that aging research and awareness is gaining! Maybe 2020 isn't so bad! 😁

@teemlee51 3 года назад

Don't know about you Dr. Patrick but my sauna is making my telomeres grow like a weed under a rain gutter, ha. Always excited to hear your information! Cheers...

@ChannelAA 3 года назад

Great presentation as always. However, background music a bit irritating though. Thanks.

@rezavaziri6900 3 года назад

What are your thoughts on David Sinclairs work on OSK-induced epigenetic reprogramming? It sounds like a pretty unique way to achieve the desired methylation patterns, and strengthens the the case for a correlation between epigenetic age and biological age. Thanks for posting more epigenetic content!

@MichaelWilson-cx1hh 3 года назад

I did my genetic makeup test with ancestry. Would I be able to use this data with the grim clock to find out my epigenetic age?

@johnmausteller 3 года назад

I’m curious if it does alter it

@keepme5225 3 года назад

You hit it out of the park Rhonda. I was wondering on a loosely related note: do you think I could get away with a mustard seed capsule taken right after my broccoli sprouts or does it need to be blended into the smoothie? I want to take my sulforaphane optimally, but I’m having a lot of trouble getting down that spicy taste.

@melissacostin4464 3 года назад

Great info, clearly explained..sharing ..I'm wondering if you've looked at ox DNA ie hydroxylation as also accelerating aging ...hence value of antioxidant rich whole foods ..I reccomend you look at cannabinoids as fat soluble membrane components which prevent oxidation and thus DNA damage ..might pitch the clock to cannabis industry looking at research ..thinking topicals on sundamged skin cropping SCC would be great patch to test prevention and treatment of senescence / advancing oncogenesis ...I'm glad my myotherapist Reccomended your channel ..

@deanj6722 3 года назад

OMG! doc you scared me at the end! i have never seen you speak so loud and energetically haha

@williamtomkiel8215 3 года назад

Thank you how to access these resources- who can provide these tests?

@FoundMyFitness 3 года назад

The work Dr. Horvath is talking about is still ultimately an investigational tool in his lab. But, there's been some attempts at commercialization for the *chronological* part. Check out myDnaAge.com (no affiliation).

@ac27934 3 года назад

Whoops, only one A. Link should be www.mydnage.com

@borissman 3 года назад

Hey, Rhonda! Can you PLEASE have a friendly debate with Paul Saladino about the dangers of sulforaphane? He is a really nice and respectful guy. Please consider!

@synsynsy 3 года назад

no he is not. he is not nice and not respectful.

@borissman 3 года назад

@@synsynsy i watched many-many hours of his debates. I must conclude that he is. Why do you say that he is not?

@Earwaxfire909 3 года назад

Can you review the paper: Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome, by Holger Hueyn, Sebastian Moran and Manel Esteller?

@toddvolpe6396 3 года назад

Yes, I do 🔥

@christopherellis2663 3 года назад

Hibernating between meals, like from Friday to Monday, is a great epigenetic hack, the sauna is, too.

@brandonessick775 3 года назад

Interesting.

@tonakkie635 3 года назад

Indeed should be an interesting interview 👍 Do David Singlair and Dr. Horvath work together?

@sleepsmartsmashstress740 3 года назад

There is a generational gap there

@damonustin1355 3 года назад

Hello Rhonda, What type of sauna would you recommend to install at home? Infrared or regular? Thank you.

@sleepsmartsmashstress740 3 года назад

Cardioprotedtive effects of thermal conditioning have been reported only in a Japanese study with infra red sauna. Regular sauna might not be cardioprotective but might help otherwise.