Michael Addition

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More enolate stuff with the Michael Addition. Look out for tautomerization!
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Опубликовано:

22 сен 2024

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Комментарии : 108

@Jeffrey_Wong 5 лет назад

Your explanation of electrophilicity at 1:40 is so good! Really clicked for me.

@isabellesilva1102 6 лет назад

I was going crazy looking for organic chemistry lectures in Portuguese until I found you! You're the best chemistry teacher ever. THANKSSSSSS

@annawulfert36 9 лет назад

Dat Intro....stuck in my head forever...xD Thx

@shreya2864 4 года назад

I always sing with it xDDD

@curiouscat1487 3 года назад

@@shreya2864 same

@GigaLordShinyMudkip1 7 лет назад

I appreciate the efficiency you explain things. Thanks mate.

@5minchem563 4 года назад

Very easy and accurate explanation of 1,2 and 1,4 additions differences/similarities. Well done 👍🏻

@johncaruthers315 9 лет назад

professor dave grohl

@rambles2727 19 часов назад

Dave grhoul if he didnt cheat on his wife

@nicolasb3248 4 года назад

Huh...2 weeks of class in 5 minutes, and I feel I understood it 10x better! Thanks man! :DDD

@gracedemalona9197 8 лет назад

Just got yourself a new "biggest-fan" ! SO thrilled I came across your fabulous videos - so many things are much clearer now :-)) Thanx!

@sabrinahaque5672 4 года назад

Your videos have been great in helping me study for the MCAT. Thank you so much!

@PunmasterSTP 2 года назад

Did you take the MCAT already, and if so, how did it go?

@shreya2864 4 года назад

all these seniors from years ago feels good to be here! and thanks sir that was flawlessly explained :DDD

@youtubeuserlovesyoutube2207 3 года назад

Sir i just wanted to say that you are doing a great work

@iueiumiener160 8 лет назад

Your videos are very helpful and organized, keep up the good work. Thanks!

@shanemichael9011 5 лет назад

Once again, thanks Prof. Dave. Learning chemistry out of pure interest is one of the many oddball things I do. I had no idea until the other day that you had videos on astronomy. Pretty much taught myself that over 20 years ago. I said an astronomy type joke the other day to my daughter and of course, none of the family laughed. Except me. I told her she needed to finish cleaning her room before our Star moves out of its main sequence ! When I explained it to her naturally she didn't laugh !! I try to joke like that with her in an effort to get her more involved with science. It works, sometimes ! 😉

@puppyteacheshindi-didithed7077 2 года назад

This comment made me smile

@PunmasterSTP 2 года назад

Michael addition? More like "Amazing if you listen!" Thanks for putting together such high-quality and easy to listen to videos.

@SillyGeneva 5 лет назад

The marker sound is so asmr

@djennings-DDS 6 лет назад

Thanks Dave!

@jenzzzzz 7 лет назад

I have a final exam in 3 days and I just learned it in class but didn't understand it. Thank you so much for the help

@PunmasterSTP 2 года назад

I know it's been awhile, but how did your final go?

@max97s1 6 лет назад

Thanks Professor Dave!

@SWEETHEARTHEREFORYOU 9 лет назад

thank you for this video ..its done perfectly

@anjansaha4357 5 лет назад

very very thanks from India. So clear explanation🙇🙇🙏🙏

@gargitripathi6331 3 года назад

Thank you so much sir

@SaurabhKumar-ud7sj 6 лет назад

Great explanation

@songohan393 2 года назад

Lets donate for this man

@badashby 3 года назад

Question Dave: Why would you go to a more energetic bond? Aren't lower energy molecules favored?

@somakavittalkothakota4102 Месяц назад

Here, by energy he meant bond dissociation energy, not the potential energy of the molecule I think..

@camilacarolina388 8 лет назад

Amazing! Thank's from Brazil :)

@vinodshuklaMSc 6 лет назад

Camila Carolina , are you from Brazil?

@neelarghyakundu1942 4 года назад

@@vinodshuklaMSc no

@mamnoonraza1429 8 лет назад

Thank you!

@cbort8223 9 лет назад

Great video, just have to be picky with what you said at 3 20...the keto form does not have more energy in the bonds, in fact it has less since nature proceeds toward forming the most stable, therefore, least energetic state...I think you knew this but just misspoke.

@ProfessorDaveExplains 9 лет назад

C Bort ah yes, more as in more energetically favorable would have been a better phrasing.

@paftaf 5 лет назад

Yes. Thanks for the clarification

@myprettygirl91 6 лет назад

great explanation!

@isaacmudau5589 9 лет назад

You good hey.....Graphics, Audible, I can't wait to watch more of your videos

@pontusgeorgsson4339 Год назад

Great stuff, as always. Go Dave.

@fredmartinez9866 3 года назад

awesome explanation prof

@sukainaalherz3554 9 лет назад

you are such great professor....thank you very much for this video you just make the subject as piece of cake for me...

@jonassimon7061 7 лет назад

Thanks from Germany!

@maheepalkumar3725 5 лет назад

very helpful

@douglasdvs1997 6 лет назад

Parabens!, m from brazil and here, we dont have videos like yours. Thanks

@chaunguyen761 4 года назад

Thanks professor Dave. I’m glad you went into the theoretical reason why the beta carbon is targeted.

@ghazalfallahazad3376 Год назад

thanks

@ashahersi8599 9 лет назад

thanks alot, this was an awesome video

@prasadkulkarni7686 5 лет назад

Please explain abnormal Micheal reaction mechanism

@limegreen793 9 лет назад

Thank you!!!!!

@mye7381 Год назад

My english ist realy bad... But i understand the most. More then i expected.. thanks

@IutubRider 8 лет назад

Thanks!!

@prathameshwagh5503 3 года назад

It's a Game Of thermodynamics Game Of Thrones 🤣

@hamedhosseini4938 7 лет назад

You are a man, you are a legend

@justuswolf5551 2 года назад

Omg i LOVE Professor Dave. I mean how pretty funny is the intro?

@azadprasad856 5 лет назад

The site of nucleophile attack is changed due to alpha beta unsaturation . Is it that if we use strong nucleophile such as RMgX, the site will not be changed ?

@CraziiBOY504 9 лет назад

this is great ty!

@songohan393 2 года назад

thanks alot

@maelviolette7698 4 года назад

thx from france

@newspace050 4 года назад

How is the stereochemistry of this going to work? I'm having a hard time figuring it out with the carbonyl on the 4. I was at these notes (14.1B: Stereochemistry of Michael additions and β-eliminations) from Chem LibreTexts, but it's still not clear to me.

@korangalalita1229 6 лет назад

Thanks sir

@rupeshknn 5 лет назад

why does the enolate prefer the beta site to the carbonyl carbon?

@babysinsfreefire4127 4 года назад

love from India

@freeenergy7189 6 лет назад

could u pls make video about amines reaction and synthesis ?

@entertainingfootball4871 5 лет назад

Thanks from India

@ellisraduenz6724 2 года назад

Does the spatial distribution part hold true even in cyclic structures?

@paulsren5800 4 года назад

could you use a cyanid instead of a enolate?

@souma2943 6 лет назад

thanx

@ranjanpaudel698 6 лет назад

ur lecture is always awesome and informative as always ..bt i thing u might have misspoken about the energy related stuffs...btwn ketone and enole type arrangement

@ProfessorDaveExplains 6 лет назад

How so?

@ranjanpaudel698 6 лет назад

isnt it ..the one with more energy are less stable and less likely to form......in the case of keto and enole typ configuration ...u told that enol typ structure tautomerizes to give more energetic keto form.....or i m being dumb.. haha.....if u could help me out with that.......thank u ser..

@ranjanpaudel698 6 лет назад

@3:15

@ProfessorDaveExplains 6 лет назад

the keto form is the more energetically favorable, so that form predominates.

@rassimsimou1594 10 месяцев назад

Good

@ThuyPham-gf3ez 6 лет назад

is this also the mechanism by which thiol-reaction with C=C bond on maleimide?

@vasuaggarwal9740 3 года назад

Isn't there hydrogen bond possible? Like product formed as enol shouls be more stable in my opinion. Can anyone confirm ?

@ProfessorDaveExplains 3 года назад

bond enthalpies are more significant

@monad1580 8 лет назад

Hi, for the product why didn't you count the carbon on the most left as the 1st carbon and the carbonyl carbon as the 2nd carbon?

@ProfessorDaveExplains 8 лет назад

it's just a relative numbering scheme, in this context we consider the nucleophilic carbon number 1, and then count over to the carbon where the new functional group is, so it's a 1,4 addition. this is unrelated to IUPAC numbering.

@monad1580 8 лет назад

Thanks. Love your videos a whole lot!

@wrednykocurek 3 года назад

everything cool except u cant tautomerize like that, 4 membered ring will be formed in transition state, thats wrong... to high energy

@ProfessorDaveExplains 3 года назад

I have no idea what you're referring to, the tautomerization has nothing to do with ring formation.

@htatr09 8 лет назад

hi thanks from Turkey, peace :)

@asiapetitte6059 5 лет назад

so in this case would the keto or enol form be more stable? would it be enol because of hydrogen bonding?

@ProfessorDaveExplains 5 лет назад

Almost always keto because of bond enthalpies actually, but there are times where the enol tautomer is preferred, such as when it is aromatic.

@inyourdream309 3 года назад

Could u plz do a vid about ATRP🙏🥺🥺🥺

@songohan393 2 года назад

did I say thank you yet, ups yeah I did

@ishmeetsingh1146 5 лет назад

Prof m confused help me out If m given ketone/aldehyde having at least one alpha hydrogen I have to do Aldol condensation or Michael addition ???

@ProfessorDaveExplains 5 лет назад

those can act as enolates in either reaction, it depends on what else is in there.

@gregmosier5908 8 лет назад

Don't recall you talking about 1,2 with the adols and now I can't follow this. I do recall hearing about the 1,2 vs 1,4 in class, but lost on it now :(

@ProfessorDaveExplains 8 лет назад

+Greg Mosier the key is the double bond between the carbons that are alpha and beta to the carbonyl on the electrophile!

@gregmosier5908 8 лет назад

+Professor Dave Explains I found what it was that I was recalling from my course. It was addition to dienes where 1,4 addition is thermodynamically favored and 1,2 is kinetically favored.

@ProfessorDaveExplains 8 лет назад

+Greg Mosier ah yes, 1,4 thermo because it usually results in a more substituted double bond and therefore a more stable product, whereas 1,2 kinetic because there will be a lower activation energy associated with a nucleophile approaching the edge of a molecule due to sterics.

@cl8926 8 лет назад

Hi, What does delocalizing the side of electrophilicity mean?

@ProfessorDaveExplains 8 лет назад

+Carol because 'Murica if the site of electrophilicity is say, a carbocation, if that positive charge is delocalized because of adjacent pi bonds, then the site of electrophilicity, or the location that a nucleophile would attack, will also be delocalized, because the electron deficiency is not centered at one location.

@cl8926 8 лет назад

+Professor Dave Explains oh ok, thanks! :)