Neuromuscular Blocking Agents 

Wow this was so easy to understand! You literally made medicine so much more interesting 🔥

In depolarizing one why did the sodium gates remain opened and if sodium influx takes place then intracellular membrane potential will be positive so how did the persistent depolarisation will take place While in non depolarizing one you told that drug will block the binding of ach along with closing of sodium gates

This was such a great explanation! Thank you.

honestly very well made and explained

Hello! SRNA here! We are currently learning that one of the mechanisms behind the decreasing amplitude in TOF twitches has to do with the NDMR blocking a n-ACh-R auto-receptor on the motor neuron. This blocking inhibits the movement of VP1 ACh vesicles to VP2 position thereby decreasing the amount of ACh released with each impulse. Here in the video it is saying that the NDMR is blocking ChT (Choline transporter) and blocking the uptake of choline into the cell, thereby decreasing the actual production of ACh. Just wondering if you can tell me which is correct or maybe it is a combination of the two?

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Very helpful, thank a lot

Was part 3 ever made? I cannot find the video about the antidotes.

Thank u

Great video!

Thanks a lot 🥺💗

Very helpful

Why depolarizing neuromuscular agent act on post synaptic and Non depolarizing act on pre synaptic

Depolarizing nmb's are the agonist bind with receptor and sodium channel gets open and sodium influx take place.Intra cellular charge become possitive.Then how skeletal muscle relaxation take place. Ach also depolarize cell. How its happen?

thank you

Great, ty

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👏🏻👏🏻👏🏻

Sooooo great!