"An Isotope Dilution-Based Method for the Analysis of Microcystins and Anatoxin-a for Improved Accuracy and Robustness"
Dr. Xavier Ortiz, Adjunct Professor at IQS School of Engineering of Ramon Llull University in Barcelona, discusses the analysis of cyanotoxins, including neurotoxins like anatoxins and hepatotoxins like microcystins, which have over 300 known variants with different levels of toxicity. He highlights how climate change and human activities like agriculture are creating the perfect conditions for cyanobacteria to grow out of control and produce toxins. Dr. Ortiz shares how his lab has developed an LC-MS/MS method using fully 15N-labeled internal standards from Cambridge Isotope Laboratories to analyze four of the most common microcystins and anatoxin in the same run. He discusses how the use of these labeled standards improves accuracy by mitigating ion suppression caused by complex matrices like those found in algal bloom samples. Dr. Ortiz answers a question about whether he anticipates an EU-based standardized method for cyanotoxin analysis will be developed in light of increasing regulations.
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16 сен 2024
