Making [1.1.1]Propellane 

I love how everyone is talking about the cubane synthesis to make Tom finish it

One of the PhDs in my lab did a lot of work on Propellane and similar molecules. After he defended our group made him a "doctor hat" which is a traditional thing here, and at the top of the hat I added a giant 3D printed propellane molecule powered by servos that would rise up and spin around when you pressed a button.

I love that you seem to invest in reagents and stuff. Like, I get the whole "only hardware store chemicals" concept, but sometimes you just wanna watch someone pop a fresh bottle of commercial methyllithium, y'know.

Things I absolutely love about this channel: -The subtle humour: text smileys, appropriate emoji/regular memes -The inclusion of mechanisms -"I can finally *propel* myself out of here -Yellow chem pain is not ignored -Many more to come

we get to chemistry vicariously through Sam :)

I love how your channel started as a "proper" chemistry vlog and then it slowly Chad-ified into what it is today. Please keep going this style is awesome Edit: OMG the 18-crown-6 has returned!!

C'mon man it's not a crack shed, it's a cocaine shed in the very least

Cube: who are you Propellane: im the captain now

I can't express how much I love this channel. High quality and exciting chemistry, good explanations and exactly my kind of humor. Keep doing what you do!

Love that you show the reaction mechanisms 🙏🏻 makes me really appreciate what I’ve learned in Orgo so far

I live for E&F shade in chemistry youtube these days.

I love this kind of humor coupled with solid chemistry, AAA content my man also nice explanation of the mechanism!

I like the green highlight during the mechanism explainer phase, makes those of us not too familiar with chemical synthesis able to follow along.

Super cool, loved to see the mechanisms behind this, takes me back to OCHEM. Also, 69% yield. Nice.

I love how this guy is going more insane in every single video 😂

A useful tip for doing those types of dihalocyclopropanations is to add the NaOH over a period of time, and not all at once. This helps to generate a fresh amount of carbene and will increase the yield.

Just wanna say that I lovr your new green highlighting during mechanisms! Can't believe you still manage to improve.

Love the little green circle in the reaction breakdowns, helps my small brain understand

Always a good day when you can break out the Gigachad molecule 18-crown-6

That’s a great final yield, it’s my favorite number

This is a great mix of Nile red and explosions and fire. The perfect mix of two extremes.

I love your videos, because you're the person who DOES "in more detail..." bits. If it was boring, I can skip it, but if it wasn't there I couldn't just summon all that knowledge from ether xD

Drake shunning the cube dismissively, then smiling approvingly at weird propeller thing.

at this point youtube chem is starting to become just nano-scale solid geometry lmao

That Chemist called. He says this is cursed.

You had a lot of fun with this one

Thank you for this organic tour de force! OChem is my absolute favorite and difficult synthetic schemes are even better.

I love all puns in this video XD Who needs cube when you can propel yourself through chemistry XD Great work!

Excellent work. Very easy to follow, thanks for showing the reaction mechanisms.

Pretty cool! I been watching the Cubane synthesis saga. This might've been the first time one of those lil chemical equation diagram thangs has made sense in my mind.... Thanks for sharing!

Right on I think I've only ever seen one other thing to do with pentaerythritol. Badass thank you

Pinacol is the pinnacle of compounds.

Try microwave assisted chemistry for the carbene synthesis step. The crown catalysts work extremely well with microwaves

Fantastic! That is what I call “good old chem”. You just nailed that propellane .

E&F is going to make it, i believe it

Yeahhhh he uploaded!!!!

Its amazing what you can do with a proper budget

Wow. That looks like it takes at least a day between all of those steps.

YES FINALLY A PROPELLANE ENJOYER YEEES

Am I the only one who absolutely fucking LOSES IT! Every time he says "I set the filtrate up for Short Path Vacuum Distillation."

Yes, now make all the different hydrocarbon cyclic molecules

penta Er and hno3 are quite a spicy mix in other contexts If for some reason the chlorination does not go to completion, you might get some jumpy esters.

senin gibi bir yeteneğin 108k abonesi olması büyük haksızlık. harika işler yapıyorsun. takipteyim...

If you're in search of an extraordinary experience that combines the wonders of chemistry and the limitless creativity of Minecraft, look no further than the mesmerizing world of cubane! This mind-blowing molecule is sure to leave you utterly spellbound with its exceptional properties and jaw-dropping effects. Let's talk about cubane, the star of the show. This tiny molecular powerhouse is nothing short of a marvel. Its flawless cubic structure is a sight to behold, capturing the essence of symmetry and stability. The sheer elegance of this compact arrangement will leave you in awe, pondering the mysteries of the universe. But what truly sets cubane apart is its explosive nature. Brace yourself for an adventure like no other as you unlock the potential of this mighty molecule. Just a tiny spark can unleash a spectacular display of energy, captivating everyone around you. It's as if you hold the power of a supernova in the palm of your hand! And now, let's journey into the world of Minecraft, where cubane shines brighter than any diamond sword. Immerse yourself in a universe where the possibilities are as vast as the digital landscape before you. In this pixelated wonderland, cubane becomes the ultimate game-changer. With cubane as your ally, you can reshape the Minecraft world with unrivaled creativity. Watch in amazement as you effortlessly build towering structures, defying the laws of physics and gravity. But that's not all! Prepare for mind-bending explosions that will rock your virtual reality to its very core. The destructive power of cubane is at your fingertips, providing an adrenaline rush like no other. The synergy between cubane and Minecraft is a match made in gaming heaven. It's a thrilling fusion of science and imagination that propels your Minecraft experience to unparalleled heights. Every block you place, every explosion you trigger, becomes an exhilarating testament to the infinite possibilities that await. So, if you're seeking a game-changer that will revolutionize your Minecraft adventures, cubane is the secret ingredient you've been searching for. With its explosive energy and mind-bending capabilities, this remarkable molecule will redefine your virtual reality experience. Don't miss out on the opportunity to witness the awe-inspiring beauty of cubane and unleash your creativity like never before. Step into a world where chemistry meets gaming, and prepare to be blown away by the sheer brilliance of cubane in Minecraft.

Sounds like you were smiling through most of the narration on this one 😁 Amazing work!

Poor molecule, it wants to get rid of the central bond as much as any woman wants to get rid of her bra at the end of the day.

All the amazing interesting knowledge about organic chemistry given in fun entertaining way

I’m ending school chemistry soon. My life never will be the same after this video…

You know what is better? Just do both :)

I really enjoyed this one

Hi Chemiolis, Super nice video and synthesis; it furnished me ideas for some of my own synthesis that called for (Cl-CH2-)3C-CO2H and C(CH2Cl)4; and also for (ClCH2-)2C=CH2 so thank you for that all. Just as a side note; are you sure that (Cl-CH2-)3C-CO2H and (Cl-CH2-)4C are inert for their alkyl halide part towards NaOH solution? I imagine that the Cl atom can leave easily as Cl(-) replaced by a OH(-) thus yielding highly soluble alcohols ((poly-)methylol group(s)); this could remake some of your starting pentatetraerythritol aside with halides (mono-, di- and tri-) idem for your acetic acid related molecule of interest. Anyway nice job. PHZ (PHILOU Zrealone from the Science Madness forum)

Okay. Fish meets MeLi and becomes spaceship. Got it👍

Neat! Now waiting for smt like tetrahedrane!

Nicely done. Tom (the guy with the crack shed) is probably gonna mention you in an upcoming video!

I wonder if the propellane can polymerize to form polypropellane.

great video, i'm surprised during the MeLi step, that the major product isn't formed from MeLi doing NS on the carbons bearing chlorine. Also i would have expected some dimers and trimers forming during this step. Do you or the authors have any explaination of why the systems seems to prefer forming this creazy strained propellane ?

This channel has to grow

Ring strain champion caught by Chemiolis.

You earnt my sub with just that intro haha

I'm new to this channel and I already love how water is called dihydrogen monoxide

Sweet 187 step synthesis.

Nice nice nice^^ needed to be sayed… that green dot is lit :) I like it

The best shape was already there i.e. shape of benzene because "Hexagons are Bestagons" - CGP Grey

This is incredible, and very enjoyable to watch (as always, actually 😊). I do have some constructive criticism about the handling of the MeLi in the video, if you're interested.

I love that intro lol! I'm also surprised at how relatively easy it is to synthesize such an unstable, strained compound. I assumed that, aside from the dibenzo 18 crown 6, it would require some weird exotic reagents and/or UV light, like with cubane. Edit: I read about it, and the propellane can undergo a polymerization reaction to form various staffanes. I wonder if these compounds have any energetic properties if they're combined with suitable oxidizers.

I Officially love this channel

Man, chemists are crazy. "Today we are going to do a simple 300 step synthesis of this complicated molecule which requires at least 3000 obscure chemicals, 2000 of which we have to personally make which in turn adds 6500 more steps, during which if a single atom touches my skin I won't be able to taste colours any more." XD

This dude just casually glossing over using 73mL of thionyl chloride, like it's a reagent you can pick up from Home Depot. lol. Love your content :-)

Absolute legend

That Aussie crack shed filled with yellow stuff going boom, is a bit sus... 🤨 😁

Amazing. Very well done! Keep it up :)

LOL the “200ml dihydrogen monoxide” in the corner

Damn this chemistry's getting good!

As an avid viewer of explosions and fire, can confirm it is in fact a crack shed

thiophenol has such a memorable smell... but its almost like meaty at really low concentration

Nitrate this and it would make an extremely potent energetic material.

Idea for a video: chloromethyl furfural chemistry (supposedly one of the most promising celllose-sourced raw materials, with the possibility of turning it into polymers, fuels etc)

Interesting stuff - side quest completed

@E&F cubane project was like a research he changed lots of things away from literature .Meanwhile pthers have been like industrial synthesis reaction fuelled by well optimized litrature. As researcher i know how painful it is to optimize a protocol.

Molecular origami. Love it.

Great video dude!!

Amazing job well done how are you

Shots fired I see

Ok Senku😃

Nice final yield

Yes propellane army letsgoooooooo!

5:11 put "the thing"back in 😱😱😭😭 it still has some stuck to it. Ohh and can to try to make dinitro acetylene

ah yes favorite hobby, playing god

4:20 I think it's better to pour your mixture into (ice) water. This should produce larger particles making the filtration easier

BRO THE SHOT YOUR SHOOTIN DOWN UNDER IS GUNNA CAUSE CANCER OMGGGGGGG

I have learned that most problems in chemistry can be solved with short path vacuum distillation.

Now make a molecular swivel joint to attach it to

Can we have a lab tour video ?

Can you make molecules that look like insects. A dragonfly perhaps…

I do wonder. How one can acquire so much knowledge about all of the proper procedures and how to set up the synthesis reactions to such perfection as I see it in this video? Also how to know what clean up steps are necessary?

Mate ya making enemy's with a drug fuelled explosive genius here., I'd watch my letter box if I where you.

Is there a reason why you directly dry the liquids with MgSO4 and don't use a previous drying step with concentrated NaCl solution (in the seperatory funnel?) At least this was the way I was taught it back then 😅

"This one is so strained, you can open her up real good. 😏" _moaning sound_ I hate you, lol.

"1,1-dibromo-2,2-bis(chloromethyl)cyclopropane has a pleasant artificially sweet smell to it" _but does it taste good?_

Ah yes some refreshing dihydrogen monoxide