Nattokinase: Plaque Reversing Supplement, or Biased Science?

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Full Analysis: • Does Nattokinase impro...
References [Copy & Paste DOI into Search Engine]
[1] doi:10.3390/nu15194239
[2] doi:10.2147/IBPC.S99553
[3] doi:10.1291/hypres.31.1583
[4] doi:10.3389/fcvm.2022.964977
[5] doi:10.1089/jmf.2019.0183
[6] Lipid-Lowering Effect of Nattokinase in Patients with Primary Hypercholesterolemia (No DOI)
[7] doi.org/10.3233/CH-211147
[8] doi:10.1039/c8fo02324g
[9] PMID: 19786378
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#nattokinase #heartdiseaseprevention #heartdiseasetreatment

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9 июн 2024

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Комментарии : 565

@Physionic Месяц назад

No Amendments, currently. (But I probably still messed up the pronunciation)

@mballer Месяц назад

Nah toe. Naw tow.

@MemoryAmethyst Месяц назад

Please do one video that is just a stand up science comedy routine. You underestimate your comedic chops.

@hctim96 Месяц назад

Really mess up the verbal police and call it NANO kin-a-see😜

@LithaMoonSong Месяц назад

I use it to stop blood clots forming, which given the new white clots which are mainly fibrin that form from either Covid or exposure to Covid vaccines, makes a fibrinolytic very attractive as a supplement in our post pandemic world. If you doubt the existence of white clots, you have not been following Danish or Japanese pathologists who are studying them.

@OnlyKaerius Месяц назад

@@mballer Naht awe.

@concernedpatriot.2221 Месяц назад

I’ve been taking 8000 FU’s of Natto for approximately 1.5 years. I have cardiovascular disease and I’m checked regularly by my cardiologist. I do an ultrasound one year and a CT scan stress test the other year. According to my doctors, my blockage in one artery has diminished greatly, I went from an estimated 60% blockage to now a 30-40% blockage. I’ll never stop taking Natto.

@BushyIV Месяц назад

Would you name the product you take for Natto?

@concernedpatriot.2221 Месяц назад

@@BushyIV Zenavea nattokinase 2000FU from Amazon. Which I could provide a picture. Black. Bottle

@garypierce7380 Месяц назад

Thanks...that's what I've been taking for two months or so. I'm not aware of any studies where people have taken over 6000fu, but everyone taking a higher potency seems to be benefiting.

@biggoldsun1852 Месяц назад

Did your cardiologist approve of this supplement for you?

@carolmcdowell3783 Месяц назад

⁠

@jedwards1792 Месяц назад

Today I learned that an FU is an actual unit of measurement.

@arnoldm5891 Месяц назад

🤣

@hamidaabdenour9092 Месяц назад

hhhhhhhhhhhhhh

@RobNokes Месяц назад

Fecal Units

@RagdyAndy Месяц назад

I measure people with 2

@Cineenvenordquist Месяц назад

Yo Japan Supplements Industry, fix us up! FU? Pay me!

@rick13953 Месяц назад

Came for dashing good looks. Stayed for the cruel mistress that is science

@Physionic Месяц назад

You have a low bar for what you consider “dashing good looks” 😂

@Cas3620 Месяц назад

@@Physionic😂 I had to comment on your reply. Seriously, I watch you because you resemble my younger brother who departed this world in 2009. So you make me smile because your sense of humor reminds me of him as well. ❤

@madelinedelvalle3666 Месяц назад

@@Physionic Hey buddy, I beg to differ😁 you're a little stud muffin! 🙃

@mysty0 Месяц назад

@@PhysionicI'm an old man now, and you're a good looking lad. One day you will be old too, and you will look back on photos of yourself and appreciate how good looking you were.

@Rachel_2112 Месяц назад

Nah. You're cute. And you know it. @@Physionic

@hughb5092 Месяц назад

I started taking Nattokinase (6KFU) about seven years ago. After taking it for 5 years I had a calcium score done. My cardiologist was adamant that supplements have no effect on atherosclerosis. He was shocked when my score went down! Yes it was mild, but going down is better than up. I've been taking 8KFU for the last 4 months and will bump that up to 10K.

@Vinsue96 Месяц назад

I have not seen a cac go down?? Which company do u order your supplements?

@hughb5092 Месяц назад

Dr's Best 2000FU ...My score had a modest reduction, which as my Cardiologist had mentioned that at the least, I had stabilized the plaques.

@Vinsue96 Месяц назад

@@hughb5092 ty!!

@ohbaby-baby Месяц назад

@@hughb5092 As Vinsue has mentioned, calcium scores rarely, if ever go down. It's all a part of the natural aging process. So the fact that yours hasn't risen, and actually slightly decreased after 5 years passing, is a testament to the power of nattokinase. You might want to check out Lumbrokinase as well.... >>> ohbaby's substack

@donalkinsella4380 Месяц назад

To remain the same would have been impressive. Reduction is excellent.

@samuelbonacorsi2048 Месяц назад

I realize that the high dose natto atherosclerosis study lacked a control arm, but given that pre and post dosing arterial wall blockage measurements were used, it seems to me that each subject acted as their own control. A physical measurement is a much better assessment than a softer criteria like suffering fewer heart attacks because other factors come into play.

@ohbaby-baby Месяц назад

Plus that study was a follow up study by the authors. They did one earlier that was smaller, and had very similar, beneficial results on atherosclerosis and hyperlipidemia, just as the latter, much larger study did. And whenever you can duplicate outcomes, that is strong evidence the results were authentic... Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022) Clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidemia (July 2017)

@copisetic1104 Месяц назад

The amount of nattokinase they use makes a big difference, a lot of these studies under dose in the studies. I take 22,000f/u a day 11,000 morning and night. NK has a half life of about 12 hours, you have to keep your blood saturation up or the gains are very small. It’s like cleaning a piece of iron in the morning and not putting a rust inhibiter on it by night it’s rusted again. it has absolutely reduced my atherosclerosis. I have the images to prove it. After a year I included 1,500,000 units of lumbrokinase twice a week with 500mg of Berberine morning and night. For angina the best thing is Ouabain. Also you need to be on what I call the trifecta A,D3, K2-Mk7. You need at least 380mcg of K2-Mk7 to have any real effect.

@CommodoreGrayum Месяц назад

lol, the capsules I got to break up any residual spike broteins after having bovid are only 2000 FUs each, I think about 100mg? So you must be taking half a gram twice per day I guess. Had any side effects?

@SniperMonkeh Месяц назад

@@CommodoreGrayum Try Augmented NAC instead. Denatures up to 100% of spike protein. Unless you've already recovered from Covid, I guess it may not be necessary.

@kountchotrifonov4751 Месяц назад

Nattokinase is not only pseudo-science, it is fraud. How is it possible huge protein molecule to pass through the intestinal wall and to enter bloodstream? Only short proteins up to 10 amino acids can eventually pass through the guts. Nattokinase has >250 amino acids - who is saying that monster protein is passing freely through? Pure nonsense and fraud. Mainly fraud.

@gmw3083 Месяц назад

I had powdered Nattokinase a few years ago. 2 kilo bag. I overdosed sometimes. It was hard to measure. There were definitely side effects. It doesn't seem to be available in loose powdered form anymore.

@copisetic1104 Месяц назад

I don’t go by grams with nattokinase or lumbrokinase I go by f/u. I had a thrombosis from my ankle to my hip, was in the hospital for four days with four insertion sites along the leg pumping atp into my leg. The hospital said I’d reached my maximum on this treatment even tho some of the thrombosis was still there I went home and started taking approximately 33,000f/u though out the day and night. The leg hurt so bad I want to vomit every time I got up to urinate. After day two the pain was receding fast so to get the pressure off the leg I started walking chest deep in my pool, and starting on lumbrokinase at the same time. I threw the blood thinners away. Nattokinase has an action that stops inflammation and pain very fast. In a week that leg was 99% normal, I went back for a scan a month later and they couldn’t see any signs of clots at all. They told me I’d probably be on blood thinners the rest of my life, HA. This a front line treatment for thrombosis and blood clots in Japan. I have taken this protocol for two years now and feel great. I’m 75. BTW I have a background in microbiology. I know how to read research it’s my hobby in my retirement years, I pay for and use Ai in my research to go thru hundreds of research papers ever year. I have developed a protocol for CVD and atherosclerosis that works I’m my own lab rat.

@jeromedenis4754 Месяц назад

I've taken Nattokinase and Serrapeptase for over ten years. Not all the time but for a-period-of-time on and a-period-of-time off. I've seen results with both and I do recommend them for the slow healthy ways to reverse some conditions. For instance, my scars are gone. I say gone but the color of some spots where there was scar tissue is still a lighter tone but no bump where there used to be a bump scar tissue. Natural medicine should be included with all medical insurance. Rockefeller has had enough power over human body health. I had a good friend who was an MD and he used to laugh about using vitamins. He died about 7 or 8 years ago of cancer. Who knows, maybe if he had taken preventative supplements he might have never had cancer. I have taken Curcumin with Ginger daily for at least 15 years and have no health issues at 73. I also take no drugs, prescription or otherwise.

@mbarlev Месяц назад

It seems you would have loved to revive your MD friend just to be able to tell him 11000xFUs!

@mattl8774 20 дней назад

I always laugh at MDs who turn their nose up at vitamins. Linus Pauling was one of the greatest scientists of the 20th century and he saw the value in vitamins.

@aliceclearmanphd984 Месяц назад

That bit about the ad!🤣🤣 I greatly appreciate your work. Yours is the ONLY channel where I watch EVERY video - often several times. Thank you for your work! ❤

@Physionic Месяц назад

Thanks, Alice :) missed you at Office Hours! Hope you’re well :)

@aliceclearmanphd984 Месяц назад

@@Physionic Thank you! Yeah, my day got away from me. My loss!

@whitewolf6730 Месяц назад

Well stated.

@kennethyuman1940 Месяц назад

The name nattokinase comes from the Japanese word nattōkin (納豆菌), which is the name for Bacillus subtilis var natto. Nattokinase is an enzyme found in the sticky part of natto, a traditional Japanese food made from fermented soybeans and Bacillus subtilis. In 1980, Japanese researcher Hiroyuki Sumi discovered that natto could dissolve artificial fibrin and extracted an enzyme from it that he named "nattokinase". As it is not a 'kinase', some pronounce it nuttOkines.

@klet7333 Месяц назад

Thank you

@jaymehatfield9540 Месяц назад

My Japanese American friends pronounce it like "gnatto" rhyme with CAT. The way Nick is saying it, wouldn't we translate that as "notto" ? Yeah, Nattokinase Gnat-o-kin-aze

@patrick8128 Месяц назад

I had a TIA seven years ago.My whole right side went numb. By the time we arrived to the ER, it resolved itself except for very minor numbness at the tips of two fingers. Two weeks ago, I had another incident with my left leg becoming half numb as well as a small area on my left side. It stayed with me for two days. I started nattokinase 4000 FU 2 times a day. Within one day, the slight numbness in my fingers all but disappeared, the numbness in my leg also started to lessen - now gone- with the small patch still there in the mornings. I am going to stick with it. I must take baby aspirin so limit the dosage. I believe it works for me.(Arthur Andrew Brand)

@DCGreenZone Месяц назад

Since inflammation is the root cause in much of this, you may find this paper interesting: Serratiopeptidase Attenuates Lipopolysaccharide-Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1

@donalkinsella4380 Месяц назад

I thought serrapeptase was a scam. I took ridiculously high levels for twelve months at a time. Didn't feel any different, but I guess not declining is probably a better marker of it's effectiveness.

@DCGreenZone Месяц назад

@@donalkinsella4380 Google Serrapeptase and WebMD. See how much of a scam it is.

@sarveshwellness 26 дней назад

Chronic Inflammation is the devil for cardiovascular diseases.

@jedwards1792 Месяц назад

To answer your question: I believe there isn’t enough info to conclude Nattokinase is effective, but there is reason to test further at the higher dose, with well designed and controlled studies.

@kathleenking47 Месяц назад

It could, since Natto lowers BP.. only people on blood thinners, need to be careful on nattokinase/natto

@ohbaby-baby Месяц назад

It is effective. It's an official medicine for over a decade in Asian hospitals along with Lumbrokinase. The west is far behind the times. Big Pharma can't have these cheap effective supplements wiping out their blood thinners and statins. Statins are their biggest seller by far... “Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, and to treat cardiovascular diseases in clinical [practice] for more than 10 years." Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury - (nih.gov) (June 2018)

@dextermorgan1 Месяц назад

I've been on bo medicine for years. I started taking Nakk a few weeks ago. My BP is down to 117/75. I haven't taken my BP medicine in a month. It works.

@Shadow1-cf7nw Месяц назад

Your breakdown of this subject was exceptional! I've watched quite a few videos on RU-vid about this, and none were explained as well as yours.

@Physionic Месяц назад

Thanks! I actually felt I could have done a bit better, but I'm always aiming to improve

@Unitedstatesian Месяц назад

Natto is popular with people suffering from LongCovid. It seems to help reduce "microclots" and leads to better outcomes a large cohort. Similar to nicotine patches... It helps 2/3rds of those that try Natto. Timing is important because it needs to be taken on an empty stomach. Some can stand 10k FUs...but I can only take 2000.

@drizler Месяц назад

The FLCCC ( you can Google them yourself) medical group was onto this for Long Covid early on. They also recommend it as a method to help clear the body of the Spike Protein that is In that extremely questionable vaccine🤨

@williamlee6079 Месяц назад

I had sensitive stomach after taking 2000 Fu 2 to 3 times daily before foods for 3 months. That was 2 years ago. I will try again but will take olive/ sesame/ castor 10 minutes after taking it to protect my stomach. How in your case and you cud only take 2000 FU ?

@Unitedstatesian Месяц назад

@@williamlee6079 Natto will affect all kinds of proteins... so it is best to take it when you first get up and to wait an hour before eating anything. I do not know what effect oils would have on absorption or effectiveness.

@williamlee6079 Месяц назад

@@Unitedstatesian ok tks, i will try with the oil to find out, perhaps to post an update in a few months time

@PeteNice29 Месяц назад

That’s because long covid is actually a response to the vax. So, anything to reduce clots is a good idea.

@harold18659 Месяц назад

I can only attest to the benefits of Nattokinase anecdotally. One important thing to note is that Nattokinase is destroyed by stomach acid. I think that is the reason why higher doses are useful. At a high dose some smaller percentage will survive to make it to the bloodstream. I use Nattokinase in conjunction with Natto. The reason is that I will have to eat took much Natto to get the 12,000 fu I need. Natto at this dose will add to much calories to my diet and lead to weight gain. Natto has a slime matrix which preserves the nattokinase from stomach acid and survives it the passage intact. I mix 8000 fu nattokinase powder with 100 grams natto( probably aroung 1400fu/day). I make the natto myself to keep cost down. I can only say how Natto/ Nattokinase has helped me overcome many health problems. The list of benefits are much too long to enumerate here.

@walterjeworski4618 Месяц назад

Natto should be in enteric coated capsules so it survives into the lower intestine

@kountchotrifonov4751 Месяц назад

@harold18659 Месяц назад

@@thomasmuller1850 I couldn't find a reliable supplier. Careful there are a lot of fake nattokinase supplements. Beside Natto gives good microbiome bacteria...a probiotic.

@harold18659 Месяц назад

@@walterjeworski4618 Taking it in the morning before meals helps.

@sharonillenye8036 Месяц назад

the nattokinase I take (Nattovean from Arthur Andrews) says that since it is derived from a food source, it is naturally acid stable so it does not need an enteric coating to protect from stomach acid.

@carlpike9502 Месяц назад

I love your posts! From dismantling and dissecting studies to exposing the RU-vid hacks. I even broke out my old college stat books and watched a few refresher stat vids so I could be mathematically abreast of your findings. So please continue to be that one positive outlier to the right and let the rest endlessly prove The Law of large numbers with their average (or below) work. Thank you! 👍👍👍

@ohbaby-baby Месяц назад

Nick fails to mention Nattokinase has been an official medicinal used in hospitals and clinical settings in Asia for over a decade. You would think that would be important to consider before summarizing it has little to no effect. >>> ohbaby's substack

@beautylover8138 Месяц назад

You can make natto cheaply in large batches and freeze it. Eating about 3.5 ounces daily with mustard (tastes a little better) and provides roughly 20,000 FU of nattokinase. I think it’s a little healthier to eat as a food source rather than as a supplement because it has protein, vitamins K2, minerals, probiotics , nutrient synergy, and fermentation benefits. I’ve been eating this daily for the last year for the following possible benefits: 1. **Cardiovascular Health**: Helps reduce blood pressure and dissolves blood clots. 2. **Bone Health**: Rich in vitamin K2, which supports bone density. 3. **Digestive Health**: Contains probiotics that improve gut health. 4. **Immune Support**: Enhances immune system function.

@Vn-ye3km Месяц назад

But how to skip the smell n the slime

@beautylover8138 Месяц назад

@@Vn-ye3km I throw all my healthy food into five vitamix blenders on Sunday and blend them right before consuming every morning. This is going to sound vile but oddly all the ingredients kind of cancel out how disgusting each one is 😂2 cups of white tea, 3 tablespoons lemon juice, 2 tablespoons apple cider vinegar, 3 ounces natto, 6 sweet Jared beets, 1/4 cup sauerkraut, 1/3 cup kefir, 1 teaspoon olive oil, 1 teaspoon black seed oil, 1 teaspoon cod liver oil, 1 tablespoon of sea moss, fermented papaya, 2 pickled garlic, 1/4 teaspoon kimchi, frozen berries, pineapple, arugula, dandelion, honey, Tumeric ginger shot, kale, frozen broccoli, carrots - been drinking this for over a year and it actually tastes surprisingly really good

@cw9343 Месяц назад

Would you please share your recipe explaining how you make nattokinase?

@m.gilbert1176 Месяц назад

I'm with you concerning the use of natto. Have been eating an ounce a day and my blood is thinner, meaning when I cut myself it takes a little bit longer to clot. The Japanese also discovered that eating Kiwi with natto helps with bone building.

@terrysmith5486 Месяц назад

@@Vn-ye3km Can't do much about the slime but the smell you can just pick premade natto that contains less ammonia. Personally I use Mizkan which is a reddish package, and innoculate batches of soybeans with it. You can check out natto dad's videos on how to make them and which brands to pick.

@blinddudedc Месяц назад

You pronounced it correctly! I wish there was a study done on Nattokinase and serrapeptase.

@consistenc51 Месяц назад

The wife says, all she needs to survive is rice, miso soup and natto.

@forgodsolovedtheworld3389 Месяц назад

The husband disagrees...

@patriciawebb5579 Месяц назад

I love how you say the FU portion with a straight face.😁

@larryharvey7709 Месяц назад

You had it right before. Enunciation on the TOE sound. I’ve been making my own Natto for years. Good stuff. ❤️

@jackijura7728 Месяц назад

Loved the "i'm taken" line. I subscribed b/c of it.

@Berniz123 Месяц назад

Awesome video! I loved your creatine breakdown for kidney function. Could you maybe do a video on ashwaghanda and liver damage? Many people like Peter attia take it but seems there are studies proving it can lead to liver failure

@howardsimmons8981 Месяц назад

After using it along with a 90% plant based diet... I'm happily relieved to report that over a period of 9 months my blood pressure decreased from 165/120 to 138/89 !!!! I hadn't checked my BP in 6 months and didn't expect any changes so I was very thrilled with the results... I even changed the batteries and checked again. Same result. I do exercise and take potassium, magnesium, vitamin K2, D3, zinc, lumbrokinaise as well. Pitched amlodipine and losartan 18 months ago despite the warnings from family and the medical community.

@gazorpazorp9798 Месяц назад

Great video! Thanks for all the hard work. I developed a natto habit while living in Japan for two years. I still eat natto 6 days a week. Love it! Unfortunately it only contains 1400-2000FU per serving. As much as I enjoy it eating 5.5 servings per day is not an option lol! Too bad we can’t get an unbiased study at 11k fu a day.

@wookix Месяц назад

My personal experience is getting a way lower blood pressure. Went from 145/90 to 115/75 in a month. The reason i started taking nattokinase was a discovery of plaques during a CRT scan. They aren't a risk factor yet, but i thought to try this. Will keep taking it for a total of two years and then take another CRT scan. Note: Dosage is low (4,000f/u a day), and i also cut back on sweets.

@anomalousdelirium 20 дней назад

Any progress ?

@pattersonellen 19 дней назад

Let us know after 2 years please?

@SeanAllocca Месяц назад

Thanks for what you do.

@pauleagle6281 Месяц назад

About the dose. The information from one you tube is ... In the high dose study, they also had data on lower dose. There were ~60 participants take 3,600 fu and result is plaque reduction 4%. The high dose of ~11,000 fu(~1,000 participants has plaque reduction 22%.

@jp7357 Месяц назад

Been taking 12000FU for 18 months .. no reduction in FIBRINOGEN ANTIGEN or LP-PLA2 .. although mine were both extremely low. I’m now taking 8000FU … just as an anti coagulant. Safer than aspirin. Ps: excellent insiders today .. SO happy to see it come on my podcast feed.

@Physionic Месяц назад

Thanks, JP. Glad to hear it.

@BMBFilmsMMXII Месяц назад

Very much enjoy your channel, thanks for the content. Any thoughts on the claim that natty-k is good for reversing the effects of/flushing the spike protein from the old vaxy vax?

@dannymajestici6344 Месяц назад

Just became a follower….. I like your short and packed videos I can’t watch all the research that takes two hours to explain I’m not looking to become a scientist lol …. Keep up the good work brother

@Physionic Месяц назад

Totally fair :) Welcome!

@Vn-ye3km Месяц назад

@@Physionic could you pls make a video on the effects of long term use of supplements esp Vit D versus natural sun exposure

@karlhungus5554 Месяц назад

Thanks for the video, Nicolas. (I did not skip the ads.) Have you any information on lumbrokinase? Specifically, the product Boluoke from the company Canada RNA? There's an article titled "Lumbrokinase - An Enzyme for More Than Just Circulatory Health" by Martin Kwok that gives some information on the product, along with the Canada RNA website itself.

@veronicaheaney3464 Месяц назад

Love your pictorials.

@asdf9769 Месяц назад

Good one as always. Consider looking into serrapeptase, which has similar claims made about it (and often you can find nattokinase + serrapeptase combined in a supplement).

@humblecourageous3919 Месяц назад

My own Anecdotal Experience with CAC score results done by a radiologist who had no access to my medical chart (I paid outside of my health care at Kaiser). June 7, 2017 CAC 107 Cholesterol 216 August 5, 2019 CAC 193 Cholesterol 117 Had taken atorvastatin and K2, D3, magnesium for two years. Possibly had been taking bromelain July 2, 2021 CAC 164 Cholesterol 249 Had stopped the atorvastatin but kept taking K2, D3, magnesium for two years. July 10, 2023 CAC 292 Cholesterol 218 Unfortunately I took a tablespoon of lecithin every day for two years to lower cholesterol. I found out later that lecithin may lower your cholesterol but it increases you TMAO which causes plaque. Did not take bromelain. I now take K2, D3, magnesium, and bromelain. My cholesterol at the blood bank in May 2024 was 197. K2, D3, and magnesium without anything to lower cholesterol DID decrease by CAC score from 193 to 164 in two years. It could be the bromelain. But I'm sticking with the K2. K2 MK-7 100 Mcg

@niceadz6164 Месяц назад

Don't worry about cholesterol being high. It's essential for life. If you want to lower cholesterol, then eat 12 oreo cookies a day for 2 weeks... yep it's absurd thing to do but 2x effective as a statin. But equally pointless. For your lipid panel focus on having high HDL and low Triglycerides. LDL Cholesterol ( ldl is just a transporter) only becomes an issue if you are eating sugars, refined carbs or vegetable oils.. all of which cause inflammation. Im no dr but there are plenty here on RU-vid explaining the plaque formation mechanism and blaming LDL is like blaming the firemen for the fire.. because they are always there. Statins are poison and serve no purpose but generate billions every year

@humblecourageous3919 Месяц назад

@@niceadz6164 I've been a 100% vegetarian for 53 years (as has my husband who has a CAC score of 6). I make 98% of our meals using whole grains, beans, lentils, etc. I am 75 but I've never been to the ER, never been hospitalized, never had surgery, never broke a bone. I've been my own guinea pig to find out what stops plaque build up and what increases it. The plaque I now have is not causing any physical problems. I believe that for me it is that my body doesn't make K2 from all the greens I eat as it does for others. (I take probiotics.) I think it is inherited as both parents had heart issues in their 80s. But they weren't vegetarian.

@TheShotenZenjin Месяц назад

Natto does taste delicious once you acquire a taste for it.

@mettejensen8653 12 дней назад

I love the smell of my nattokinase capsules, so I can imagine, it is good

@jefftang3661 Месяц назад

Hey @Physionic, could you consider making a video about AC-11, a cats claw extract claimed to have longevity benefits? Im not sure if it’s necessarily good. Sometimes, don’t we need to expunge older things to keep things refreshed? Apparently, AC-11 reduces transcription degradation/error.

@mballer Месяц назад

Damn dog, you broke his heart. Now he's howling at the neighbors.

@ats89117 Месяц назад

Thousands of FUs to you for putting together this video! ;-)

@Kevin_Street Месяц назад

Thank you so much for this video! I've been taking nattokinase at a low dose, but it sounds like it isn't doing much. Ah well, at least I know now thanks to you!

@KungFuChess Месяц назад

This needs a study of the whole fermented food which has PQQ and other elements not just the isolated nattokinase.

@richardmoeller3143 Месяц назад

I’m using a brand that has multiple enzymes, Natto kinase, serrapeptase, lipase, and protease with 15000 Fu per capsule they each work differently I take eight a day on an empty stomach. I use to only take Natto kinase but switch to this formula because of the other enzymes, I m not sure about reversing plaque, but I think it is possible that it stops progression . My blood pressure is excellent it hasn’t been over 115/70 for a year and I can tell my blood viscosity it better

@STARFLEETC0MMAND Месяц назад

Thanks For The Awesome Videos. ✌️🖖

@JermynDavidson Месяц назад

This video is highly informative.

@jeffg4686 Месяц назад

Definitely dosing, and duration too. Over a period of a year - how about 5 years of that dosing? The dosing is pretty high for effective arterial clearing and people should take that with caution as it is a blood thinner. Don't take too high of doses and don't take with other blood thinners. I don't think it's a strong blood thinner, but at high doses it likely is. I think a big part is having the blood "non sticky" for a long period, and the existing sticky slowly dissolves out. Another big one is omegas, oc. Getting flaxseed oil or hempseed oil in your diet..., or just hte seeds themselves. oc, omegas can be blood thinners too, especially fish oil (not sure of the others), so be careful with combining omegas with nattokinase (especially if in high doses). Oh, and getting the toxins out - and exercise - get your body looking for food - it will find some in your arteries. And Chanca Piedra - but not on same day. It's another blood thinner... Pomegranates have something that reduces plaque. And staying adequate in B vitamins

@geoffreylevens9045 Месяц назад

Did the "large dose" natto group take it as one bolus/day or divided? I've been taking 24000FU/day but divided into 3 doses. Also taking 200 mcg of MK-7 and 45 mg of MK-4. And CIMT about 9 months after 1st one was noticeably improved.

@ohbaby-baby Месяц назад

Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants (Aug. 2022) >>> ohbaby's substack

@MrBilartur Месяц назад

A smart move 😂 great thx 🙏 I saw a study in Poland that it works but only a dose like 12000.

@gasanilu24 Месяц назад

Being a protease or a very complex protein can you explain how it escapes the hydrolization into amino acids in the digestive system. How can it work as an enzyme if when gets to the circulatory system the enzyme has been decomposed into the aminoacids. On the other hand if it is injected how come it doesn't work against other proteins in the body and kills us

@sharonillenye8036 Месяц назад

I started taking nattokinase 2000 FU and for the days I took it I began having my first times of what I could only call angina pain. Not sure if I should give up on it. I also have a high LPa of 486nmol/L and know that LPa mimics plasminogen so not sure if there is something good or bad going on.

@Carbivore67 Месяц назад

There's no reversing death. Just eat natural foods and don't sit for long like my Grammy and you can live to 101 like her.

@quandmeme9970 Месяц назад

No reversing death but stopping and reversing aging.

@openureyes Месяц назад

Great information

@IntuitiveInterpretations Месяц назад

Thank you

@nirajshuklaNL Месяц назад

I'm just commenting cause I haven't commented in a while. Thank you for this video though. I just started taking this about 3 weeks ago. So hard to find this in NL, Canada.

@AI-vs7sm Месяц назад

A better question about nattokinase might be," does lifelong consumption, as per Okinawan/ Japanese population, even at lower dose , account for the vaunted longer lifespan," aka blue zone" effect"? In other words, can it hurt?

@garyr1934 Месяц назад

The company Arthur Andrew’s medical has a product with both Nattokinase and serapeptase It’s branded as Neprinol It helped me tremendously with fibrin deposits from injury scars I was considering surgery then found it

@tracymullane8818 Месяц назад

Interesting, thanks for the tip. I take both nattokinase and serrapeptase and recently had a heart CT scan show zero calcification. Along with that I take D3, K2 and berberine. All good.

@garyr1934 Месяц назад

@@tracymullane8818 this is all great to read Keep going I had my issue with fibrin gone a long time ago but still take the combo as a preventative Maintenance Thanks for replying I take the things that you take as well and I also take all I of the DoNotAge supplements

@tiz6549 Месяц назад

@@tracymullane8818- how much nattokinase & serrapeptase do you take?

@esvajcarac3527 Месяц назад

⁠@@tracymullane8818 could you please give us the dosage of Nattokinase and Serrapetase you are taking?

@Mugwumps107 Месяц назад

Care to expand on that?

@angstvision7108 Месяц назад

It all comes down to belief. Since there's no negative effects from dosing Nattokinase, a person can run the experiment on themselves, especially if they're hypertensive. If you can afford coffee at Starbucks and go for drinks on the weekend, you can more than afford the supplement.

@thomasmuller1850 Месяц назад

Some experienced for example colon bleeding from too much though (200mg).

@brucec2787 Месяц назад

Great work. It all comes down to any possible side effects and cost. Are there negative side effects? If not and you have atherosclerosis that current medicine is clueless on, why not give it a try? High dose seemed to lower my BP about 8-10 points. If I'm around in a couple years to remeasure my CAC and IMT, will decide then.

@streamdungeon5166 Месяц назад

Both my mother and myself had headaches for months above the ears and other problems. Once we took Nattokinase it first got worse for 2 days and then suddenly disappeared. When we take 2000 FU of Nattokinase things just feel a little better. At 4000 FU things start to move in some part of the body somewhere and it usually hurts. This can take 2-3 days before things are suddenly much better. Like a finger that had little feeling since an accident 15 years ago now is recovering quickly to normal levels. Or my mother's cold feet that hurt for a while when being "worked on" by Nattokinase and now are normally warm. The stuff is absolutely crazy.

@ohbaby-baby Месяц назад

Whenever you improve your cardiovascular system, which is the entire point of this enzyme, the benefits can be very wide ranging. I have had improvements with my psoriasis, arthritis, blood oxygen, etc.. With better circulation, more nutrients, more oxygen, reach more cells in the body and will have systemic effects.

@idealstoic Месяц назад

I noticed my dad’s cold hands becoming warm, too, after a while of supplementing with 2000FU almost daily.

@williamlee6079 Месяц назад

Is it 4000 FU once or 3 times daily ? Tks

@williamlee6079 Месяц назад

Is it 4000 FU once or 3 times daily ? Tks

@streamdungeon5166 Месяц назад

@@williamlee6079 2000 FU once or twice per day. I would not go beyond that myself but everybody is different. I once tried 6000 FU and next morning had tons of blood stains on my sheets, because of my Psoriasis.

@KayFlowidity Месяц назад

2:05 👌👌👌 3:30 Fibrin 4:40 Studies 5:35 Lipoprotein 8:55 Atherosclerosis 9:45 Argument 2 10:55 Summary

@DavidPaulNewtonScott Месяц назад

I have you glasses I liked them and they are big so very good at keeping crap out of my eyes.

@AmphibianDev Месяц назад

Can you make a video about HBOT, hyperbaric oxygen therapy?

@patriciawebb5579 Месяц назад

Thanks!

@Physionic Месяц назад

Thank you!

@BillyBoy66 Месяц назад

Dude.... great segue into your ad!

@Physionic Месяц назад

Thanks!

@dpasek1 Месяц назад

There is a suggestion in a web page by the Japan NattoKinase Association, titled "What is Nattokinase?" that states it is best to take nattokinase supplements shortly before bedtime. It seems that YT will not allow direct posting of the link.

@mballer Месяц назад

Hmmmm.... Bacillus natto seems to live in the gut, any studies on live natto supplementation?

@narkybark Месяц назад

I like to hear more about Lumbrokinase, which is supposedly a more powerful version with a slightly different mechanism.

@paigevanpelt1967 Месяц назад

I used this recently, resulting in the resolution of fibrin which had attached to my BD Power Port. However, it might have also dissolved the fibrin in the fibrocartilage in my arthritic knee. After discontinuing lumbrokinase and adding glucosamine I can walk without pain again. Very little information is available about lumbrokinase. I did ask the FDA to look into it further.

@lapislazuli7876 Месяц назад

@@paigevanpelt1967the 3 “ase’s” : natto, Serra, and lumbro all do different things. I wish they’d just do one video telling us how to take all 3, the correct dosages and timing. It’s really hard to watch every clinical study and understand it all, plus very time consuming.

@user-gn8fl1uu4t Месяц назад

I am aware of this research. Now so far I am always sticking to bromelain for other reasons but ultimately I am wondering if these digestive enzymes are not all doing the same.

@matttee1319 Месяц назад

Good thing i was scrolling for other videos during your "ad"

@RoyBruce007 Месяц назад

Could vitamin B3 the flush version clear plaque too? It definitely lowerd my LDL by a great deal. B3 at 1500mg a day for 2 months with 500mg Tudca and 600mg of NAC.

@pamgroetzenbach5812 Месяц назад

Maybe someone can help me with this. Taking NK helped me reverse angina symptoms within days. I also experienced many other positive noticeable effects. Sadly, I also started developing facial acne from it. I know most say that their skin imoroves while taking it, but I am apparently in the fraction of a percent of people who experience this. I can't understand why. Does anyone have an explanation?

@dancarlson8449 Месяц назад

I've been an infusion patient for several years as well as having decades of experience using supplements of all types.....I'm skeptical of anything I ingest these days, proven or not. I also monitor my BP daily and have blood draws/labs at least once a month. I decided to try this supplement for a couple weeks before my infusion/labs. I had several very experienced staff try and draw blood with 14 pokes in all. I am usually a 1 poke guy and good to go. Also, I noticed BP numbers dropping 10 points. I have no other explanation as to what happened other than attributing it to this supplement. I can't tell if my experience was a good thing or a bad thing, but with blood draws being critical in my life, I stopped taking this.

@bobjoatmon1993 Месяц назад

They kept trying inside the elbows? I've had troublesome veins there all my life so I tell the phlebotomist at each draw and they use the back of the hand instead, and it's always one stick, good draw. Try it, a lot less painful in the long run.

@skincraftorganicsllc8537 Месяц назад

Thank you!! Will you be doing a review of the new Ornish study for Alzheimer's??

@barrybockus Месяц назад

My concern is that natokinse is a blood thinner. That means you must be careful about dosage. If you take too much you can have trouble with blood clotting. Dental work, small cuts can become dangerous.0

@dwdwone Месяц назад

Arent there marked differences in effects of nattokinase vs serapeptase vs lumbrokinase? I think one is more preventative and one other leans more towards reversal.

@mwtrolle Месяц назад

Can you look into IBM sickness and what helps to limit its progress?

@richardkudrna7503 Месяц назад

I can say taking clopidrel plus ASA plus two NK I was finding a lot of bruises. Cut back to one capsule and significantly less bruises. Cut ASA and bruises stopped.

@bcc1955 Месяц назад

I'm confused. Why would eating nattokinase or other whole proteins (e.g. bGH from milk) allow them to get into the bloodstream rather than be broken down and inactivated in the digestive system? Is this relying on a leaky digestive system, and if so how consistent would that be in various people.

@exosproudmamabear558 9 дней назад

I have autoimmune ensefalite and take serrapeptase (a similar enzyme to the battokşnase but it passes bbb and have antiinflamatory effects by figesting inflamatory cytokines). My thromboflebits stopped after I started to take it and it has an amazing anxiokytic effects it makes me ferl amazing when I take it but my needle punctures werent healing so I needed to stop. Gonna start taking şt again after iv steroids because it also degregades amiloid plaques and covid spike protein.

@markdr3727 Месяц назад

Thanks for another great video - as a layperson can you explain why a study wouldn’t have a control group, this seems to come up quite a lot and the people doing these studies are obviously highly educated so feel like they must have a reason?

@rookie1514 Месяц назад

The dosing of Natto is as important as when it is taken and the overall diet of the person in question. It is recommended that Natto be taken 20-30 (or longer) minutes before meals or 2-3 hours after. When taken with food it becomes a digestive supplement and most likely would diminish its heart and blood circulation benefits. A person diet rich in sugars and carbohydrates would definitely impact the benefits of taking Natto as this diet triggers artery inflammation. In order to really fully understand the benefits of natto a control group would need to follow the same diets, Natto dosing amounts and timing of the dosing relative to meals.

@jasonbromano Месяц назад

There is another study showing atherosclerosis reversal from nattokinase. Search for the title "A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia" which uses a dose of 6000FU and compares nattokinase to a statin. It probably needs to have more participants but it's certainly data to be considered. I think it also has a couple of the scientists in the positive study you mention in the video involved with it, which is another important factor. However, I think you should check this one out - it may support the idea that the issue is the dose.

@ohbaby-baby Месяц назад

That study is by the same authors of that larger study Nick showed, that he questioned. Both studies had similar results. Any time you can duplicate outcomes, reproduce comparable results, that is strong evidence the results are real, genuine, authentic.

@jasonbromano Месяц назад

@@ohbaby-baby It needs to be duplicated by other scientists, not the same ones. It's nice that they got the same results, but until someone else is able to duplicate them, it could be the result of inherent biases or methodological issues from these people. When I mentioned in my original comment that I thought it had some of the same scientists involved I intended that as a point of caution, which I realize now was not clear on my part.

@ohbaby-baby Месяц назад

@@jasonbromano No, It was clear. And it would be better if other people did the experiment. But it is so rare, that researchers would repeat the same study, using appropriate doses. In both studies they showed, under 3,600 FU's had no effect, and almost all studies on Nattokinase are using doses under that threshold. Yes the authors have ties to a nattokinase pharma company. Sungen is the original research and production enterprise of nattokinase in China. We have nothing like this here in the US. It is a medicinal there. Could you imagine Big Pharma getting behind Nattokinase? It would wipe out there biggest seller (statins). And it should be noted, no one questions the work of these authors. Both studies were peer reviewed and published in established medical journals. Even with the conflicts in interest. Nick questions this. But here's my question. Why is it the majority of studies done in the west, employed very conservative doses? When there is no level of toxicity ever found with Nattokinase? So like Nick said in this video,.... who do you believe? Studies in the west, going out of their way to show no effect using low doses,... or,.... Companies studying a product that is used medicinally in all of Asia, the largest continent on earth? Just look at all the ancedotal reports in this comment section, when using the proper amounts. When you take in all the evidence, and not just 9 studies, the picture is very clear.

@enkidughom2508 Месяц назад

9:55 what was the high dose used in the second experiment?

@Dreamer-dq6tf Месяц назад

10,800 FU

@PostImperfect 25 дней назад

Love your sense of humour 😂

@sandyharman5067 Месяц назад

My sister & I both used natto & nattokinase to rid the body of long Covid. Nutrient form, not all manufactures are reputable. If you have a Japanese market near by, highly recommend eating a pack & using nutrient for 2nd dose. Ex natto AM, capsule PM

@lapislazuli7876 Месяц назад

What about the calories? Even though something is “good” for you doenst mean you can eat large amounts. Olive oil is also good for you but is also high in calories so it’s a problem. It’s about finding the sweet spot and this is why supplementation is crucial. We simply can’t eat each and every food that is “good” for us everyday or we would be consuming too many calories, whether they’re “good” or not. Then weight becomes an issue.

@alansnyder8448 Месяц назад

Serious question here. Do YT content providers get paid more if those of us watching watch the full ad instead of skipping ahead? Occasionally (i.e. 10% of the time) an ad appears that is interesting to me, and if I liked the YT channel like this one, I would consider watching it to completion.

@Physionic Месяц назад

No idea, to be honest.

@unrecovery Месяц назад

The dose means everything… obviously. the first phase and sometimes into the second phase of a clinical trial focus on the dosage efficacy for this reason. Some drugs have different applications depending on the dose size. The way I see it, the high dose studies are promising and natto consumption is shown to be safe with some precautions to be taken (do your research). I personally take 16kFU in the mornings and have been contemplating taking 12kFU before bed. Why not incorporate it into your routine if you can afford it as part of your maintenance?

@karlint39 Месяц назад

For people who just eat natto every day, it would be interesting to know how many FUs are in a 40g portion of store bought natto. In Japan natto is considered a health food, but doctors usually say no more than 3 packs per day, or about 120g of natto.

@xio3857 Месяц назад

question on "high dosing" 😉 what effect does it have on clotting time? even "low dose" contributes to a higher PT/INR.

@1969spp Месяц назад

I didn't realize that endothelial cells "get pushed" out of their normal linear configuration. Is this sorta like the crustal displacement that moves continents? My understanding is that these cells are mechanically exposed and damage secondary to the damage/disappearance of the overlying glycocalyx.

@stacy3581 Месяц назад

Possible it was men vs women on effects for BP? (stronger effect for men) Thought I had read that somewhere about Nattokinase

@davidking3699 Месяц назад

Fibrins are not only seen in arterial clots - throughout the body... Natto seems to be in a similar group with Serrapeptase - which is reputed help break down fibrous materials such as scars - esp. when added in to an active autophagy process - say a 3-5 day fast... wonder if there are studies comparing those similar compounds or other applications for anti-fibrins such as Natto - for joint health, muscle quality etc. ?

@joyoflearning2124 28 дней назад

what about lumbrokinase ? what group do they belong to ?

@not-a-boar3148 Месяц назад

Nice portal reference

@dadpaysproductions Месяц назад

I'd like to know if nattokinase can dissolve a fibroid as it is believed by some.

@louisehay723 Месяц назад

Good video.

@pauleagle6281 Месяц назад

Should i stop baby aspirin once daily. Take nattokinse 4,000 u for two time a day instead?

@vojkostar Месяц назад

Combination with serapeptase, can you check?

@dr.julia-heyakarcic8862 Месяц назад

Since natto is a daily staple of the Japanese diet I would like to know the following: What is the preponderance of atherosclerosis among the Japanese, what concentration of nattokinase is consumed in daily Japanese food? Finally, how best could someone living in the US obtain natto for consumption in food?

@Mrcleanmo 5 дней назад

Asian store

@texaslovelylady Месяц назад

I took it once for the anticoagulant abilities but having natural low blood pressure it was not good. Maybe the dosage was too high. Maybe I will try Natto the food from Japan 🇯🇵🗾 before totally thinking it's not for me.

@BillyBulletPewPew Месяц назад

Effects even if miniscule is an effect; people have unrealistic expectations for things when hoping for the outcomes to be in there favor in trials. But here's the thing, throwing multiple tools in your tool box can have a compounding effect.

@Physionic Месяц назад

Sometimes, but not everyone can afford 500$ a month of supplements :)

@BillyBulletPewPew Месяц назад

@Physionic that's true. Good point. Personally, I rotate things around, because I can't afford all my supplement wants either. I appreciate your videos.

@TorqueMonsterAWD Месяц назад

Exactly! What is pharma going on the benefits of statins, 1%.

@ohbaby-baby Месяц назад

@@Physionic $500 a month? Are you crazy? Where do you come up with such a figure? You trying to scare people off very safe supplements? I take a ton of sups, so I know that figure is out of left field and misleading. You won't even spend $100 a month. Nattokinase, D3, Mk-7, Mg, Multi, Iodine, NAC, probiotics, garlic (allicin). On average, these sups costs you $5 per month. 9 sups $45. Amazon, iHerb, etc...

11:13

4 Factors that Clear Plaque in your Arteries

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