WHAT IS THE OPINION OF ENDOCRINOLOGISTS ON USING MEDICINES FOR GYNECOMASTIA? Most endocrinologists invariably agree that drugs might help in reducing the size of the breasts a little and people in the early stages of gynecomastia might be happy with the results. Also, these drugs do help in reducing the glandular pain that occurs as a result of gynecomastia. However, after six to twelve months, the rate of reduction might stop or the condition might recur. So drugs might not be the complete solution for gynecomastia. The main course of treatment worldwide for this condition is surgery only.