Loop Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications 

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You just saved me, i was about to cry because I didn’t understand diuretics and you made it so easy and fun💚

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Can diuretics cause slow stomach releasing

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A question: If we block the Na/K/2cl channel, then, like other ions, K+ is also not entering into the cuboidal cells. Doesn't it mean that K+ will be high in the lumen as Loop-Diuretics are blocking them from entering through the channel?

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loop diuretics act on the loop of henle Na K 2 Cl transporter type I has the sulfa groups: Furesemide. Bumetanide. toresemide type II no sulfa grp: Ethacrynic acid leads to loss of great volume of water na and cl. helps in reducing bp, bv, Fluid overload: corrects Ascites, Pulmonaey or peripheral edema eliminiation of toxins by flushing out a lot of water adverse effects Hypovolemia, hyponatremia, hypochloremia,hypokalemia metabolic alkalosis hyperuricemia, hyperglycemia Acute Interstitila Nephritis

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So does anyone know if loop diuretics can actually reverse damage/scaring in the liver or kidneys. Or does it just temporarily improve the symptoms while your taking the diuretic and once you stop taking it most of symptoms will come back. ? I know a lot of it has to do with life style and stuff too but let’s assume I’m doing everything correctly diet and exercise wise and sleeping well. Will the loops actually reverse some damage that might have been done??

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Im curious abt the mechanism of action of beta2 receptor agonist (albuterol) on how it can help shift potassium into the cells😢 according to google it’s because of insulin and glucose additive. Is that true?

Thank you for your videos, they are really helpful. Do you think that it could be mentioned the fact that loop diuretics are much less likely to cause hyponatremia than theiazic diuretics?

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If there's high bicarbonate in the blood, isn't it decrease the pH and cause acidosis instead of alkalosis?

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Why tolvapton, ace inhibitors and arbs not included in diuretics while they also increase urine production ?

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Found 2 mistakes: 1. Loop diuretics inhibit the renal elimination of lithium. so they shouldn't be used in lithium intoxication 2. The Ototoxicity is result of a increase of potassium and change of potential in the endolymph (not decrease), what decreases is the potential which results in dysfunction of the hair cells. its mostly reversible.

The lecture is amazing. The anion gap formula though is not correct

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Thank you!!

Great lesson. Would like make a suggestion. Loop diuretics are very unlikely to cause hyponatremia. The thiazides have a much higher propensity to cause hyponatremia. Loop diuretics can in-fact cause/contribute to hypernatremia. Also, they have a role in the treatment of hyponatremia caused by SIADH.

My dear partner died last year almost certainly due to kidney failure. She was aged 86 and had been prescribed Furosemide for several years. This was intended to treat her oedema (ankle swelling), and her ascites (extended abdomen). The Furosemide was not a "cure" for either condition, although it might have had a mitigating effect. But I believe that it was the direct cause of her kidney failure which caused her to die earlier than she would have otherwise. I believe that diuretics should be prescribed only for short periods of time, if at-all. Apart from causing ultimate mortality the other side-effect is to reduce the quality of the patient's life to less than zero. My partner became a wretched prisoner in her home. This was because she needed constant access to the toilet, so she was unable to go far from her front door. What is the point of prescribing a medication whose side-effects are more distressing than the condition it is intended to treat? (I have never heard of anyone dying from oedema). I know nothing about medical science, but that is not necessary. For whatever reasons diuretics stimulate the kidneys into "overdrive". Surely this amounts to an abuse, and we should not be surprised when negative consequences arise. When physicians prescribe diurects their patients are entitled to receive a warning that their death may be one of the side-effects.

heyy senseii ! excuse me but.. in my textbook it says that Diuretics (thiazidic // loop) are "contre- indicated" for patients with cirrhosis if that's correct, why did you mention cirrhosis when it came to edemas !!???

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The best of the best , 42 minutes of pleasure. Keep going , many thanks to you . I just have one notice in the minute 35:14 , the anion gap is NA - (Cl + HCO3 ).

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anion gap=Na-(Cl+Hco3)

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Make more videos on pharmacology

Hypocalcemia causes Tetany. Tanks for showing me Loop diuretics cause hyperglycemia.

Contraindications of loop diuretics?

i uave watched few videos on ytb, n only ur video make me undesrtand mechanism of diuretic. thank u my hero

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Thank you soo much for this video! One question: if loop diuretics could possibly cause hyperglycemia, why should we give patients D50(and also insulin)?

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I wanna start with Thank you for providing amazing lectures for free. The content you create are one of the best i've ever seen. Just wanna point that in the minute 35:06, you inverted a sign in the equation for the AG formula. You put AG = Na + (Cl + HCO3) instead of AG = Na - (Cl + HCO3)

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