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How Do Cilia and Flagella Move? 

XVIVO Scientific Animation
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xvivo.com/examples/mechanism-...
The XVIVO team collaborated on a project with Dr. Daniela Nicastro, Associate Professor at the University of Texas Southwestern Medical Center. Dr. Nicastro and her research colleagues had completed some complex and ground-breaking research into how cilia and flagella generate their whip-like motion, and they asked XVIVO to help them visualize the results.
Dr. Nicastro’s group used a novel technique to visualize the molecular machines inside flagella to better understand how they work and, in the process, they confirmed a previously unproven hypothesis. Their research showed that flagella get their whip-like motion by a coordinated activation of motor proteins on one side of the flagella and inhibition of motor proteins on the opposing side.
XVIVO was tasked with taking the research results and creating a 3D animation that helped viewers better appreciate how the motor proteins in flagella work. The final animation steps through the process of flagellar beating by diving into the flagella structure and bringing the research to life.
Learn more about this animation in our blog: xvivo.com/blog/activate-inhib...

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9 мар 2020

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Комментарии : 111   
@almasfarooq9547
@almasfarooq9547 3 года назад
The caption should be "Movement mechanism of flagella", yes Cilia and Flagella have similar internal structure but they differ in their pattern of movement.
@jianfenglin7450
@jianfenglin7450 3 месяца назад
You are correct regarding their different movement patterns. This video aims to introduce the Switch-inhibition mechanism shared by cilia and flagella with 9+2 axonemes for beating generation.
@dev5966
@dev5966 3 года назад
the animation is so much better than a verbal approach to understanding this sort of thing thanks
@mrnerd73
@mrnerd73 2 года назад
I'm very much overwhelmed to learn in the ways our older generations couldn't even imagine ❤️
@malikkazimkhan3681
@malikkazimkhan3681 2 года назад
Excellent !! plz come again and again with such awosome and appreciable stuff..
@DBS608
@DBS608 4 года назад
That's great work... Thank you
@waliaphellps1745
@waliaphellps1745 2 года назад
Do not know what is more amazing: the reality or tha capability of getting to know all this mechanisims by human scientists.
@Crystal_Scott
@Crystal_Scott 3 года назад
This was very Informative and visually appealing!
@diyasoni8524
@diyasoni8524 3 года назад
Beautiful video, keep uploading such content 😊
@NebulaTornado
@NebulaTornado 4 года назад
professional job.! I give you a win medal... thanks for this high level formation..
@WDCallahan
@WDCallahan 4 года назад
This kind of stuff absolutely fascinates. It's great to be living in the future.
@Zoooooooooooo
@Zoooooooooooo Год назад
we live in the present
@inferno38
@inferno38 3 месяца назад
You lived in the past
@Chris-sv8ty
@Chris-sv8ty Месяц назад
Yo this type of shit has been going on for roughly 3.5 billion years
@ElNietoPR
@ElNietoPR 4 года назад
Excellent! More videos, please!
@icysnake1989
@icysnake1989 4 года назад
It's a great job! Thanks!
@voetius
@voetius 2 года назад
Everything perfect but for a thing: This is the *eukaryotic* flagellum. The bacterial type is totally different. Otherwise, a wonderful, clear and insightful animation.
@jianfenglin7450
@jianfenglin7450 3 месяца назад
Appreciate your comment. But when eukaryotic flagella are mentioned together with cilia, the word "eukaryotic" is often omitted for conciseness.
@voetius
@voetius 3 месяца назад
@@jianfenglin7450Well, if conciseness is the key, then all stuff about dyneins and mechanisms so on has no place. However, I still believe it is the best animation available on the issue.
@lilspacebunnny
@lilspacebunnny 6 месяцев назад
Such a good video thank u sm!
@sankalpsharma9947
@sankalpsharma9947 Год назад
best explanatory video ever
@marcelnowakowski945
@marcelnowakowski945 10 месяцев назад
Reading about this in the "Microbiology for Dummies". The video is very, very helpful. Good work - thank you!
@ilkesar9841
@ilkesar9841 4 года назад
Amazing!
@andersnelson6888
@andersnelson6888 3 года назад
EXACTLY what I needed. Whoever made this animation is beautiful
@rabiulhasaneee
@rabiulhasaneee Год назад
But whoever made this machine? It's out of the blue.
@intensecutn
@intensecutn Месяц назад
​@@rabiulhasaneeeWho made the machine? The machine made itself, through genetic mutation and natural selection.
@CherifHadji09
@CherifHadji09 12 дней назад
​@@intensecutn that's god engineering
@sachinmore8376
@sachinmore8376 4 года назад
Amazing
@mariamnegm7865
@mariamnegm7865 11 месяцев назад
greatly animated....❤
@kannaiahk1848
@kannaiahk1848 3 года назад
Super teaching
@ina.v
@ina.v Год назад
WHOAAAA u guys helped me SOOOOO muchhh
@AnilkumarGulia
@AnilkumarGulia 2 года назад
Great stuff
@daviddaniels3853
@daviddaniels3853 3 года назад
This is a truly bad-ass video!
@fabiopiras7642
@fabiopiras7642 Год назад
Thank you!!!!
@Muuip
@Muuip 3 года назад
Great concise visual presentation! Very informative, much appreciated!👍
@DerEpistokrat
@DerEpistokrat 2 года назад
Wow, now I understand! Thanks. Especially the spatio/temporal coordination of Dynein movement is shown perfectly and correctly. There is one little mistake in it though, I think...(And I am only writing this in order to check my own understanding). The system would not work if all activated Dyneins "walked" synchronously, as shown in the animation. Because then the bent would immediately relax when they all let loose at once. Am I wright? Best wishes and thanks again for this beautiful and clear animation.
@maryamqussay1273
@maryamqussay1273 2 года назад
thank you
@user-vf5jr1wv8k
@user-vf5jr1wv8k Год назад
Amazingggg❤
@avivayash4857
@avivayash4857 2 года назад
amazing
@shailjha3397
@shailjha3397 3 года назад
Awesome
@yougotsnipedbro6060
@yougotsnipedbro6060 Год назад
Thanks I was wondering how was axoneme a part of flagella Great help
@ksaladin
@ksaladin 3 года назад
This is a superb video and lucid explanation that gave me new insight into this process and will be useful in my textbook writing in anatomy and physiology. I love seeing this application of cryo-EM to deeper functional insight. However, the video is titled "Mechanism of Cilia," yet speaks only of flagella. It leaves me wondering how much of this translates to, or would be different in, cilia. This is in light of the difference between the corkscrew motion of a sperm tail propelling a mobile cell, versus the cilia on a stationary epithelial cell (as in the trachea or uterine tube) undergoing a stiff power stroke and limp recovery stroke.
@outkast334
@outkast334 4 года назад
Excellent video and description
@RenatoPinali
@RenatoPinali 2 года назад
fantástico...
@suneetsharma907
@suneetsharma907 Год назад
BEAUTY
@spreeze3468
@spreeze3468 4 года назад
Me and my girlfriend will try the mechanism. Thanks!
@imnayab7136
@imnayab7136 Год назад
Animation 💯
@Steve-vf7se
@Steve-vf7se 9 месяцев назад
It kinda moves like snakes...or electric eels. I like it, by the way, I want to see more of it. This is so cool
@peterv4189
@peterv4189 3 года назад
Awesome video. Thanks. But I am thinking the opposing side to side firing mechanism illustrated would cause side to side bending, not up and down movement? Correct me if I'm wrong. Still amazing graphics
@fratlows
@fratlows 3 года назад
Yeah it must beat side to side
@jeherulislam6903
@jeherulislam6903 4 года назад
pleaSe include closed caption for HH
@meducla
@meducla 4 года назад
WOW !
@SAPANAACHARYA-gz2xm
@SAPANAACHARYA-gz2xm Год назад
perfect>..
@peterbuckley1794
@peterbuckley1794 Месяц назад
You can't stop me from moving
@samgnanaraj
@samgnanaraj Год назад
breathtaking! The beauty of creation
@gamingtilldusk6712
@gamingtilldusk6712 5 месяцев назад
Wow
@i.amnasim
@i.amnasim Год назад
Rishab Sir❤
@ChrstphreCampbell
@ChrstphreCampbell 4 года назад
how do atp's provide power, do they have to be there for each tiny, tiny, tiny action, or do they merely 'heat up' The general environment & allow chemistry to do it's thang. ( sic ) ?
@MrFarber31
@MrFarber31 2 года назад
lots and lots of ATP
@peterbuckley1794
@peterbuckley1794 Месяц назад
What was the bathroom flagellum
@user-ei3ek4ke2x
@user-ei3ek4ke2x 2 года назад
روعه
@shalina356
@shalina356 7 месяцев назад
Nice. But the colour change confused me a little.
@frankjaumajubert6124
@frankjaumajubert6124 2 года назад
Don't the flagella move in a chorkscrew-shaped way making the action potential round?
@thedisintegrador
@thedisintegrador 2 года назад
that's so in prokaryotes, in eukaryotes it's like this
@greathornedowl1783
@greathornedowl1783 10 месяцев назад
No, you're thinking of bacteria like E-Coli and Salmonella. This is a sperm cell, a eukaryote, totally different organism.
@rimplekour3882
@rimplekour3882 3 года назад
👌👌👌👌
@SeanRhoadesChristopher
@SeanRhoadesChristopher 4 года назад
Now, how does it know where it's going? It must have programing directing it to a target destination.
4 года назад
sperm chemotaxis
@jeherulislam6903
@jeherulislam6903 4 года назад
when u typed these letter, your actin and myosin doesnot know where o0r which way too fire, like that, their firing direction is dependant on other aspects of physiology( not brain per-se but chemotaxis or so
4 года назад
​@@jeherulislam6903 The movement of sperm is directed by chemotaxis; a biochemical pathway responds to concentration gradients of chemicals released by egg cells. It takes these oocyte-released chemicals as input, and the reactions we see in this video are the outputs. Imagine a simple little robot built to move in the direction of a stimulus (like light); the same thing is happening here. Without the stimulus (chemoattractants), the sperm would presumably just move around in random directions.
@FutureAIDev2015
@FutureAIDev2015 4 года назад
Taurus Londoño So basically, the cell can smell where it’s going?
@jeherulislam6903
@jeherulislam6903 4 года назад
@@FutureAIDev2015 yes, for layman term something like guide by smelling. To understand how it works u need to dig deeper aspects of chemistry.
@hassaneltras1579
@hassaneltras1579 3 года назад
If it depened on action potential
@A3Kr0n
@A3Kr0n Год назад
No rotating motor?
@agnelomascarenhas8990
@agnelomascarenhas8990 3 месяца назад
Left me confused. Bacteria have rotary motor coupled to the flagella. Our own cilia are back and forth motion like the one described.
@fabiopiras7642
@fabiopiras7642 Год назад
my brother
@s81am
@s81am 4 года назад
سبحان الله الذي أتقن كل شىء
@ina.v
@ina.v Год назад
go girl my lion my bear my cilia
@AfifDidar04
@AfifDidar04 3 месяца назад
0:34 0:55 1:40
@bradhilton2283
@bradhilton2283 2 года назад
If you have ever gotten baked off your ass and watched yo Gabba with a favourite nephew ....You are going too love get baked and watching cellar science animation.
@Muuip
@Muuip 3 года назад
Billions of years allowed life to create such complex systems and integrate them with many others to create living beings on one (or more) planet of this universe. Amazing!
@stevenklein9228
@stevenklein9228 6 месяцев назад
A powerful example of intelligent design!!
@username2516
@username2516 10 месяцев назад
created , no doubt about it
@Makeshiftjunkbox
@Makeshiftjunkbox 3 месяца назад
Electromagnetic plasmoid dynamos of the organism that is the Universe transmuted under high pressure not machines!
@paulobichara3213
@paulobichara3213 Год назад
God is a perfect designer that we can witness even in a fallen world because of sin. Mesmerizing
@Ourndemailweshared
@Ourndemailweshared 7 месяцев назад
God is amazing. He creates in ways we could never.
@intensecutn
@intensecutn Месяц назад
The unviese created these things. Universe is the one and only creator. God is just another word for it.
@benski0573
@benski0573 Год назад
it’s like a biological engine
@drkthemusicman
@drkthemusicman 2 года назад
so we were similar as sperm form??
@ammarhaider1727
@ammarhaider1727 3 года назад
GOD is the BesT
@alsame9376
@alsame9376 10 месяцев назад
More evidence of Intelligent Design. Molecular machines are the biggest and most blaring evidence of intentional design for an intentional purpose. All glory to the Creator.
@user-dx4mi6uz7o
@user-dx4mi6uz7o 4 месяца назад
Yes say that to a gay
@mirfan-2020
@mirfan-2020 Месяц назад
And who created this apparent creator who should be even more complex? If you're gonna say he always existed you have to prove it, as there are way better explanations with concise and plentiful evidence to support evolution and to disprove intelligent design. The intelligent design is a classic example of argument from ignorance.
@sandinoblackmamba9174
@sandinoblackmamba9174 Год назад
Result of Intelligent Design and not darwin's evolution.
@agnelomascarenhas8990
@agnelomascarenhas8990 3 месяца назад
You should be studying the Bible or such creationism, don't waste time in science.
@Tejano._.
@Tejano._. 2 месяца назад
Fr سبحان الله
@FLORIDIANMILLIONAIRE
@FLORIDIANMILLIONAIRE Месяц назад
Nature indeed is intelligent at making micro molecular mechanisms
@Lerenthial
@Lerenthial Месяц назад
Interesting fact is that these micromachines working on molecular level evolve faster than your “spiritual lot” 😅
@succulentravioli954
@succulentravioli954 Месяц назад
Bro it's not that deep 💀
@partyakshvatsal1301
@partyakshvatsal1301 Год назад
Amazing!!!
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