It boggles my mind how this channel only currently has 30k subs. I love your content Simon. Keep it coming. Just settling in with this one now, looking forward to it.
Brenner and Sinclair have a well-known feud that has gotten personal and nasty. They both push unproven supplements, but only Brenner has attacked Sinclair on this basis, which is incredibly hypocritical. Brenner attacked Sinclair so much on Twitter that Sinclair blocked him. He also attacked Aubrey de Grey, retweeting sexual harassment allegations that were never the subject of legal action. Yeah. This interviewer is doing a really good job of keeping Brenner focussed. In another debate with Aubrey de Grey, the moderator didn't do anything and Brenner behaved appallingly. That default smirk on his face gives me quite the vibe from him. I don't want to dump too much on him. To have a guy like Brenner out there is good for the longevity community, because he forces it to up its game. But he's a piece of work and can be just as disingenuous as Sinclair. Basically, an unreliable interviewee.
Simon, I am more impressed with you doing the research and pushing back and asking the definition of terms most people are not familiar with, because if all Lay people can follow your channel more would; Also admire how respectful you are and avoid taking sides , though it hard when dealing with such giants Dr. Brenner and Dr. David Sinclair. I have a great deal of respect for you, because I sense you treat this interview as if Dr. Sinclair was there and you present some of his rebuttals, which is very impressive. Like NMN doesn't directly get into the cell but it goes via NR. Stay ego free as you are, so "beautiful".
If he didn't push back, Brenner would crap all over everything as I have seen him do before. He's very smart, but his feud with Sinclair is personal and nasty and he's also attacked Aubrey de Grey by retweeting de Grey's sexual harassment issues that were ultimately dismissed and were definitely none of his business anyway. Not cool. Pushing back shows that Brenner is not as solid in his stances as he pretends to be when he is not challenged. He uses complicated language because he hopes a lay interviewer will not be able to push back. He also can't criticize Sinclair for NMN but also market an unproven supplement himself. I really don't know what to make of the guy, he's all over the place. The irony is that Brenner looks much younger than his 61 years and appears lean and fit, so he's aged very well, whereas he knows many other people are not so fortunate and are falling apart by then through no fault of their own. You know what a 61-year-old roofer or mason's body is like? Not like his. My mason friend had back surgery at 32 and retired at 51 with arthritis everywhere. He died at 64. The job had taken its toll. So maybe the real cost of aging is not personal enough for Brenner yet, or he has Stockholm Syndrome like 95% of the world does when it comes to aging. Or both.
Simon, I think the overall concept Dr. Brenner is making that longevity research in yeast or animal models doesn’t necessarily translate to human longevity comes through. But it would be appreciated if you could summarize his ideas in a future short. At some points his concepts were hard to follow. Appreciate all the great work you and your team does.
Greetings Friends, Which segment of our discussion struck you as the most compelling? I'd be delighted to read your thoughts. Additionally, if you've any related questions, kindly leave them in the comments. I'll make sure they're addressed in our forthcoming conversation.
Charles Brenner is full if interesting facts, studies and perspectives. More on how long lived human women are would be great. Women feel a bit left out in society after 50, but it appears there are essential biological reasons for us to live this long. Loved that.
Living in Cleveland, Ohio in the mid 70s, I met several 3-generational families from around the world where grandma joyfully raised the babies while the mother and father developed their professional skills. Yes, it had some rough edges at times, but nobody looked overworked and stressed out like the smaller households with no grandparents nearby.
In many traditional cultures older women are essential to family formation as they help raise their grandchildren. In many cultures its common to have grandma move in after a new baby is born. Typically grandma handles alot of the housework type stuff, cooking, cleaning etc so that mom can focus on bonding with baby. I've had coworkers from cultures where this was the norm and it made things so much better for new moms (especially working moms) than the US "standard" of mom doing everything by herself or putting baby in a daycare with strangers.
❤❤❤ Charles Brenner. Truth is hard to swallow, while hype is embraced. Advantage of B3 is that it is not a patented substance. I will continue to keep animal foods in my diet just for this reason alone. Also eating plenty wholegrains, mushrooms, chickpeas and veggies high in B3. I tested low in tryptophan trying to calorie restrict and fearing mTor and Igf-1. I am 65 and in the age group where repair processes are reduced. As a female my longevity and vitality is the number one factor that ensures my offspring and future generations survive in these uncertain and turbulent times. 😢
I would love to see David Sinclair and Charles Brenner have a discussion on these topics. There have been quite a few MDs and scientists have questioned David Sinclair's claims...even to the point of calling him a liar! I'm hoping this is not true because I loved his book and his claims. However, if David Sinclair is not being truthful....he needs to be called out by the Longevity community.
Believe me, as a grandmother I felt as though I had enough wisdom and resourcefulness to begin parenting! Up until then it was all exploration, trial and error 😅
I am so glad you brought this wonderful expert to respond to some of David Sinclair's claims, I never liked how David states his claims as facts & doesn't really cover the science details behind them!
If David Sinclair refuses to come on the show together with Charles Brenner, then I would be strongly inclined to agree with the views of Charles Brenner.
Wow! This is a fantastic interview. Thank you so much for bringing this information out there. Healthy debate is invaluable for science to move forward. How do you not have hundreds of thousands of followers?🤯
I felt the same way when I first found his channel interviewing the awesome will bulsiewicz, what a banger!!!! I think he is just still a young channel
Lifespan extension drugs like metformin works by slowing down the metabolism such that it burns less glucose and allow for more fat burning over time which is what caloric restriction, time restricted eating, and fasting, essentially do at the same time.which is known in mice models to extend the lifespan by 20 percent or more. By reducing glucose burning, the risk of tissue damage from glucose oxidation, inflammation,, pathogen infection progression, and tumor growth is lessen which is associated with a shorter lifespan. Glycosis the burning of glucose puts the metabolism in a high energy output mode and delays the immune system and the repair autophagy cycle via the insulin and cortisol hormones - so too much glucose burning can delay cellular maintenance that eventually kills the cells needed to extend lifespan.
I am 66 years old and I have been following David Sinclair protocol for the past four years. My life has been significantly better. Everyone thinks I am in my forties. He is a trailblazer for mankind.
Totally agree. I'm 61, started NMN after a stroke, atherosclerosis, angina (unstable), almost 4 years ago. I looked and felt dreadful. But aside from the give away grey hair, people say I have the face and ability of a 48 year old. It's disheartening to hear the opinions of proffessionals who do not follow Sincalirs Protocol. All I can say to others is try it, you'll be astonished.
I have a feeling that the 90% of the things what he says is the same as any refular MD would say. Eat well, sleep well, exercise if you can meditate...
We are the same age group💫✨💯 May I ask what dose you get your main two molecules eg NMN & Resveratrol? Also your diet regime, please. Just in two sentences if you reply me will appreciate when you are available . Thank you🕺💊💊🏃♂️🌅☀️
I’m 46 and after 7 months on NMN and resveretroal, I feel 25. Not exaggerating. I feel healthier than ever. I do exercise and fast too. Great combo all three. David Sinclair is God’s gift to mankind.
Dr. Brenner has many good points, I learned that circular ribosomal DNA is an important factor that contributes to the yeast life span of the mother cell. However, he is a little off-topic. The term longevity or lifespan is applied to individuals, not population. When I separate the yeast daughter cell from her mother, I focus on the mother cell- i.e.an individual cell, not the whole flask of yeast cells.
'People used to live to 40 and now we live longer'. That statement maybe true in your part of the world but certainly not true in mine. I remember playing in my great grandparents house when I was a child. Before they moved to Thailand to clear a jungle for rubber plantation. They both passed away when I was in my thirties. My grandmother, their daughter, died just over a hundred. Also when I was in my thirties. They were not exceptions. People in my part of the world used to live that long. I'm 59. By today large portion of my school friends already passed away. Since we went to prestigeous premier school, most of them died in expensive private hospitals. Ask anybody in this part of the world, who was from and born in rural areas, they'll tell you the same story.
Everyone eating farm food lived longer. Most people were in the city and dying of pathogens and also eating much worse, and the diet is even worse now.
That is because lifespan statistics can be misleading. Average lifespan in Thailand 100 years ago was indeed around 50. This is because lifespand stats include all people who die, not just those who survive until adulthood. Historically alot of people died as babies and young children. Maximum lifespan hasn't really changed in centuries, but average is much higher now bc we are better at keeping babies alive. Pretty much as far back as we have records, people who survive early childhood, aren't killed in war, and didn't die in childbirth had a pretty good shot of becoming quite old.
@@DM-ql6ps That is very true. When I was a child nearly all families that I know had at least 1 child death. Nowadays I haven't known any. But my friends in their 40s 50s and 60s are dropping left and right. Being richer good for babies but apparently not for aging.
Did you notice that Brenner avoid to talk about Niacin? And about SIRT6 activators (V. Gorbunova research)? Good scientific results in those two compounds seem to be legit, and a bit against his own narrative/benefits. I guess he is not completely clean and still has some work to do on himself to be fully transparent. Anyways, I really appreciate his critics of the bad science in anti-aging research. (Please pass this message to Brenner too)
Hey Simon! Big fan of your show / podcast. I'm from Sydney Australia too! Would you ever sell any t shirts / merch? I would love to support you and your brand. Please keep doing what you're doing!
His position on rapamycin doesn't consider a dosing regiment in which the drug is taken intermittently. But I think he may be correct in the over arching position that drugs like rapamycin may only impact health and longevity within the scope of a maximum age (e.g. 120). At this stage, we're still working within the confines of our genetic destiny. Perhaps in future we'll be able to alter genetics or epigenetics in a living person. Hopefully this will happen in my lifetime.
If our maximum age is 120, that means, say, if you're 50 today you could live until 2093. If 120 is still our maximum age in 2093 I will be very surprised. If any of us are still around to be surprised lol But it would mean something has gone bizarrely wrong with basically everything in medical research.
@@squamish4244 - I'm inclined to share your optimism, but it's worth noting a few cautions. Firstly, 120 is the maximum. There's no guarantee that you'll come anywhere near the maximum. Secondly, science may progress before you die but you may be too old to benefit from the treatments by the time they pass through the glacially slow approval processes. The hope is that new therapies will come online quickly, but I think it's reasonable to assume that we will need to see them very soon in the research pipeline or they won't come in time for us. The next decade is critical.
@@Mondoplayer I'm 44 now. I have no idea if I'll make it to 120. But what is happening in the AI space is truly unreal. It happened much faster than almost anyone predicted. I can't wrap my mind around the fact that AlphaFold can suddenly predict with 93% accuracy all 200 million known proteins, and Facebook (I'm not calling it Meta) developed ESMFold, which is not as accurate but 60x faster. AlphaFold has been open source for 2 years almost exactly and it already found a potential liver cancer drug in January. In 30 days. Like, what? AlphaFold was completely reworked and rebuilt this spring, so it is even better now. I watched a presentation by Demis Hassabis where he talked about how AI can be used to accelerate progress along the whole pipeline, not just drug discovery, but including the clinical approval process. Two years ago, my dad's friend had Stage IV cancer at age 68 and had a month to live. He was so weak he could barely walk out to his garden chair. He had a 12-year-old son. His wife thought she was in menopause at 58...she wasn't. A grad student at a university in town tried an experimental immunotherapy drug on him. He had a fever for a week and the cancer was gone. He's still in shock. Stories like this are still unusual, but the fact that they are happening at all is insane. Jimmy Carter had immunotherapy at 90. He was fine with dying, but thought, why not, because it wasn't gruelling. Well, he got eight more years, most of them, good quality. He's in hospice care now, but he'll be 99 in two days. I've had IV NAD+ for a horrible benzo addiction that devastated my life and really fucked up my brain. It repaired the exhausted receptors and drastically reduced the benzos I take, by like 90%. I still need to take a small amount because they are ridiculously strong and I was on them for 16 years. But I also had much reduced back and knee pain, and for several weeks after every treatment, increased stamina and flexibility. It's not cheap. I could only afford it twice this year. But it cleans house - as in, you'll be sitting on the porcelain throne, as it helps your guts a lot too. You feel pretty blech during the process, but that just shows how much potentially damage-causing garbage is being washed out of your system. I'm not in denial. My uncle and two aunts died at 70 of cancer recently. But my parents are going to do NAD+ for their aches and pains. They're just holding out because they're stubborn. But even if it helps give them ten more quality years, that's - ten years! Maybe they'll get 20. My adult life has mostly been a disaster because of doctor-caused addiction and mental health issues. I'm very grateful that I can feel like I'm in my 20s again even for a few weeks every four months. If we're already at this point now, well... So nobody knows what will happen. We'll have a better idea in a decade as you said. Keep in mind that Dr. Brenner has his own agenda. He's a professional contrarian. He's SO contrarian that it's gotten ridiculous. His spat with Dr. Sinclair has turned nasty and personal, to the point where he sounds like a jilted lover on Twitter and I don't blame Sinclair for blocking him. He attacks Sinclair for pushing NMN, when he himself pushes NR, an equally unproven supplement, and the guy called him on that. He hits below the belt too. He retweeted Aubrey de Grey's sexual harassment allegations when nothing legal ever came of them and...what the hell does that have to do with science? It's none of his business! He behaved appallingly in a debate with de Grey, snorting, shaking his head, talking over him, and interrupting him constantly. That's why I like this moderator - he kept a leash on Brenner. And you can tell Brenner at times tries to confuse him by getting overly technical, employing his own tricks in the same way that Sinclair doesn't answer some questions. So yeah. He's good for the industry because he challenges it, but I don't take everything he says at his word either.
Professor Charles Brenner once gave an interview to Dave Asprey. He has since dedicated his life to burning anything and everything to do with longevity or health span to the ground.
@@SquatFull But there is plenty of anecdotal evidence. I mean that those who take it and follow a reliable protocol such as Sinclair's, they experience astonishing results.
Can Dr Brenner duplicate same OSK yamanaka, Right way ? Use mice without eliminating cells and P53 induction ? If So can we say this experiment can be valid ?
Can’t be happier to see our Handsome Prof Charles Brenner talking with Simon👏 on a sofa, relaxed & confident🕺💊🧬💊🧬 This cool look, made him look more handsome🕺 Don't know his age but looks similar to my son's age cause they are both bold😊& handsome. So happy to see our valuable Prof Brenner also talking about cool for our valuable PHD Dr David Sinclair 🕺💊🧬💊🧬 Love you both what a big gift are you both for Science on this Planet Earth. I feel so privileged to know you both. I'll never forget that you replied to me couple of times from tweeter😅 when I was in need🙏😔 God Bless you all Scientists and People who are working for humanity🙏🙏 A grandma👵 from London☔️
In Yeast, NR .NAD Co enzymes essential for repair capacity. DNA damage and inflammation target repair mechanisms.Insults like Covid attack repair mechanisms like DNA repair, lipid formation,NAD decrease in kidney diseases, heart failure 50:31 NMN is NR with phosphate which must be removed before used as NR ,3 kinds of B3,
NR improved blood flow, moderate rise of hypertension, improving body composition.Work out recovery faster and better.NAD in mitochondria diseases.NAD metabolic test.
He explains his own theories incredibly well but it still doesn't explain why people who follow the Sincliar protocols look, feel and move like they are younger and why DNA test show this.
@fatboydim.7037 Do you know that NAD+ precursors isn't Sinclairs idea? Actually Brenner pioneered that with NR. Sinclair's NMN does the same job, but both work basically the same. Resveratrol, though, is Sinclairs child. But even Sinclair has said that EVO works better! Sinclair is a much better salesman than Brenner is, though. Too good salesman, in my opinion. So, I'm not suprised you bought into his story.
@@larsnystrom6698 Perhaps what people "buy into" is the countless people saying they're looking and feeling great after taking supplements recommended by Sinclair. If this was placebo, was is it only happening with NMN and resveratrol?
PS @46m on the issue of NR supporting the NAD+ system which helps with DNA repair, it has been shown that exercise in older people maintains NAD+ to more youthful levels, suggesting that people who exercise regularly and to sufficient levels can also improve repair mechanism (Ref. R Houtkooper 2021 presentation at ARDD via RU-vid, and "Healthy aging and muscle function are positively associated with NAD+ abundance in humans" Janssens et al 2022 in Nature Aging).
During the discussion of regenerative medicine/"information theory of aging" (starting 1:44:13) using Yamanaka factors Brenner points out the potential to create autologous body parts. This sounds very similar to the "WNT Pathway" by which a company called Biosplice has developed a way to regenerate cells to replace diseased parts of the body - this was discussed in the book Life Force by Tony Robbins, Dr. Peter Diamandis and Dr. Peter Hariri. All pretty amazing stuff!
Since I take Elysium's Basis I was concerned to hear what Brenner said about Pterostilbene raising LDL. Right off the bat I found Aug 2021 published research saying the exact opposite: pubmed.ncbi.nlm.nih.gov/34439528/
Interestingly enough, whales are some of the only other animals that require assistance when giving birth. Another whales has to help the new mom carry the newborn to the surface to breathe.
I am confused about the sponsorship of this interview by Inside Tracker? A company owned by David Sinclair? It sits funny with me that there is a bias before it starts. But in saying that, the interview seemed good and despite the sponsorship seemed to critique arguments well.
Can it make YOU live longer? If so, it's anti-aging. Exercise and healthy lifestyles are anti-aging. Any problem with this language by Brenner and others is highly suspicious. Whatever you want to call living past 120 years, it's definitely going to happen. How could anyone deny that we'll live longer than humans before the information age, before computers and modern diagnostics. I could go on and on about how things have changed since we reached 120 year lifespans.
I’M sure a lot of things discovered in 1997 have changed with discoveries of today 2023. What I’m impressed with is the difference in mice who we’re brothers and one is gray and can’t move and the other one is running with tons of energy and looks like it’s one of its kids. Not sure how you explain that energy and look even if it is a mouse. I think calorie restriction, NR, or NMN, TMG, resveratrol must have something to do with it. Otherwise, there would be no effect on the mice so something is happening?
This guy totally ignores the point of exercise at the cellular level, as though any possible benefit of it doesn't really matter.... metformin as David Sinclair states, applies a stress at the cellular level... thats how it works ... "exercise at the cellular level!" This guy totally represents a very conservative approach to aging, whereas Sinclair represents a very optimistic view. We would like some OPTIMISM from Scientists to get med research moving these days WHILE WE'RE STILL ALIVE!! We all know that its a stretch, but we need some optimism here! At least Sinclair is trying. What have we heard from this guy? .... crickets while he stays "comfortable." This guy acts soo conservative (which i am also) that its as if he couldn't care less if we all die before any progress happens. As if he just cares about his having a prestigious job and he's set ...very negative. Tooo conservative, almost to the point of obvious jealousy. SOOO, SOOO NEGATIVE! Probably reality is somewhere in the middle after further study, but at least try! ...And Sinclair explicity says activate only 3 of the Yamanaka factors NOT all 4! Sinclair himself says that is a total no go! Plus he DOES state in all his interviews i've seen that they did use a damaging enzyme to artificially age the mouse! And that these things are just early testing. Show some bloody Optimism and a little less jealousy! Slow to speak as well, as if he doesn't share knowledge much. Could care less about us....and entropy too? Unbelieveably negative!
To think that a lab can come up with a single molecule or multiple molecules to reprogram an organism as complex as a human, for longer life or even health, at this early stage of our advancement is wishful thinking.
Has David Sinclair ever engaged in a public debate with individuals holding divergent perspectives on longevity? I'm thinking that this may be the red flag.
Growth hormone receptors,synthesis of NAD pathways,Found NR is pathway to NAD.Metabolism is bio oxidative catabolism energy, built structure, anabolic and repair,
literally eliminating cells but they didn't want to tell you about that because they literally didn't observe 1:58:06 the mice for a month and we know from their prior work that the cell death 1:58:12 happens within the first month of what they did which is treatment with this 1:58:19 restriction enzyme so they treated with a restriction enzyme that cuts DNA 1:58:24 we know that that leads to p53 induction and cell elimination but they didn't report on that they kind 1:58:31 of put that under a rug and then they came back a month later and they said there's no mutations in 1:58:38 this mice there's also a lot of the cells are gone the cells that experienced this DNA 1:58:48 cutting were eliminated we know that from their prior work 1:58:53 then they did this yamanaka Factor treatment they used three out of the 1:58:58 four yamanaka factors and they said we've rejuvenated the mice 1:59:05 but they didn't use any functional experiments to show that the mice were rejuvenated 1:59:11 the only thing that they showed was rejuvenated was this epigenetic state 1:59:17 so but the epigenetic state as measured by age tests mostly some gene expression
It's worth watching and re-watching many times, so interesting... Yet can sb pls explain why we hope to manipulate information (DNA in this case) through such basic methods as surgery ( inserting a nucleus in a new cell, removing genes) or chemistry (supplementation) instead of trying to work on a physics level as even ATP production is a matter of moving electrons and protons, after all. Isn't M.Levin actually working on sth like that, electrical blueprints directing the functions of the body? Also, how come we applaud the fact that primitive creatures like gut bacteria should send signals to our immune cells and to our brain and control them instead of things being the other way round? How come our brains cannot control our own cells and their DNA? Why is this considered unsuitable for scientific research, mumbo-jumbo etc., and not the most logical thing in the world?
Will nicotinamide riboside (NR) enhance NAD+ levels in the mitochondria matrix? If so, will the NAD+ be used for the citric acid cycle to transfer electrons to the electron transport chain? I am not a fan of the anti-aging scientists. The question regards aging more healthy since ATP production is essential. I am 74 years old and using resistance weight training to minimize the impact of sarcopenia.
1. David Sinclair is a different league. Why would he debate that guy. He doesn’t need to prove himself. 2. Go ahead and explain to the people who follow DS recommendations that longevity theory doesn’t work. They see that this theory works by looking in the mirror everyday.
If a ceiling to lifespan is generically encoded, why can't it be genetically un-encoded? I know it's a multifactorial and complex issue, but this seems a little defeatist?
Some religions try to keep males and females apart at younger ages. Not very successfully though. And so far I don't think they live longer, but maybe if they stick to it for hundreds of generations, and keep mating later and later. I wonder which is the society or tribe that has the latest mating ages. Most have probably been in a hurry to mate in order to have any survival advantage at all. It seems that in societies where survival becomes easier we naturally tend to have offspring later in life.
A way to prolong longevity in humans would be to force women to freeze their embryos. Those embryos would be implanted on young women, only if the actual genitors lived a long life, without serious illnesses. Women would only be allowed to carry their great grandmother's babies, on that condition. As frightening as 1984 !
Interesting idea. Should be possible to do without force, as an experiment. I haven't had any children, but now, at age 65 I seem to be aging well and wish that someone would carry a child of mine.
Exercise nutrition sleep water coffee maybe don't eat late, fast over night. Mental social stimulation, hygiene, immunisation, dont be over fed, goldilocks body weight & muscle mass. Don't eat unless hungry. Breathe, joy, purpose......I got to the end, avoidable stresses eg uv+, alcohol. Explore NAD NR, Use it or Lose It. Thankyou felt a honest educational conversation. At least I know their are some basic leavers I can do.
Way above my head, but still interesting to listen to. Last night I started to re-watch a fun Canadian sci-fi horror film called 'Splice', seems quite appropriate :-)
Great discussion. From listening to quite a number lectures by aging researchers it seems that the damage/repair hypothesis keeps coming up, and central that is DNA repair. Vera Gorbunova who looks at long lived animals has shown that longevity seems to be correlated with ability to repair double strand breaks (or prevent them) this is apparently a key mechanism by which the bowhead whale can live to over 200 years.
Dr. Brenner is 62 and he looks his age. He isn’t crazy about anti- aging, as we just learned. Dr. Sinclair is 54 and he looks way younger and we all know what he does to stay young. Isn’t it ironic? And then there is Bryan Johnson, 45, who looks like 35 and who sacrificed most human pleasures to reverse his age and achieve excellent health. Time will tell, of course, but mirrors don’t lie…
What is Pro Charles Brenner value to all of us? He only said what we have long believe that aging is evitable. Did he bring something new to the table?
We already have the genes to live a very long time, but our repair mechanisms are only fully engaged while fasting. Some benefits of doing occasional extended fasting: High blood pressure is lowered to normal levels very quickly while fasting. Fibrosis/scarring is reversed over time, including in the heart and lungs. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' like spikes that are not supposed to be there. Whether natural or unnatural in origin.. Blood sugar and insulin are lowered when fasting, allowing white blood cells to move more freely throughout the body and do their job. Fasting increases nitric oxide release. Fasts from 36-96 h increase metabolic rate due to norepinephrine release! Telomeres are lengthened and fasting also increases anti-aging Yamanaka factors. After 72 hours or more fasted, your body recycles up to 1/3 of all immune bodies, rejuvenating your entire immune system. This helps prevent the onset of new autoimmune conditions, which develop through a leaky gut and damaged immune system. Fasting can help with MS, Depression, BPD, Autism and seizures. Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose extra tissue like loose skin while fasting, but the skinny or frail will have increased growth hormone release than the obese, which helps to make more lean tissue and reduce frailness. When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. What breaks a fast? Anything with protein or carbohydrates in it will break a fast. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS. Fasting reduces pain and anxiety by stimulating the endocannabinoid system in a similar way to CBD oil. One day of fasting can cut your leptin levels in half and gets your immune system working properly again! This reduces leptin resistance, which impairs immune function. Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers. Some patients may need continued acid reduction medication while fasting. Does the body preferentially prefer glucose as a fuel? No. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose. Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells Lowering insulin via fasting virtually eliminates chronic inflammation in the body. It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency. Increased mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! Fasting releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with. Fasting also increases telomere length, negating some of the effects of aging at a cellular level. When you fast, this stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs. Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. Glycine and trimethylglycine can also be useful supplements while fasting that won't break ketosis and have many benefits. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast and seek advice. Resources: www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html www.ncbi.nlm.nih.gov/pubmed/10859646 academic.oup.com/ajcn/article/81/1/69/4607679 www.sciencedirect.com/science/article/pii/S0005272806000223 pubmed.ncbi.nlm.nih.gov/6859089/ www.ncbi.nlm.nih.gov/pubmed/10232622 www.clinicaltrials.gov/ct2/show/NCT04375657 pubmed.ncbi.nlm.nih.gov/31877297/ n.neurology.org/content/88/16_Supplement/P3.090 pubmed.ncbi.nlm.nih.gov/31890243/ pubmed.ncbi.nlm.nih.gov/2518860/ pubmed.ncbi.nlm.nih.gov/29727683/ www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ www.sciencedirect.com/science/article/pii/S1931312809002832 pubmed.ncbi.nlm.nih.gov/15522942/ faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 www.biorxiv.org/node/93305.full www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ www.ncbi.nlm.nih.gov/pubmed/25686106 pubmed.ncbi.nlm.nih.gov/21410865/ www.ncbi.nlm.nih.gov/gene/25712 pubmed.ncbi.nlm.nih.gov/23707514/ www.ncbi.nlm.nih.gov/pubmed/24905167 www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ clinical.diabetesjournals.org/content/36/3/217 www.ncbi.nlm.nih.gov/pubmed/23876457 www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ pubmed.ncbi.nlm.nih.gov/20921964/ pubmed.ncbi.nlm.nih.gov/25909219/ www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue pubmed.ncbi.nlm.nih.gov/28235195/ www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ pubmed.ncbi.nlm.nih.gov/23408502/ www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext europepmc.org/article/MED/22402737?javascript_support=no onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x www.nejm.org/doi/full/10.1056/NEJMoa012908 www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ pubmed.ncbi.nlm.nih.gov/7714088/ www.cell.com/cell/fulltext/S0092-8674(19)30849-9 pubmed.ncbi.nlm.nih.gov/27569118/ www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ www.nejm.org/doi/full/10.1056/NEJMc2001176 pubmed.ncbi.nlm.nih.gov/20102774/ This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed! My community tab will always contain an updated version of this list of fasting benefits. I also have playlists on fasting and health topics.
Although i relish in this topic and want to hear any and all opinions and discoveries, I have a lot of gripe with Brenner here. "Longevity genes". No one is talking much about these but rather epi-genes, eg sirt6 and other examples of genes are needed for longevity. Is this just semantics like saying food/water is a longevity factor? Another gripe in general, I've been focusing on sleep quality to do two things in particular, increase glutathione and increase growth hormone. Now Brenner makes a fervent point that GH will shorten our lifespan while making us healthier. There's debate out there on this point and i dont think its settled. Here's a more balanced quote from the web with this nuance: "However, there is also evidence indicating that higher growth hormone levels decrease longevity. In some cases, higher growth hormone levels may increase the risk of certain diseases and may cause some conditions, such as cancer, to accelerate.Jun 15, 2022
There's great discussion here of NMN/Sirtuins, but I think he isn't super up to date on rapamycin/MTOR1. Its true that MTOR is generally speaking a regulator of skeletal muscle maintenance but even the experimental evidence we have already shows that the effects are anything but straightforward.
The growth hormone treatments mentioned are transient, and not through the remaining lifetime, if he is referring to TrimX+. They are intended to regrow the thymus, and prolong immune system function. This remains to be confirmed through larger clinical trials, but has shown signal in the original small cohort on nine, and pending results from a larger one. It is misleading to imply that the treatments are intended over the course of the remaining lifetime, which would probably shorten longevity as asserted. There was also persistent epigenetic rejuvenation from the transient growth hormone treatment, albeit for the small cohort. Those results are also pending being confirmed with a larger cohort, which is in process.
In a word yes. Genetics are absolutely paramount and the massive role they play is often downplayed by the so called experts like Sinclair, Attia etc. There are way, way too many “anomalies” out there who do all the wrong things and live long lives. And by the same token, there are way too many people who do all the right things eg diet, exercise etc and go out like a light at 60.
