Making Schizo Powder (PCMO) 

WE'RE MAKING IT INTO THE MENTAL HOSPITAL WITH THIS ONE

Three out of four wall voices agree that PCP is the best.

I think they should invent a kitchen knife that doesnt whisper

The voiceover of you saying: "It wasn't an issue and the condenser kept everything inside" while we can see a column of liquid rising in the liebig condenser was extremely funny. We really like to play down near-misses on accidents.

I absolutely love how this guy casually makes HCN as a biproduct and doesnt bother putting any disclaimer. Btw love your content 😘

Just seeing 3 rings arranged like that screams “I will fuck you up”

We making it on the watchlist with this one🎉🙂‍↕️🗣️❗️

I can still remember watching myself, from the street corner, riding a bike, while riding a bike and watching myself on the street corner..... Don't smoke angel dust, kids..

Making [REDACTED] powder, only on RU-vid!

we all are waiting for you to make legal meth analogue

I’ve never liked people referring to psychedelics or dissociatives as “psychotomimetic.” Veeery early on in their discovery, some scientists did kind of dismissively assume “Oh, LSD is altering your consciousness in this extremely complex & hard to characterize way… This must be what it’s like to experience psychosis!” But this is a profound mischaracterization, which is why (at least for most 5HT2a receptor agonists), it’s largely been dropped as we’ve come to understand both psychotic mental illness AND psychedelics better. The fact that people are still inclined to talk about PCP this way probably has more to do with media sensationalism than anything (though I’ve never done PCP & can’t say for sure)- from what I’ve heard it’s really just more stimulating than other dissociatives & therefore not suitable as a tranquilizer/anaesthetic. Beyond that difference… Like, sure, there are people who freak out & have mishaps on it, & I’m not saying people necessarily should be using it, but people freak out & have mishaps on too high a dose of all kinds of things. That doesn’t necessarily mean it was truly comparable to psychosis. I think psychotomimetic is a perfectly reasonable label for deliriants, & really that they’re the class which should’ve been labeled this way from the beginning… Completely hallucinating whole scenarios/people/conversations/animals/shadow people/etc. that aren’t there; hearing schizophrenia-like voices in your head; extreme fear/paranoia; extreme confusion & disorientation/disconnection from reality… These are the very psychosis-like symptoms of deliriant poisoning, or having intentionally taken Amanita Muscaria mushrooms, or diphenhydramine, or whatever- terrifying, awful, nightmarish stuff which I strongly suspect TRULY comes as close to simulating what a psychotic condition like schizophrenia as any chemical can induce… There’s not much else to it- those are the primary effects. You JUST feel like you’re losing your mind & living in a waking nightmare. On the other hand, dissociatives have considerably more interesting content to them, & far fewer of the truly psychosis-like symptoms. I’ve rarely heard or someone taking ketamine, or MXE, or DXM, or even PCP & legitimately hearing terrifying whispering or screaming in their head for hours they they just couldn’t shake off (whereas I’ve heard of people taking Amanita Muscaria extract 1 time in not that high of a dose & experiencing those kinds of symptoms for DAYS or WEEKS afterwards). You don’t have true hallucinations or dissociatives… You may have beautiful closed eye visuals, but that’s quite different from a nightmarish waking dream state where you literally don’t know what’s real & what’s not. I’d place dissociatives more as a middle-ground, because they do have a tendency to induce some delusions (usually just during the experience, which is why the issues mainly come about in cases of addiction/dependency, where someone is taking them all the time & never getting a breath of air from that state & assessing their experiences from a more lucid, rational perspective). Classical 5HT2a agonist psychedelics, IMO, are the farthest from “psychotomimetic” of any of these. I think it really was just ignorance that led to this labeling for LSD & psilocybin & the like early on; keep in mind that it was being applied so early on that we were only just even learning that serotonin had anything to do with mood/behavior- in the very earliest days of the discovery of LSD & it’s effects. It’s very much a vestige of an impoverished earlier state of psychopharmacological & psychiatric research. The effects induced by psychedelics like these may seem very chaotic & overwhelming, especially to the uninitiated, to someone who didn’t know what they were getting themselves into, or to someone who takes an excessive dose for their first time & plunges in deeper than they’re ready for… But upon the kind of deeper inspection that mystics & shamans have been giving these experiences/states for ages, & the kind that psychedelic scientists & “psychonauts” have more recently devoted themselves to, there’s actually a profound & beautiful order to that chaos; the fact that it’s unpredictable & too complex for our minds to easily put in a box, to reduce & identify with some very simple pattern or experience we’re familiar with, doesn’t mean that it’s actually untethered from reality or random or meaningless or in any way equivalent to symptoms of psychosis. And especially as classical psychedelic doses increase (besides n,n-DMT, which seems to go in exactly the opposite direction), you move towards boundary dissolution & ultimately full ego-death & mystical experience… Which is quite wildly different from any kind of psychosis. There’s really no comparison. If anything I think it romanticizes psychosis to compare it to something as favorable as psychedelic experience. Even in the fringe cases where someone has a predisposition to mental illness & psychedelics catalyzed the precipitation of a psychotic state, the psychosis it precipitates is going to be very different from the psychedelic state itself.

Dissociative substance synthesis in a chemistry youtube channel? We're truly living a eventful decade

You do not expect to see a full Arylcyclohexylamine synth every day on RU-vid, good shit

This is some groundbreaking shit in terms of youtube chemistry, love to see it and also that you explain your mistakes so us chemists can learn from them and not make them ourselves

Congrats on 100k!

I know when mixing insoluble powders with liquids (cocoa powder + soy milk) I add a very small amount of liquid to the powder initially to wet it so it does not clump up (then I add the rest of the liquid). In your case I say use a pre-made solution of base since the base is soluble. I assume your base clumped up and got coated with something that prevented mixing.

I dont know why i expected a taste test at the end of this

From an average person's perspective, it simultaneously looks like suffering and like some sort of dark magic. I actually appreciate that you post videos even though it's not a complete success.

When I (didn't) do it, I used potassium cyanide to form the nitrile intermediate instead of the sulfate. I'm guessing using morpholine, you have to form the sulfate first? The phenyl grignard reacts directly with the nitrile to give you your product arylcyclohexylamine, if you use piperidine. The first sulfonation step wasn't necessary for that.

Nothing quite like a good dissociative anaesthetic synthesis in the morning to begin an excellent day!!! Cheers for Chemiolis!! and for H Morris

I typically use the "dissolve the NaOH in H2O first" trick exactly because of situations like this. Even finely-prilled NaOH takes forever to dissolve and change the pH of a solution.

It's not surprising that you had the problem with the base not dissolving. It makes a basic solution immediately around it which causes the product to precipitate onto it. Next time, dissolve the base before adding it and you won't have that issue

awesome video, this was informative and quite funny that you could skirt regulations just enough to post this. I am just curious why you chose this route? as opposed to higher yielding cyanide free methods using para toluene sulfonic acid and azeotropic separation of water, do you not own a dean stark trap?

I happen to run a shop that has a lot of ex-convicts, and I get to see all their criminal records. Though PCP may not be nearly as prevalent as meth which causes many more problems due to how common it is, PCP easily takes first place for "most likely to cause a violent crime". It's disproportionate, really. Terrible drug.

I’m no stranger to fun substances but never have I ever come across this fancy molecule available for exchange.

"Coz it's trash" Yeah it really is. A very solid analogoue for ketamine in 4-MEO PCP. Same dissociative anesthetic effects, but has a much longer effect with greater chance of hallucinogenic effects. It is very difficult to be mobile once ingested, which isn't great if one has anything to do for about eight hours

Me: buys toluene DEA and ATF: rock paper scissors shoot!

Hamilton Morris is definitely watching this

Pcp is fun, peyote is better though, .... but you want to know a secret. You can either golden orb spiders and eat them for a strong hallucinogenic effect. I also hear some snake venom does the same If you could isolate what ever compound that it, it might be 100% legal. But as a person with schizophrenia myself please understand schizophrenia is not just hyper mania, I mean yes that's a part of it, but schizophrenia is so much more. It's a huge spectrum.

you know it might be good when youtube/google gives one a "please get help" type of message

WHERE GETING ARESTED BY THE FEDS WITH THIS ONE 🗣🗣🗣🔥🔥🔥

The medicinal chemistry stuff is extremely interesting! Keep it up! Did you keep the aqueous layer from that neutral solution at the end? If so you easily could have remedied the error, and included the result in the video. All well. Is 5-MeO-MiPT controlled in the Netherlands? If not, that could be an interesting project. You could start from melatonin by conversion into 5-MeO-Tryptamine. Then reductive alkylation with one molar equivalent of acetone, and an excess of STAB-H (prepared ex-situ from borohydride, and 3 equivalents AcOH in THF, or DCE). Followed by the reductive alkylation with sodium hydroxymethylsulfinate, excess Et3N, and STAB-H under similar conditions. Both reductive alkylation reactions can be conducted in a one-pot operation. I think doing these reactions in that order is absolutely necessary to avoid formation of the dimethyl substituted product due to the steric bulk of the isopropyl group. For the same reason, the formation of the diisopropyl product by a second reductive alkylation is unlikely to occur. Furthermore, while this compound is certainly active, I don’t think 5-MeO-MiPT has much value recreationally. If I’m wrong the use of succinaldehyde to give 5-Methoxy-N,N-tetramethylenetryptamine (5-MeO-pyrrolidyltryptamine) would be an interesting alternative. The methoxy group could also be swapped for an ethoxy, or similar group by starting with 5-hydroxytryptophan. Thus, decarboxylation to serotonin, protection of the amino group as an amide (or carbamate), Williamson ether synthesis to give the desired alkoxy group, deprotection, and finally the reductive alkylation sequence would give the desired analog. This gives a large degree of freedom to design a compound that is certainly inactive. For example, 5-Propoxy-Pyrrolidyltryptamine; there’s no way that is active, so it could make for a cool project without legal worries.

Dissociatives make me feel like im not real.

Ketamine is extremely interesting when you research how it acts in the brain and how it acts on deleting trauma based memories causing instant depression relief

You had me at "subscribe for better yields"

I really love PCP Analogs, especially O-PCE or 3-MeO-PCE

Last extraction you could perform with dcm It nicely dissolve organic bromides But not toluene Then drying, turning back to bromide and recrystallization from EtOH That should work

A guy I went to HS with in the 1970's that never did anything but drink decided to try "drugs" by doing a big line of PCP. I remember being at that party but left before anything f ed up happened. Somehow he got home that night and was freaking out and his parents called the rescue, but two cops showed up also. He was trying to fight the cops and from what they said he tried to grab one's gun. (Back then the cops weren't psycho like they are now). He ended up in a locked ward in a mental hospital for about a week. He told me he went nuts when he was at home in his room and the giant mice attacked him

When do the 200mg samples drop @ the shop? ;)

The way you drew that ketamine structure made me angry. Liked and subscribed.

4:03 *casually*

Whenever you're saying "phenyl" I hear "fennel" which is kinda funny and I can't unhear it, sorry ^^

Wheres the taste test at????????

PCP has newer been popular here in Europe.mainly because it produces relatively low euphoria and huge hallucinations

DISSOCIATIVE ANAESTHETIC GANG

this is like an extractions and ire video

noice

“‘Schitzo powder’? What could this possibly be-“ “Better known as PCP” “HUHH”

jokes on you i dont need drugs to have schizophrenia

WE'RE GOING TO LOOSE OUR MINDS WITH THIS ONE🔥🔥

PCP's fine and gentle, try 3-MeO-PCPy and rewrite that intro ;)

I was here before his lab got raided

What chemists see: A threeneck flask. What I see: A glass bagpipe

Now we just need a proper trip report from Chemiolis. There is no way that you didn't test it, and we know it.

That hcl salt may be moisture sensitive and also amount of solvent used was also more, hence yield was less Alternate method is that you can purge hcl gas to the solvent and take amine along with that solvent in another rbf, added hcl gas purged solvent at 0 to 5C, under nitrogen and filter it under nitrogen, dry it in vaccum oven

This is intresting as hell. Not because of the chemical being synthesized, but because the chemistry of it is fascinating.

What a time to be alive, where we have an online tutorial to make schizo juice.

Oh you poor bastard, you're never going to break your brain with yields like that!

Angel dust. The only medicine that keeps you alive after your dead. except your still dead.

This destroys the brain 🧠🤯🧠

Wait no way you are dutch too, Nice edic : congrats on 100k subs

Great video and synthesis! Love the content of making compounds of interest :) while casually making HCN as byproduct Just a few notes: - 4:55 Arrow to oxygen atom is redundant since lone el. pair moves to sulfur atom and is not conjugated with S-O pi bond system. - 5:06 Resonance not equilibrium (both structures describe the same molecule). Resonance arrow should be used instead. Congratz on 100k!!

I already subscribed years ago and the yields have not improved. I want my money back.

Detachment=Loss of Control

Generic Delsym chased with some DM cough gels always did the trick for me. Best yet, these products are legal to purchase, possess, and consume.

i don't know what i watched but it was stimulating.

yummy good job. this is my first video but i enjoy it ,hypes me up for more chem classes in the fall.

I added some to the kids formula, it actually calmed the little assholes down!🎉

you're the only one that can use the s word without it being offensive, i love you chemiolis

I have made it several times. It is fairly simple and easy. That is why it was so prevalent in the 70's..

*me half way through the work day*, "oh my God, they are here! They are here! Grab all of the fire extinguishers and follow me men, to war! Woohoo!" * coworkers*, "He has been in the pcp again"...

Never tried the original PCP, but I had an intense relationship lasting a couple of years with its cousins ​​3meo-pcp and 3ho-pcp

Good, now make a gallon of it. I need for my work downtown at an investment firm, mostly land acquisitions.

ive smoked loads of PCP, and ive never had what is called a "whack attack" but ive seen people freak the fuck out, strip naked, get hit with stun guns with no effect, ive seen people walk into traffic. they were indeed having a "whack attack" but every time ive had it i just felt really good, really high. kind of like a mixture of THC, nitrus oxide, and opiates. thats probably why its so addictive and why people keep doing it regardless of how crazy it makes them act. i think some people dont have the brain chemistry to handle the stuff because some people dont act any different and some people loose their minds.

GG on 100k subs! Huge milestone!

It's not always normal for the face of Christ to appear in a brick wall and tell you to break your own nose..... but on PCP it is.

6:53 *Forbidden Rootbeer*

I would have skipped adding acid, filtered out the excess magnesium, then went streight to base. You would get the cyanide back and have a cleaner pull of your free base. ❤

The first reaction was very satisfying.

For intiating bromobenzene, you dont want that temparature,with iodine it initiates at RT preventing what happend in heating

My popcorn ceiling is always very kind to me

You're doing gods work my friend. Someone has to, that lazy A-hole must be sitting at home all day watching "The Honeymooner's," because he been MIA forever now. Or maybe he just doesn't exist. Either way good job brother, keep up the good work...✌️

done too much dumb shit in my life to try something like this. scary shit.

I really want to learn to make the real deal so I can smoke dipped Rambo blunts

Makes me think of that time I was walking on a warm tropical beach, hand in hand with my beautiful wife. Then...the Angel Dust wore off and I realised that I was dragging a broken mannequin around a Wendy's parking lot

This synthesis is gonna kill you before you can make it to the end, if not properly trained. Great video and great demonstration of frequent chemistry issues in a life of a synthetic chemist.

How about inventing something that cures schizophrenia instead of making you feel like you have it. The world really needs that

PCP is a really nice buzz. It's way more chill than Ketamine actually, at least in the way it effects me. I don't like the K-hole & cold sweats that comes with Ketamine. PCP is more chill actually, it's euphoric and really good with $€×.

Time to figure out what Deleuze was always on about

A good old friend took out 2 vans full of coppers back in the 80s after a week taking angel dust on and off. He thought they were flies and he was swatting them away. He was definitely swatting something away. He was hospitalised for 2 weeks and got away with all charges except posession. I'd say that was a good day for him...

More arylcyclohexylamines!

PCP is an amazing drug

Stigma around pcp needs to end fr

Remember when Schulgin tested all the RCs on himself?

@chemiolis when will you be uploading the taste test? Can't wait to see that one 🎉😅

Ahh, brings me back to my wet lab days. Made a novel analogue of moramide once! Don't tell my supervisor :P

I guess I’m the only dummy to watch smart stuff on RU-vid and retain absolutely none of it.

Chemiolis has completed his transformation into sketchy gas station rchem bro

Dewey, this is PCP.. You don't want no part of this!

I wouldn't even want to be in the same room as any of these things.