NeoFox: Foxy-5, a WNT5A mimicking peptide, in stage II/III colon cancer 

Ramon Salazar, MD, PhD, Institut Català D'Oncologia, Barcelona, Spain, discusses the Phase II NeoFox study (2018-003074-27) of Foxy-5, a WNT5A mimicking peptide, in stage II/III colon cancer. In the trial, Foxy-5 significantly reduced venous and perineural invasion and increased TNM downstaging. Foxy-5 additionally was well tolerated and had an acceptable safety profile. These findings suggest Foxy-5 may enhance patient outcomes and warrant further prospective validation. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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