depending on your version of chemdraw, you can use reaction clean up which will automatically line up reactants, products, substrates/solvent/temp/time above/below arrow. ctrl+shift+x on windows
Noooo dont ever waste your time doing this gain You either ctrl+shift+x to clean up the reaction (auto aligns everything perfectly) or you align it manually going to Objects -> Align -> align however you want (probably horizontally)
