Making a Hypnotic Sedative From Acetone 

Yeah sounds like the worst torture possible. Tbh this chemical got scarier and scarier the more I read about it

Some people looking to not be in this reality would find its extended action a positive, but the hat man will not have that 🎉

It doesn't work like that with super long acting benzos or phenobarbital. The high is still like 20 hours, and yes with phenobarbital it's half life is like 20 days, you are not feeling the phenobarbital for 20 days more like 10 to 12 hours yet you will test postive for weeks after it wears off.

Oh, yes, this is the longest acting substance, ever heard! 😮

Facts

Yeah thats what I figured. I honestly am not sure if your body can even oxidize it at all, I think I read somewhere that it is metabolized by glucuronidation or sulphation, and then eliminated renally.

@@integral_chemistry I wonder if it could worsen liver or kidney function if there is already a reduced function of those organs. With its half life, I wonder if it could cause a stead and long term decrease in renal function for someone that has CKD and does not know it.

@@user-nu8in3ey8cif it’s that hydrophobic, probably not. Kidneys typically filter out H2O soluble compounds, that’s why the CYP enzymes and glucoronidation exists. I bet there is some reactive intermediate from depletion of glutathione from glucoronidation pathway saturation.

@@isaackimball6716 That sounds reasonable.

Thank you so much! I'm very glad to hear it. Feel free to shoot me an email if there's anything specific you'd like me to try

He is the GOAT 🐐

@@twirlyturd4364 :) I wish I was better at taking compliments lol. So happy you guys like my videos!

@@integral_chemistry pls adrenochrome synthesis lol

Lol honestly that is my bad 😅 I should have made my own graphics with chlorine instead of bromine but the ones I found looks so clean I couldn't help it

Why would anyone make this stuff in the "tons range"?

@@Standing.W.Israel it is used as a preservative in cosmetics and pharmaceuticals

very clever Jimmy Carr reference +1

😂🤣😂

Why yes! Yes it does in fact smell of chlorobutanol! Might I have another whiff?

They just haven't eaten before. It's loveliness smell is too nasty to consume, but to make that joke more fun, the question would have to be, "excuse me, does this cloth smell like chloroform?"

*thump*

Good job man! 😎👍 🛋️ 😴 💤

I'm gonna take it anyway. What dosage would you reccomend? I was thinking something like 200 mg would be active yet not too overwhelming.

@@lagrangiankid378 I'd keep it under 300mg which was the medical dose for sleep and I wouldn't take it more than once a month.

​@lagrangiankid378 if you aren't going to listen to the SERIOUS AND EMPHATIC warnings to not do this, I would not recommend starting with something so large as 200mg. With a halflife of over a month, you would not process out all of the chlorobutanol for 5-8 months, with 6mg remaining at 5 months and finally reducing to >1mg at 8 months. I will not provide a suggested dosing amount as I am not a pharmacist not do I want to encourage anyone to attempt this, but anyone stupid enough to do this needs to be aware that a half-life time is the time to half the original dosage and should plan accordingly. You will be in a highly suggestive state for at least a month, you will have a bad time and you will make regrettable actions.

@@jacobbrown7367 200 mg is not that large of a dose for something with this level of psychoactivity. For comparison chloral hydrate is dosed at 500 to 1000 mg. The OP of this thread ingested a gram or so if I remeber correctly and this lead to overdosing. And (unlike you) I know precisely what the elimination half-life is (which by the way usually refers to blood levels, not to the total amount in the body). And by the way 37 days is the half-life as measured in vitro at a pH of 7.4, terminal elimination half life in vivo in healthy human subjects is reported to be only 10.3 days (C Tung et al., Biopharm Drug Dispos 1982). I have quite some free time as I'm currently taking a vacation so there's plenty of time to recover and this self experimentation won't have any significant consequence. I know what I'm doing and I'm highly prepared, experienced and equipped. I just asked some anecdotal dosage information as there is little or no human data on this obscure and very old CNS depressant.

LMAO love it! I unironically want to work jokes like this into my videos someday I think all the old alchemy stuff is really funny

@@integral_chemistry like if the witcher was an INT only class

even taking it as a drug would NOT be fun you don't get "high"

@@Aaron-zu3xn it would put you in a state of feeling dead for a month and change which sounds like something a necromancer would do to get close enough to the other side to talk to it lol

There's a paper out there that even describes terminal self-harm from ingesting mouthwash that contained chlorobutanol. Whether or not the incident was concomitant with other ingested substances due to the past behavior of the poor soul could be debated but it isn't seen as an anti-fungal, antibacterial additive in personal care products anymore.

Literally. There's some scary ones out there, this one is in the same area as benadryl where it's such a miserable experience they don't bother regulating it

@@integral_chemistry ever done it?

​@@integral_chemistrythey'd better Can't imagine the damage of someone unleasheing this agent on a unknowing group of people

Sounds wretched.. literally the more I hear about it, the worse it sounds

So I cant use it to hypnotize someone into robbing a bank for me? Damn XD

Is this a common method for recrystallizing compounds that sublimate? I’m not far along in my chem education but it seems like that would cause a bit of loss.

​@michaelevans6216 as with any re-x there's always a loss.

Yeah good luck with that.

Thank you so much! The haloform reaction is super cool, been trying to think of ways to implement it lately.. maybe iodoform next?

Thank you so much! And yeah it got worse the more I read about it. Interestingly enough in my research I came across what is absolutely the most horrifying chemical I've ever heard of: EA-3167. It has the same effect as datura or extremely high dose Benadryl but with a psychoactive peak of 10 days instead of a few hours..

@@integral_chemistry Why do I get the feeling that EA-3167 got some research done on it by a certain 3 letter agency here in the states? They had a period where if it caused hallucinations or removed you from reality they figured they might be able to use it as a weapon of war. (Spoiler Alert: Not really, no.)

@@integral_chemistry on the scale of the things they were making and testing on people at Edgewood Arsenal, that stuff was relatively tame.

​@@integral_chemistryI cannot begin to fathom how terrible this would be. I sitting here after the video thinking it would be like being on Ambien for a month... I thought about how bad my ketamine treatment experiences lasting that long. Not I'm sitting here trying to comprehend datura for a month.. absolutely wild stuff. Thank you so much for the videos and comments.

LMAO that is the best way I've heard it described

Hahahahaha

Thank you so very much, that mans a lot. I worry often that the pace I go through topics is maybe too fast to the point of being confusing so I love hearing that is "hypnotic" because in a way that's what I'm going for. I love chemistry, and I get so entranced in the process that it sort of becomes this mesmerizing experience where nothing else exists for a little while. I try to channel this vibe through the very focused way I edit down the videos, which I'm very happy to hear you appreciate. I also love hearing about your interest in chemistry! Its a subject most people dislike in my experience, so its refreshing to hear people appreciate the wonder of it all.

The pace is great I wish I would have paid more attention in high school. 40 year pipefitter, no chemistry but, always did love it and was intrigued by it. I have a newfound interest in primer recharging which has fueled the desire to learn some simple synthesis for a few different labs that I will need. I'm in process of gathering equipment now. I have some really good chemists to lean on and ask questions to through a couple different groups. You guys are all top notch! Thanks again for the knowledge keep up the great work

@@magua1368have you seen the videos on nickel hydrazine nitrate? It looks like it would be a decent component of a primer composition.

Chemistry is one of those fields that really weed out the "ill-doers" believe it or not, the mad scientist that media portrays is a stock fiction character and nothing else. People with unmotivated malignant intent are usually addled by extreme emotion and are usually not the types to go through academic or technical education. The worst harm happens by accident, or gross negligence by administrative authorities. This is why you see most instances of mass violence committed with guns or garden variety explosive devices, and rarely with chemical, biological or radiological weapons. Media loves portraying violent anti-social types "the psychopath" as these smart, coldly calculating geniuses that hold dark secret knowledge that they apply flawlessly in the execution of sick fantasy or whatever, but real life criminally insane perps usually have very low cognitive capacity. The more intelligent ones are rarely found in violent crime or terrorism, but are the ones in business making life as a worker in corporate hell. The fear of the knowledgeable/literate dates back to early medieval times and has sadly been deeply embedded in our culture, people fear computer literates too, and respect their mechanic about as much as their dentist. Just had to point that out, dont fear the knower, the knower is likely why you survived childhood and enjoy a relatively peaceful existence :)

@@magua1368 get into it be careful have fun start small thats all you gotta start with to have a sometimes nice and at other times annoying hobby peace

Huh.. to be completely honest I've never considered that explanation before but it does make perfect sense. Also would explain possibly why the more reactive molecules (like pyridine) just smell bad instantly from the get-go

Glad to hear you were fine, that sounds terrifying.. You aren't kidding though, the sheer heat these type of reaction generate are honestly shocking and you really have to get it as cold as you possibly can (and even then expect the worst case scenario)

lol yeah tbh I'd prefer almost any other sedative to this stuff, seems like a real bad time compared to some of those others.

@@integral_chemistry Midazolam IV in the ER was top notch! 😱😂

even phenazepam would be better than this shit. great video nonetheless

I like to make every video a surprise that only rewards you if you actually take the time to watch to the end. I think its fun and a nice little way to foster continued interest (jury is still out on whether it'll work lol) And yeah I actually noticed the same thing.. I think its a "settling" due to the weight of such a large sep funnel on such a tiny ring stand. I did leave it overnight once or twice and it never failed, but it is still not ideal by any means. Think I'll probably bolt some bars to the inside of my fume hood for greater flexibility but also to support some of these heavier objects.

@@integral_chemistry I made a custom-made lattice inside my fume hood just to accommodate different clamps, I find setting up the clamp and stand every time quite annoying, stands are also prone to tip over which I am not a big fan of.

@DangerousLab thats exactly what I want to do, honestly I might have gotten the idea from one of your videos. Where did you source the metal bars you used for the scaffold?

@@integral_chemistry I didn't use metal bars, those are carbon fiber rods I got from Aliexpress, and the interconnection is made out of PP.

@@integral_chemistry Those are not metal bars, they are carbon fiber rods I got from Aliexpress, and the interconnections are made out of PP.

With a half life that long you might be right.

This is too toxic. I'm telling you, you really don't want to do that to yourself. Use tert-amyl alcohol if you gotta use some drug like this. Please be careful with the dosage.

Would have been good for the 6 weeks I was in rehab. Zero sleep for 3 weeks.

@@stringlarson1247 It's a shame that rehabs try to detox people as quickly as possible. I suppose that's mostly due to insurance, and an ethos among a lot of people that addicts should suffer, and this mistaken idea that the most important thing is to get someone as drug-free as possible as quickly as possible. Are you talking about detox from methadone or something else? There isn't anything this does that other, better drugs don't do. If you really need something other than a benzo that lasts forever, phenobarbital is better. But a long-acting benzo is probably fine, in which case they could use librium or tranxene or valium. They usually just go too fast. I don't understand it. It's sadistic.

@@stringlarson1247 What were u detoxing from? There's a reason this isn't available as a pharmaceutical AT ALL. Barbiturates are still on the market because there are still reasons to use them. Almost no one ever prescribes them (except phenobarbital and the one in fioricet, I forget the name), but they are still important. Sometimes alcohol itself is used to manage alcohol withdrawal in hospitals, even (usually along with something else).

Tbh I doubt it would even work for that. The whole time you're drugged you're just kinda unable to speak properly or comprehend anything around you

@@integral_chemistry sweet jesus, "too toxic for Saddam." think about that.

you're thinking of sodium pentathol and it doesn't make you tell the truth you can even confess to things that never happened so it's worthless for interrogation,there was once a case where the police went looking for bodies a person claimed they buried in central park NY and there were never any bodies they just implanted the memory.

These types of hypnotic sedatives would likely render the person a deadhead and rather irritable as well similar to the first generation antihistamine like phenergan - horrible in large doses and even worse in even medium ones.

Lmfao

Thank you very much for checking and letting me know! Also I don't have any idea why it keeps hiding your comments, I almost want to ask youtube support on Twitter why that might happen. In any case I hadn't tried the ammonium ion test yet (only read about it on Wikipedia). I also didn't realize until working with it just how EXTREMELY sensitive it is to magnesium ions. It's to the point that when diluted in a sufficient quantity of tap water it is certainly more blue than violet, and when I added 2M magnesium sulfate to a freshly-prepared alkaline sample of azo violet, I got a thick blue precipitate.. which I can't remember whether or not you mentioned in your video. The intensity of the colors with this one are actually such that it's hard to get good footage, and in all honesty I might just be using to much of the azo dye. This stuff seems like a little goes quite a long way

I'm assuming a pill to be honest I'm not entirely sure. It still has limited uses these days but the concentration is so low they do just dissolve it

Thanks man!

Honestly I'm shocked it took me so long to get around to this one. Very straightforward and satisfying. I'm a big fan of any organic reaction where the products have vastly different properties than the reagents (especially a vastly different smell)

@@integral_chemistry that’s how I knew I succeeded was the smell. Ofc the chcl3 I used was made from pool bleach and was not distilled before using it for 2nd step. Sample prolly had sodium acetate and KOH impurities even tho I tried to remove KOH via filtration. Chlorobutanol is hard to store it likes to sublimate on the lid of the jar I put it in.

Right? Super unique and pleasant smell (at least at first)

I will definitely be saving this! Thank you so much. Crazy how many azo dyes there are, might see how many I can make with what I have lying around

its honestly a classic

Ooh honestly this is one of the more feasible ideas I've heard. It is unfortunate that with chemicals like this that have clearly better alternatives, nobody is ever going to really bother with clinical trials at this point and so we can really only guess at the biochemical mechanisms for such things

@@integral_chemistry went to college for pharmacology and it reminded me of other halogenated hydrocarbons beyond the basic 2 carbon structure that would be more volatile and certainly not aromatic

lmao I feel that in my bones. TBH I think I could manage a one month nap no sedative required

Yeah.. that's something I need to do more often in general. I hate using chemicals unnecessarily, but salt is literally dirt cheap lol

@integral_chemistry I hope a 1/4 cup of salt won't break you.. lol. You can always recycl the salt.

Hm so maybe I wasn't using too much.. this stuff is just STRONGLY pigmented. As a side note I made para red as well and I want to try using it as a fabric dye, but I read that in order for the dye to be permanent it needs to be coupled with phenol or aniline. You know anything about this?

@@integral_chemistry Yes, azo violet is a fairly rich dye. The reference to phenols and amines refers to the coupling process itself and does not indicate an additional work step for fixation. I have to admit that the last time I dealt with textile dyeing was in my senior year - that was over 30 years ago. So here is a translated text from one of my school encyclopedias at the time: Developmental coloration: In contrast to direct dyes, developing dyes are created on the fiber. They are often azo dyes. Two components are required for their production, namely an aromatic as a coupling component and an aromatic diazonium salt. The coupling component is dissolved in a basic, aqueous medium. The fibers, which are mostly cellulose fibers, are soaked with it and then dried. They are then treated with the diazonium salt solution. The coupling reaction that creates the dye therefore takes place on the fiber. Like the vat dyes, the developing dyes are not water-soluble and therefore very wash-fast. Naphtol AS (3-hydroxy-2-naphthoic acid anilide), a derivative of naphthalene, is often used as the coupling component, which is why it is also referred to as naphtol-AS dyes. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.

@@integral_chemistry The mention of phenols and amines does not mean an additional work step, but rather the well-known coupling reaction itself, which must take place directly on the textile and thus leads to a wash-fast color. For your coloring with para-red this means that diazotized 4-nitroaniline and β-naphthol would have to be coupled directly on the textile.

@experimental_chemistry oh really? Huh so I'm guessing two different dilute baths? Does order matter?

@@integral_chemistry The concentration of the developer solutions influences the color depth of the dyed textile. Here are instructions for dyeing with Para-Red: Solution A: 10 ml diluted sodium hydroxide solution, a little beta-naphthol. The dyed material is immersed in the solution. Solution B: 25 ml water, some sodium nitrite, some p-nitroaniline, 10 ml diluted sodium hydroxide solution. The solution is cooled to below 5 degrees Celsius and then 25 ml of diluted hydrochloric acid is added until it turns yellow. The dyed textile is then transferred from solution A to solution B. Following these instructions (I dug out my notes that are over 30 years old) we dyed T-shirts in our senior year of high school chemistry class (of course the amounts of the solutions were adjusted accordingly). The instructions are probably universally applicable. Depending on the desired dye, the phenol and aniline components can be exchanged accordingly.

I could check it out! It would definitely be much more complex, but my main concern would be with legality. I'll check first to make sure it wouldn't get me in trouble but if it clears I'd love to give it a try

Oh yeah I had considered that possibility. I didn't use that email to set up the account, but for security reasons I'm considering setting up a third email just to be safe.. I always underestimate the willingness of bored idiots to hack into people's accounts just to make their lives miserable

That is definitely possible, honestly probable. I'm convinced there are definitely multiple side reactions going on here, not least because after the formation of the deprotonated version of the chlorobutanol, there a big chance that free oxygen just displaces a chlorine and closes in a ring with the adjacent carbon

Hmm ill definitely look into it. I'm pretty sure legally that would be fine, lately the big concern is not getting stuff removed by youtube's AI. Lots of things like that get auto-flagged

@@integral_chemistry Awesome. I appreciate it. Hopefully RU-vid's robot army leaves you alone.

Thas chem. Bio would be flinging plague rats.

is someone gonna tell this guy about TATP?

@@user-tx9so7om5t that's not a bioweapon that's just homemade explosives

Thanks! I did wrap up the azo violet a few weeks ago, but I've just been too busy to do the voice recording and editing. Likely have it out within the next week or so. BTW I read that azo violet gives a color change with ammonium similar to the blue color change with magnesium. Would you happen to know anything about that?

​@@integral_chemistry No, but I will try it out and report about it. Ammonium often is a disturbing ion in analytics, so it has to be driven out beforehand by boiling the test substance with sodium hydroxide solution.

​@@integral_chemistry Since this platform is ghosting my answering comments I have to answer via my German channel account:

Huh I've never heard of that before but definitely worth looking into. I know you can make barbituric acid from malonic acid (which does occur in apples) and urea (which is definitely in pee lol). I'll have to check it out and see if its feasible

😬

I’ve used sodium hydroxide and had no problem with it. I doubt sodium carbonate would work.

Yeah sodium hydroxide would work fine, I just used the KOH because it tends to dissolve easier in organic solvents. Carbonate aren't alkaline enough for effective deprotonation though

I doubt it would be using this route, and I can't find any literature about it. May indeed be possible by another route, but fluoroform is really hard to work with (boils at like -80 degrees) and deprotonation wouldn't work due to the extreme electronegativity of fluorine. Also thank you very much! I was worried people wouldn't care much for this vid

Not by this route, also the end product would act like an acid more than an alcohol because fluorine is pretty greedy for electrons. 😂

I didn't add any to make the chloroform, bleach already contains a good deal of hydroxide to keep it stable over long periods of storage

Yeah youtube is not a particularly flexible platform.. and this guy doesn't sound very scientific. As scientists we are supposed to relish in and rely on other people out there with the knowledge to point out our mistakes. Can't imagine how boring science would be if I knew everything about everything and nobody out there knew enough to challenge me..

@@integral_chemistry The creators on this platform are mostly not interested in scientific discourse, but rather in being soldiers of fortune and cultivating vanity. Accordingly, openness to criticism is weak. People like us, who see mistakes not as a personal flaw but as an opportunity to grow professionally, are the exception here.

@@experimental_chemistry I have noticed that to be the case unfortunately. It is to the point that I've had several commenters on here surprised by how open I've been to their critique because they've come to expect hostility and defensiveness. Its honestly quite sad considering how valuable an open discourse could be in the RU-vid chemistry community..

Yes, you bubble Cl through it and then reflux to drive off HCl and hydrate if necessary to form chloral hydrate

Huh I'll have to give that a shot. Not like I had any other ideas of what to do with this stuff lol

@@integral_chemistry first, try to find something in literature

Hm.. I'll have to ask him about that. Potassium hydroxide is so crazy soluble I didn't consider that a possibility, especially since it has to dissolve to react in the first place. Never know though, definitely worth looking into.

@@integral_chemistry I think it’s one of those things where, it’s not super soluble in organic solvents, but moreso, it’s driven forward by the higher solubility of the product relative to the hydroxide. Also, it would make a lot more sense as you saw in your mechanism. No formation of carbines or loss of product due to some weird side reaction. I suppose also, you could filter it, dry it out and see if it’s hygroscopic, or reacts with something like calcium to make calcium hydroxide, which wouldn’t be the case with potassium chloride.

It's either KCl or a KHCO3/K2CO3 impurity from CO2 uptake by KOH.

@@toseltreps1101 I really don’t think that could be it just by how much there is. If you look at the equation, hydroxide is regenerated, so it would make sense that’s what it is. Also, in basic medium, conversion of KOH to K2CO3 doesn’t usually happen that readily and that quickly

@toseltreps1101 also, as I stated, you could easily determine if it was potassium chloride by washing it well, drying it, redisolving it in water and adding calcium chloride. That would precipitate calcium hydroxide if it was just powdered hydroxide, but nothing would happen if it was potassium chloride.

​@@GH-jl2tdOnce the graphic switches to bromine as the halogen it proceeds all the way to bromoform.

Yeah my bad. Bromine is much more often used in this reaction and so the general mechanism I used shows bromine instead of chlorine. I made a note about it on screen but it's quite small

Mines’ took three booths at the China Buffet.