Factors Affecting Drug Absorption: Rotue Specific Factors || Pharmacokinetics, General Pharmacology 

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Rotue-specific factors affecting drug absorption:
In the oral route, the degree of ionization affects how much portion of the drug, is available for absorption. However, most of the drug is absorbed from the intestine, regardless of ionization, because of the higher surface area of the intestine. For the same reason, gastric emptying increases absorption. Degradation, and extrusion, decrease the absorption of some drugs. The presence of food, and concurrently given drugs, also affect the absorption. First-pass metabolism decreases the bioavailability of some drugs. Gastrointestinal diseases also affect absorption. In the subcutaneous and intramuscular routes, heat, and exercise increase absorption, by increasing blood flow. On topical administration, abrasion on the surface, increases absorption. Bioavailability in the intravenous route is 100%, and nothing can affect this!
Chapters
00:00 Introduction
00:32 Degree of ionization
04:32 Gastric emptying
04:57 Degradation
05:21 Extrution
05:48 Prences of food in GIT
06:48 Concurrent drugs
07:11 First pass metabolism
07:57 Gastrointestinal diseases
08:24 Heat & Exercise
08:44 Abrasion on the surface
09:09 Summary
Dr Vipul Navadiya
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