The problem over here is that you can be at the bottom of the normal range, symptomatic and they still don't want to treat. Happens with thyroid panel, iron and b12 specifically.
Very good point. There are, unfortunately, caveats and exceptions to almost any of these tests. Thyroid hormones, as you mentioned, could look normal in a peripheral blood draw, but not work properly in the brain -- central hypothyroidism. - Jarred Younger
I also don't understand why clinicians don't look at the symptoms and the tests that show someone just inside the range and determine that, since they are symptomatic, they should be diagnosed with xyz. Not every single person fits in the same box. Especially when comparing women to men, race to race. In fact, if that same symptomatic person gets so bad that they fall outside of the range, then doesn't that make them *very* sick at that point. It's dangerous. Believe patients. I get people are looking for pain meds, etc but if your patient has never asked for them, then they are probably just want B12 or whatever.
@@youngerlabmy mom said the same thing and has been taking thyroid hormone since the 80's. It's good to hear it from a scientific source that blood tests can be deceptive. My mom said a basal temperature test when you wake up is the better measure because it's measuring symptoms of thyroid deficiency, not blood levels based on an average.
@@kikijewell2967 My T4 levels are at the very bottom of the normal range (or below depending which standards you look at), my T3 is also low but my THS is in the middle. My thyrologist says that's ok but I have severe chronic fatigue. How can I do the basal temperature test? Can you describe what temperature I should have? Thanks!
Also do not assume every vitamin supplement is of the same quality. I've been taking B-vitamin complex for years, but I recently changed brands to a methylated kind and it made a huge difference in efficacy. I used to have pretty severe POTS symptoms, and they're mostly gone now.
Same here, though I’m still somewhat symptomatic. Working my way up the dosage, though. B12 rally did some heavy lifting for me, which I suppose isn’t too surprising with ME.
I know how medical surveys have to be worded. The survey has too many of the same questions and not correct choices of a tire answer to match symptoms. Way to long of time to complete with repeat questions. We poor sick folks use free government cell phones and internet services. This does not allow to pauses then continue the survey. This is causing us stress because we want to positive support your research. I ask support group folks and no one could complete your survey. Too long to respond on cell phones. Please correct by not having same question repeat control. cell phones ran out of battery time. We do not always get internet service in this area. Most public internet use is limited to one hour or less time Or we have to buy coffee or food to stay to connect to business internet. Most folks are below poverty level . You need to question how this affects disability. I can not afford to buy all the supplements and vitamins on 900.00 dollars of SSDI and SSI. Or afford functional medical doctor visit. Untill I got free government cell phone and internet I would not known about your research. My question about your research is how correct treatment is going to be paid for by Medicaid or insurance. Insurance companies have never lost profits. Know the day you will die. If you are honestly developing a treatment who will profit from we the disabled folks. Can we afford to pay cash for treatment you develope. Been there for 38 years
When I began taking 10k IUs of D3 during the pandemic, close to 75% of my fibro symptoms went away!!! It blew my mind. No prescription I’d taken till then accomplished what that did. My doctor was concerned at the dosage, but that hasn’t posed a problem over the past three years. Mind you, I’m black and “fluffy,” so I know ethnicity, weight and as you mentioned, sun exposure, affects how much we should take. Lately, I’ve added 100 mcg of K2 with that. Now that I’m not spending every ounce of energy battling pain and fatigue, I’ve been able to focus on addressing other deficiencies and eating from the best food sources I can get.
That's amazing - I really glad to hear that! As you probably already know, there is a strong genetic component to Vitamina D absorpton. I can't know in your particular case, but it is possible that you need the high level of Vit D supplementation just to overcome genetically-driven low Vit D synthesis, absorption, transport, utilization, and/or metabolism. There is probably a company that would run tests for those variants, but I don't know immediately who to recommend. - Jarred Younger
Can I ask you how many days passed before you felt this benefit? My wife has been struggling with fibromyalgia for 3 years, and so far the only thing that has significantly reduced her symptoms within just a few days is the ketogenic diet. Given that fibromyalgia is a multifactorial syndrome and the causes are not evidently the same for everyone, we are willing to try anything that can alleviate the symptoms. Thank you
@@simonep3443 Actually I started with keto first which led to me learning I needed more D3. I focused on healthy keto (vs dirty) for six weeks, and that alone was a big help for seriously reducing probably fibro flares. But it was about two-three weeks into taking D3 when I realized it was making a significant difference. Most of the flares that I still deal with come from either the weather, me pushing myself too hard physically/doing too much, or me going back to inflammatory foods. I hope your wife can find some relief soon. It’s so inexpensive, it’s absolutely worth trying. Good Health to you both! 💕🫶🏽💕
@@CraftsBayou thanks for your feedback, she actually already takes D3 but small dosage like 2k UI daily, we will try to add more UI, making attention to her blood level of D3.She incorporated both cardio and weight training. At first, it may seem like her condition worsens, but if one perseveres and performs it consistently, it eventually improves overall conditioning. As a result, daily activities no longer feel as heavy. At least in her case, this is how it turned out. Good health to you too!
I tried that over a decade ago. Found deficiencies & treated them; even tried IV Vitamin C (expensive), and had no change. Then I was finally diagnosed with Ehlers-Danlos Syndrome (EDS). Finally answered lots of questions. So the pain is not going away, but I wish they would do serious research on ME/CFS, because getting rid of the chronic fatigue (and especially PEM) would greatly improve my life. I’ve been waiting since 1980. Still testing positive for 4 active viruses.
I've been seing doctors for 20 years for a mystery breathing problem that none could diagnose other than "it's in your head". It ruined part of my life. At the very thick of my last ongoing crisis (went twice a day to emergency for not virtually, precisely 2 years) I eventually found out, with the help of one these geniuses doctors (I don't know of another) that I had severe vitamin D deficiency (precisely 7 of the given metric). I've complemented (one bulb of 80.000 IU of vit D a month, lifelong). After a month, I was feeling OK. After 3 months it was gone. Problem solved. That was 8 years ago. (more precisely, it was hyperparathyroidism, that appeared to be secundary to vit D deficiency ; textbook in endocrinology).
Hi Finding a doc who is expert (or even interested, in treating serious conditions with supplements and diet May I ask if your genius doc is USA based? I am in the UK
@@stephenstephen1505 Speak to Chris at British Supplements, as they have a Clean Vit D and K2 10,000 iu supplement that i've been taking from them with no nasties.
This is such a great video! When my chronic pain started, I was so desperate for answers. I fell down tons of medical journal rabbit holes, including this exact topic. Scary story about medicine in the US... I spoke with my Dr. and brought up magnesium and vitamin B12 specifically based on my symptoms. My Dr's response.. . "Yeah, IDK. We don't really take many classes on vitamins." He shrugged. I pushed for tests. I was met with an eye role, but finally, he agreed. (To no surprise of my own) Guess who's tests came back as deficient in magnesium, b12, and vitamin D? 🙄 I'll be honest. Getting these balanced out has not cured my chronic pain. But I 100% can tell you it helps a small amount. It's definitely not a fictitious "snake oil" cure as some providers will lead you to believe. Sharing all of this to say to people in the comments... be your own advocate. Don't let a Dr. Disregard your concerns. So happy to see videos coming out that make this information more accessible to the general public. 🎉🎉🎉
Thanks for sharing! There are so many stories of individuals researching and discovering the cause of their own medical condition. I wish the clinician-patient relationship was always collaborative, but I know many times it isn't. Yes I agree that patients need to be their own advocates, and I know that can be really hard to do sometimes. - Jarred Younger
Yes, a good thing to mention. I do not think this condition is uncommon, but it may not be pursued appropriately. I hope ferritin is run annually as a general checkup for blood chemistry. Iron is a tricky thing to supplement properly - I think intravenous route is used in some of these cases. I hope you get to the bottom of it! - Jarred Younger
@@youngerlab Yes I got an iron infusion on the NHS and my levels went up from 7 to 258 as my hairdressers suggeste d iit after she saw I was losing hair.
How can most folks afford to just buy correct vitamins and supplements. To live in a mold free space . Or have the physical energy to just go to get clean food to eat.
Good advice, but it's sooo complex to get it right. I messed my brain up with a combo of drops to get the EBV out, thyroid meds and kelp, and ever since I'm super-sensitive to anything, including supplements. I respond to them within an hour and 'know' which to take and which ones to skip (that's around 90%). Oddly enough I do better on cyanocobalamin than hydroxo- methyl or adenosyl, but only accompanied by 5MTHF. And lately I've been wondering if the universal B12-deficiency, also in meat-eaters, is not just a result of a potassium shortage...
I take lots of vitamins and it has helped my pain but not my fatigue with ME. I keep thinking that something I try will be a miracle but nothing has yet. Everything has helped a little but wish it would have helped my fatigue more. But I definitely feel much better than before. The specialist I see has me test some things about twice a year.
Thanks for another informative video! Glad to hear you found a solution to your palpitations. I had some off & on, also some HR spikes as measured on my FitBit. I seem to have gotten better after taking vitamin K1 100 mcg. I had been taking K2 (MK7) 45 mcg, then added the K1 after some bleeding issues. My diet is restricted due to MCAS symptoms - lately have had neuropathic pain when I eat brassica veg (I think it has something to do w/ TRP channel activation as I also have issues w/ allium veg, peppers, heat/cold exposure). I have since dropped the K2 as there is an epidemiological study linking dietary K2 to breast cancer. At first I thought, well, all the K2 foods in the American diet also probably have oxidized cholesterol (cooked cheese), but after doing some more reading it seems like K2 itself could possibly be an issue. OTOH, before I started the K1, I had also been eating Jarlsberg cheese 20 g / day for bone health since it contains DHNA as well as K2, & noticed some improvement in the heart issues, but it did not completely clear it up until after starting K1. Interestingly my vit D was at 106 - too high. I had been taking vit D 5000 IU per day & was worried my daughter would also be too high since she had also been taking it, but hers was 45. She had not been eating the Jarlsberg (not a fan of the taste even tho she loves cheese). She has Celiac, has been on GF diet for yrs now & when she first became ill she was not deficient in any vitamins or minerals, tho vit D was suboptimal. So I'm not sure why the difference in blood levels of vit D. I do go outside more than she does. She weighs 15 lbs less than me but probably has higher percent body fat. So I don't know if the difference was due to sun exposure, Celiac, or Jarlsberg cheese consumption. Also, my daughter's HRV & resting HR may have improved a bit since starting K1.She's recently been able to do 5 min on the recumbent bike. prob. She meets diagnostic criteria for ME & POTS. We should probably repeat the POTS stand test to see if she has improved. Since she no longer wants to go to the doctor (really bad hospital experience) I had purchased Life Extension's Vegan panel for $85 on sale - which includes most of the main micronutrients you mentioned plus thyroid & lipids & CMP-14, and added on homocysteine for a bit more $. Blood draw was thru Lab Corp & they only took 4 vials. I'm interest in CVD markers since she had HBOT as a newborn & there is a rat study showing disturbance in lipid metabolism as adults after neonatal HBOT. Anyway, everything normal, but LDL suboptimal at 99 (should be 70 for a 21 yr old). They did not report anion gap, tho & I think it might be high if I use the carbon dioxide number to calculate it comes out to 14, but I'm not sure if that's the same as using bicarbonate (not reported on their CMP-14).
I can see you are really hitting this from every angle. This seems similar to how a funcitonal medcine doc might approach the problem. I like their approach - investigating, looking for links, considering alternatives, and testing. - Jarred Younger
@@youngerlab Thanks! I'm trying. We live near enough to the Lapp clinic to drive, but we would have to stay overnight. I'm hoping she will consider a trip in summer. We tried a local functional doc when she was 1st released from the hospital - kind of a funny story, but a long one. Did not work out. Initial blood work he ordered took 25 vials (why I mentioned the only 4 vials thing). Thanks again for all your hard work.
I was just telling one of my friends today to get off the methotrexate for that very reason, every cell needs folic acid. You shouldn't be on it for extended lengths of time.
Your friend can take folic acid (except if taking methotrexate for cancer). In my case, I needed to take L-methylfolate (such as Metfolin or Quatrefolic), a more bioavailable form than the folic acid prescribed by my doctor.
Yeah, great example of a medication that can seriously deplete certain vitamins. I hope your friend is monitoring B9, and probably taking the supplements. - Jarred Younger
How about learning to use kileaseology correctly. Like muscle strength of your fingers as you hold the food or vitamins or drinking water. Has helped me to avoid buying food brands with change ingredients i am allergic or sensitive to. For example a brand of food change from cane surgar to gmo corn syrup. I tested all the food i ate in 24 hours. Only can of bakebeans made my fingers come apart too easy. You can set up your own blind testing to know if you are dolng correctly. Saves me alot of money not to buy food products i can not eat.
Curious as to whether your b12 was in the “normal” reference range before you supplemented. The normal b12 range is huge, and it seems like no doctor has a grasp on when a value is too low for YOU even if it isn’t flagged by a lab.
What about Amino Acids and Fatty Acids? I was recently learning about Pentadecanoic Acid being a newly discovered essential nutrient… I had never heard about testing these things..
I haven't begun to dig into Pentadecanoic Acid. I don't test it in my study participants, but I might need to start doing so, given how severely a deficiency would damage the body. Thanks! - Jarred Younger
My primary care said I needed b12 even though I was within range. She said because my homocysteine is high that it indicates low b12 and that it’s a better indicator than just b12 level?
It could be malabsorption. If you have type 1 diabetes or chronic pancreatitis and no lipase. You can't digest fats. Vitamins A,D,E,and K are fat soluble!
@@rebeccaaldrich3396 "Premature Ventricular Contraction"= Ventricle of heart (1 of the 2 lower chambers of heart) is contracting too soon/ie is out of synch with rest of normal heart contract-relax rhythms➡& that effects the efficiency of heart chambers filling & expelling the blood to circulate thru heart & rest of body...🙃
the real question is: why would you wanna eat a diet where you get vitamin deficient by default? why dont you eat engough meat? you rrealize humans are carnicores in the evolutionary context - right? also, you look like you're metabolically unhealthy, chronically inflamed (you're holding too much water) and "skinny-fat" (meaning, muscle too low, fat too high). pro tip: switch to a low carb paleo diet (excluding all grains and industrially processed foods) and see what happens. you gonna be suprised! tip 2: put all the food you eat in an average day into a tool like cronometer and see how your nutrient coverage look. on a proper paleo diet you will be able to cover ALL nutrients (incl. vit D, B12) just with food.
Have you heard of Dr. Nicholas Gonzales? I just learned abt his work (he died 2015). There are lots of YT interviews w/him➡he describes in detail the facts proof re: one diet/food plan does not work for all people, & presents the researchers from late 1800's & 20th centuries whose research documented the differences. Based on an earlier researcher's work that our Autonomic systems' proclivity toward being in sympathetic, para-sympathetic modes, or balanced versions between those poles, results in our bodies may actually require the opposite of /or a mixture of whatever is being touted as THE diet all humans were meant to/ should all be eating...He talks very fast, but gives detailed info re: how each physiological system is made ill when, for eg carnivore diet is being used by a person whose physiology/Autonomic system needs plant-bases. I haven't looked at them yet, but he & Dr Linda Isaac came up w/10 different types, tho they don't force/pigeon hole folks into them...His main work was w/cancer, and his mentor discovered connections re: foods that worsened particular kinds of cancers, & based on the individual, foods, together w/Vits, minerals, enzymes that shrunk/disappeared the cancer..eg .on stage 4 pancreatic tumors. Mentions that application of same correct-for-individual foods cures ME & Fibro...
Meat allergies are a thing, brainiac. And, in evolutionary terms, sapiens are and always have been omnivores. Our digestive systems are structured for an omnivorous diet, and some anatomical features adapted to eating plants, such as flat molars. In fact, some say that humans have more characteristics of plant eaters than omnivores, and lack the anatomical features of meat eaters. For example, humans have trichromatic vision, while meat eaters have dichromatic vision, which makes them essentially colorblind.
