The information provided here is simply based on the scientific review that's linked. Some people have mentioned that foods can decrease 5a-reductase activity, which may very well be the case, but keep in mind there are a number of isoforms of 5a-reductase and the advantage finasteride has is its specificity, since the inhibition of all 5a reductase is not wanted. Keep the points coming, I'm curious on your take.
Finasteride feels very uncomfortable to me. It gave me long lasting problems with cognition. I don't think that Dht and maybe more important inhibition of Allopregnenolone and other Neurosteroids, that act as potent positive allosteric modulators of Gaba a receptors, (but not the same subunits as benzodiazepines), is a good thing. Also Androgens have heavy implications for the development of atherosclerosis in men due to their immunomodulating effects, their vasorelaxant and pro nitric oxide effect. Also Dht has to be found to be neuroprotective, the same goes for Allopreg. Androgens seem to be very important hormones!
@@Daniel-hp3tk Hey dude, it’s going well, only been using it for a week so far, my stuff just came in but so far no sides and it’s going well! I’ll keep you updated.
ive been micro-needling on the scalp 1.5mm depth once a week and ketoconazole shampoo twice a week (on different days). i have new terminal hairs all over my thin areas including hairs on my temples which have been bald for nearly a decade.In just 6 months of treatment i havent used minoxodil or finasteride but ive heard they can be utilized together with red light therapy ala Derek from mpmd!
I thought you could only get hair back if you only been bald in that area for 6 years. Pretty cool if it grew back in 10 years. I wonder if it'll be rare in 30 years for people to be bald.
Been on it for about over 6 months i see improvement my hair stop less falling off , see alot of hair regrowth as well and no sideffects on my sex drive that thing still hard like a mtfk!!😅
@@ohplezz For some reason, your previous comment doesn't show. I'm surprised to hear that, considering this review of the literature mentioned no negative effects other than a slight change in estrogen and testosterone.
@@Physionic I have taken the drug for hairloss but it had profound effects on my sex drive. So much so I would question who funded those studies. When I stopped taking it within a week I was back to my old self but I only took the drug for a month or 6 weeks. I would truly be afraid to take it any longer than that. I would rather be bald than possibly do permanent damage to my endocrine system.
@@dlong7146 Really? Just because you as an individual developed severe side-effects, that means that the scientific literature on finasteride isn't to be trusted?
I'm the 69th liker on the vid!btw I've been on dut since June 2020 and idk if it's side effect but i def got more hornier on this medication which ik is completely opposite of what others experience
@@mantoshow8852 i never used fin, I noticed my hair was getting thinner and i went to a dermatologist and since I'm just 20 i was recommended dut probably because my hairloss is aggresive which sucks
@@shutupidiot16yearsago79 i was on Fin 1.5year but still got thinner on the crown, but overall my hair got better. Its my 21 day on dutasteride and i hope to maintain.
I haven't looked much into it, but I likely will, because people have mentioned it a number of time. I know it occurs, but it may not be as prevalent as some make it out to be - we'll see as I dive deeper into it.
Post finasteride syndrome is a real thing. There are many people who have serious side effects (depression and complete sexual failure among others) that persist for years after discontinuation of the drug. I feel like you go really easy on it. Also the androgen hypothesis of hair loss is quite confusing to me. For example baldness increases while we age and androgens (including dht) decrease as we age. If dht sensitivity is the only culprit of mpb then we would all be bald as teenagers and then gradually restore our hair as we age. 🤔
I didn't mention it, because it wasn't mentioned much in the scientific review. I'll be sure to cover it in future content. You can have differences in gene expression with age - increases in local, or intracellular levels can be different from serum, but I agree, there may be more there than meets the eye.
