Evo-Devo (Despacito Biology Parody) | A Capella Science 

Finally! Someone translated despacito to English. I'm pretty sure the translation is very accurate.

This is literally an entire semester of a 400-level Evolutionary Developmental Biology course, summed up in a 5 minute song. Fucking legendary.

At first, I was thinking, "There's no way he can make that song work." I was, clearly, wrong.

Biology aside, someone has to mention how absolutely INSANE this acapella is musically. He is not using any external instruments apart from his damn mouth. Absolutely incredible.

Friends : What type of music do you like to hear ? Me : It's complicated

When I get demotivated studying biology, I comeback to this and get hyped to study bio again.

This is a masterpiece and must be protected for future generations

I STILL get shivvers from how good this is. 3 years later.

This is genius. As a molecular biology grad (whose favourite class was evo devo, cause I'm a nerd like that)...this hit the exact right chords hahaha

This deserves as many views as the actual song.

The only problem I had with Despacito was it's lyrics, thanks for fixing it.

This is so incredible. The fact that he can put all these talents into one. The singing, the acappella, the scientific knowledge, the brilliantly clever song writing. Literally amazing

I need "Switch a couple bases in the proper places, you'll be watching flies grow legs out of their faces" on a T-shirt. ASAP

When your Mother wants u to be a Musician but ur Father want u to be a scientist...

So you made a well-constructed parody song about biology, with matching lyrics and metrics that also serves as an accurate educational summary of genetics.That requires... a strange combination of skills.

Is it just me, or does anyone else get all teary-eyed towards the end when he sings "in this manner life's beauty grows..." Man, I love evolutionary biology

The fact that I can listen to this over countless times and each time find a deeper reference, meaning or beauty to it is reminiscent of the field of biology itself.

Hey Tim, are you aware that a guy called Luis Fonsi made a parody of this song called "Despacito"?

Normal person* cant understand despacito* Science geek*forcefully puts science into it and everyone loves it* (Including me)

I watched this video four years ago, and since I was interested I bought and read one of the books he talks about in the end (Endless forms most beautiful, I think, I read it in Italian so the title was different but still). Anyhow that is how I got into evo-devo. Four years later and I am currently enrolled in a master's degree in Evolutionary Biology after completing my Bachelor's. Finally about to get those detailed classes :) Keep doing this kind of work, it can really capture the attention of young scientists!

SPECIAL THANKS TO MY PATRONS: Antonio Juarez, Bruce Mount, Paul Christian Sommerhoff, Robert Carpick, Victoria Huyer, Donal Botkin, Aaron Kannan Warnongbri, Lisa W Gardner, david adler, Jeffrey Cooper, David Strong, The Schalick Family, Grant McCracken, Yonatan Zunger, Tiberus Quadson, Alex Karantza, Jeff Shaevel, Carlea Duque, Tom Rawdanowicz, Hilary Fried, Aza Derman, Dania Drewing, Sarah kingham, Tim McElroy, Mark R. Williams, Lowell Chapnick, Magnus Haw, Amber Murray, Mike Mollman, Tybie Fitzhugh, John & Frank Lampert-Hopkins, Walter Smith, Theo Cooper, Elliott Sumers, C. Carnes, Gabriel Nichols, Mark A Laffoon, Nathan Williams, Steve Condas, Aaron Cai, iain, DarrenXu, Robert Becker, Timothy Goh, Justin Le, Mark Heinlein, JOHN D GRAVES, Richard W Evert, Lauren Weiss, Colm Ó Riain, Arnfinn Christensen, Cloe V., Paulo Carvalho, Geekeh, Paul Foster, Iris Liu, Steve Bryson, Bryan Andersen, Gregory Toto, Janne Granroth, Alex Altair, Sub Comediante, Fiona Routley, Phillip Broussard, Marinovic Family, Scott Cartwright, Lorena E. Rosaleny Peralvo, Robert Mcbrayer, Jennifer Hoffman, Will Handy, Rebecca Rickly, Álvaro Arias, Patrick Dennis, CW Robertson Jr., Cynthia Shafer, Jonathan Zucker, Mark Abbott, Sam Dick, Carl-Johan R. 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"Back before we blew up the Cambrian like a bomb, bomb" Shout-out to the Precambrian explosion!

It's nice in some way because the original Despacito is about how he wants to do that process of making a new human with her, and the emotions involved, while this is about the actual biological process that occurs when this happens :P

"What genre of music do you like?" *"Science."*

I study biology and I play this song 8 times a day in my exam's period ("take exams" too). Actually I was listening to it today before my develop biology exam to motivate myself and guess what??? Drosophila's develop was question 3😂

That was awesome! Thanks for the shoutout to this fascinating field of evolutionary biology!

I'm a biology student........and OMFG each and every word is so damn true👌👌👌👌👌👌better than spanish despacito😂😂😂🤣🤣🤣

When u find out u are 1% Latina but *99% Laboratory technician*

You really should make a video where you explain all the science behind every line. Even if it was an hour long I know that I and many other people would watch the whole thing. If you don't then someone needs to because it feels like a waste for all this amazing science to go over the heads of so many people

Original version- Sounds good but means shit. Biological version- Sounds good and is a meaningful song.

Finally, a version of Despacito that enhances your brain, rather than melts it.

I really love the line at 2:24 where it goes „switch a couple bases in the proper places you‘ll be watching flies grow feet out of their faces“ 😹

The first Despacito version that you can actually listen to!

WHY IS THIS SO DAMN GOOD?!

This should get more views than despacito.😂

I am not a biology major, so I ended up googling each term in order to understand it. This song is fascinating.

This genuinely sounds better than the original, even disregarding the cool science stuff.

As a biologist I'm drinking a Stella, working on some bioinformatics stuff, with this in the background. It's midnight. Oh boy...

Anyone prefer this to the original Despacito? :)

"Aesthetica in vivo" gives me chills every single time. Amazing work.

Lyrics, your welcome! : EVO-DEVO Huxley B. Mac Oh Carroll, Carroll Gould, Stephen Jay yeah D-D-D-D-Davidson and Peter See One cell divide and decide on a thousand fates Did you ever figure how they know? B. Mac We Are built of modules combined in a planned out way Each new piece must be told where to go Oh Now there's a science helping us to understand How our cells encode this architectural plan Signalling each other with genetic tools oh Oh yeah Wow Phenotype the interface for mouse and man Genotype the files and the subprograms What then are the switches, circuit boards and boot code? Evo-Devo Looking at the logic in the ways that we grow Every gene directed by a signal key code Proteins that can activate, enhance or veto Evo-Devo Signals are controlled by other genes that signal Calculating in a network labyrinthal Where the heart and liver and the hands and feet go Signal mapping tells each region what it ought to be yo With circuits so deeply built upon They're older than the Paleo The Paleozoic Era baby In a crucial pathway changes tend to get torpedoed Where they go calamity goes As this cyclopic sheep knows.. See down they cascade like a domino Like you and I drosophila The path that makes us optical Was laid a long long time ago Back before we blew up the cambrian like a bomb bomb Now my eye protein can make you see out of your bom bom And Hedgehog and its relatives like Indian and Sonic Set up set up in a gradient on segments embryonic Split forebrains and asymmetric parts depend upon it Flipping on genetic switches and logic From devo to evo Adult and embryo Mostly don't evolve in the genes of the genome Safer the mutation aimed at regulation Keep the building blocks and swap their activation From devo to evo Parts have alter egos Homologs evolved from repeats in the schema Switch a couple bases in the proper places You'll be watching flies grow legs out of their faces oh yeah Evo-Devo Stick around for Modern Synthesis the sequel Only by combining can a new theory grow Evolution and development amigos Evo-Devo Signals trigger patterns of complexity so Switching up the switches of a signalling node Gives a modular and simple way to evolve Look at how our spinal segments generate a neat row Built on a molecular clock One cycle, one vertebra One vertebra one vertebra baby Speeding up its rate is snakes' developmental cheat code That and where a lizard's feet grow They turn off distal aminos Evo-Devo This is how we go from single cells to people Every generation and in life primeval Life in variations endless and beautiful Badaboom From devo to evo Larva to mosquito Patterns are resolved as the signals proceed yo Map out a gene with a glow tag Kill it with a morpholino Short oligo morpholino baby From devo to evo Voyage of the Beagle Body plans evolve when proteins steer the genome In this manner life's beauty grows Aesthetica in vivo Evo-Devo

Listening to this song brings me tears of pure joy. Aesthetica in vivo.

I love well you give your lyrics the same rhythm as the original ones, many parodies fail to do that and end up worse for it!

This song is Fuckin Legendary! It's been 4 years and I still can't get it to stop playing in my mind. At totally random times, I sometimes shout 'Signal signal!' or hum random parts of the song while reading. This song is like the Genetic code itself, tightly packed with the entire summary of Evolutionary and developmental biology in a few minutes. I was starting out with Embryology when this song came out and this made me understand the genetic regulation part so well. Still waiting for some more amazing songs like this one. This is still my favorite though. It was my ringtone for a year.

Song is even greater when u are actually able to understand it. Each and every line of the lyric is biologically correct. Voyage of the beagle!!! Hats off man 😂😂

Some fool: Evolution is a myth! Me, an intellectual: This is so sad. Alexa, play Evo-devo.

This is excellent. Truly excellent.

I come back and watch The Molecular Shape of You and this video back to back every year or so. They flow together so well. Two of my absolute favorite videos on RU-vid of all time.

I love how the animations at the end of Molecular shape of you and the beginning of this song line up seamlessly

This is beyond genius 😂 I love it!

People already look at me weirdly when I sing "ligo feels the space is rippling through...", I'd love to see their faces the next time I hear despacito and I start singing evo-devo hahah

These videos make me cry because of the beauty of the universe

Damn, boy. As every song comes out I think - "There's no way he can ever top THAT one" . . . and then you do. Utterly amazing.

WAY BETTER than Despacito, I don't care what my friends say 👍

hi!! i'm a high school student from south korea. i'm planning to go to college and major in biology. my favorite part is evolution. this song is fascinating. can't say i understood all of them, but there are some things i do know. thank you for the wonderful songs and please keep making them until you become rich, lead an amazing life, and live to be 120!!

I've listened to this probably 30 times recently. As a recently recovered Young Earth Creationist who wasted the best 15 years of his life absorbed in that crap, finding actual science and seeing it so eloquently put together gives me immense joy. Thank you for all you do.

Why can I only like this once? You are a freaking genius! Your musicality is phenomenal and your scientific explanation is perfect!

As a biologists, I love this song

when u realise the beaats were coming out of his mouth..

Still listening, added 100 more plays. My favorite line starts at 3:13. “Molecules-to-man evolution” (and similar alliterations) is a favorite phrase used by Creationists to describe the apparent foolishness of thinking that humans could've evolved from single-celled organisms. I get chills every time I listen to you sing that part because of the joyful freedom of escaping those shackles. I have so much catching up to do, but people like you inspire me to seek out more knowledge everyday.

I have actually never heard the original version of this song (since I avoid pop music as a rule and have not listened to it on the radio as a matter of principle for most of three years) and, judging from the translation I looked up, I'm glad I haven't. That said, this is brilliant! My passion is physics, but I often feel that I don't spend enough time thinking about the other sciences. This excursion into the world of biology is refreshing and fascinating. Thank you so much Tim Blais for the wonderful work you do. (On a different note, the spelling of "sequel" at 2:33 is bugging me more than it probably should.)

I was wondering when a Despacito parody was coming. Incredible as always!

If radios play this guy’s songs, kids these days would be a lot smarter.

This Made Me Fall In Love With Biology And Inspired Me To Become A Doctor

my professor just showed us this video in class today so i guess i'm subscribing now. also looking back on your older videos, dude, you've gotten so good at singing. congrats!

*slams fist on the table* THIS IS THE TYPE OF SCIENCE I WANT TO SEE

As a developmental biologist, I cannot like this enough! If there are any questions, please reply here and I'll try to answer when I have time!!

How far have these kinds of videos come. In high school they had some videos like these for classes but they made me cringe out of my skin to the point I couldn't even watch them. Meanwhile, I'm in my mid-20's and watching this on repeat because the animations and lyrics are addictive.

"Switch a couple bases In a couple places You'll be watching flies grow Legs out of their faces" Omg 😂😂😂

Watched like 356454 times while studying for my final exams....the best form of procrastination, I don't feel so much guilty cause you know, it's still biology...

Absolutely Fantastic, How do you do it, you are Mozart with the mind of Einstein.

Seeing biological ideas combine so flawlessly in this video is so fascinating, I don't know how to explain the feeling this video gave but the complexity and the connections are displayed in such a magnificent way, far better than my textbook, that I feel reinvigorated to learn biology once again with ferver

man im not a bio person but this shit is lit

Honestly this song is one of the reasons that keep me going with my degree in biology and biomedics applications, i listen to the song and remember why i'm doing this.

Syncronized the audio with Despacito. Fits perfectly

Holy... every line gave me severe chills. This was the coolest song I ever listened to o-o

Lmao this was played in the intermission at the biology quiz in our school 😂😂

OMG Dude you made my day :)

If I could I would give this guy a Nobel in medicine AND a grammy for best lyrics, MV and song in pop category.

I maintain, and will forever, that this video is perfect. Your performance is flawless, the song is incredible, and it's literally a college level bio lesson in lyric form. Incredible! Please keep doing what you've been doing

My copy of "Endless forms most beautiful" just arrived! Thank you so much for making me aware of this amazing field of knoledge!

This is such a great song! I can’t imagine the amount of effort put into this video. I remember watching this at school two years ago- my science teacher would randomly play your videos in class sometimes! This deserves so much MORE attention! Love the content on here. Keep Going!!

This is objectively the best channel on RU-vid.

This video introduced me to Evolutionary Developmental Biology, and the field has really changed how I see life and really help set my life forward in a direction I'm happy with. So, thank you A Capella Science.

Only legends noticed that this started from where molecular shape of you ended ;D

This is the most unique channel I've come across on RU-vid. Thank you for sharing your talent and giving us science-nerds food for the brain.

It truly made me cry... on awe and respect. Kudos, man!!!

I was studying evolution and suddenly I remember this masterpiece exists.

Guys I think RU-vid is broken...It says that this video has 367k views but I'm pretty sure I've seen it more times than it!!!

The Acapella is the toughest part and it has been made so beautifully

Finding this video made me so happy I almost burst into tears.

How many times have you watched this? Me: *Yes*

My favorite line: "this is how we go from single cells to people". Excellent video.

So talented person. A person must have creativity in high level for such production of these videos. Hats off sir🧢🧢👋👋

This came up on my recommended just in time. We learned about evo devo this past week in my genetics course. Great way to study!

This was my first exposure to Acapella Science (I was on a mission to find as many covers of Despacito as I could). What an absolutely brilliant piece of work. I spent days after going down internet rabbit holes trying to learn as much about evolutionary development as I could.

How did I only now notice, that the beginning of this video is a continuation of 'Molecular Shape of You'?

I've been in love with this for a long time. And so has my wife. And my son. It was our son that introduced his mom to the songs. I shared it with my brother, Stephen who has always been into Darwin and in fact did a voyage simulation of the Beagle to follow Darwin's steps. He is a rock star! And so is this. Keep listening. I am.

I'm a developmental Neurobiologist and I can confirm this is an accurate video xD

I listened to this a few years ago for the first time, being an innocent high schooler. After studying genetic biology from 1 year , this is a masterpiece. This song is filled with creativity and knowledge and it is entertaining. I am definitely showing this to my teachers.