How do Bile Acid Sequestrants Work? (+ Pharmacology) 

I have a question plz What about the people with gall bladder eradication ...why do they give them cholestyramine if they already have No gallbladder..?!

This video is so informative. Thank you for posting actual drug names. I was doing lots of research before. I wanted to ask you, what drugs can lower cholesterol, but be safe enough for those with high triglycerides? Thanks so much!!!

I have a question. Is Ursodial a bile sequestrant?

Yes it is!

Very well explained! I watched numerous videos prior to this and they weren't very helpful explanations. Yours didn't go over my head and it was a great help with my pharmacology course!

Exact same thing happened to me! It took me 12 years to finally figure it out on my own, even after being told it was definitely not BAM causing my issues. Glad to hear there are others figuring it out for themselves too. I wish the SeHCAT test were offered in the US,

@@basedgodjoe9541 not the OP, but my symptoms that were fixed from bile acid sequestrants were focused around a false urgency I would get soon after eating. It felt as if the food I just ate had already passed through me, which obviously was not the case(although there was definitely a rushed transit time I could observe through eating corn or some greens, 10-14 hours or so at times), but I would feel the need to rush to the toilet and then would be unable to go. This was all accompanied by pain almost all the time. If the pain subsided and I'd get up, the urgency and pain would then come back. I spent far too much time on or around the toilet with no relief. When I finally went, it was almost always diarrhea. I only ate 1 meal a day for around a decade, never breakfast or lunch. I would go to basketball practice having not eaten yet that day. I avoided going out to eat or going places where I would not be close to a bathroom with which I felt comfortable. I missed so much school, and since starting sequestrants ~1.5 years ago, I have missed 0 days due to those symptoms. I still feel pain and discomfort sometimes, but it pales in comparison. I now eat what I want and religiously take my Colesevelam alongside it. Good riddance low FODMAP diet. I think the false urgency is due to the accumulation of too many bile acids in the colon that would then draw in substantial water and salts(which I believe is a natural mechanism to form stool, why 5% aren't normally absorbed as it is), which, along with the gastrocolic reflex after eating, pushes food too fast through the intestines. Our already sensitive guts would likely feel that related pain and interpret that surge as immediate urgency when, in reality, it is still not quite there. I know this is late, but I hope Colestryamine has brought you some relief.

I had a similar experience. I suffered for 20 years after having my gallbladder out before a Doctor told me to take Bile Acid Sequestrants. It changed my life! I also was afraid to go out of the house!!!!

@@3311lee Im so glad to hear of another person who has seen such wonderful improvement as well. How long have you been taking BAS?

I started wuth resin cholesteramina powder about 6 weeks ago. I take one packet in water every morning and it helped immediately

Thank You for the support! Glad it helped! 😁

Thank you so much for watching! I appreciate the support!

Glad it helped! Thank you for watching!😁

Thank You!

I now understand pharmacology because of you!!!!! I really appreciate your effort👏👏

Thank you for watching!!😄

You're very welcome!

You're welcome! 😁

Thank you so much!😁

Youre welcome! Thank you for watching 😃

You're welcome! Hope it helped!

My pleasure!

Thank you for your support!😁

Thank you for watching!

Thank You! Glad it helped!😁

You're very welcome! Glad it helped! 😁

Thank you for your support! 😁

Thank you so much for watching!

Thank you for watching!😃

Glad it helped! Thank you for watching!😁

You're very welcome! @Humi 😁

Glad it was helpful!

Thank you very much for watching!😁

Thank you for watching!😃

How long did you have to take it??

@@jdakid156 I still do after five years. After a year I tapered down from one packet per day to one every three days. Seems I'll stay there forever according to my doctor

Thanks for watching!

Glad it helped! Thank you for watching!

I was out on anti acid meds, diarhea started

I'm having similar issues. Been taking cholestryamine and it's not working, Sucralfate had been working but my doctor took me off of it for some reason.

Ah yes, this is also an indication! Thanks for sharing

What tests did you do to find the 2 percent retention.

SeHCAT test. It's supposed to be a capsule containing bile salts and a radioactive tracer. You have two gamma scans done 1 week apart. Anyway, my symptoms have long gone since my last comment. @@glengarbera7367

I have been gallbladder-less and drugless for over 15 years, if you stick to a low fat diet (low processed foods), I have no need for meds

Appreciate it G✌

Have you found an answer?

Binding the bile acids should prevent them from having the effect of drawing in excess salt and water that cause the urgency and diarrhea of BAM. From what I have read on the matter, the 3-5% of BA that are not reabsorbed help to form proper stool in a healthy person, but in excess, they cause these symptoms. When they are bound by BAS, they do not draw in water and salt, which I think is why constipation is a side effect.

Thank you for your support! @Rhonda I put the answers in the description below, only because I want to give everyone time to answer them without accidentally seeing the answer! 😁

@@DrugChug That would be good. I looked in the description thinking I would find them there,but I did not see them.

@@rhondagregory5253 They should be there! (You have to click on "Show More" on the bottom and it will open up the entire description with the answers)

This is actually one of the other uses besides lowering LDL. With no gallbladder, the liver can continuously drain bile, and it can cause "bile acid diarrhea" and there is also "bile acid malabsorption" there the body does not recycle the bile. If it isn't bound to anything, it is a powerful laxative. So taking a BAS can bind to all the excess (that would normally be kept in the gallbladder until you eat food) and prevent the laxative effect.

People here describe taking cholestyramin for BAM (bile acid malabsorption), too. So I'm a bit confused.... Edit: in BAM it "just" prevents the laxative effects of BAs

It is a bile acid

Mold? What symptoms? Does it help?

I wonder if this helps as well because I was exposed to mold for 4 yrs before then I already had issues with my digestive system due to not having a gallbladder and mold exposure made it worse even though it’s been a yr since I moved out of that toxic environment

Cholesterol is literally part of each cell's membrane, FYI 😜

The different bile acids are reabsorbed (to the blood stream) in the small intestines (terminal ileum). Then the liver filters it out (probably it has some storage capacity too). Gallbladder has nothing to do with reabsorption. It's there to store and regulate the release into the guts (duodenum) ...but honestly I don't know how one functions without it. Going to look it up.

BEANS AND LENTILS, OAT OR RICE BRAN. BENTONITE CLAY, ACTIVATED CHARCOAL..

Have you found an answer?

@@Littleprinceleon nope, mystery of med I guess