A Day in the Life of a Motor Protein 

True

😂😂😂

I dont think he gets paid at all

I can’t afford to pay , ya know corporate cutbacks and all

And a union

Serena Koehler Yo... same

@@ryn.999 but serena will help it...

bro, my tears just left my eyes while ı am reading this

There was a major accident on their usual roadways, and the detours set up for them are a lot less efficient for their commute.

well it seems you need to change aspects of your life to fulfill that need. a mental attitude change will be light and day for you.

Yeh! what I loved most about this animation, his legs moved like the actual thing.

Nowadays I can’t tell if it’s sarcasm or a joke

@@BeauxLo it’s neither, in fact it’s true

Kinda adorable sounding

So basically Motor Proteins are like Sonic the Hedgehog

You would not have much fun because proteins have no volition whatsoever: it's all determined for them, they are machines. No choice-making, no fun.

Yeah. One guy built a space shuttle in his back yard after watching several animated episodes of Superman.

Sergio Ezquerro - Sounds both cool and very challenging, but for what I know most videogame designers tend to simplify, because more complexity = more work = more processing power load = more lag and problems of all kind, etc. Ask Extra Credits, let's hear what they have to say about that.

You are really late into this I think, then: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-zAvKlfXE4S8.html

You could play that ancestors the humankind odyssey

Pink and fuzzy, mind you

Victrola Fix whahahhahaha. You're damn funny! LOL

wtf is a motor protein? I only know a John

Victrola Fix ГOГ

@@megamushroom GOG

Random Guy what

Random Guy how

Cringe

John lives in a neuron.

yeah... no. Hollywood and Pixar's idea of scientifically accurate is "Inside Out".

@@jamestheotherone742 nah, they specifically went for a non physical intepretation

Osmosis Jones

Why there is not one already?

def would watch

inside out: realistic mode

Yeah Disney is starving for new ideas.

103% in my opinion. Dynein and Myosin are adding -3% work.

@@indianministryofilluminati3531 OMG LOL yes. I just attended a meeting yesterday with Dynein and Myosin busily contributing their negative three percent!

I can't say how they found it, but yeah that's how motor proteins move

They look somewhat like pairs of shoes walking along wire/chains. Obviouly, what is actually happening is that the "feet" interact chemically with the sections of the microtubule alternatively attaching and detaching from it, but still is funny to think of them as tini tiny pairs of shoes walking around.

@@qdaniele97 Do we know that because they have literally been watched moving that way in real time via microscope, though? Or is it a guess based on their structure or other information we know about them?

@@Shadowmech88 as far as I know they have in fact been observed. I believe by an electron microscope if I recall correctly. I hope someone else responds who knows for sure, I'll look it up and tell you if I find out.

@@Shadowmech88 scientists usually run simulations of how proteins would fold which then can get depicted visually. Proteins are far too small to be seen to my knowledge.

and annoying way to walk

after this terrific explanation ...u just cared about slippers !!!!! damn

​@@mohamedmagdy621Hey Mohammed, lighten up.

Haawhqkjq

​@@HOTD108_the mohamed must chill brou

watch your language.

no

Dylan Branch he or she can say anything they want u don't like it? Get off the intetwebs bruh. U know how much cussing there is in middle school? High school? Even online gaming. Grow up

Travis Maenle agreed

How can someone watch language, it does not have any state.

I was, thanks

Then what does the bell tower represents? (lol, jk, no need to answer)

No it's not. It's a cell

4:46 „University of Utrecht“

⁠John lives in the Netherlands

Check out kurzgesagt then! It has tons of illustrated stuff about biology, science, and physics! Also why we should terraform Venus instead of mars.

Bruh, in high school the cytokskeleton was only a footnote

The macro world where we are educated by a 'free' platform funded by advertisers hoping we'll be snagged by their clickbait, is much weirder than John in his pink fuzzies and his buddies!

😆😆👏🏻❤️❤️

Andrew Dominguez through dyenin which can only travel in the opposite direction. without each other, they'd remain stuck at one end of the microtubule

Mind posting a sources? Would like to read this

Andrew Dominguez I found this which explains it a little bit, but I had a class this semester about the cell biology and metabolism which included a good component on motor proteins such as kinesins and dyneins. I thought it was really interesting and definitely worth learning about! www.ncbi.nlm.nih.gov/books/NBK21710/

Also taking a cell bio course. Assuming dyneins and kinesins are both bound to a membrane. How are the ATP binding site's globular head domains inhibited to allow movement in one direction or the other?

Andrew Dominguez we didn't cover the part explicitly explaining why one goes in one direction whereas the other goes the opposite. I'm assuming the shape of the head domain can only bind in one direction to the tubulin dimers which make up the microtubules due to each molecule's dispersion of charges and overall shape. The dimers all assemble in a specific configuration if you look up the structure of microtubules in a picture, so perhaps the motor proteins' head domains bing their front edge to say the alpha-tubulin while the back end of the head domain binds the beta-tubulin or vice-versa? Again, we didn't cover this part so I can only hypothesize.

+Smooooth Just a lil' motor protein swaggah, lol.

That's actually how the motor protein actually walks, and it has nothing to do with being a gay or anything of the sort.

Can't believe shits are walking in my brain

That's the best part about this video, because of how accurate the walking is

John lives in a city called Donald Trump, that's why.

Except for what has been explained in the video, John is on a one way street.

Electric polarity of the microtubules. John is a molecular machine obeying chemical laws, the overall machinery of the cell is still amazing.

@@LuisAldamiz Sorry for necroposting, but I thought I would mention that the polarity of microtubules is not electric but instead based on which direction the microtubule is assembled in. The plus end of the microtubule is the direction that it is produced in, and the minus side is the part of the microtubule attached to the centromere (the structure on which microtubule production occurs.) It is kind of difficult to visualize, so here is a video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Rbbtbt2i8xA.html As for the basis of John's direction of movement, it is based on the asymmetrical shape of tubulin, the protein that microtubules are made from. The subunits of kinesin (John) will only bind to a tubulin molecule if they have a particular orientation. It is similar to how sticking a 3-pointed plug in an electrical outlet only works if you push it in the correct way. The orientation at which they bind causes kinesin to point towards the + end.

@@wingsofpurityofficial4031 - Not bothered by "necroposting" myself, as long as the info is relevant. So you're saying that polarity is only "accidental" and does not itself determines how the kinesin moves? OK, I take notice, thanks. Always cool to learn.

@@LuisAldamiz The polarity is not accidental. The microtubules actually start being made at distinct structures in the cell called microtubule organizing centers. And it does determine how kinesin moves, but not in a very direct way. Kinesin cannot determine which side of the microtubule is which, but it can determine which direction a single tubulin molecule is pointing. Since all tubulins are oriented the same way in a microtubule, kinesin can indirectly recognize which direction to move in by only binding to tubilin molecules that are pointed in a specific direction.

his body is so sexy

John is love, John is life... and I mean that 100% literally, he literally is what make tose to tings possible

I'm flattered

Hands off skank!

Don't get any ideas *Cough* -fanfictions- *Cough*

And what use will it do you without a degree?

well, like most thing i know, it doesnt do me any good, but it doesnt mean knowing it, is a waste of time. for example, if my kids happen to ask "why do we eat?", i can go deeper then "we eat because our body need the energy"

***** Excellent reply, rundor just got burned :)

+DOGE™ wtf doge ur everywhere

Yomomma Sofat omg I'm so famous :O

Oh sad. Portraying motor proteins as animated persons has a bit of a drawback there. I am shifting in my mind to seeing John as a Lego bot, for whom disassembly and reassembly is a natural function! (Edit: but I do still appreciate the fun animation)

OK I understand dynein now, he helps John get home, and vice versa. But myosin, what does it do?

+Josh Giesbrecht what does dynein do? Or how does he do that?

+amina ali I'm limited in this field, but my understanding is dynein is essentially "turned off" while the motor cell goes to its desired location. Once it is there, I believe chemical reactions or instructions "wake up" dynein so that it can continue its journey back to its home. Like I said, I have very limited knowledge in this field. But that is my understanding.

+Josh Giesbrecht I've just seen this post, so sorry if you've found an answer already! If John walks along the main roads (microtubules) that run lengthwise along the axon from point A to point B inside of the cell, you can think of the myosin as (basically) 'wanting' to walk along the alleys or side streets (actin filaments) to the cell's surface.

+Josh Giesbrecht The other two proteins seem to allow the protein package to be passed into other cells, iirc.

Me too!!!!!!!!

Yeah i know, this is like nerd comedy

+Christopher Gudgeon ikr! ^^

@Yahawah is God False.

@Yahawah is God why would god bother making it so complex..

@Yahawah is God wouldn't it be more impressive if the body worked magically without all these little molecules controlling it..

@Juno Donat I dont know much about what you say. But I can say definitiely your last sentence is wrong! It is historically proven that Jesus did exist! There were just too many witnesses that saw him! And there are even historical people who saw Jesus after his crucifixion, so after he was risen.

Still waiting

Sam protein?

Sam Kinison

Yeah I am really eager to find out what this is all about, but I still don't get the reference. A more thorough explanation would be required for it all to come together, I think.

It's a kinesin....and Sam Kenisen was a famous American comedian. (the names sound almost exactly the same)

@Pendejoto666 Pretty sure it's from "Tomorrow's Harvest", I forget which track

@@owleyes551 Split Your Infinities

kek

+miraj tawa They chop him up and eat him

he travels on the back of another protein going the other way.

@@95johndeering thats terrible he has a wife and kids to support

Nicole Makarowski Lol! 😆👏🏻❤️

It comes to show that necessity is very scaleable.

dynein takes the vesicle back the other way along the microtubule, and myosin allows it to connect to actin filaments(which make up the structure of the outer membrane).

because it looks like slippers in the 3D model of actual thing: watch?v=B_zD3NxSsD8

+Mallinda name please?

Boards of Canada - Split your infinities

Mallinda Thanks

+CleanKillJACK no problem! :)

+Mallinda +CleanKillJACK do any of you know what's the song that starts at 2:51? :s

I guess the feminists would represent cancer!

greg77389 so true.

You can't just appreciate science for science without pushing your fucking victim complex onto an animation of a very interesting biological mechanism? Apparently the Johns of your neurons aren't allowing those (few) brain cells to function correctly?

Steph Smith yeah right? Can’t even watch a video and learn without a man coming in and complaining about how oppressed they are :(. Look how tough my life is :( all I have is the right to vote the right to clean water and food. omg :( these feminists man:( really ruin my life :(

Anti-feminist cringe fuel. Lol