First of all start simple with the xmen and then expand the teams with x factor new mutants x force alpha flights, excalibur, and exiles with some solo heroes like deadpool and x manz with the other mcu heroes still rememebering the previous multiverse and confused how the world changed and starting to interact with the mutants. Literally the whole dawn of mutants would be a reverse no more mutants the main plot could lead into either age of apocalypse house of M or even krakoa with a war between mutants and humans, let's see One thing i suspect is the jonathan hickman's run would be the main basis of the xmen
The only reason I suspect they won't do an adaptation of the Krakoa era is because it ended almost immediately after Kevin Fiege gained some amount of power over the direction of the comics. I feel like it isn't a coincidence, but who knows. I'm down for pretty much anything as long the teams are composed of logical and interesting rosters.