Thanks for having me round your garage, Dr Crisis! If we cure ageing, we can look forward to decades of extra healthy life to enjoy nearly-two-hour RU-vid interviews.
I saw this video and thought: "Huh I know that turtle". It's the same as on your books cover! Great to see two of my favorite channels covering medical topics collaborate.
Great interesting information in this podcast😉 thanks for putting this out there guys. As for a billion causing 50% of the co2, an Oxfam report put it at the wealthiest 10%, more recently I've heard it's mostly the 1%, which when I see their lifestyle is really easy to believe.
This is the kind of discussion that could possibly inspire someone, somewhere to make a breakthrough to improve our lives by orders of magnitude. Please continue creating videos like this. This was riveting.
The cholesterol research is leading to some fascinating insight, looks like cholesterol plays a role in Alzheimer, furthermore there are trials ongoing to literally cure high cholesterol with a genetic vaccine. Basically a vaccine for heart diseases. There are already some people around the world that received that vaccine so it's not some sci-fi thing.
Timestamps / Chapters 0:00 Intro 5:37 Why you got into the anti-ageing field? 7:15 Ageing as a cause of death 9:18 What is ageing? 13:32 Hallmarks of Ageing - Senescent Cells 17:25 How do we target senescent cells? 20:10 What are telomeres? 22:40 How do we stop telomeres shortening? 26:00 Evolution optimised for reproduction, not ageing well - BOFFFs 33:54 Autophagy - cellular recycling 42:00 Testing of rapamycin - Effective Dose 45:35 Why don't we have human data on rapamycin? 46:24 Metformin - TAME trial monetary issues 49:04 What is Metformin? 52:50 How does Metformin work as an anti-ageing drug? 54:03 What therapies excite you at the moment? 58:39 Thoughts on Calorie restriction 1:04:53 Rhesus Monkey Diet Trials 1:08:14 Potential Therapies - theoretical mechanistic science 1:12:46 Amyloid Studies 1:17:20 Should we stop ageing? 1:31:29 Where do you see the anti-ageing field being in 2050? 1:43:03 Outro
There comes a time when gravity takes your butt and your triceps…overnight seemingly…around 50….when this starts to happen your not thinking of living another 150 years. There is a turning point in the psyche as well.
Very informative and pleasurable interview. Thank you from a 76 year-old who lives a life of gratitude, pays attention to diet, exercise, (including taking the stairs from and to my 8th floor apartment), and who I let into my emotional space. I remain pain and meds-free, and feel this is the best time in my life so far.
Your mothers prenatal environment and your dads epigenetics set you up for almost guaranteed success. Just because you are healthy doesn't mean you get full credit for being so. The opposite is true too. Most people who have terrible health were set up to fail for those same reasons.
It's always exciting to see a video from Rohin Let alone a video about a topic that's saturated with medbros and pedlers of sudoscientific nonsense _Let alone_ a video that's the length of an extendened documentary All the best things rolled into one That was a very very interesting watch/listen. I'm vaguely familiar with Andrew's stuff and hearing more from him is always good (I should really subscribe) The next 30 years look to be full of very interesting things in terms of medical science from the studies being done just now, to ones that could be done in the near future I like to think that I'll get to live to at least 120 years old but I'm very clued into how short one's natural life can be considering I live in Glasgow (a very depressing shout-out but it's one that's present in the minds of everyone I know haha) Very exciting and interesting Rohin should do more podcasts (if he can get the time)!
@@konbini2004 sudo science is where you force your computer to do your science for you (and thanks @Sandwich247, looking forward to hearing you’ve become a 120-year-old Glaswegian! PS you subscribed right)
Pseudo longevity science is much more palatable than the FAKE statin science from Merck. Why do I hate Merck? My mom was prescribed Vioxx and had a bad stroke. Fake data from Merck killing and maiming again and again. Who is selling snake oil? Rohin.
Hyped for some well evidenced, grounded conversation about longevity! I'd like to make it to the triple digits, and I'd like to hang out with my parents for a good portion of that time as well. Immortality would be nice, but another decade where I can spend quality time with family would be nice too :)
If that’s how you feel, you must still be relatively young, and you never had any horrible experiences in your life. Getting old may seem like a good thing, but only if people stop breeding at the incredible rate they do today.
@@jessip8654Correct. And it has repeatedly been shown that increased quality of life (food, water, shelter safety, education, access to medical help) reduces birthrates greatly. So as more of the world experiences those listed things, the more the birthrate will even out.
Growing up I had a high opinion on all sorts of medical interventions. While studying chemistry and biochemistry, I got more and more disillusionised to what medicine is really capable of. Learning how finely tuned our bodies homeostasis works and following the medical news where common practices and medications are retracted on a regular basis because they don´t work after all, you really get more pessimistic. Rohin has a very realistic view on that, which I like.
I think it's possible to go too far the other way and assume that no medications are effective or that exercise cures everything. When you have a body that misbehaves like mine, medications are needed to stay alive. I tend to have low blood pressure and I struggle with POTS. If I stand up too quickly, I faint. Obviously this isn't good. I take medication to boost my blood volume and raise my blood pressure so I don't faint. It's easy for doctors to default to diet and exercise as cure alls when they're absolutely not. The body tends to homeostasis, but sometimes our bodies just don't work in the way they need to.
@@katfoster845 You’re not wrong in a certain sense, but I think the complexity of the situation is so beyond us because of how much tampering humans have done to their environments and their own bodies. I personally am diagnosed with a chronic illness, chron’s disease specifically, and for most of the time I’ve basically been told that my life is over, I will be on medication for the rest of my life and there’s nothing I can do about. Here’s a pamphlet on why vegetables and nuts are good for you. They gave me meds and I had a surgery to remove some intestine that was beyond repair, but after the fact I never got healthier. I wasn’t dying anymore, but the entire time they couldn’t tell me anything about the disease, why it happens, where it comes from etc. And I was so pissed throat they thought they could just give me some meds that seem to work without actually telling me why it works and why I should use it. I stopped listening to everything anyone would tell me and exclusively listed to what my body told me. Eventually I found a diet and exercise routine over the course of 10 years that was able to help me come back from this hell that I was told I had to live in. My point being that not all is set in stone, and while medication can be useful, I think it is used too much as a crutch to solve problems.
@@Maakyo Multiple things can be true at the same time. It is totally possible that 1) you were not recommended enough diet and exercise and 2) Kat here was recommended too much diet and exercise.
@@katfoster845 I think one of the biggest problems is that in many cases we legitimately cannot figure out what can and can't be dealt with using medication or lifestyle modifications, because we can't untangle the underlying disease process(es). Possibly the purest example of this problem that I can think of is the two types of diabetes. Type 1 diabetes is _only_ treatable with insulin, no amount of non-medical interventions will help. Type 2 diabetes is partially caused by this aging process, partially caused by this diet and exercise stuff, and giving insulin to these people would be completely missing the point. These both present clinically as diabetes, as a struggle to maintain blood sugar, and yet one is absolutely reliant on medical science and the other really needs to be treated with something that isn't a medicine at all. Now - what if we didn't know that the difference between type 1 and type 2 diabetes existed at all? Then we would be flailing around trying to give insulin to people who have no reason to be on a highly perishable injectable for the rest of their lives... and/or we could lose people to totally preventable consequences of type 1 diabetes because we would be too scared of having people dependent on a highly perishable injectable for the rest of their lives. All this is to say, it can be absolutely true that you cannot possibly be helped by anything short of vasopressins and Makyo needed to get away from medical science entirely, _at the same time._ I think about this a lot because I am somehow in both camps simultaneously. Specifically, I take several medications for my treatment-resistant depression (due to C-PTSD). I am absolutely reliant on a significant amount of tablets and pills... and one of them is a probiotic supplement. Let me repeat this: I take _probiotics_ for my _depression._ There's probably some gut-brain stuff going on there, but part of the most difficult symptoms for me is a lack of energy, and apparently improving my digestion helps with that part?? ...At the same time, if I am out of even _one_ of my actual prescribed psychiatric medications, I collapse entirely. So I can't stop relying on modern medicine either. Human bodies make no sense and this whole thing is a mess.
@@orngjce223 I’m aware multiple possibilities exist. I’d be dead without medical intervention. My point is more that none of our collective knowledge is 100% true and that our contemporary standards for medicine and health are highly flawed and need reconsideration. They talked to me about my illness like they knew anything about it, but really there solution to my problems was a shot in the dark with a medication for which it’s primary purpose was not even related to the illness they were trying to heal inside me. I might not even have an illness I might just be ruined from America’s garbage health standards. It pissed me off and I want to be a force for good change in this regard.
Life expectancy is dropping in the US at least, partly due to the horrible healthcare "system" and the ever widening chasm of the wealth gap. People don't get paid enough to afford the terrible health insurance and even if you do have it, the quality is complete crap if you're not rich.
When you are broke, processed food is the least expensive and most available...and heaven help you if you've no way to cook or safely store uneaten food. Gained 150 lbs that way....
@@RICDirector That's pretty sad when one is broke. I've been in that situation a few times. In Europe you can still eat on a pretty tight budget (maybe less than 3 Dollars per day), but you will definitely lose weight, so if you are a labourer it might not be enough energy.
Very interesting to me, as the caregiver for my 97 yo mother. Bedbound and in hospice due to dementia, but very strong physically with better skin and vitals than most 50 yo. Her nurse said she did not know what would be the cause of death. Mom is forgetting how to swallow and therefore harder to feed, so that will probably be the cause , in my opinion.
@BIGFOOOOOT You're right that cognitive health is just as critical as physical health. The field also dedicates a lot of research on the brain and maintaining cognitive healthspan.
Mustache is FABULOUS. If I were to select my family doctor based on a photo of the doctor, a person with this kind of mustache would get me as a client 100% of the time
I don't think people dislike the idea of anti-aging because they don't want Alzheimers cured. Rather the idea of being stuck another 50+ years in your current job (which most people dislike) and paying rents and trying to make ends meet even in the Western world is incredibly stressful. Of course the billionairs are pumped about living longer though
I've always found that a really odd way to think about lifespan. However suck-y life may be, aging and age-related diseases are likely to make it worse. There is always the potential for life to improve and if it really, really doesn't, suicide is an option, as dark as that may be. It's like disliking your house and so wishing it'd be seriously damaged in a flood. You aren't going to be happier as a result.
Yes right plus f humans could prolong lifespan for 200 years there would be so many other problems too. Many more murders, suicides. More & more food production is required.
If you don't age as quickly you can work fewer hours since you don't need to save as much for retirement and the future medical bills aging causes which could drastically reduce the amount of stress you get from your job. Literally no quality of life improvements come from aging, and if you want to live a currently normal lifespan with a relatively normal retirement age while working just as much you could still live a much better quality life especially in the last few years up until to the point at which you choose to die
@@merrymachiavelli2041the comment is talking more about systemic issues and individual feelings and you're speaking of a rationalization to justify anti-aging, but still keeping the individual feelings, you're saying the solution is for people to suicide instead of trying to solve the systemic issues, yall are putting 2 separate problems as one, aging and capitalism sucking, both need to be solved and both have very different solutions, and neither of them are solved by suicide or not wanting to live +50 years
A lot of us are used to 3-4 hours podcasts, so feel free to go at whatever length that feels necessary to cover all the most interesting aspects of a given topic!
This discussion makes me really hopeful but also a quick look at the current landscape of which communities have access to medicine makes this really worrying. The topic of the massive resource consumption inequality was brought up and if an anti ageing drug is developed it would surely be a really valuable product which might not be available to everyone further increasing the inequality.
Fascinating conversation. Even when you got to a subject that I happen to know a lot about professionally (Alzheimer's), you covered it incredibly well and in an unbiased, balanced way. A treat to listen to.
I know nothing about any of this so this is very reassuring to hear! For me it is quite rare that I find people talking in a knowledgable way about my field (computer science, AI) on the popular media
Turmeric powder taken with powder and pumping iron, while eating 'clean' prevents Alzteimers. Of course most professionals in the field refuse to acknowledge this simple truth because they themselves refuse to lead from the front and pump iron. If you're searching for a cure, then you just found it. Thanks
as a teenager who recently got diagnosed with mitochondrial dna disease caused by spontaneous mutations (kearns sayre syndrome) this talk is very intresting. thanks for the video.
I have the exact opposite reaction honestly, I never understood why people are negative about life extension research. Sure it's probably being funded by greedy billionaires or whatever, but I'd absolutely be one of them if I had the money lol. As long as the rest of us can benefit from the research too then I don't see the issue.
over population is doubtfull for lots of reasons. I could agree that there is population density that has exceeded comfortable levels in certain areas, sure. But some places such as japan they have a population crisis because they do not have enough people being born for as many people that are dieing. And the result of that is entire towns are collapsing because they don't have the population to upkeep it. Top that off with the drop in first world countries of fertility. According to some ladies who deal with pregnant women they said still births have increased over 500-800% in just several years. they were talking how a drop in fertility and loss of life is not just bad, not just a desaster, but a catastropy. (yea probably screwed up some spelling here ) anyway have a good day.
the algorithm has been hiding this from me since its release, i think youtube hates podcasts now. great work as always! you never fail to cover interesting topics and bring up insightful questions, leaving me to rethink my career choice in chemistry. fascinating stuff.
I've had a Nebula subscription for over a year but I still watch 90% of the creators' videos on RU-vid because there's no comment functionality on Nebula.
"Not doing something is a choice in itself." Best quote from @DrandrewSteele in this video. Another reason that doctors should start treating the individual patient and not just following "standard protocols." After almost three years with Long-Covid, I am constantly weighing interventions to reduce symptoms or "cure" the disease. It is amazing when I ask doctors for advice on "low-risk" interventions and they say "There are no RCTs for that treatment and your medical issue. Just wait (suffer) for 5, 10, 20 years for a proper treatment protocol." Luckily, there are some doctors willing to look at the early data or medical reasoning and help patients do controlled, low-risk, n=1 experiments. I have done many n=1 experiments so far that has led to large improvements! BTW. Have you done a video on Peter Attia and his stance on nicotine patches?
@@Sarandib22 I am not fully recovered yet either, but the path seems clear. If you only need a bump to get back to work I suggest looking into doing Yoga Nidra and brain training. There are lots of free videos out there and different books that can help... let me know if you want recommendations. There are also lots of recovery stories... Look at the ones from "Kyle" on RU-vid. He gives a good simple rundown of how brain training helped him...and he is not selling anything 🙂
@@Sarandib22 So many people out there need help with that it almost makes _me_ sick. @physicsgirl is one currently bedridden and I wish I knew what might, or who could help them.
@@Sarandib22 I am still at 75 or 80%. At this stage it becomes harder to rest and pace....since pushing a little lets you have an almost "normal" life. At this stage we still need to run at 80% energy use most days so we can recover well during sleep. The temptation to push and run at 105% keeps us stuck... in my opinion. Each person has different journeys.
Metformin helps with my asthma too. It's all good. But, sorry, born with asthma and it's unlikely that anti-aging anything will help that. Most of the severe asthmatics in my family die by 35. My aunt is 71 and I am 62, We're both here thanks to advances in the treatment of asthma. My asthma is a symptom of Mastocytosis.
Poor Rohin, it must be difficult to balance having such a really really really ridiculously good-looking face but also [Educational] RU-vid's best beard
1:16:25 I literally, most genuinely burst out laughing. I love this interview - you talk about specific studies, the questions invite deep elaborate responses and you're funny... which coincidentally is what I look for in a partner.
To the climate change and population point, if the population of human beings remained constant and we were targeting equality, we would all need to have carbon footprints
Rapamycin definitely isn't pence per dose. I've recently started taking it for aging and it costs in the pharmacy 3,6 euro per 1 mg tablet (because aging is not a recognized indication health insurance doesn't cover part of the cost).
To manufacture it is pence per dose he said i think. So generic versions will be very cheap. Some drugs are genuinely expensive to produce and their price does not have the potential to ever drop below that (even if the government or insurance is the one paying that price, i.e. tax and premiums)
I watched this on Nebula, I will watch again here. Such an interesting conversation. My husband says he wants to live 150 years, I need to show him this, and probably make him exercise more to get his heart rate down (as per Andrew's video).
Exercise and some vegetables! Do they mention it in the video? Every single type of movement counts - get off the bus a stop early - vacuum - don't bulk buy milk so you have to walk to the local shop to get it - stairs (always try to live somewhere that has stairs if possible ) - think of things like say, someone who has an upstairs and downstairs bathroom, always using the upstairs one if you mostly live downstairs. Things like that where the habit is the version with a bit of movement so you don't even notice it. Obviously officially "exercise" is important too 😅
Dr. Rohin is in his 30s!?!? He made quips in his first several videos about how advanced in age he is! I figured he must’ve recently turned 40 to be saying such things.
Oh I'm starting to get it; working just actually kills you and your body is telling you to stop because you should just actually stop; it's always right, only "you" can be wrong. This is probably why I look 24 as a 36 year old and if people knew this the real value of physical work the value of things would change in a way that might be undesirable to rich people, therefore this will not become widely known or acted upon knowledge in our lifetimes.
Not to take away from the rest of the discussion, but, I do think that looking at population numbers over just a 25 years horizon is misguided at best. 2 billion people extra in 25 years? That already sounds like a lot. How about in 100 years, 200 years, a millennia?
Hello Dr. Rohin did you ever manage to ask your guest off camera whether anti ageing will allow women to have healthy children with low pregnancy risk at more advanced ages? Shoukria
Great question. The one issue you can’t change is that eggs age as they are present in the woman from infancy. However if you freeze eggs at a young age then yes, anti ageing technology will definitely make pregnancy possible at later ages, as we’ve already seen over recent decades with conventional medicine
Rohin, you say near the end that you wouldn't want to live 1000 years. Why? Do you want to die now? If not, why do you think the answer to that (or the considerations that might factor into your answer) would change, simply based on having spent more time alive? Not existing anymore, forevermore, not being privy to anything at all that might happen the species or the universe, not finding out what happens in our narrative or learning along with the best minds the rest of what there is to discover about our reality - all of that is both terrifying to me and immensely saddening. Sure, people feel ready for a REST as they get older, or as they plod through years of work in this capitalistic society that demands it, but why should the future be like that? And how is DEATH at all rest, regardless of RIP being a common condolence? One cannot kick back in one's grave and ENJOY no longer having any responsibilities or being plugged into the general hubbub of busy urban life, as if the grave is some sort of island holiday resort sunbed. And of course, if you get to live that long, so will your loved ones, most likely, so they will still be around to cherish and see enjoying their own existence. Smart people realise that there is always something more to learn about any subject - not even the most renowned experts in the world know everything there is to know about their subject, let alone EVERY subject, and that as time goes by, new avenues of current knowledge are opening up, along with whole new fields and disciplines. Just as overpopulation is a common but silly complaint, so is the idea that life will get so boring and tiresome and that death will be a welcome alternative - that's just seeing things as they are and extending the time, rather than realising how many things will change along with the time. By the way, all these common arguments have been thought about and rebutted years ago by the longevity community - go visit fightaging dot org and scroll down the links on the right-hand side until you come across a heading "Common Objections" for the evidence (that page has been there for at least the last 20 years, I think).
I'll live, try to be healthy, and eventually grow old and die. That's just how it goes. Keep moving until I die, and try to enjoy the good things in life.
Could it be that metformin makes diabetics live longer because it’s effective against diabetes? And then if we add health-consciousness that people normally develop after the diagnosis making them aware of other problems they might develop
In 2014, as a mature-aged student, I got my degree in Molecular Biology and Biomedical Science - largely due to people like Aubrey de Grey, who was only briefly mentioned at the end of the video. For a long time these ideas were seen as "fringe science" or not as scientific at all, so I think it might have been nice to pay some respects to those who fearlessly pioneered the whole concept of increasing life-span and health-span via biotechnology and serious research into both ageing mechanisms and potential interventions based on what we learn about those mechanisms. It's only been in the last few decades - literally as I grew from a teenager to an adult (now 43) that those pioneers forced the scientific community to take this field seriously. It's a major achievement by Nir Barzilai to have convinced the FDA to allow an interventional study that treats ageing itself, as they previously refused to classify ageing as a target pathology. Hopefully people interested in this stuff, who can now see serious discussions and papers on it in virtually any health-related sphere, realise the paradigm shift they are looking at and will undoubtedly benefit from.
Reach sexual maturity at 2 1/2, lifespan 3 - this is pretty much the life of the octopus, which is one of the most highly evolved and multi-talented, multi-specialised (and intelligent) creatures on earth. Maybe evolution HAS to give you lots of tricks in the toolbox if senescence is such a looming terminator. Live fast and talented, die young. I do think the gerontologists should look at what can be gleaned from the animal at the opposite end of the senescence continuum from us.
Oh my god, is that an Earthworks Icon? (The pretty stainless steel mic) That's an end-address cardioid microphone, not omnidirectional, and not side-address. In the opening shot it's off to the side miles away and in the interview it's definitely in a side-address positron but way too far off. It's way too expensive of a mic to treat so badly
This is more entertaining and cheerful and less dogmatic than I thought a video about anti-aging would be. I tend to avoid anti-aging videos because of my experience with them.
Thanks for your content &, just to let you know, I kinna like your jokes ;) But hey... maybe my sense of humour is lousy too, in which case.. neither of us is funny :) XD
I wonder how the medication that refreshes collagen works for people with Elhers Danlos Syndrome. Mostly, we look years younger than we are but feel decades older.
As far as we know right now, it doesn't really help unfortunately. Rather than having a lack of collagen, people with EDS have a mutation that produces messed up collagen. So, the assumption is that any additional collagen ingested would just get processed in the same messed up way
@@riley3984 only half the cells though, so if the other cells, the ones without the EDS, could be helped, could make a huge difference in the progression? (Not by eating, eating collagen does nothing for anyone, your body breaks it down and uses the component parts, it doesn't help anything that they were once collagen, it's a scam product )
As a 21 year old prospective doctor I love your content so much. I fall in love with so many topics but medicine has been such a special love just because of how immense of a future I see for it. I know maths isn’t a big subject on your channel but I would love to see some content on the flaws of peoples capacity for diagnosis. I hope to see some sort of system that allows physicians themselves to input clinical signs and symptoms in and receive a chart of some sort going over the probability of possible illnesses and ways to cross off the more lethal prognoses. Complex probabilities are just a process that computers are way more adept at than humans.
I think a big inpediment to this is just sheer data. A few years back my partner came down with a mysterious chronic illness, and I spent evening after evening trying to find datasets of all the diseases and symptoms and their relative rates of occurrence, but I could not find datasets that had this data. But for this to change I think the whole medical information pipeline has to be rebuilt from the ground up. Where GP's comprehensibly record all appearantly symptoms and ask after less obvious ones. Then as diagnoses roll in over time a true dataset can be built up than can be used to make a predictive model like you want. Maybe with improved natural language processing a lot of this could be extracted from current medical records, doctors notes, etc, but just the medical confidentiality aspect of it would make this very hard. In the end it took almost two years for my partner to get diagnosed with chronic fatigue syndrome, but this was more down to the stubborn headedness of the GP than anything else.
This is very comforting, my life goal is trying and lerning everything the world has to offer but l've always dreaded the thought of not having enough time
Nonsense! People live long enough! We need to get our beloved pets to live longer as they now come into our lives and die too soon and take our hearts with them when they do! Yes, like so very many pet lovers I have shed more tears over pets than people! Pet lovers, not "owners", understand this! Best of luck to all of us and it is great to know "Medlife Crisis" exist!
Research that slows aging has the potential to solve the demographic crisis plaguing developed countries around the world. Rather than destroying the world by allowing people to live longer it could save the world by allowing us to live as a society with a greatly reduced birth rate.
I would prefer that you directed your research so that our pets could live longer. Think about it as their lives are so short and we love them so much.
The content is fascinating and the almost-dad-jokes are much loved. I say "almost-dad-jokes" because a proper dad joke includes having the chutzpah to not apologize for the dad joke. I know your kids are young so haven't quite grown into that yet. I look forward to seeing it.
I wouldn't like to live longer if I still have multiple joint osteoarthritis that started at 39 when I was a marathon runner, eating super healthy (mostly vegetables, fish, low fat meats, whole grain, reasonable calories), and generally taking great care of myself. I feel like my cells quickly self-destructed at that point and it's pretty much too late for me to have a good _quality_ of extended life.
That's the one that is super unusual in young people, isn't it? Fran the engineer from Frans lab got that very young too and has it decades now. She found a lot of the doctors advice wasn't helpful because they'd only seen it in old people
the mind, the soul, idea, ignorance, arrogance, dream, stray, patience, fear, life, worker, success, graduation, power, festival, deception, i struggle with myself, use reason so you can live for yourself
Actually in C. elegans at least 7 different methods of calorie restriction have been tried. From bacterial dilution to medium without bacteria (axenic culture) to genetic mutants that have defects in eating (eat mutants). In all different feeding protocols the worms lived longer.
To expand on what they said about dieting - losing weight is incredibly simple. If you don't eat, you'll lose weight. Something being simple, however, does not make it easy. Adherence is the most important factor in successful long-term weight loss, so that's what you should optimize for when choosing one.
Where is the skull off the skeleton? If it is a real skeleton it must be a child.....if its real...which I doubt did the person whom the skeleton belongs give permission to feature their skeleton in this vid...
Great talk with Dr. Steele. Would be awesome if you could make this a regular series with frequent updates from the age experts including Dr. Sinclair.
Quite remarkably (to me) when I quit the corporate world and moved onto a bit of bush land, I changed from eating three times a day plus snacks, to eating just once a day without any intention to do so. If I don't have a drink in the evening, then I have no desire to eat any dinner, and fasting 23hrs a day requires no effort at all.
