Frank-Starling mechanism | Circulatory system physiology | NCLEX-RN | Khan Academy

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Carefully follow 5 different preload scenarios to see how each one will have a different effect on how actin and myosin line up. Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai.
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1 окт 2024

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Комментарии : 88

@cleugenecabanillas7382 4 года назад

off topic but u sound like pewdiepie when he's serious lol

@nellyhoffman6194 8 лет назад

If i become a great doctor you are one of the reasons :)

@imsungjaesmelody.thesnorte5623 6 лет назад

Nelly Hoffman same 😂 I am just living it by the hour now

@maryroseabadilla7378 4 года назад

just entered med school hehe any updates? :)

@afairusputri4604 3 года назад

Soooooo hi doctor :)

@TheRebellefleur27 3 года назад

*When

@buqbooQ 11 месяцев назад

updates?

@chuckday147 8 лет назад

You are an excellent teacher and make things simple and easy to remember! Thank you

@DOC_951 7 лет назад

7 minutes in... still waiting to see how this is about starling forces >__

@DrewBaye 5 лет назад

All of this is relevant. Extrapolate.

@Amit42415 4 года назад

Exactly! It is hard to say if the makers of some Khan Academy videos are themselves dumb or they make these videos for blockheads. Too much actin overlap here - a straightforward explanation that should have taken less than 5 min can get extended to almost 15 min... Unbelievable!

@rr.studios 3 года назад

This is NOT the video for starling forces...I don't know where the hell you got that idea from.

@KHANMOHAMMADNAZMUL 4 года назад

সহজ বাংলায় এবং প্রনবন্ত উপস্থাপনার মাধ্যমে,ফ্রাঙ্ক স্টার্লিং ম্যাকানিজম সম্পর্কে জানতে,ক্লিকঃ ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Efjr_mjrNBM.html বি.দ্রঃচ্যানেলটি একদমই নতুন!নিয়মিত লেকচার পেতে সাবসক্রাইব করে,বেল আইকনটি বাজিয়ে দিন!

@osamamatar4 6 лет назад

But from my understanding of basic histology shouldn't the myosin and actin not overlap during relaxation? Like the first drawing I'm pretty sure it's how contraction looks with the actin closer and overlapping the H zone and it's definitely not relaxation

@AhmadHassansays 5 лет назад

5th myosin actin would be drawn according to graph giving maximum pressure

@mzkittiechick 11 лет назад

This is true but it's not the whole mechanism. Increased cardiac muscle length also increases calcium release from the sarcoplasmic reticulum.

@Longwalktravel 10 лет назад

It's normal due to increase of diameter and sarcomeres of cardiac muscle fibers , therefore have much sarcoplasmic reticulum ----> increase release of Calcium.

@Anconeusify 10 лет назад

With the increasing cardiac muscle length you have an increase in contractility of the heart. When with increasing contractility you increase heart rate that in turn increased the number of action potentials. Increasing the number of action potentials you increase intracellular Ca2+ content and you increase the inward movement of Ca2+ current.

@janerosiecurran 7 лет назад

You are correct but this description of the Frank-Starling mechanism is still incomplete. Although stretch does not directly lead to more Ca2+ being released, it increases the sensitivity of the myocytes to Ca2+ as the troponin C has a higher affinity for it. The mechanism for this increased sensitivity is yet to be determined but it does contribute to the Frank-Starling concept

@alphadoppiodelta3799 2 года назад

@@janerosiecurran Yes!

@f.kosfeld4223 9 лет назад

Great video, thanks alot for explaining the Frank Starling in an easy yet still in debt way. Btw your mouse drawing skills are impressive!

@khanacademymedicine 12 лет назад

Not quite. Check out the video on active contraction vs. passive recoil.

@pamtoon5357 9 лет назад

Very clear explanation of an otherwise confusing concept. Thank you for your help in teaching my team.

@jamesr5931 6 лет назад

Overall poor example of Frank Starling, should use a Frank Starling curve to explain this, not a pressure volume graph. Try looking at a book on Cardiac Physiology

@rena783 5 месяцев назад

Imagine being rude to a guy who’s offering free help on the internet. Wow!

@vee-5697 7 лет назад

Shout out to Frank & Sterling

@andrerafizadeh1791 8 лет назад

This was immensely helpful.

@ramzeschavez 10 лет назад

what software is it? (drawing)

@rhoadess 12 лет назад

Is this a spring force? F = k*x where k is a spring constant and x is the distance of stretch.

@adaneboateng 10 лет назад

Shout out lol... Nice!

@jonathanstarling432 6 лет назад

"STARLING LAW" " WATER GAIN " ' THEORY ' I like to get all my books up please.

@danaejohnson1582 7 лет назад

Wonderful explanation, thank you.

@jonathanstarling432 6 лет назад

hey

@saniakoondhar4883 3 года назад

That's why hypertrophy leads to reduced force of contraction ultimately.. Actually what I didn't get, is whether the condition no 1 normally present in myocardium.??

@dininmaxfacs 3 года назад

Watch in 2x. Still was not clear about preload and after load. Due to auto regulation, (calcium sensitivity to troponin is increased) increase in after load and increase in preload, both increase stroke volume, right? Is this true with regards to Frank-Starling law? Have my exams, would like to clarify before it.

@TheTubeyou1993 6 лет назад

Why is the graph flipped the other way???

@myaznbui 10 лет назад

What is the relation of this to heterometric and homeometric reserve?

@Schatten2712 6 лет назад

This is the basis of heart failure, I learned this back in pathophysiology and then forgot. Came back to remember this stuff and holy fuck it clears things up, thanks.

@nataliasupit4884 4 года назад

what causes to get the myocytes goes to 5th stage in frank-starling law? in other word what causes the myocytes overstretched and can't give force?

@comedy0stuff 7 лет назад

شكرًا

@Girlinterrupted955 Месяц назад

These videos are just AMAZING!

@jonathanstarling432 6 лет назад

hello

@VickiBee 9 лет назад

They're talking about one heartbeat and what's happening during the 0.08 seconds it takes to complete a cycle. Myosin & actin are motor proteins. They help muscles move. I'm a paramedic. Cardiac care is my area of special interest.

@VickiBee 9 лет назад

It might be 0.8 seconds rather than 0.08. Anyway, there's an 8 in it and that's how I remember that the "golden hour" for cardiac collapse is no more than 8 minutes to arrive on the scene and start care.

@gautammure 8 лет назад

Absolutely gorgeous illustration /// thank you so much

@jaaferammarjouini893 3 года назад

So when senerio 5 happens, we get congestive heart failure ?!

@devalpatel8816 4 года назад

1:43 Preload is Stress? Is it not the Volume? (Preload = LVEDV)

@diplomat2623 9 лет назад

AWESOME!!!!! Very helpful. Thanks! :)

@ingeborgschmidt-huser9299 7 лет назад

Nice

@auroraborealis7473 7 лет назад

Thank you so much.

@lianekg 8 лет назад

What's the situation like between scenario 4 and 5?

@sophi708 5 лет назад

thank you thank you thank you thank you thank you thank you

@aqabdulaziz 6 лет назад

There are so many things wrong with this video. Myosin cross bridges and force of contraction do not happen the way he is saying here. My professor at UCSF tells me that thin filament does not cross over each other under physiological or any condition because of other structural elements that prevent shortening of sarcomere the way Rishi is showing. My prof thinks that medical doctors do not try to understand or update how Frank-Starling mechanism works and they keep parroting text book information.

@arshisiddiqui7657 3 года назад

Thank u so much for crystal clear explaination👏👏👍

@christenes9966 10 лет назад

So does the heart normally start somewhere between situation one and two?

@fatm4403 3 месяца назад

Thank you so much sir

@anjilareddy2324 8 лет назад

At step 5, there is no force, right? I kind of imagine preload as a rubber band being stretched out. So at step 5, is this the point at which the rubber band breaks? or the ventricle wall breaks at this point leading to no force?

@eam5608 5 лет назад

Are you left-handed?

@MrKingPC 12 лет назад

Thank you so much dude ! you're doing a great job, that was really helpful, thanks for the new creative way of learning, as i was watching this vid, i wonder what future projects do you have? what new dreams do you wanna accomplish? what new semiological lessons do you want to make? but that's not the think, isn't it ? it all about time, time is precious, so precious that we would want to study them carefully, taking as much time as planning a holiday, or party... :) good luck

@shwetapandey1194 3 года назад

Thank you so much for helping me 😊

@invinciblegamer1019 11 месяцев назад

Best❤

@brhaneamha 9 лет назад

thanks very much guys

@supergooz 11 лет назад

Thanks. This really helped

@farmarcos 11 лет назад

Thank you very much. You make these subjects seem easy learning.

@AfiqahRosdi 3 года назад

the drawing is so satisfying

@rjannpiabianca 10 лет назад

well explained! thank you for sharing useful information for heart failure

@welmoedoverzet638 3 года назад

AMAZING! Thank you:)

@jonathanstarling432 6 лет назад

Enoch Starling

@DaughterOfChrist1997 2 года назад

Really good & helpful

@moishah7 11 лет назад

amazing, thanks!

@alijassim1323 8 лет назад

عشت حجي

@altair2594 7 лет назад

:DDDDDDDDDDD

@ajayjones81 10 лет назад

dont know what there talking bout

@clarencecarter1606 10 лет назад

Like it

@VickiBee 9 лет назад

They're talking about cardiac output and cardiac volume. It has to do with the beating of the heart and how much blood is going through the heart during a heartbeat and what the pressure of the blood is. I'm a paramedic, and cardiac care is my area of special interest. I'm also an EKG (aka ECG) Technician.

@dhyaism 10 лет назад

thanx

@ahedshdooh604 4 года назад

good !!!

@orlandomanganottineto1918 7 лет назад

Excellent.

@muhammadaaqibshamim8763 9 лет назад

great video 👌

@laurenlinares2140 6 лет назад

so good!

@sheilafebrilia4460 6 лет назад

this helps me a lot!! thankyou! :)

@stephaniebeaucham8996 11 лет назад

does the tropomyosin, troponin C, and g-actin play a role in the Frank/Starling Mechanism? Thank you for your great helpful videos.... I am a fan of you