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Liquid-Liquid Extraction

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Separation techniques are important in chemistry, and they won't always be as easy as filtration. Sometimes we need to separate two compounds that are dissolved in the same solution. Often we can take advantage of a difference in solubility or reactivity to perform an extraction. This is where one component is pulled into another solvent that is immiscible with the first, and we can separate the two layers using a separatory funnel. There is a lot to learn to do this efficiently, so let's get a closer look at how to perform this technique!
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Опубликовано:

2 окт 2022

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Комментарии : 109

@Kualinar Год назад

I remember doing liquid-liquid extraction. Our teacher explained how it worked, then, we had a lab to put that in practice. He told us to use the second liquid in three parts. I instead divided my liquid into six parts, and stated that clearly in my report and exactly why I did it. My yield was significantly higher than that of the others to nearly 90% compared to the 65 to 75% that they had.

@AkkaOniVA Год назад

Did the teacher give you extra points for that? If not, they should have.

@Kualinar Год назад

@@AkkaOniVA I don't remember. That was about 40 years go...

@AkkaOniVA Год назад

@@Kualinar Oh wow, scuse me for asking then. That's really cool though!

@matherman1111 Год назад

I swear reading people's successes makes me feel so good

@eatshitlarrypage.3319 Год назад

As a long time fan of NileRed, it's cool to learn the more technical aspects of what he's doing. Like this is the textbook portion of the class while he's the demo portion.

@MM-tz3we Год назад

I am here for Dr Jamal Muhoza!!! well done. Mamello

@kylemoore7746 Год назад

Kinda fun to be listening to this while writing up validation documentation for Capillary Electrophoresis and HPLC instruments.

@chetanupadhyay8367 Год назад

I did this extraction recently during my organic chemistry lab... I separate ternary mixture using this technique... Firstly, I dissolved my mixture in ether... Then, the ether insoluble part settles down and ether soluble part dissolved completely in it (two compounds)... After that, I added small amount of sodium bicarbonate in it and there was a precipitate formation... Then, I transferred that solution in separating funnel and there was a formation of two layer... Finally I separated the all three compounds that were present in that mixture... Really, this was a really helpful technique...

@Pokemonzeldabro Год назад

This is just the video I needed right now, thanks!

@andrewjones6693 Год назад

Another interesting lesson, Dave! Thanks for identifying the compounds this time! I think it adds to the completeness of the video!

@fsdsketching3370 Год назад

I love this channel,I never questioned your explanation

@IAintGonnaDrawHeliohi Год назад

That's beginning of blind faith. Trust is one thing but blind faith is dangerous.

@borttorbbq2556 Год назад

You can trust what he says but you should always question what he says

@burgruk Год назад

"Trust, but verify" buddy!

@fsdsketching3370 Год назад

@@burgruk chill guys am not that dumb 🤦

@akshayg4754 Год назад

Great job mate

@Thaumius Год назад

Does the way that you hold the separatory funnel while mixing impact the extraction efficiency?

@martinarenzi4744 Год назад

Thank you Prof Dave! In what the extraction in this video is different from cromatography?

@BradSchmor Год назад

I worked as a development chemist and there are some real-world problems that come along with liquid-liquid extractions, some of which can become a serious problem on large scale (12 L - 10,000+ L). Anything bigger than 5 L is too big to shake by hand so you must use an impeller (basically an overhead motor with a long blade to whip the stuff). Emulsions can form which sometimes take hours or even days to break; gentle agitation sometimes helps with that. Sometimes we add salt (NaCl) to the aqueous phase to either help break emulsions or reduce the solubility of organics, especially if the solvent has appreciable water solubility, like ether or ethyl acetate. Btw ethyl acetate remains in wide use in academia, but I promise you- isopropyl acetate is much better behaved in every way. Start using it.

@eatshitlarrypage.3319 Год назад

Reminds me of what happened to Cecil Kelley. They had a vat of sub-critical plutonium in an aqueous solution that had been sitting for a while, so a lot of the more radioactive material had risen to the surface. When he turned on the impeller, it formed a vortex on the surface, pulling all of that radioactive material down to bottom of said vortex where it reached criticality and absolutely blasted the poor guy with a shitload of radiation. (Yes, Kyle Hill etc. Love me some science Thor.)

@galileog8945 Год назад

This series is about LAB techniques, not about pilot or production plants.

@BradSchmor Год назад

@@galileog8945 I'm aware of that. I just wanted to put it out there that this technique as described has some limitations. Emulsions can be a serious problem at any scale

@vedmaburuxova68 Год назад

@@BradSchmor I remember when I had organic chemistry class some of us managed to make an emulsion doing this and lost several hours waiting for it to fix itself.. Sucked to see the others go, luckily mine wasn't too bad

@halimali8132 Год назад

thank you .I wished explain all methods to purification organic compounds

@Way345 Год назад

I would say a great separation technique alternative to energy intensive distillation processes, or at least a great initial step for separations to save on energy costs

@elliejohnson2786 Год назад

I always wondered how the two layers are perfectly separated, I thought you just poured out a tiny bit after the first layer was dumped, I didn't know the stop cock actually held that fine line between the layers.

@andrewjustin256 8 месяцев назад

Right! This makes chemistry teeny bit unreliable. This is what I always think like hey how do I add hydrogen ion to a molecule and only to that portion not any other. It pans out that it is about snatching-and-obtaning-one-atom-from-the-other kind of business. And that is why Physics rules Chemistry!

@sciencenerd7639 Год назад

this is great, thanks so much

@waelfadlallah8939 Год назад

Thanks professor

@agile52 Год назад

holy cow, I didn't think a forge would be a liquid-liquid extraction, crazy

@yepyep2315 Год назад

Decantação usa misturas de líquidos-líquidos e usa as propriedades da solubilidade geralmente adicionamos um novo solvente à mistura que só se mistura a um dos dois componentes para separar as camadas usamos um funil de decantação a camada inferior é o componente mais denso, enquanto a superior é o componente menos denso misturamos com movimentos suaves (desenhando um 8 deitado no ar com o funil de decantação) tendo certeza que está bem tampado (coloque a mão na tampa e não aponte o funil para ninguém)

@urielpolak9949 Год назад

For all your chemical needs??!! I am happy its a scientist saying this not some random dude on the street

@rosiecesareo8092 Год назад

So true

@dedlunch Год назад

You need a business address

@samuelmarger9031 Год назад

Not a chemistry student, and damn I want to try and see these steps for myself. (I used to be in a science-focus high school curriculum)

@bonganimondlane2908 9 месяцев назад

Professor Dave for president

@ZezimaTruth Год назад

Fisher aka God of Chem Lab

@manodyapalindiweerasoma6150 8 месяцев назад

Thank you very much..🔥👍

@ambarwaleed2750 2 месяца назад

Instead of methoxy naphthalene which compound can be added?

@ahmedmajmaee7755 Год назад

So with Vaccum filtration of benzoic acid we get NACL on the filter and a liquid which is Benzoic acid ?

@armoireaborila1646 4 месяца назад

thx

@mycupinpeace7227 Год назад

A life saver

@defeatSpace Год назад

Is that actually an alternative to Sigma A-holes?

@ambarwaleed2750 2 месяца назад

Sir i have a question? If we simply add benzoin acid in water and extracted in organic layer? Does it work? Or we require methoxy naphthalene?

@tomhunt354 Год назад

Reminds me of how I would helps organic I students as a TA

@sevrent2811 Год назад

why remove the organic layer only to put it right back in?

@ahamdomar731 Год назад

Good dude I'm a pharmacist so useful for me

@borttorbbq2556 Год назад

Interesting

@mohamedredhaaidel9943 2 месяца назад

Hello Pr, i need a reference articles of this video please

@TasneemOmar-dx9wq 8 месяцев назад

What is the website or tool you use for video

@motionsick 8 месяцев назад

Whats the ESG score of this series?

@slowbro6871 Год назад

Why are these videos so riveting?

@Futt.Buckerson Год назад

In a pinch I've seen people use the Gatorade sport-cap (twisty spout thing) and bottle, turned upside down, as a sep funnel. But I don't recommend it.

@duarteolim6473 Год назад

Hello. What if you want the lighter layer? the one that stays on top. And the bottom layer is greasy, stays on the walls and contaminate a little bit the top layer. Normaly i transfer to a graduated cylinder and use a pimpette, is there a better or easyer way?

@sabrinastyblova 11 месяцев назад

I would use a pipette to pipette the upper layer out :)

@sanskrita4 Год назад

Thanks! What solvent do we use to separate trialkylamine and dibromoalkane from the product salt? I've tried with DCM but it gets dissolved fully and no two layers are formed for separation.

@borttorbbq2556 Год назад

What are they dissolved in currently? Or are these dry salts

@Noldor97 Год назад

u can try a two phase system like water and diethyl ether or something. trialkylamines are mostly pretty water soluble, the dibromoalkane shouldnt be most of the time

@sanskrita4 Год назад

@@borttorbbq2556 they are dissolved in acetonitrile

@sanskrita4 Год назад

@@Noldor97 will water not dissolve my product as well?

@BradSchmor Год назад

DCM (and chloroform) is notorious for extracting amine hydrochlorides from aqueous phases when you don't want it to. I'm not entirely clear as to why this is (perhaps the ammonium having almost like a hydrogen bond to the DCM chlorine atoms?). You're probably better off with isopropyl acetate or MTBE.

@eldiablo-yt6089 8 месяцев назад

Lifesaver

@frankopahovic9724 Год назад

You should never evaporate organic solvent outside of a fume hood because many of those are quite flammable.

@Max_Chooch 3 месяца назад

How do you separate 95% ethanol from flavor/smell terpenes? They're pulled out of solution during the solvent reclamation phase of a whole extraction for the purposes of Rick Simpson oil. Asking for a friend 🙃

@JamesVestal-dz5qm Год назад

Disabling my myu account helped me focus on teaching my k state students.

@rassimsimou1594 Год назад

Good

@niloofarkh4779 8 месяцев назад

wow great

@sotecluxan4221 Год назад

@borttorbbq2556 Год назад

Would molecular sieves work for this purpose or would they not be selective enough

@borttorbbq2556 Год назад

I know that you can use molecular sieves to dry ethanol and other alcohols but I don't know how much use they have outside of that

@borttorbbq2556 Год назад

I meant for drying the separated product

@BradSchmor Год назад

Molecular sieves are used to remove small quantities of residual water from a solvent.

@happyandhealthy888 6 месяцев назад

liquid or gel

@JamesVestal-dz5qm Год назад

Jane wissinger engineered it based on my ochem lab technique

@strahligefbhv6395 Год назад

0:59

@DeconvertedMan Год назад

if you mixed liquid nitrogen (edit/hydrogen) and liquid oxigen would you get liquid water? :D

@borttorbbq2556 Год назад

No nitrogen and oxygen will not produce water

@DeconvertedMan Год назад

@@borttorbbq2556 what about two parts of liquid oxygen? :D

@borttorbbq2556 Год назад

@@DeconvertedMan it would be more likely to produce nitrogen dioxide

@borttorbbq2556 Год назад

@@DeconvertedMan not dihydrogen monoxide

@borttorbbq2556 Год назад

@@DeconvertedMan I don't really know the chemistry of liquid elements when it comes to gases but I mean I would presume the chemistry would still happen or at least would happen at like the surface or something but either way in order to produce water you need hydrogen not nitrogen

@carcrashjayson Год назад

Finally, synthetic watermelon

@sarahcasm7893 Год назад

I haven't watched the video yet, but Nernst? :D

@happyandhealthy888 6 месяцев назад

liquids for erasing small capillaries called spider veins

@keegan6388 Год назад

Hey Dave, does it ever bother you that your "controversy/drama" content is viewed exponentially more than your tutorials?

@ProfessorDaveExplains Год назад

Kinda. But whatever, that content also serves a purpose.

@borttorbbq2556 Год назад

@@ProfessorDaveExplains so with your series on organic chemistry and your series on regular chemistry which should I watch first

@borttorbbq2556 Год назад

@@ProfessorDaveExplains I'm planning on listening to both but I just don't know which one I should start with

@ProfessorDaveExplains Год назад

General first then organic.

@borttorbbq2556 Год назад

@@ProfessorDaveExplains okay thank you Dave

@flaps805 Год назад

W/black Dave

@Manimmut Год назад

Funny Just today our teacher showed us that

@PotatoChips-jy9pk Год назад

Extract caffeine from caffeine pills and then put it into capsules (500 mg) :D

@arteasa Год назад

Cheers😅

@theroadnottakentravel Год назад

Dude that’s literally my lab tmrw😅😂😆

@laiaplaiap1688 Год назад

👍🏻👍🏻👍🏻

@-JA- Год назад

❤️👍

@anuragsinha3042 Год назад

4th comment

@neuro-physicstalks450 2 месяца назад

Advertising thermo-fisher and 'using' a brown skinned student is literally a scam. Thermofisher is famous for its racist attitude when it comes to staffing.

@ProfessorDaveExplains 2 месяца назад

He’s a chemist with a doctorate, and I don’t know what you’re talking about.