Insulin Secretion 

My only issue with this video is that your biceps are distracting me from learning the content 💪

Points: 1. Glucose enters cells through GLUT 2 transporter on the Islet cells of the pancreas 2. Glucokinase phosphorylates glucose to make Glucose-6-phosphate. G6P turns into pyruvate via the glycolysis pathway. 3. Pyruvate then enters the mitochondria to make energy via the Krebs cycle and also undergoes oxidation at the membrane of the mitochondria. The result is production of ATP that is produced from ADP. 4. The potassium channel remains open with ADP bound to it so K+ moves freely through it. Once more ATP is made, the ATP binds to the K+ ion channel to "close its lid" - increasing K+ in cell. As the cell becomes more positive on the inside, the Calcium channels open to push the vesicles that hold insulin to merge with the islet cell membrane and release its contents

Seriously can’t THANK YOU enough!! This is another topic that makes my brain melt. You have a way of explaining to where I can somehow understand, therefore… remember it!!

Amazing video and description of GLUT2! Makes the rest of the process regarding insulin secretion easier to undertsand.

when I need clarification I always check your videos first. Thank you !!!!!

Thank you Dr Mike, I really appreciate how you made understanding the endocrine system a very easy. 😉

Thanks Doc this is the most simple and complete explanation I've found.

I am going to watch alla of your videos in the summer. Fantastic! Thank you.

I'm a vet student and your videos helped a lot ... much appreciated!

Most problems happen at the protein channels called a channelopathy that can be inherited or acquired. The acquired channelopathies are disrupted due to heavy metals chemicals that disrupt the protein channels as well as causing oxidative stress to the channel itself or to the cell membrane. great videos and would love to see more info on the cofactors that make the enzymes work. thank you for the great explanations...

Why didnt i find these sooner 😑i have been studying all the steps at different times so I couldn’t see the big picture of how it all works actually i just understand all so clearly now thank you 😊

Student of Zoology here. Your videos are really helping me for preparing for my finals . Thank you so so so much.

You are a phenomenal teacher.. I never thought I'd ever like chemistry and biology...you made me think that maybe I should've chosen to study medicine...

My life is easier with this channel.🙌🏽

Your videos are absolutely amazing!

This was an amazing refresher for me!! And probably even a better explanation than when I first learned it :D Thank you for an excellent breakdown!

Excellent, ur skills as well ur physique Inspired by both, keep it up Dr Waiting for more, thank you Dr

Wow! Doc, awesome video. I was impressed. Thanks!

Brilliant!! Thanks, please keep doing these videos mate :)

Perfectly clear. Thank you

Amazing explanation!!! You make Any concept a lot simpler!!! thank u so much

Your videos are so great! its easy to understand!!!

Excellent video. Thank you.

Really great and informative lecture,thanks alote sir

superb sir well understood and easy to follow.

Perfect explanation thank you doctor

Great Information 👍

Superb.

i cant thank you enough dr.

Pls put translator in the explainer videos,we follow u from the Middle East, and keep going 💚💚

what the helll maaaaann how can you be so perfect???? istg im sure all of my profs are so jealous from you

Great video mate

Great explain. Thanks. I have just been diagnosed with insulin resistance. My 1-hour values were 5x the normal range. Is keto and metformin my only option?

❤❤❤ thank you for making this video. It is full of knowledge..

Another great vid

Nice thx Dr ... you are the best 👌🏻

Please throw more highlights on insulin and ATP

hey Doc! just brilliant explanation. well done mate.

You are a blessing.

bloody brilliant!

Hi Sir you are doing a good job.you are my teache. May God make ease for you.

Hi Doc, love your vids. I am confused about how insulin is actually released. Do the beta cells respond to glucose already in the blood stream which I presume would be a ongoing process so long a glucose remains high? Or is insulin only released upon ingestion of food?

Thank you Dr.

Dr Mike all the way 💞🙏👏

So if we say that insulin vesicles release is a quantitive measure of how much insulin should be released, then where is the sensor that determine how much vesicles should be released? I mean who determine let's say the release of S, M, L, XL amount of insulin in response to S, M, L, XL amount of glucose increase in blood due to small candy(S), donut(M), meal(L), ice-cream jar(XL). Is it the K+ channel activation via ATP concentration (S, M, L, XL ATP concentrations) or is it something else? anyone knows?

Thanks for explaining all of this but how do you regulate insulin release if your insulin is too high? Potassium and sodium? I feel like missing that part. I think my insulin may be high because while my glucose is normal, i fast, and watch my calories, i think my insulin is still too high and preventing me from losing weight. Any info is appreciated. Thanks 🙏🏾

You are amazing 🙏🏼🙏🏼🙌🏼🙌🏼💪🏼💪🏼

Hi Dr Mike, great explanation, But all Diabetics looking for a full cure,

Thanks for your AMAZING Videos!!! But isn't it GLUT1 (and GLUT3) which transfers glucose into the beta-cells instead of GLUT2?

Thank you very much indeed

Thanks very very much❤❤

thank you doctor you are the best

Awesome!

Hello Dr M's. Can you tell me what the strength of natural, pancreas produced insulin is? Similar to U-100 R ?

U r amazing♥️

Mahalo Dr. Mike

Wow! I’m a lot more smarter than I was 15 minutes ago! 🙏🏻🙏🏻🙏🏻

Am I right that depression, stress (high cortisol) and smoking (jumps of adrenaline and noradrenaline) killing my cells through that process? For the last 6 month I lost about 15 kg of healthy weight and look much older. Increased insulin I guess just drained me. Besides i am sure that I pretty healthy in general or was. So there is some real guidelines about how to fix my hormone system, which blood analysis pass at first? p.s professional medical help very expensive so I need to figure out by my self

You're the best

here's what happened - I wasn't even going to understand it because in my school I don't have to go into so much detail about physiology. But I watched this video and inadvertently understood how insulin secretion is stimulated. How is this even possible? 😂

Dr. Mike💪 😍

When does Insulin starts secreting: as soon as we start chewing or after the food reaches stomach?

I have a question, that is, insulin is both produced and secreted by beta cells then how does decreased insulin release by adrenaline is an alfa2 effect?? Same for glucagon - produced by Alfa cells but increased release by adrenaline is a beta2 effect??

So how do they say that artificial sweeteners cause insulin release since they don’t produce glucose?

glucose energy intake why break down and waste or process of waste is important related to diabetes relationship

The best

Does beta cells need insulin to absorb glucose to produce pyruvate?

No you can't measure a charge difference in millivolts, the charge difference needs to be in Coulombs. You mean that, charge entering or leaving the cell changes the potential difference

Does beta cells bind to alpha cells?

Enzymes 👍

Sir good but make the video explanation long & conceptually.

Why you explain so fast ,but instead of this all of your video are good.

Can you be less handsome that my pervert ass can give proper attention to my study😭

Ur teaching skill is very killer Ur body ,Ur chest is very attractive and only these thing attracting me too see Ur vedio love you

I'm too dumb for this

Man... This bony professor explained fully abut the humans number one illness .. Now I can fight my home doctor about his cheating me in diagnosing my illness..

0:40 lowkey laughed

👏👏👏👏👏👏👏👏👏👏👍

You are so handsome!

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you write toooo small, difficult to read