First Supplement To Show Greater Than 10% Life Extension In ITP History

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Here we review the latest result for astaxanthin from the ITP. Mice given astaxanthin showed a 12% median life extension.
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
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#astaxanthin #lifespan #healthspan

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18 сен 2024

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Комментарии : 86

@ModernHealthspan 9 месяцев назад

ProHealth 15% discount Code MODERN: prohealth.pxf.io/Vm9BoA Astaxanthin prohealth.pxf.io/anV2EN Renue By Science 10% discount code MHS: tinyurl.com/35jyuk33 DoNotAge 10% discount code MHS tinyurl.com/6dbvhv8 Fisetin tinyurl.com/mrxfymte Momentous Supplements 15% discount Code MHS momentous.go2cloud.org/SH2s Oxford Healthspan Primeadine Spermidine supplements: 15% discount Code MHS tinyurl.com/28admfxr Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan

@Santa-ny1yp 9 месяцев назад

The best source is clearly, freshly squeezed flamingos.

@Ardentic-better-eat-meat 9 месяцев назад

Astaxanthin fitting perfectly in the lipid bilayer should make it obvious that it supports the membranes and thus cell signaling... mouse data or no mouse data

@stevewexler 9 месяцев назад

Add a little ginger for a zing!

@Rick_Sanchez_Jr. 9 месяцев назад

@Santa-ny1yp The source is not flamingos... Flamingos have copious amounts of astaxanthin in their system because they consume algae from water they are near. The actual source of astaxanthin is an algae called Haematococcus Pluvialis. Other animals known to have high amounts in their system are sharks, naked molerats, elephants and salmon.

@Viertelfranzose 9 месяцев назад

Sure sometimes people's Mind is squeezing in the same way

@Ardentic-better-eat-meat 9 месяцев назад

@@Rick_Sanchez_Jr. hey, I don't know where you picked that up, but thanks for that info.

@theancientsancients1769 9 месяцев назад

I was taking Astaxanthin since 2008 and it helped with skin i think and virtually has zero side effects up to 12mg, i recommend upto 4 to 12mg max a day . I feel refreshed when i take it with longvida Tumeric and Omega 3 fish oil, they are anti inflammatory and strong antioxidant combo! Any head or body aching will reduce too . If young and healthy 4mg is enough, if middle aged 8mg max 12mg when required

@ModernHealthspan 9 месяцев назад

Hi thanks for sharing. Glad that it is working for you!

@bq3538 9 месяцев назад

every day at least 20mg for me

@darkhorseman8263 9 месяцев назад

I have also tooled with fumarate. It can increase lifespan, but people with specific mutations can get cancer from it, so I moved on to other electron acceptors. Fumarate is only good for quenching free electrons if you have excessive inflammation or are taking too many anti oxidants. H2S donors will work, but they need to be counter balanced with 2 other epigenetic signalling molecules. Alone, it's marginally beneficial.

@ModernHealthspan 9 месяцев назад

Hi thanks for sharing. As it happens, this round of interventions in the ITP included a SG1002 which generates H2S but it was not effective.

@smoothemoveexlax 9 месяцев назад

Great news for mice. At this rate we could make immortal mice with all these supplements.

@davidgifford8112 9 месяцев назад

Great news for male mice. It squares the curve a little, so in this study male mice median mortality rates more closely resembled female mice. As ever, extending the life of lab mice never translates the same way to humans. The effect seems to be the consequences of damping inflammation. Humans tend to be better at that than mice.

@Viertelfranzose 9 месяцев назад

Astaxanthin works for me...for 100% sure even with 4mg a day...i started it many years ago...as Loges came out in Germany with this Stuff...and I felt it really on my bicycle!!! I could drive like a Tank😊..and even with 8 mg...Suncream in Summer I use never again..i bumped my Day Dose to 12 mg...and never had Problems...so I count this Mice Study too strong..just need what works for me...besides every Calculation in Theory. Greetings from Andreas in Alsace /France

@blindandlearning9379 9 месяцев назад

I always enjoy your personal analysis

@ModernHealthspan 9 месяцев назад

Hi thanks!

@luckssj 8 месяцев назад

The Impact of Taurine on Lifespan have you heard of this and what is your take on it?

@jaykraft9523 9 месяцев назад

loads of supplements increase lifespan of mice by 10%. there's a good number that get over 20% as well (e.g. glynac)

@jb_1971 9 месяцев назад

Was it shown in heterogenetic mice? Because that's the point of this video.

@moniquebrachet5698 9 месяцев назад

Yes, I even saw lion's mane.

@jb_1971 9 месяцев назад

@@moniquebrachet5698 Interesting. Maybe it's the Ergothioneine in it?

@larryc1616 5 месяцев назад

+Taurine

@VishalRaoOnYouTube 9 месяцев назад

ppm typically means molar concentration, not by weight. So in order to calculate the concentration, you'd need to know the moles in the chow, which is super weird because there could be 1000s of different types of molecules in the chow. Very strange that the study did not supply an absolute dosage in mass units.

@Ardentic-better-eat-meat 9 месяцев назад

It's probably just water, starch and fiber and the rest is negligible.

@incognitotorpedo42 9 месяцев назад

No, ppm is just like percent (parts per hundred). It's always based on weight. The molecular weight of a diet is too poorly defined to base it on moles.

@Ardentic-better-eat-meat 9 месяцев назад

@incognitotorpedo42 no. Absolutely not always, perhaps sometimes. Isotope content is measured in ppm. That's also a case where you're counting atoms and not mass. Just look into the deuteration level of different fats.

@eafadeev 9 месяцев назад

ppm is parts per million - probably by weight in this case.

@ModernHealthspan 9 месяцев назад

Hi Vishal, thanks for your comment. That was my first thought too. That I would need to figure out the molecular weight etc. But, it seems that when it refers to feed it is based on weight not moles. So it is just mg per kg.

@SilverFan21k 8 месяцев назад

Awesome video! For the algorithm. ❤

@lc5740 9 месяцев назад

7:05 Great information, but 1.3g per day will be very expensive for normal people.

@CrossoverManiac 9 месяцев назад

Mice have much higher metabolism. Mice eat 10 to 15% of their body mass per day. For a 200 lb human, that's 20 to 30 lbs of food per day. That is way too much. Humans only consume 3 to 5 lbs per day and that's during an obesity epidemic. Roughly, this is 1 to 2% of body weight. If you are going by proportions, go by percent of food consumed and not by body weight. If the amount in the experiment is 1840 ppm by mass, then that translated to 1.84 grams of astaxanthin per kilogram of food. If the average human eats 4 lbs (1.8 kg), then the dose is 3.3 grams per day.

@gungadin164 7 месяцев назад

This point makes a lot of sense! Makes me wonder about the recommended dosages of many other supplements that are also based on the relative mass of mouse & man rather than the ratio of food intake to mass. We may be hyperdosing recklessly indeed.

@larryc1616 5 месяцев назад

Nobody can afford 3.3g/day

@charlesharkleroad9923 9 месяцев назад

I have a question in my journey of trying really hard to determine whats factual and whats not. I have been recently taking astaxanthin and stopped because of what Dr Barrie Tan said on RU-vid about the body not being able to absorb astaxanthin at the cellular level. Has anyone else saw that video and have concerns about if he is credible.

@mattdamon2419 9 месяцев назад

That is why they actually made glycosidic astaxanthin, a patented liposomal method of carrying astaxanthin into the body better via highly increased absorption. If you want to use just regular astaxanthin, you need at least 100-200mg a day for it to do anything noticeably positive.

@Ardentic-better-eat-meat 9 месяцев назад

I'm quite certain I've seen research that it even impacts mitochondria and most definitely lodges into cell membranes. If beta carotene can do it, ast can too.

@Ardentic-better-eat-meat 9 месяцев назад

AST is usually sold in some oil containing gel capsules. Why would we need a liposomal version? Take it with fats or egg yolks.

@bernhardwalther 8 месяцев назад

There is many human (not mice) studies showing impact on many various place. AST can cross the eye and brain barrier. I take it for this reason but it is a very long bet and it is not for longevity. I saw the video and thought that NMN receptor was found recently and there was the same kind of things said. If it has an impact on human body it must enter the cells. We simply didn’t find how yet. My guess. Your body, your health.

@Ardentic-better-eat-meat 8 месяцев назад

@@bernhardwalther how is AST unable to get into cells or impact cells if it can lodge into the lipid bylayer influencing intra and inter cellular signaling?

@allurbase 9 месяцев назад

So works good for young mice, Median lifespan seems more controllable than max lifespan. I'd optimize for median lifespan until middle life and for max lifespan from there on.

@ModernHealthspan 9 месяцев назад

Hi thanks for sharing. That is a great way of thinking about aging and the requirement to modify the tactics over time.

@zer0nix 9 месяцев назад

If it only affects males, I wonder if this is an e2 analogue and if it stacks Timing is also important as I believe this is another of those supplements that blunts the effect of exercise if taken at the wrong time

@ModernHealthspan 9 месяцев назад

Thanks for sharing. There is evidence that antioxidants impair the adaption from exercise, so certainly something to consider. The half life of astaxanthin in serum is 52 hours, so if taken daily it seems timing would not matter that much.

@jb_1971 8 месяцев назад

What other supplements do this to your knowledge? I know of metformin and rampamycin, but I would hardly call those "supplements".

@ronm6585 9 месяцев назад

Thanks Richard.

@ModernHealthspan 9 месяцев назад

Hi Ron, thanks!

@AnulaibazIV 9 месяцев назад

This is not true! Taurine has shown to increase lifespan by 10-12%.

@ModernHealthspan 9 месяцев назад

Hi thanks for your comment. This statement was specific to the ITP and Taurine has not been tested there yet. The ITP is interesting because of a couple of the points I make at the beginning of the video, that they use genetically heterogeneous mice and run tests in three locations at the same time.

@AnulaibazIV 9 месяцев назад

@@ModernHealthspanHello, I thank you, Richard for your reply. I may have been too hasty in the making of my comment. The paper by ITP was indeed interesting. Astaxanthin seems very promising, albeit I would like to see more research on it, especially since it is an antioxidant.

@jb_1971 9 месяцев назад

@@AnulaibazIVMaybe it's not the antioxidant part but rather the NRF2 activation? If so, then we should see similar results from sulpharaphane, but it - to much knowledge - has not yet been tested in mice. However, it does seem to benefit humans.

@jameswarrington9402 9 месяцев назад

So if it has similar effects to prednisolone could a daily dose help control illnesses such as asthma or crones disease etc?

@ankur0682 9 месяцев назад

Thanks Richard. Are you using Astaxanthin? If yes, how much and what time of the day?

@ModernHealthspan 9 месяцев назад

Hi Ankur, good to see you and thanks for your question. Yes I take astaxanthin, 12 mg a day. It is meant to be better with food so I take it after breakfast.

@rene-rv6pp 9 месяцев назад

Hello richard. I can say take about 5 or 10 mg astaxantin every two days or three also. I feel an effect in elasticity on my movements. At 68 yo. But have you minded those doses you mentioned? I mean side effects? May be sometimes the medicine can harm?

@ortcloud99 9 месяцев назад

I was taking astaxanthin 15 years ago and my legs turned red, I looked like a lobster.

@larryc1616 5 месяцев назад

I wonder if I'll turn into a fire crouch

@nickjacques6087 8 месяцев назад

I tried it but after using it for some time, I get a lot of acne/pimples like a teenager.

@metaphysicalArtist 9 месяцев назад

Richard. Are you using Astaxanthin?

@ModernHealthspan 9 месяцев назад

Hi, thanks for the question. Yes, I take 12mg a day.

@MikeG-js1jt 7 месяцев назад

Well, if it turned out that humans needed to take over 1 gram of astaxanthin a day, that would prove to be unsustainable price wise for most, the human dose of 12 mg is not because of some study derived information, but just some ambiguous amount derived by some industry scientist employed by a conglomeration of the astaxanthin industry to derive an amount sustainable by the industry for maximum profit, not necessarily the benefit of the consumer................. so, considering everything I just said as the truth, astaxanthin use to help extend lifespan is not sustainable at the current "recommended" human dose nor at the current production capacity of the industry itself.

@robrichardson1356 9 месяцев назад

I think the mg to kg conversion is 10 to the -6, not -3 (that's mg to gm)

@incognitotorpedo42 9 месяцев назад

But Richard's conversion there was from micrograms to milligrams, so it looks right to me. The computed human dose of 1.3g seems excessive, but I can't find a problem in the calculation. 1840 ppm = 1840 mg Asta/kg food = 1840 ug Asta/g food * 4.8 g food = 8832 ug Asta *(1mg/1000ug) = 8.8 mg Asta That said, I don't have a lot of confidence in this result translating from a short lived rodent to a long lived human.

@ModernHealthspan 9 месяцев назад

Hi Rob, thanks for looking at this. I think the line you are referring to is correct. My thinking of it as 1 kg of chow contains 1840 mg of asta. A mouse eats 4.8 grams of chow. I want to know how much asta is in the 4.8 grams. So I am converting kg to grams not mg. 4.8 grams is (4.8 * 0.001) kg

@lalisa2486 9 месяцев назад

What is itp?

@ModernHealthspan 9 месяцев назад

Hi thanks for the question. The ITP is the Interventions Testing Program which is an organization which tests whether interventions increase the life span of mice. As mentioned in the video they have some special features, first that there is three labs which test the interventions in parallel, doing the testing and reproduction together and secondly they use genetically heterogenous mice as most experiments are done with genetically identical mice which makes things simpler but less applicable to real life. You can find more here www.nia.nih.gov/research/dab/interventions-testing-program-itp

@CraigHocker 9 месяцев назад

I think you are underestimating the dosage for humans. Not exactly following your logic, it's never a good practice to have units on one side of an equation and no units on the other side of an equation. Makes mistakes easy.

@ModernHealthspan 9 месяцев назад

Hi Craig, thanks for your comment and the feedback. You mean in the way that I present the calculations? I had not noticed that I did that before. You are right, I should be consistent and put the units on all numbers.

@Earwaxfire909 9 месяцев назад

Going by ratio of blood volume a human might want 100x the daily dose of a mouse.

@ModernHealthspan 9 месяцев назад

Hi thanks for sharing. I am relying on the conversion methods proposed in the papers that I find, which I think are based on metabolic rate. The 12.3 figure was taken from "A simple practice guide for dose conversion between animals and human" which you can find on pubmed.

@Earwaxfire909 9 месяцев назад

@@ModernHealthspan Intriguing. The paper seems to suggest a body surface ratio calculation. Not a blood volume ratio. So I must have missed that they were applying the substance to the surface of the mice.

@royromano9792 9 месяцев назад

So in mice.. its like resverotrol

@ModernHealthspan 9 месяцев назад

Hi Roy, thanks for your comment. Well better than resveratrol, in the ITP they did not see lifespan extension with resveratrol. But yes, it is in mice.

@jb_1971 9 месяцев назад

@@ModernHealthspanIs there one place that lists all the interventions that have been tested in the program together with their outcomes?