Progression of SIRS
Vasodilation and so hypovolaemia
IL-1 and TNF-a directly affect endothelial surfaces, leading to the expression of tissue factor which initiates the production of thrombin, thereby promoting coagulation
If unchecked, this coagulation cascade leads to complications of microvascular thrombosis, including organ dysfunction.
Infection-related procoagulant activity is generally more severe than that produced by trauma.
Management
Treat underlying cause, eg. blood cultures followed by antibiotics
Supportive, oxygen, fluids, control hyperglycaemia, monitor serum lactate, monitor urine production
2 окт 2024
