I have a question mark about haptoglobin . the reason why it decreases is actually caused by the binding of free hemoglobin which increased in the serum bc of hemolytic anemia. not because they are attacked by the neutrophils . so actually free haptoglobin number changes there is no harm to its structure
Yes. Haptoglobin only binds free hemoglobin in the plasma (not inside the RBC or macrophage). With extravascular hemolysis, the macrophage degrades the hemoglobin, and no free hemoglobin is released into the blood. So haptoglobin levels remain constant in extravascular hemolysis. But they bind to free hemoglobin released by increased intravascular hemolysis, meaning they're used up, so then in intravascular the haptoglobin value is decreased.
Medicosis perfectionalis, you asked us to explain the difference between macrophage, monocyte, and histiocyte. This was a very good question because these terms are confusing. But there is not a perfect answer, because these terms are confusing. Ideally, the macrophage is the umbrella term for any phagocytic agranulocyte. This can be divided into two major categories: 1) The histotiocyte is the macrophage of solid tissue. 2) The monocyte is the macrophage of blood. However, there is a lot of misuse/confusion/disagreement on how these terms are used. I had to look at dozens of definitions before I figured this out. Did I get it right? Thanks for making me investigate this. I had been lost in the confusion up to now. It's starting to become clear now.
this video is super helping me to solve the learning objectives that i need to be coping with right away tomorrow and easy to understand. big shout out to the owner of this channel tho. BIG LOVE😍
Watch this video to understand the whole picture: Intravascular Vs Extravascular Hemolytic Anemia ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-RIA_v4PLimc.html
I love how you integrate biochemistry in pathophysiology! Can you please tell me, if you were to start from the very beginning, is reading Goljan the best initial step? haha or biochemistry? I just started studying for step 1 and I'm so lost from where to start. WAY past pre-clinical years in md school, forgot it all
Very helpful and to the point video!Thank you!!May I ask....G6PD deficiency causes both intravascular and extravascular hemolysis?Have I understand right ??
I think hemolysis causes normoblastic macrocytic anemia. As there is increased demand the immature red cells having bigger mcv will be released into the circulation resulting in macrocytic anemia. As there is no B12,folate deficiency there will be no dna maturation lag and normoblastic anemia (not megaloblastic). Am i right ?
These celles are the same cells the difference is in their localisation ,when they are in blood circulation we call them monocytes , in pulmonary tissue we call them macrophages ans in other tissues we call them histiocytes ... i know something is missing in my explenation 😅😅😅