First comment I ever left on a youtube video, just wanna let you know that your lectures are really helping me a lot with biochemisty since they are well structured and easy to follow through. Plus your drawings are perfectly visible, which is definitly not the case for every ''youtube lecture''. Thanks a lot and keep up that good work!
Your lectures are literally my go to. You do the connections, you give the overview, there's no searching no pounding for answers. Thanks for your fantastic channel.
Great lecture! for funsies/clinical tie in: the differences between nonclassical v. classical galactosemia. Since you also talked about fructose: essential fructosuria and hereditary fructose intolerance. (Not sure if you have a time limit on your lectures? Clinical ties in helps me remember the pathways better.)
Thank you very much for all your efforts put in making these comprehensible videos. I tried to study this topic from my Biochemistry textbook and the ppt I got from the lesson, but i just could not understand it. Thank you for explaining this process in a structured and a simple way.
Can you recommend a RU-vid vid on the differing mechanisms for absorption at the intestinal canal for each sugar to show the difference between sucrose and fructose uptake?
Hi There! Question: Why is it called the Galactose-Fructose Pathway? It doesn't seem like fructose in involved. More seems like a Galactose-to-Glucose Pathway?
i always end up looking at the comments half-way thru his videos to see if everyone else is as shook as i am by how easy he makes these hard ass concepts lmaoooo
Amazing lecture, thank you! Just one question: At 13:32 the substrate of Phosphoglucomutase is presented as G-1-P. But didn't the previous reaction yield UDP glucose?
from what i understood, it just regenerated it (kinda in the way enzymes work, they aren’t used up in the yield reaction) so udp glucose just goes to exist in the cell, while phosphoglucomutase acts on the product of the second reaction - glucose 1-phosphate
I thank you so much for all your efforts you do not stop saving my life every time I break down you are just up to it sir! you're making me loving biochemistry lol
Good afternoon, I'd very much like to understand where on the fructose metabolism is the flaw that leads to fructose malabsorption... I have fructose malabsorption, as well as lactose malabsorption, and i'm trying to learn what's happening to my body. I'd be very greatfull if you'd be kind enough to give me some instructions on the matter, for I'm having a hard time finding good material online, such as yours is.
A year late but Galactose1p is converted to UDP Galactose via a UDP transferase. Then UDP galactose is epimerised to UDP glucose via epimerase. UDP glucose then dumps its UDP to another galactose and itself becomes G1P which then is converted to G6P by a mutase. So overall it's a cycle.
@@alicegillingham421 I hope that went well for you. I have just started a week ago, so step out if the way, miss, it's MY turn to suffer. Have you got any advice for the new recruit? Need I some antidepressants?
@@sammipanini it went really well, i recieved A+. Partly cause of the great teachers for sure. My advice is... repeat again and again and try to make a complete picture of how these processes cooperate within the body. And again, repeat! Tell me about your exam once you pass it)
@@alicegillingham421 That bioc A+ sure is one of the biggest flexes a person can have. Congrats :) I will make sure to keep your advise in mind. Will let you know when I pass it. But more importantly, I will also blame it on your advise if things go downhill for me. Cheers, Stranger. Take care.
Reading some articles on mitochondria I keep seeing the claim that galactose produces no net ATP when fed into glycolysis. However, I can’t see what step is making its metabolism more costly (by 2 ATP!), can someone point it out?
I've heard that 80% of glucose goes to the muslces and 20% goes to the liver whereas Fructose is the exact opposite i.e. 80% to the liver and 20% to the muslces... does anybody know what the split for lactose is?
+Ekene Okeke Mutases shift a group from one position to another within the SAME molecule while a transferase shifts a group from one molecule to a different molecule. Hope that helps
