Genetic Testing For Prostate Cancer | BRCA |

Подписаться 83 тыс.

Просмотров 7 тыс.

50% 1

Donate to PCRI: pcri.org/donate/
For more information, visit pcri.org
0:22 What is the difference between a "genetic" and a "genomic" test?
1:12 How important is genetic or genomic testing to the average prostate cancer patient?
3:31 Do 5% of people have a BRCA mutation?
3:42 Should all prostate cancer patients test to see if they have a BRCA mutation?
5:09 What are "somatic" and "germline" testing?
5:56 What tests are most often used to check for BRCA mutation, and when?
7:40 Why is that patients on active surveillance are so unlikely to die from prostate cancer?
8:21 In what other contexts are genetic tests useful for prostate cancer patients?
10:14 What are the usual next steps after a patient gets their genetic test results?
10:45 How can patients best understand the results of their genetic test?
12:19 Are genetic tests usually covered by insurance and Medicare?
12:34 Is it a matter of all men should be tested?
14:01 How impactful are genetic tests on the average patient's treatment plan?
15:08 Alex's conclusions
16:39 If you need more information
Don't know your stage? Take the quiz: visit www.prostatecancerstaging.org
To learn more about prostate cancer, visit www.pcri.org
Sign up for our newsletter here to receive the latest updates on prostate cancer and the PCRI: pcri.org/join
Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

Опубликовано:

14 апр 2024

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 56

@d.r.martin6301 2 месяца назад

An acquaintance had gleason 6 and a "high risk" result from the Decipher test. His urologist said he could book him in two weeks to remove the prostate. My friend was not keen on that and found someone else who was cool with active surveillance. He's pretty sure he made the right choice.

@demitasse07 2 месяца назад

Gleason-6 here and all healed up from Tesla 3, MRI-targeted biopsy after 13%-17% low volume found in 2 of 12 (counted 18+) cores. We sent some material to lab for genetic, 'background' testing. Will discuss it with doctor in appointment scheduled for the 18th. Not worried about it. Uncle, grandfather, cousin died from prostate & bone cancers. Aunt died from a lymphoma and dad has skin cancers being removed regularly at 88+/- but has no prostate problems. I don't drink alcohol, smoke, chew weird gummies, eat sugar, few carbohydrates and only moderate amount of dairy. I exercise every day. Thank you for the video. Interesting.

@nickstrapko7549 2 месяца назад

You're lucky at 51 i had psa it was 8.7 I had surgery 6; weeks ago to remove I had. 70 ,% Gleason patern 4 at the tumor and 60%. 50%. In two other cores .seing that yours in still in the prostate with the biopsy. The comparison is Quite apparent . It's slow growing in your case

@demitasse07 2 месяца назад

@@nickstrapko7549 Thank you for responding and I wish you peace and health.

@robertmonroe3678 2 месяца назад

If you go on an active surveillance program there will be MRIs and future biopsies to ensure more lethal varieties aren’t elsewhere in your prostate (missed by the most recent needle biopsy) and to ensure more lethal varieties don’t begin in you prostate. Genetic testing might yield a reason to be even more vigilant or possibly to consider earlier treatment.

@kczbluesman 2 месяца назад

Thanks for the informative videos.

@groove9tube 2 месяца назад

The somatic gene test such as Decipher is useful but as Dr. Scholz says Gleason score is what determines treatment. Also my oncologist emphasized the PSA level as an indicator of tumor aggressiveness. So pathology and PSA most important. That’s why it is good to get second opinion on biopsy specimens from urological pathology at a major university medical center.

@TiHerr74 2 месяца назад

Timely topic. I am meeting with my Urologist this week to discuss genetic testing. My goal is to use these tests to avoid another biopsy. My MRI showed a PI-RADS3 7mm lesion and I’m on the fence regarding a targeted biopsy. Neither Decipher nor EXoDX is covered by my HMO.

@mikekratt3110 2 месяца назад

Did you get an MRI with contrast (gadolinium based)?

@TiHerr74 2 месяца назад

@@mikekratt3110 - yes, sure did. This MRI was done two years after a negative 14 core random biopsy. My PSA had jumped from 2.2 to 5.6 in one year which triggered the random biopsy.

@mikekratt3110 2 месяца назад

@@TiHerr74 interesting. Almost identical PC diagnosis. I requested the brac genetic test given family history of HGCA. It gives you one more data point in an already complex decision-making process.

@TiHerr74 2 месяца назад

@@mikekratt3110- thanks Mike. My dad’s father died of PC and my maternal first cousin is fighting metastasized PC now so I am on high alert.

@nickstrapko7549 2 месяца назад

Enlarged prostate BPH ?

@fredflintstone8574 2 месяца назад

Decipher at surgery can give useful info on how aggressively to treat possible recurrence.

@larrychrisentery6671 2 месяца назад

Very interesting we have come advance in treatment from wend I was treated 2012

@TERRY-cb2ku 2 месяца назад

Will talk to my urologist about this. I've had a calcification or lesion on prostate for 15 years. According to recent MRI its still confined to the capsule. Will probably have biopsy soon and then I'll know for sure what im dealing with. Im almost 73.

@mrpawpaw7023 2 месяца назад

What if they find something? Will they refuse to operate due to your age?

@ricknowak4582 2 месяца назад

Don't have a biopsy.It'll only spread and you will have to be treated for cancer.

@thomash681 2 месяца назад

I have a lesion which shows up on my MRI. I also know the doctor who took my first set of biopsies said I had calcification. I was told I have Gleason 6 - so active surveillance for me. I also had a targeted biopsy of the “lesion” - and that result showed no cancer in the lesion. Go figure….

@hyway62 2 месяца назад

@@thomash681lucky u

@billhamilton7524 2 месяца назад

how did they find the lesion 15 years ago ?..I though it was poke and hope back then

@samkumar8062 2 месяца назад

Thanks! Great information as usual. I was wondering about the potential of the recently approved Episwitch PSE test in the diagnostic scheme.

@jabster58 2 месяца назад

Could you speak about reoccurrence its almost 50 percent that doesn't feel like a good cure rate and when it comes back its harder to cure

@antoniodelrey164 2 месяца назад

Are these the same or similar to a Decipher? Maybe called a decipher code?

@popeyetoot Месяц назад

Can you please comment on PTEN loss found in biopsies? Does this impact what type of treatment or AS in case gleason 6 with PTEN loss? Does Decipher add more info in this case?

@ThePCRI Месяц назад

Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline

@hyway62 2 месяца назад

If u test positive for brca 2, will that make your prostate cancer more aggressive and my oncologist told me if your positive for braca 2 that radiation will not work well, is this true???

@jabster58 2 месяца назад

I didnt know that the cancer reoccurrence was so high at 40 percent. And somewhat higher for people who choose radiation .

@tonytahmasebi1926 2 месяца назад

I asked you a question sometimes ago but I never got an answer for it so I will ask you again..I am 68 with enlarged prostate my PSA is 2.5 couple of weeks ago my urologist without doing any kinds of tests he scheduled me for the procedure .but I canceled my appointment because I wasn't comfortable with his decision...please help me and tell me what I should do.....thanks so much in advance.......

@ernesthanks6125 2 месяца назад

I'm not a doctor, but i would have made the same decision: cancel the appointment. Then I'd look for a new doctor.

@tonytahmasebi1926 2 месяца назад

@@ernesthanks6125 thanks

@PredatoryTeeth 2 месяца назад

@@ernesthanks6125I agree with BOTH of you. I'm 54 and had a PSA of 3.24 which is likely attributable to BPH (enlargement) and both myself and the urologist felt I didn't need a biopsy until further surveillance. Six months later there was no "velocity," staying stable at 3.23. Six months later it trended downward to 3.08, then six months later remaining stable at 3.07. Dr. Scholz has mentioned here several times that bigger prostates bring a bigger PSA. Needless to say, a 52 year old guy (2 years ago) with a PSA of 3.24 can raise eyebrows, if not border "alarming." A PSA of 2.5 at 68 years of age is typically considered quite normal.

@nickstrapko7549 2 месяца назад

Was the dre result ok

@tonytahmasebi1926 2 месяца назад

@@nickstrapko7549 Hi I am sorry I don't understand your question...

@larrychrisentery6671 2 месяца назад

I like that you give your patients the opportunity to make their own decisions as explained to them what side effects they will have .

@marinefarmer7494 2 месяца назад

off topic but I don't understand that on one side they say.. Gleeson 6 will never metastasize then on the other 50% of patients with Gleeson 6 go on to have treatment within 10 years.. Can gleeson 6 change to Gleeson 7.. Anyone. Please help.

@hyperlinkphilosophy Месяц назад

Hi, Gleason 6 does not turn into a higher Gleason grade. A higher Gleason is a different tumor altogether. And Gleason 6 does not metastasize. Here is a link where Dr Scholz presents really good information about Gleason 6. Hope it helps: m.ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nOmK2B5Y9Go.html

@SeekingWisdom17 Месяц назад

It can change to higher Gleason.

@hyperlinkphilosophy Месяц назад

According to Dr. Scholz, Gleason 6 neither metastasizes nor does it turn into a more aggressive cancer. I provide 2 quotes and a link to the video that is the source of the quotes provided here. Can Gleason 6 metastasize? “We now know Gleason 6 is a harmless variant of prostate cancer that never metastasizes. Arguably, maybe shouldn’t be even be called cancer.” Can Gleason 6 change into a more aggressive cancer? “Low grade prostate cancers don’t turn into high grade cancers.” Here is the link to this part of the conversation that is the source the of quotes and provides more details. It starts at the 5 min 34 second mark: m.ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nOmK2B5Y9Go.html

@marinefarmer7494 Месяц назад

@@SeekingWisdom17 It shouldn't as completely different cancer...

@SeekingWisdom17 Месяц назад

@@marinefarmer7494 Look for 'Risk for prostate cancer grade “progression” (from Gleason 6 to Gleason 7 or higher)'

@nickstrapko7549 2 месяца назад

Here is my situation .. 51. Original 8.7 psa Gleason 4 +,3. Borderline Johns Hopkins re read my pathology and called it 3+4. Very much ambiguous . I did genetic testing with Invitae theough hospital . I had robotic protestectomy 6 weeks ago.. . NO genetic mutations were found . I had my sperm frozen and my results only showed recessive for. Cistic fibrosis. To make it more complicated . I have a uncle who had pc at almost the same age and also removed . So whete is it coming from . Bad life decisions, diet . Who knows So my genetic are negative for PC i guess

@demitasse07 2 месяца назад

You seem to have a lot of questions and I want to encourage you to manage your case and find answers that make sense to you with your doctor(s). If you have an hour or so, this video is an excellent starting place about how to understand cancer as a metabolic disease not a genetic disease. However, prostate cancer can be different than other cancer forms. This is why most men work with a doctor they trust to help them understand the options. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-nGo0mtPX-JQ.html

@nickstrapko7549 2 месяца назад

@@demitasse07 actually not I've been through the gammit and just got my undectable results PSA back

@jimbaker2698 2 месяца назад

Answers is a problem ,my oncologist talks to me about 5 mins ,that's it,if I mention u all and utube info they just laugh and leave the room asap,,my doctors are corporate company😮

@SeekingWisdom17 Месяц назад

Maybe worth trying to find another oncologist.