House tells the ugly truth about Vogler's drug 

Extract from "Role Model", the seventeenth episode of the first season of House, which premiered on the Fox network on April 12, 2005.
At the conference, House gives an extremely brief (two-sentence), monotonous and lackluster speech in a weak attempt to pacify Vogler. However Vogler is not satisfied and orders House to step it up or he will force him to fire either Foreman or Cameron again. House then returns to the podium and tells the ugly truth about Vogler's drug: it's not a new drug at all, but rather an old drug whose patent is about to expire, forcing Vogler's company to reformulate it with an additional medication to create a "new" drug, which they will encourage doctors to prescribe rather than the soon-to-be less expensive old drug that's about to go into generic status. House's staff, all present for the speech, react in ways showing their disbelief (Foreman shakes his head, Chase downs the rest of his glass of wine, Cameron looks torn between admiration and sorrow). House sarcastically mentions to Vogler, "I threw in a joke" (after Vogler had earlier asked him to), leaving Vogler to speak to the audience.
This is one of my favourite clips, I think House shows true integrity here.