A summary of the mechanisms and classification of antibiotics, with particular focus on penicillins, cephalosporins, carbapenems, quinolones, and aminoglycosides. A brief description of the discovery of penicillin is also reviewed.
Errata: @9:00 Aminopenicillins are NOT penicillinase-resistant penicillins. @15:52 As pointed out by a viewer, there should be a negative sign next to MSSA (at least here in the United States) due to the high rates of penicillinase production in Staph aureus. For example, MSSA is ~20% sensitive to PCN among patients at both Stanford and San Francisco General, which is definitely low enough to be considered inadequate. This may be different in other parts of the world.
I've discovered this video in 2013 during the residency and I still believe this is the best lecture on antibiotics on RU-vid to this date. The picture at 07:50 is very helpful for organizing different classes of antibiotics.
If it's the later, there are a couple of playlists on the main channel (e.g. antibiotics, EKGs, ABGs, cardiac auscultation, etc...). Hopefully, the playlists will seem more robust once I have posted more videos.
Thanks! I hope u r enjoying the videos! For the most part, my slides are created in Powerpoint. Simple diagrams/illustrations are drawn right in Powerpoint, while I use Adobe Creative Suite for the most complicated stuff. Slides are exported from Powerpoint as jpgs & imported into Adobe Premiere, where it is synched with narration that I've recorded in Audacity. There are certainly quicker workflows that can produce something superficially similar, but I find this one affords more control.
Thank you for your lectures and for including photos of the three scientists who won the Nobel Prize for antibiotics here, especially Chain. His kind, averted eyes seem so humble. I am glad he came to UK in 1933 and did not die in the camps like his mother and sister and undoubtedly like so many brilliant minds whose innovations we will never know.
Hari, I'm glad you are enjoying them. Regarding organizing the lectures into systems, do you mean the antibiotic lectures specifically, or all of them? If the former, I'm going to post some more videos in the next couple of days organized by type of pathogen (e.g. gram positives, negatives, anaerobes, etc...), and have a few supplemental lectures at the end of the antibiotic series on high-frequency sites of infection (e.g. lung, skin/soft tissue, GU tract, etc...)
Hi! [I'm referring to 9:00/24:20.] Indeed, Aminopenicillins are NOT referred to as the penicillinase-resistant penicillins. They DO NOT resist beta-lactamases. I'm sorry to point it out, but some viewers may get the wrong message, which can be a serious issue. Apart from this, the lecture is good! Concise and clear!
+Chau-kuen Chan Ugh. I can't believe that mistake has been there for almost 3 years... thanks for pointing it out. I've added an annotation correcting it.
This is helping me prepare for an interview I have coming up this week as a Supervisor in a Microbiology lab testing CRE INFECTIONS AND N. Gonorrhoeae surveillance project. Thank you for breaking it down in a clear way that is understandable. I found this to be a very helpful video to refer to.
I am resident of ICU from India...Sir,ur lectures of antibiotics really helps me lot..i n one word sir, u r awesome...thank u very much...thnx a lot for ur video
It's true that beta lactam antibiotics are generally bactericidal. They not only inhibit new cell wall formation, they also trigger autodigestion of previously formed peptidoglycans in the cell wall, which eventually leads to cell lysis. There are a couple of unsual circumstances when they act more bacteriostatic, but these are rare exceptions.
Thank you so much for these truly wonderful videos sir. Id really like to appreciate the immense effort you have taken to research and put together this data along with the great slides and animations
uitimate lecture ,everything is presented in a concise and crystal clear manner. It is easy to understand and all the important pont is covered without any excess.I give it 5 star.
i appreciate ur efforts to help the medical students all over the world .......good work ..DrErck. it would be more useful if the lectures are system wise organised(like cvs , cns.. etc)
This was fantastic, thank you for making it. Coming to the end of 4th med school year, approaching exams, I've realised that I don't really understand how antibiotics relate to each other, and I therefore have trouble remembering when to use them. This was very useful for helping me organise all the names I keep hearing, thank you so much!
Dear Dr.Drericstrong Thanks a lot from your helpful video you have download it to RU-vid and share it to all that the student can used it. I am A student bacteriology and this kind of video can help me a lot i am from Afghanistan but because in Afghanistan we dont have the master degree i have to continue in Iran so this can help me. thanks
I am currently watching all of your lectures as part of my FNP coursework. They are excellent and very easy to follow! I am wondering if there is a link to just the powerpoints so I can download those for the useful tables and images. Thank you so much!
I'm doing my presentation on antibiotics this wednesday,fingures crossed and I'm so glad i came upon this video cause I've been having trouble remembering them all (classes and mechanism of action and what note
Great lecture.find it really helpful .Antibiotic no doubt are miracle and life saving drugs but because we doctor sometime miss used over used and abused them bugs are becoming resistant.i am an antibiotic steward and i hope all of you are too.please upload a lecture on selection of appropriate antibiotic treatment with system based guideline it will be very helpful thanks in antecepation
thank u for the reply .. a system at one place for example cvs playlist with content of some imp topics like ekg, heart failure,hypertension ...etc i know its not a one day work ...it would take some time to get in to shape as u already said...but i wanted to share my views as Ur subscriber..thank u doc !!
I have other sources saying beta-lactam antibiotics are bactericidal agents. Though they do interfere with cell wall synthesis and inhibit peptidoglycan polymerization, it is said the pressure differential and the weakened cell walls cause the bacteria to explode. So I am confused whether beta-lactam antibiotics are bacteriostatic or bactericidal.
Thanks. An antifungal video is already in the works and hopefully will be posted soon. Antivirals and antiparasitic drugs will be a bit further down the road.
